정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

Brine Shrimp Bioassay를 이용한 해양생물의 세포독성검색

손병화,조용진,이대령,노연숙,이선미,최홍대 동의대학교 기초과학연구소 1994 基礎科學硏究論文集 Vol.4 No.1

As a part of chemical study on the bioactive metabolites from marine organisms, we have investigated cytotoxicity using brine shrimp bioassay for each solvent fractions of the marine algae(12 species), marine sponges(3 species), coelenterates(2 species), echinoderms(4 species), marine molluscs(17 species), and ascidians(2 species), respectively. As the results, chloroform extract of Stichopus japonicus (LC_50 : 274 ㎍/ml), ethyl acetate extract of Anthocidaris crassispina(LC_50 : 121 ㎍/ml), n-butanol extract of Undaria pinnatifida (LC_50 : 178 ㎍/ml), and water extract of Thais clavigera (LC_50 : 61 ㎍/ml), displayed the most significant cytotoxic activity against brine shrimp. Among the marine organisms tested, echinoderms and marine molluscs were thought to be the most active Phylums on screening of new bioactive compounds.

입시제도의 변화 : 누가 서울대학교에 들어오는가?

김광억,김대일,서이종,이창용 서울대학교 사회과학연구원 2003 한국사회과학 Vol.25 No.1-2

본 연구는 지난 30년간 서울대학교 사회과학대학 신입생들의 학생기록카드로부터 입학생의 출신지역, 부모학력 및 직업에 대한 Database를 구축하고, 이를 바탕으로 출신 지역별, 부모 학력 및 직업별 입학률 및 대학성적을 비교 분석하였다 본 자료의 구축과 연구는 그간 실증근거의 부족으로 인해 탁상공론에 그쳐왔던 교육성과 및 정책에 대한 논의에 대해 과학적 실증근거의 중요성을 강조하려는 목적으로 수행되었다. 본 연구에 의하면 부모 학력 및 직업에 따른 자녀의 입학률 격차가 확대되고 있으며 서울의 강남8학군 부유층 자녀의 입학률 프리미엄도 뚜렷하게 추정된다. 이는 그간 평준화 정책을 통해 교육기회의 평등을 추구하였음에도 불구하고 소득에 따른 자녀 입학률 격차가 확대되어 가고 있음을 시사한다 또한 이는 공교육 부실에 따라 사교육의 비중이 증가하고 있음을 반영하는 결과로서 이러한 문제를 개선하기 위해서는 평준화 정책의 수정 등 공교육 정상화를 위한 다방면의 노력이 요구되는 것으로 평가된다. This study analyses the admission rates and academic performance of the students in the Social Science Division of Seoul National University by their regional snd parental characteristics based on the database constructed from the past 30-year records of the students personal cards. Both the construction of the database and its analysis are motivated by the lack of the empirical evidence on educational performance in Korea, which has so far failed to lead various arguments on educational policies to any consensus. The results indicate that the differentials in admission rates by the parents'education and jobs have been widening and also that the admission rate has remained high among those residing in the relatively affluent Gangnam 8th school zone of Seoul. These imply that the differential by the parents'income has been widening despite the equalization policy in high school education that is supposed to have offered equal educational opportunities to the rich and the poor. The widening income-differential in admission rates appears to reflect that expensive private tutoring has become increasingly more important given the deterioration of public education. As a consequence, various efforts appear due, including the revision of the equalization policy, in order to substantially improve the performance of public education in Korea.

RC 프레임면내 조적채움벽의 내진성능 평가에 관한 실험적 연구

이정한,차승렬,강대언,오상훈,이용재,이원호,김상대 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The objectives of this study are 1) to find out the shear behavior and shear capacity of RC bare frames, brick-infilled RC frames, 2) to evaluate the equation of the shear capacity of two types of RC frames by comparison the Japanese Standard and modified equation adopting the test results. The main variable is the absence of brick infill wall. The test results show that the shear capacity of specimen IF-4.2 is 2.3 times as high as that of the specimen IF-4.2.The shear behavior of RC bare frame which is governed by predominant flexural yielding is changed to predominant shear yielding by affection of the brick infill wall. A comparison of the results obtained by the Japanese Standard equation and the modified equation to the test data indicates that the proposed equation is compatible with the test results.

Clinical Practice Guideline for the Diagnosis and Treatment of Pediatric Obesity: Recommendations from the Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology Hepatology and Nutrition

Dae Yong Yi,Soon Chul Kim,Ji Hyuk Lee,Eun Hye Lee,Jae Young Kim,Yong Joo Kim,Ki Soo Kang,Jeana Hong,Jung Ok Shim,Yoon Lee,강빈,Yeoun Joo Lee,Mi Jin Kim,Jin Soo Moon,Hong Koh,JeongAe You,Young-Sook Kwak 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.1

The Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition newly developed the first Korean Guideline on the Diagnosis and Treatment of Obesity in Children and Adolescents to deliver an evidence-based systematic approach to childhood obesity in South Korea. The following areas were systematically reviewed, especially on the basis of all available references published in South Korea and worldwide, and new guidelines were established in each area with the strength of recommendations based on the levels of evidence: 1) definition and diagnosis of overweight and obesity in children and adolescents; 2) principles of treatment of pediatric obesity; 3) behavioral interventions for children and adolescents with obesity, including diet, exercise, lifestyle, and mental health; 4) pharmacotherapy; and 5) bariatric surgery.

Enteral Nutrition in Pediatric Patients

Dae Yong Yi 대한소아소화기영양학회 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.1

Pediatric patients require specialized attention and have diverse demands for proper growth and development, and thus need a different approach and interest in nutritional assessment and supply. Enteral nutrition is the most basic and important method of nutritional intervention, and its indications should be identified. Also, the sites, modes, types, and timing of nutritional intervention according to the patient’s condition should be determined. In addition, various complications associated with enteral nutrition supply should be identified, and prevention and treatment are required. This approach to enteral nutrition and proper administration can help in the proper growth and recovery of pediatric patients with nutritional imbalances or nutritional needs.

Clinical Practice Guideline for the Diagnosis and Treatment of Pediatric Obesity: Recommendations from the Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology Hepatology and Nutrition

Yi, Dae Yong,Kim, Soon Chul,Lee, Ji Hyuk,Lee, Eun Hye,Kim, Jae Young,Kim, Yong Joo,Kang, Ki Soo,Hong, Jeana,Shim, Jung Ok,Lee, Yoon,Kang, Ben,Lee, Yeoun Joo,Kim, Mi Jin,Moon, Jin Soo,Koh, Hong,You, Je The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.1

The Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition newly developed the first Korean Guideline on the Diagnosis and Treatment of Obesity in Children and Adolescents to deliver an evidence-based systematic approach to childhood obesity in South Korea. The following areas were systematically reviewed, especially on the basis of all available references published in South Korea and worldwide, and new guidelines were established in each area with the strength of recommendations based on the levels of evidence: 1) definition and diagnosis of overweight and obesity in children and adolescents; 2) principles of treatment of pediatric obesity; 3) behavioral interventions for children and adolescents with obesity, including diet, exercise, lifestyle, and mental health; 4) pharmacotherapy; and 5) bariatric surgery.

Clinical practice guideline for the diagnosis and treatment of pediatric obesity: recommendations from the Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology Hepatology and Nutrition

Dae Yong Yi,Soon Chul Kim,Ji Hyuk Lee,이은혜,Jae Young Kim,Yong Joo Kim,Ki Soo Kang,Jeana Hong,Jung Ok Shim,Yoon Lee,강빈,이연주,Mi Jin Kim,문진수,Hong Koh,JeongAe You,Young-Sook Kwak,Hyunjung Lim,Hye Ran Yang 대한소아청소년과학회 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.1

The Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition newly developed the first Korean Guideline on the Diagnosis and Treatment of Obesity in Children and Adolescents to deliver an evidence-based systematic approach to childhood obesity in South Korea. The following areas were systematically reviewed, especially on the basis of all available references published in South Korea and worldwide, and new guidelines were established in each area with the strength of recommendations based on the levels of evidence: (1) definition and diagnosis of overweight and obesity in children and adolescents; (2) principles of treatment of pediatric obesity; (3) behavioral interventions for children and adolescents with obesity, including diet, exercise, lifestyle, and mental health; (4) pharmacotherapy; and (5) bariatric surgery.

Clinical practice guideline for the diagnosis and treatment of pediatric obesity: recommendations from the Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology Hepatology and Nutrition

Yi, Dae Yong,Kim, Soon Chul,Lee, Ji Hyuk,Lee, Eun Hye,Kim, Jae Young,Kim, Yong Joo,Kang, Ki Soo,Hong, Jeana,Shim, Jung Ok,Lee, Yoon,Kang, Ben,Lee, Yeoun Joo,Kim, Mi Jin,Moon, Jin Soo,Koh, Hong,You, Je The Korean Pediatric Society 2019 Clinical and Experimental Pediatrics (CEP) Vol.62 No.1

The Committee on Pediatric Obesity of the Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition newly developed the first Korean Guideline on the Diagnosis and Treatment of Obesity in Children and Adolescents to deliver an evidence-based systematic approach to childhood obesity in South Korea. The following areas were systematically reviewed, especially on the basis of all available references published in South Korea and worldwide, and new guidelines were established in each area with the strength of recommendations based on the levels of evidence: (1) definition and diagnosis of overweight and obesity in children and adolescents; (2) principles of treatment of pediatric obesity; (3) behavioral interventions for children and adolescents with obesity, including diet, exercise, lifestyle, and mental health; (4) pharmacotherapy; and (5) bariatric surgery.

Enteral Nutrition in Pediatric Patients

Yi, Dae Yong The Korean Society of Pediatric Gastroenterology 2018 Pediatric gastroenterology, hepatology & nutrition Vol.21 No.1

Pediatric patients require specialized attention and have diverse demands for proper growth and development, and thus need a different approach and interest in nutritional assessment and supply. Enteral nutrition is the most basic and important method of nutritional intervention, and its indications should be identified. Also, the sites, modes, types, and timing of nutritional intervention according to the patient's condition should be determined. In addition, various complications associated with enteral nutrition supply should be identified, and prevention and treatment are required. This approach to enteral nutrition and proper administration can help in the proper growth and recovery of pediatric patients with nutritional imbalances or nutritional needs.