미더덕의 지질 및 Ex분중의 유리아미노산에 관한 연구

鄭玉姬,沈貞淑 新羅大學校 1983 論文集 Vol.14 No.-

우리나라 남해안 지방의 향토식품으로 즐겨먹는 미더덕의 지질의 특성과 Ex분중의 유리아미노산의 조성을 분석한 결과는 다음과 같다. 1. 미더덕의 조지질 함량은 1.6%였고 IV는 157이었다. 2. TLC에 의한 지질의 조성은 원점에서부터 polalipid, monoglyceride, sterol, tryglyceride의 순으로 나타났다. 3. 미더덕의 총지방산조성은 ??(17.26), ??(17.49), ??(14.27)순으로 가장 많았다. 4. 미더덕 중성지질의 지방산은 ??(23.57%), ??(14.33%), ??(14.0%)이 主된 조성이었고 극성지질의 지방산은 ??(20.82%), ??(11.66%), ??(11.19%)가 가장 많은 것으로 나타났다. 5. 미더덕 지질의 총 지방산 중에는 포화지방산이 22.92%, monoenoic 지방산이 32.89%, polyenoic 지방산이 42.02%이었고 6. 미더덕지질의 중성지질과 극성지질의 지방산 중에는 포화지방산이 각각 43.14%, 30.67%, monoenoic지방산이 각각 30.43%, 18.25%, polyenoic 지방산이 각각 26.43%, 50.22%,였다. 7. 미더덕 Ex분중의 유리아미노산의 주된 조성은 glycine 28.92%, alanine 19.62%, glutamic acid 14.33%, proline 9.57%으로 나타났다. This study was aimed to investigate the lipid and free amino acid components in mideuduck which is one of the local foods offered in the south coast of Korea. The results of the investigation are as follows: 1. Total lipid components contained in mideuduck is 16% and the Iodine Value is 157. 2. The lipids components by TLC is in order of polar lipids, monoglyceride, sterol and triglyceride from the baseline. 3. The total fatty acids composition in mideuduck is in order of ??(17.26%), ??(17.49%), ??(14.27%). 4. The fatty acids of neutral lipids in mideuduck consist mainly of ??(23.57%), ??(14.33%), ??(14.0%). The fatty acid of polarlipids consist mainly of ??(20.82%), ??(11.66%), and ??(11.19%) 5. The fatty acids in mideuduck consist of 22.92% saturated fatty acids, 32.89% monoenoic fatty acids, and 42.02% polyenoic fatty acids. 6. The components of neutral lipids and polar lipids in mideuduck are 43.14% and 30.67% saturated fatty acids, 30.43% and 18.25% monoenoic fatty acids, and 26.43% and 50.22% polyenoic fatty acids resectively. 7. The main components of free amino acids in the extract of mideuduck are 28.92% glycine, 19.62% alanine, 14.33% glutamic acid and 9.57% proline.

山椒脂質의 脂肪酸 組成에 관한 硏究

鄭玉姬,沈貞淑 新羅大學校 1983 論文集 Vol.14 No.-

우리가 추어탕의 향신료로서 애용하고 있는 산초 지질을 과피와 알맹이로 분류하여 실험 조사한 결과는 아래와 같다. 1. 산초의 지질량은 과피가 5.81%, 알맹이가 1.43%였다. 2. 산초 지질의 IV는 과피가 135, 알맹이가 101였다. 3. 산초 지질의 조성은 과피가 polarlipid, monoglyceride sterol, free fatty acid, triglyceride, sterol ester의 순으로 나타났으며, 알맹이는 polar lipid, sterol, trglyceride, stetolester, hydrocarbon순으로 나타났다. 4. 산초 지질의 총지방산은 과피에선 ??(30.2%), ??(17.6%), ??(9.9%)가 주된 지방산이었고, 알맹이에선 ??(26.4%), ??(20.5%), ??(18.6%)의 순으로 나타났다. 산초의 중성지질의 지방산은 과피에선 ??(42.5%), ??(11.0%), ??(10.6%)가 主된 조성이었고, 알맹이에선 ??(26.7%), ??(23.0), ??(20.0%)가 주된 지방산이었다. 6. 산초의 극성지질의 지방산은 과피에선 ??(35.5%), ??(17.4%), ??(13.9%)가 주된 지방산이었고, 산초 알맹이에선 ??(33.7%), ??(16.1%), ??(11.7%)가 주된 지방산이었다. 7. 산초 과피의 불포화지방산의 함량은 총지질 지방산에서 61.0% 중성지질 지방산에서 74.3%, 극성지질 지방산에서 75.2%였고, 산초 알맹이의 불포화지방산 함량은 총지질 지방산이 68.3%, 중성지질 지방산이 65.3%, 극성지질 지방산이 42.4%였다. The purpose of the study is to investigate the lipids of Zanthoxylum schinifolium which is widely used as a perfuming condiment for Chueutang. As concerns the lipids, the Zanthoxylum Schinifolium is classified into the husk and seed. The results of investigation are as follows: 1. The lipids contents of Zanthoxylum Schinifolium are 5.81% in the husk and 1.43% in the seed. 2. The Iodine Values of Zanthoxylum Schinifolium lipids are 135 in the husk and 101 in the seed. 3. The components of Zanthoxylum Schinifolium lipids contained in the husk are in order of polar lipids, monoglyceride, sterol, free fatty acid, triglyceride and sterol ester. In the case of the seed, it is in order of polar lipids, sterol, triglyceride, sterol ester, and hydrocarbon. 4. The main composition of total fatty acids in the Zanthoxylum Schinifolium husk in order of ??(30.2%), ??(17.6%), and ??(9.9%). The composition of the seed is in order of ??(26.4%), ??(20.5%) and ??(18.6%). 5. The fatty acids of neutral lipids in Zanthoxylum Schinifolium consist mainly of ??(42.5%), ??(11.0%) and ??(10.6%) in the case of husk and ??(26.7%), ??(23.0%), and ??(20.2%) in the case of seed. 6. As for as the fatty acids of polar lipids are concerned, the husk contains mainly ??(35.5%), ??(17.4%), and ??(13.9%), and the need ??(33.7%), ??(16.1%) and ??(11.7%) respectively. 7. The contents of unsaturated fatty acids contained in the husk of Zanthoxylum Schinifolium are 61.1% in the total lipids, 74.3% in the neutral lipids and 75.2% in the polar lipids. The investigation of the seed reveals 68.3%, 65.3% and 42.4% respectively.

Increased Cutaneous Lymphocyte Antigen(CLA)+T Cells in the Peripheral Blood of Children with Severe Atopic Dermatitis

Shim, Jung-Yeon,Lee, So-Yeon,Kim, Hyo-Bin,Kim, Bong-Seong,Kim, Ja-Hyung,Seo, Ji-Hye,Jang, Seong-Ok,Jung, Seo-Hee,Hong, Soo-Jong 대한 소아알레르기 및 호흡기학회 2004 소아알레르기 및 호흡기학회지 Vol.14 No.2

Recent Advance in Very Early Onset Inflammatory Bowel Disease

Shim, Jung Ok The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.1

Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-onset IBD has distinct phenotypic differences compared with adult-onset IBD. In particular, very early-onset IBD (VEO-IBD) differs in many aspects, including the disease type, location of the lesions, disease behavior, and genetically attributable risks. Several genetic defects that disturb intestinal epithelial barrier function or affect immune function have been noted in these patients from the young age groups. In incidence of pediatric IBD in Korea has been increasing since the early 2000s. Neonatal or infantile-onset IBD develops in less than 1% of pediatric patients. Children with "neonatal IBD" or "infantile-onset IBD" have higher rates of affected first-degree relatives, severe disease course, and a high rate of resistance to immunosuppressive treatment. The suspicion of a monogenic cause of VEO-IBD was first confirmed by the discovery of mutations in the genes encoding the interleukin 10 (IL-10) receptors that cause impaired IL-10 signaling. Patients with such mutations typically presented with perianal fistulae, shows a poor response to medical management, and require early surgical interventions in the first year of life. To date, 60 monogenic defects have been identified in children with IBD-like phenotypes. The majority of monogenic defects presents before 6 years of age, and many present before 1 year of age. Next generation sequencing could become an important diagnostic tool in children with suspected genetic defects especially in children with VEO-IBD with severe disease phenotypes. VEO-IBD is a phenotypically and genetically distinct disease entity from adult-onset or older pediatric IBD.

The Long-Term Effect of Early Anti-Tumor Necrosis Factor on Restoration of Growth in Pediatric Crohn’s Disease

( Jung Ok Shim ),( Yoon Tae Jeen ) 대한간학회 2018 Gut and Liver Vol.12 No.3

Effect of nutritional supplement formula on catch-up growth in young children with nonorganic faltering growth: a prospective multicenter study

Jung Ok Shim,Seung Kim,Byung-Ho Choe,Ji-Hyun Seo,Hye Ran Yang 대한지역사회영양학회 2020 Nutrition Research and Practice Vol.14 No.3

BACKGROUND/OBJECTIVES: Inadequate nutrition in infants and young children affects physical growth and neurocognitive development. Therefore, early nutritional intervention is important to promote catch-up growth in young children with faltering growth. The aim of this study was to evaluate the effect of nutritional supplementation with a pediatric concentrated and balanced nutritional supplement formula on promoting growth and improving nutritional status in children with nonorganic faltering growth. SUBJECTS/METHODS: Children aged 12-36 months whose body weight-for-age was < 5th percentile on the Korean Growth Charts were enrolled. Children born premature or having organic diseases were excluded. Children were instructed to consume 400 mL of formula per day in addition to their regular diet for 6 months. Pediatricians and dietitians educated the parents and examined the subjects every 2 months. Anthropometric parameters were measured at baseline and at 2, 4, and 6 months, and laboratory tests were done at baseline and 6 months. The good consumption group included children who consumed ≥ 60% of the recommended dose of formula. RESULTS: Total 82 children completed the 6-month intervention. At baseline, there were no significant differences in all variables between the good consumption and poor consumption groups. Weight and weight z-scores were significantly improved in the good consumption group compared to the poor consumption group at the end of the intervention (P = 0.009, respectively). The good consumption group showed a significant trend for gaining weight (P < 0.05) and weight z-score (P < 0.05) compared to the poor consumption group during 6 months of formula intake. The concentration of blood urea nitrogen was significantly increased in the good consumption group (P = 0.001). CONCLUSIONS: Nutritional supplementation with a concentrated and balanced pediatric nutritional formula along with dietary education might be an effective approach to promote catch-up growth in children with nonorganic faltering growth.

Recent advance in very early onset inflammatory bowel disease

Jung Ok Shim 대한장연구학회 2019 Intestinal Research Vol.17 No.1

Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-onset IBD has distinct phenotypic differencescompared with adult-onset IBD. In particular, very early-onset IBD (VEO-IBD) differs in many aspects, including thedisease type, location of the lesions, disease behavior, and genetically attributable risks. Neonatal or infantile-onset IBD developsin less than 1% of pediatric patients. Children with infantile-onset IBD have high rates of affected first-degree relatives andsevere disease course. The suspicion of a monogenic cause of VEO-IBD was first confirmed by the discovery of mutations inthe genes encoding the interleukin 10 (IL-10) receptors that cause impaired IL-10 signaling. Patients with such mutations typicallypresented with perianal fistulae, shows a poor response to medical management, and require early surgical interventionsin the first year of life. To date, 60 monogenic defects have been identified in children with IBD-like phenotypes. The majorityof monogenic defects presents before 6 years of age, and many present before 1 year of age. Next generation sequencing couldbecome an important diagnostic tool in children with suspected genetic defects especially in children with VEO-IBD with severedisease phenotypes. VEO-IBD is a phenotypically and genetically distinct disease entity from adult-onset or older pediatricIBD. (Intest Res 2019;17:9-16)

Clostridium difficile in Children: To Treat or Not to Treat?

Shim, Jung Ok The Korean Society of Pediatric Gastroenterology 2014 Pediatric gastroenterology, hepatology & nutrition Vol.17 No.2

Clostridium difficile infection has been increasing since 2000 in children and in adults. Frequent antibiotics use, comorbidity, and the development of hypervirulent strains have increased the risk of infection. Despite the high carriage rates of C. difficile, infants rarely develop clinical infection. Discontinuing antibiotics and supportive management usually leads to resolution of disease. Antibiotics use should be stratified depending on the patient's age and severity of the disease.

Recent Advance in Very Early Onset Inflammatory Bowel Disease

Jung Ok Shim 대한소아소화기영양학회 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.1

Recent studies on pediatric inflammatory bowel disease (IBD) have revealed that early-onset IBD has distinct phenotypic differences compared with adult-onset IBD. In particular, very early-onset IBD (VEO-IBD) differs in many aspects, including the disease type, location of the lesions, disease behavior, and genetically attributable risks. Several genetic defects that disturb intestinal epithelial barrier function or affect immune function have been noted in these patients from the young age groups. In incidence of pediatric IBD in Korea has been increasing since the early 2000s. Neonatal or infantile-onset IBD develops in less than 1% of pediatric patients. Children with “neonatal IBD” or “infantile-onset IBD” have higher rates of affected first-degree relatives, severe disease course, and a high rate of resistance to immunosuppressive treatment. The suspicion of a monogenic cause of VEO-IBD was first confirmed by the discovery of mutations in the genes encoding the interleukin 10 (IL-10) receptors that cause impaired IL-10 signaling. Patients with such mutations typically presented with perianal fistulae, shows a poor response to medical management, and require early surgical interventions in the first year of life. To date, 60 monogenic defects have been identified in children with IBD-like phenotypes. The majority of monogenic defects presents before 6 years of age, and many present before 1 year of age. Next generation sequencing could become an important diagnostic tool in children with suspected genetic defects especially in children with VEO-IBD with severe disease phenotypes. VEO-IBD is a phenotypically and genetically distinct disease entity from adult-onset or older pediatric IBD.

Clinical Practice and Research in Pediatric Constipation: A Pediatrician’s Perspective

Jung Ok Shim 대한외과학회 2020 대한외과학회 학술대회 초록집 Vol.2020 No.11