아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

골관절염 환자에서 관절내 Sodium Hyaluronate(Hyruan®)의 투여가 슬관절통에 미치는 영향

김훈정,임경준,위상우,정종달,유벙식,안태훈,소금영 조선대학교 2000 The Medical Journal of Chosun University Vol.25 No.2

Background : Sodium Hyaluronate has been found to be deficient in the synovial fluid of patients with osteoarthritis. We evaluate the effect of intraarticular Sodium Hyaluronate(Hyruan®) on the knee joint pain in patients with osteoarthritis. Method : Ten patients with osteoarthritis of the knee were participated in this study. Sodium Hyaluronate was injected into knee joints weekly for 5 weeks consecutively. Clinical evaluations were performed using visual analogue scale(VAS) for pain, tenderness and swollen joint counts weekly for the first 5 weeks and at 10 weeks postinjection. Result : VAS, tenderness and swollen joint were all significantly improved from 2 weeks to 10 weeks. There was no complication, except pain on injection site in two patients. Conclusion : Intraarticular injection of Sodium Hyaluronate has been shown to be effective on the treatment of patients with osteoarthritis of the knee.

아젭틴 정(염산아젤라스틴 1 mg)에 대한 아젤라 정의 생물학적 동등성

조혜영,윤지훈,서유리,오인준,이성관,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Azelastine, a phthalazinone derivative, is an antiallergic agent which demonstrates histamine H_1-receptor antagonist activity and also inhibits histamine release from mast cells following antigen and non-antigen stimuli. Thus, azelastine may be useful in the management of both asthma and allergic disorders. The purpose of the present study was to evaluate the bioequivalence of two azelastine hydrochloride tablets, Azeptin^TM (Bu Kwang Pharmaceutical Co., Ltd.) and Azela^TM (Kyung Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 22.44±2.01 years in age and 61.99±6.18㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After two tablets containing 1㎎ of azelastine hydrochloride per tablet were orally administered, blood was taken at predetermined time intervals and the concentrations of azelastine in serum were determined using HPLC with fluorescence detector. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were -6.45%, -2.60% and -7.14%, respectively, when calculated against the Azeptin^TM tablet. The powers (1-β) for AUC_t and C_max were 96.65% and 88.47%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 14.40% and 17.65% for AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -14.87∼1.97 and -12.92∼7.72 for AUC_t and C_max respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Azela^TM tablet is bioequivalent to Azeptin^TM tablet.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

A Study on the Refresher Training of Physical Therapist in Gwangju and Jeonnam

Yu, Seong-Hun,Kim, Seung-Rae,Cho, Sung-Hyoun,Jang, Il-Yong,Hwang, Jin-Ah,Kim, Yong-Seong,Kim, Hyun-Jin The Korean Society of Physical Therapy 2016 대한물리치료학회지 Vol.28 No.3

Purpose: The current study seeks to examine the continuing education of physical therapist in Gwangju, Jeonnam. Methods: A survey was conducted during the continuing education of physical therapist held in Gwangju in 2015 with 297 participants. The survey questionnaire consisted of 13 questions on characteristics of physical therapist, 7 questions on the level of satisfaction with continuing education, 11 questions regarding the need for continuing education, and 8 questions concerning how to improve continuing education. Results: As for the level of satisfaction with the content of continuing education, the survey results indicated that there were significant differences across respondents' age and career period. Regarding the level of satisfaction with the environment in which continuing education was provided; significant differences were observed across respondents' age, education, marital status, monthly pay, career period, and service period. Regarding the level of satisfaction with the expense in which continuing education was provided; significant differences were observed across respondents' sex, age, education, marital status, dependent family, monthly pay, career period, and position. In terms of the level of satisfaction with the operation method in which continuing education was carried out, there were significant differences across respondents' age, education, and career period. Conclusion: The survey found the level of satisfaction with continuing education to be average among physical therapist in Gwangju and Jeonnam. In addition, as for ways to take continuing education courses for those who have never taken it, online education was mentioned the most. Therefore, there is a need for advertising online continuing education.

A Study on the Refresher Training of Physical Therapist in Gwangju and Jeonnam

( Seong-hun Yu ),( Seung-rae Kim ),( Sung-hyoun Cho ),( Il-yong Jang ),( Jin-ah Hwang ),( Yong-seong Kim ),( Hyun-jin Kim ) 대한물리치료학회 2016 대한물리치료학회지 Vol.28 No.3

Purpose: The current study seeks to examine the continuing education of physical therapist in Gwangju, Jeonnam. Methods: A survey was conducted during the continuing education of physical therapist held in Gwangju in 2015 with 297 participants. The survey questionnaire consisted of 13 questions on characteristics of physical therapist, 7 questions on the level of satisfaction with continuing education, 11 questions regarding the need for continuing education, and 8 questions concerning how to improve continuing education. Results: As for the level of satisfaction with the content of continuing education, the survey results indicated that there were significant differences across respondents` age and career period. Regarding the level of satisfaction with the environment in which continuing education was provided; significant differences were observed across respondents` age, education, marital status, monthly pay, career period, and service period. Regarding the level of satisfaction with the expense in which continuing education was provided; significant differences were observed across respondents` sex, age, education, marital status, dependent family, monthly pay, career period, and position. In terms of the level of satisfaction with the operation method in which continuing education was carried out, there were significant differences across respondents` age, education, and career period. Conclusion: The survey found the level of satisfaction with continuing education to be average among physical therapist in Gwangju and Jeonnam. In addition, as for ways to take continuing education courses for those who have never taken it, online education was mentioned the most. Therefore, there is a need for advertising online continuing education.

연구논트: 협동조합 사례 : 도시빈민을 위한 가톨릭 협동조합운동인 명례방협동조합

유영훈 ( Yong Hun Yu ) 한국협동조합학회 2015 韓國協同組合硏究 Vol.33 No.2

Myeong-Nae-Bang Cooperative was established for the urban poor as an outcome of the Catholic Church`s interest in the community rehabilitation and self-reliance through cooperative movements in the poor areas of Seoul. However, there is a need to come up with a practical resolution on the following problems in order to achieve future growth and to fulfill the spirit of the establishment: lack of various educational projects; backing up the start of new cooperatives; diversifying of selling items; marketing activities; and switching to the legitimate business.

표면거칠기 변수에 따른 커플링 모델의 접촉강성에 관한 연구

유용훈(Yong-Hun Yu),이보라(Bo-Ra Lee),이현철(Hyeon-Cheol Lee),조용주(Yong-Joo Cho),김영철(Yong-Cheol Kim) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11

Abnormal Chloroplast Development and Growth Inhibition in Rice Thioredoxin m Knock-Down Plants.

Chi, Yong Hun,Moon, Jeong Chan,Park, Jin Ho,Kim, Ho-Seung,Zulfugarov, Ismayil S,Fanata, Wahyu Indra,Jang, Ho Hee,Lee, Jung Ro,Lee, Young Mee,Kim, Sun Tae,Chung, Yong-Yoon,Lim, Chae Oh,Kim, Jae-Yean,Yu American Society of Plant Physiologists 2008 Plant Physiology Vol.148 No.2

<P>Plant cells contain several thioredoxin isoforms that are characterized by subcellular localization and substrate specificity. Here, we describe the functional characterization of a rice (Oryza sativa) thioredoxin m isoform (Ostrxm) using a reverse genetics technique. Ostrxm showed green tissue-specific and light-responsive mRNA expression. Ostrxm was localized in chloroplasts of rice mesophyll cells, and the recombinant protein showed dithiothreitol-dependent insulin beta-chain reduction activity in vitro. RNA interference (RNAi) of Ostrxm resulted in rice plants with developmental defects, including semidwarfism, pale-green leaves, abnormal chloroplast structure, and reduced carotenoid and chlorophyll content. Ostrxm RNAi plants showed remarkably decreased F(v)/F(m) values under high irradiance conditions (1,000 mumol m(-2) s(-1)) with delayed recovery. Two-dimensional electrophoresis and matrix-assisted laser-desorption/ionization time-of-flight analysis showed that the levels of several chloroplast proteins critical for photosynthesis and biogenesis were significantly decreased in Ostrxm RNAi plants. Furthermore, 2-Cys peroxiredoxin, a known target of thioredoxin, was present in oxidized forms, and hydrogen peroxide levels were increased in Ostrxm RNAi plants. The pleiotropic effects of Ostrxm RNAi suggest that Ostrxm plays an important role in the redox regulation of chloroplast target proteins involved in diverse physiological functions.</P>

한국(韓國)의 문화(文化) : 프란치스코 교황 방한의 의미와 해석

유영훈 ( Hun Yu Yong ) 한국사상문화학회 2014 韓國思想과 文化 Vol.75 No.-

본 연구는 최근 한국을 방문한 프란치스코 교황의 방문이 한국 가톨릭교회는 물론 한국사회에 미친 의미를 역사적 내용의 파악에 유용한 현상학적인 방법으로 고찰하여 봄으로써 교황 방한이 한국사회 전반에 미친 영향을 해석해보고자 한다. 교황은 귀국 후 첫 일반알현 훈화에서 이번 사도(使徒) 방문(訪問)의 의미를 “기억, 희망, 증언, 이 세 단어로 요약”하였다. 한국의 놀라운 발전상과 훌륭한 국민성을 기억하고, 평신도들의 으뜸 역할을 기억하며 이러한 과거 증인들에 대한 기억은 현재를 위한 새로운 증언이 되며 미래를 위한 희망이 된다는 것이다. 교황의 방한은 한국사회에 가톨릭에 대한 호감을 크게 높였다. 그러나 그만큼 한국 가톨릭교회의 어깨가 무거워졌다. 현재 한국사회에서의 가톨릭의 입지가 올라간 것은 한국 가톨릭의 노력의 결과라기보다는 프란치스코 교황의 모습의 투영(投影)이다. 이제는 한국 가톨릭교회가 나서서 프란치스코 교황이 몸소 보여준 바와 같이 가난한 이들을 위한 교회, 가난한 교회를 만들어가야 한다. 스스로 쇄신하여 사회복지, 인권, 등 가난하고 소외된 이들에게 더욱 다가서는 활동, 즉 사회복음화(社會福音化) 활동에 더 적극적으로 나서야 한다. 이런 활동에 정치, 경제, 사회 활동에 직접 참여하는 평신도들의 역할이 크다. The purpose of this study is to interpret what effect Pope Francis`s recent visit to South Korea has on Korean Catholic Church as well as Korean Society, with a method of phenomenology that is useful to figure out the historical facts. After returning home, Pope has summarized the meaning of this Apostolic Visit in his first General Audience address with these three words: memory, hope, and witness. That is to remember the amazing developments and excellent Korean traits and to remember the first role of the laity. These memories of the past witness is to become a new testimony for the present and a hope for the future. Through Papal visit, most Koreans have favorable impression on Catholics. But a heavy responsibility fell on shoulders of the Korean Church. The reason of raising solid ground of Catholic Church in Korea at the moment can be translated as a reflection of the Pope Francis rather than the result of the efforts of the Korean Catholics. Now is the time for the Korean Catholic Church to make a church for the poor, a poor church as shown by Pope Francis. It has to renew itself for social evangelization including social welfare and human rights, so that it can step forward to the poor and the marginalized. Involved in politics, economy, and society, the laity has to take the major role.