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2형 당뇨 환자에 있어서 C형 간염의 유병률에 관한 연구
김구영,서광섭,유광렬,임병욱,채선애,강남훈,김창훈,권영우,김희수,류성태,이정환,박성우,오웅식,김정한 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1
Background: We have doubt about the truth that Type 2 DM is associated with chronic hepatitis C infection. The aim of our study was to prove a close relationship between chronic HCV infection and type 2 DM in korean patients. Methods: We reviewed the out-patient's medical records of 466 patients with type 2 DM who visit the Sung-ae hospital from March 2000 to August 2001. Diabetic patients were analyzed for the following variables: age, sex, waist circumference, weight, waist/hip ratio, using of self monitoring of blood glucose, method of therapy, duration of disease, experience of previous transfusion, major surgical procedure, accompanied disease, liver function tests (LFT), HbA1 c. We ruled out patients with liver cirrhosis. Results: Hepatitis C virus infection was observed more frequently in patient with Type 2 DM. Of 466 Type 2 DM patients, 13 patients were infected with Hepatitis C virus (2.79%). Compared with mean prevalence of Korean population (1.3~1.6%), it's value is very high. the other hand, 21 patients were infected with Hepatitis B virus (4.5%). Such results are similar to mean prevalence of the general public (4~5%). Conclusions: Prevalence of hepatitis C was closely associated in korean patients with type 2 DM. And an increased prevalence is independent of cirrhosis.
南廷七,朴承節,金承煥,李其哲 東亞大學校 建設技術硏究所 2006 硏究論文集 Vol.29 No.2
This study was conducted four ecological survey of field mice of in Mt. Sunghak Busan City from October, 2004 to July, 2005 for the understanding of field mice damage to forest. The results are obtained as follows. 1. The species of field mice collected were Apodemus agrarills, and Eofhenomys regulus. 2. The total collecting rate were 2.5% collected 13 individuals of field mice from 510 trap. 3. The rate among the 13 field mice collected were 69.2% in Apodemlls agrarills, and 30.8% in Eothenomys regulus. 4. The constitution of weight of field mice was 18-4 1.9g in Apodemus agrarius and Eothenomys regulus. 5. The sex ratio of field mice was 55.6% 44.4% in Apodemus agrarills, and 25.0% 75.0% in Eothenomys regulus. 6. The average body, tail, hind foot, ear lengh was 9 1.0mm, 77.22mm, 20.22mm, 13.33mm in Apodemus agrarius, and 93 .5mm, 39.0mm, 18.25mm, 13 .0mm in Eothenomys regltllls. 7. The breeding period of field mice in Mt. Sunghak presumes from about April. 8. The average litter size of field mice was 5.0 in Eothenomys regulus.
하시모토 갑상선염과 동반된 갑상선 유두암에서 BRAFV600E의 발현과 임상적 특징
남성진,최영식,박요한,김정훈 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2
Background: An association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) is still controversial. Studies to date established the coexistence of HT in 11% to 36% of PTC patients. BRAFV600E mutation was presented 90% with no HT, 64% with HT in PTC patients. Therefore, BRAFV600E mutation is associated with the pathogenesis of PTC arising in HT. The purpose of this study was to identify predictive factors for the coexistence of PTC and HT and to evaluate the association of the BRAFV600E mutation with the clinicopathological features of coexistence of PTC and HT. Methods: A total of 247 patients underwent surgery for thyroid disorders between January 2007 and April 2009. In all, 212 patients was diagnosed as thyroid papillary carcinoma only (PTC group), 33 had coexistence of PTC and HT (PTC+HT group), and 2 had been diagnosed with HT. DNA was extracted from paraffin embedded thyroid tumor specimens taken from 99 patients with PTC, 13 coexistence of PTC and HT, and 2 was HT. The presence of the BRAFV600E mutation was determined by polymerase chain reaction amplification of exon 15 followed by direct sequencing. Results: Among clinicopathological features sex, age, tumor size and capsule invasion was not significant between PTC group and PTC+HT group. Lymph node metastasis and stage was significantly lower in PTC+HT group than PTC group (p=0.044). BRAFV600E mutation was found in 34 of the 99 PTC group (34.3%), 1 of the 13 PTC+HT group and 2 HT show no BRAFV600E mutation. Conclusion: These data demonstrated that the coexistence of PTC and HT was less aggressive than PTC only.
정재영,감성훈,김건남,지상철,박은석 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2
The transdermal therapeutic system (TTS) of scopolamine has various advantages over its oral dosage forms. The ideal scopolamine TTS requires high skin permeation rate in short time after it is applied on the skin. In order to increase the initial skin permeation rate of scopolamine from TTS, various permeation enhancers were employed. Enhancers employed were fatty acids(oleic and linolenic acids), cyclic monoterpenes(menthol, camphor, cineole and limonene) and others(isopropyl myristate, sodium lauryl sulfate and glyceryl monostearate). The concentration of enhancers in the base were fixed to 5% (w/w). While fatty acids had little enhancing effect on the skin permeation of scopolamine, cyclic monoterpenes, isopropyl myristate and sodium lauryl sulfate resulted in 1.5∼2.36-fold higher skin permeation rate of the drug compared to the control. However, lag time was not affected by enhancers studied.
폐쇄성 수면 무호흡 환자의 측모 두부방사선계측사진 및 치아모형 연구
정미라,황상희,남기영,김종배,권오원 대한치과교정학회 2006 대한치과교정학회지 Vol.36 No.3
폐쇄성 수면 무호흡증이란 수면도중 주기적으로 호흡이 멈추는 증상을 말한다. 상악과 하악이 후퇴되어 있거나 하악이 작으며 수평적으로 기도 폭경이 좁고 혀가 후방에 위치하는 등 폐쇄성 수면 무호흡 환자의 전후방적인 악골 및 연조직 특성에 대한 평가는 많았으나 치열 및 악궁에 대한 평가가 부족하여 폐쇄성 수면 무호흡증 환자의 골격적 특징과 악궁의 폭경과 구개깊이와 수면무호흡지수와의 상관관계를 알아보고자 하였다. 계명대학교 의과대학 동산의료원 수면클리닉에 수면장애를 주소로 내원한 환자 중 수면다원검사와 측모 두부방사선계측사진과 치아모형이 갖추어진 38명의 남자를 대상으로 하여 치아모형과 측모 두부방사선계측사진, 수면무호흡지수와 체질량지수를 비교하였다. 수면무호흡지수와 악궁의 횡폭경, 구개깊이, 수직피개량 및 수평피개량과는 상관관계가 없었으며 수면무호흡군에서 상기도 폭경은 좁고, 하기도 폭경은 넓은 경향이 있었다. 수면무호흡지수와 상기도 폭경은 미약한 음의 상관관계를 가졌으나 하기도 폭경은 미약한 양의 상관관계를 가졌고, 수면무호흡지수가 클수록 하악 하연으로터 설골까지의 거리도 멀었다. To evaluate the cephalometric and dental characteristics of obstructive sleep apnea (OSA) patients, 23 OSA patients and 15 control, non-OSA, patients who visited the Sleep Disorder Clinic Center, Keimyung University were investigated. Patients who suffered from apnea-hypopnea episodes over 10 times per hour were diagnosed as having OSA after polysomnograph testing. Impressions were taken with alginate. Cephalometric radiographs were taken at maximum intercuspation. The dental cast measurements, including transpalatal width, intercanine width, intermolar width and palatal depth did not differ between the control and OAS groups and did not have a positive correlation with the apnea-hypopnea index (AHI). Upper airway width was statistically narrower than the control group. Upper airway width had a low negative correlation with AHI, but, lower airway width had a low positive correlation, and, the higher the AHI score, the longer the mandibular border to hyoid distance.
수용성 절삭유제 내에서 Saccharomyces cerevisiae와 Escherichia coli의 성장에 관한 연구
정광진,최희영,김장규,원성호,김남기 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.2
The water-soluble cutting oil was used in the type of the mixture of additive lubricant, surfactant, etc., as the organic nutrients, with water. Therefore it was easy to be affected by microbials ; they brought the bad odor by putridity, decreased the cutting property, and destroyed the emulsion phase. In the study using cells, Saccharomyces cerevisiae and Escherichia coli, we studied the effect of concentration and dilution ratio on the growth of cells and the cell growth rate, the pH variance and the change of oil's concentration. The results obtained in this experiment were as follows : 1) The result of test dilution ratio (water:oil) vs. cell growth was that by using E. coli, the growth was better in this order in emulsion type (sample 1) 50:1 > 30:1 > 100:1, and in the soluble type (sample 2) the order was 100:1 > 50:1 > 30:1. The effect of the cutting oil's concentration on the Saccaromyces cerevisiae's was less in this order 100:1 < 50:1 < 30:1 ; the maximum growth was occurred at 100:1. 2) In sample 1 by using E, coli, pH range was changed from 9.5 to 8.0 and refractive index(the cutting oil's concentration) was changed from 1.3327 to 1.3318. And in the test using S. cerevisiae, pH range was varied from 9.5 to 6.2 and refractive index was changed from 1.3330 to 1.3310. In sample 2 by using E. coil, pH was changed to 8.9 and refractive index was changed from 1. 3315 to 1.3313 and in that of using S cerevisiae, pH was changed to 8.1 and refractive index was decreased from 1.3355 to 1.3340.
정도영,이상호,정의남,심낙순 三陟大學校 産業科學技術硏究所 1999 産業科學技術硏究論文集 Vol.4 No.-
The switched reluctance motor(SRM) has a simple rotor construction with no windings. It also has simple concentrated windings on the stator. Thus, it is expected to be a lower cost machine to manufacture than the squirrel cage induction motor. This paper analyzed the torque of SRM including two different rotor and stator structure according to the phase current. The analyzed SRM are two types, that is, rectangle so called typical type and well-rounded type in SRM. To design and analyze the improved SRM effectively, we used FEM and compared with each other. And we presented the well-rounded type SRM as a high torque SRM. In the point of view of the static torque, instantaneous torque and average torque, the well-rounded type SRM is more improved than that of typical type which has been generally used for SRM.