만성두통 환자의 성격유형 A 행태, 스트레스, 우울 및 두통영향정도의 관계 연구

차남현,임사비나,정인태,김수영,안경애,김건식,이재동,이상훈,최도영,이윤호,이두익 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

To examine an estimate factor and grasp the relation of difference for Ype A Behavior Pattern(TABP), Perceived Stress Questionnaire. Depression and HIT-6 in the Chronic headache client. Method: Data collected by self-reported questionnaires from 38 client in S city who were selected by criteria of IHS, from the 19^(th) of October to 10^(th) of December, 2004. Result: 1) Differences between biographical data by TABP was significant by SaSang constitutions, by Stress was significantly influenced by age, and by Depression were significantly influenced health status and SaSang constitutions. 2) Correlations Coefficients among Study Variables were Stress and Depression(r=.494, p=.002) and Depression and HIT-6(r=.432, p=.010). 3) In regression analysis, HIT-6 were significantly influenced by Depression and Type A Behavior Pattern(TABP). These variables explained 38% and 34% respectively. Conclusion: The result suggest that chronic headache management with psychological aspect, as well as physical aspect should be a focus to enhance the quality of life.

만성두통환자에 대한 동서협진의 임상적 연구

정인태,이상훈,김수영,차남현,김건식,이두익,이재동,임사비나,이윤호,최도영 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : Because the cause and etiology of chronic headache are not yet fully explained, the treatment of this symptom is not simple. In order to study the effectiveness East-West pain treatment on chronic headache, we evaluated its effect of pain alleviation and quality of life improvement on chronic headache patients who were treated with nerve block and acupuncture, and only acupuncture for eight weeks. Methods : 92 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as chronic headache patients. The qualified patients were classified into two groups, nerve block and acupuncture group(EW group, n=49) and acupuncture group(E group, n=43). Treatment was applied 2 times a weeks for 8 weeks. The acupoints, GV20, HN23, ST8, HN46, TE17, GB20, LI20, LI11, LI14, ST36, and LR3 were stimulated for 20 minutes. The effects of two groups were analyzed using VAS scores and BPI(Brief Pain Inventory). Results : The VAS and BPI after four weeks of treatment showed significant improvement among two but differences between the three groups was statistically insignificant. The VAS and BPI of the EW group after eight weeks of treatment showed statistically significant improvement compared to the other two groups. Conclusion : The pain treatment for chronic headache might be contributed to improvement of quality of life as well as alleviation of pain of chronic headache patients. It was suggested that the West pain treatment in combination with East pain treatment might be an useful modality to improve the pain and quality of life in chronic headache patients.

만성두통환자에 대한 침치료가 심박변이도에 미치는 영향

정인태,이상훈,김수영,차남현,김건식,이두익,이재동,임사비나,이윤호,최도영 EAST-WEST MEDICAL RESEARCH INSTITUTE KYUNG HEE UNI 2005 東西醫學硏究所 論文集 Vol.2005 No.-

Objective : The purpose of this study was to assess the effect of acupuncture treatment for chronic headache patients using power spectrum analysis of the heart rate variability(HRV). Methods : 15 clinical experiment participants were gathered and through a questionnaire patients who experienced headache for more than 4 hours a day and more than 15 days per month were qualified as Chronic Headache patients. Treatment was applied 2 times a weeks for 8 weeks. The acupoints, GV20, HN23, ST8, HN46, TE17, GB20, LI20, LI11, LI14, ST36, and LR3 were stimulated for 20 minutes. The effects of acupuncture treatment were analyzed using power spectrum analysis of the HRV, HRV was recorded before and after acupuncture treatment. Results : HRV before and after treatment was compared after 8 weeks of acupuncture treatment. Increase in mean values of SDNN and RMSSD were observed but the increases were not statistically significants. Increase in mean values of TP, LF and HF were observed but, the increase was significant(p<0.05) only in TP. Conclusions : The results suggest that acupuncture treatment on chronic headache patients can increase the activity of autonomic nervous system. Further use of HRV for quantitative analysis of acupuncture treatment on autonomic nervous system related symptoms is suggested.

병원근무자에 대한 특수건강진단 적용 가능성에 관한 연구

이수일,조병만,조봉수,김영욱,고광욱,문남출,김주원 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

병원근무자들에 대한 특수건강진단 적용 여부를 판단하기 위한 기초자료를 제공하기 위해 1995년 3월 10일부터 4주간에 걸쳐 부산시내에 위치하는 2개 종합병원 근무자 830명을 대상으로 설문조사를 시행해 얻은 결과를 요약하면 다음과 같다. 1. 조사된 43개 항목 중 10% 이상의 대상자가 유해요인에 폭로되고 있다고 응답한 항목은 소음, 분진 등 16개 항목이었다. 이 중 분진, 소음 및 스트레스는 연구대상자의 50%이상에서 폭로되고 있다고 응답했으며 그 외 알콜류 소독제(41.3%), 방사선(34.6%), 일반약제(33.3%)의 순으로 폭로되고 있었고 VDT의 경우 25.2%, aldehyde류는 18.7%에서 폭로되고 있는 것으로 나타났다. 2. 대상자의 63.1%에서 병원근무 환경 중에 유해인자가 존재한다고 응답했고 병원의 환경측정이 필요하다고 대답한 사람은 80%에 달했다. 35.7%가 유해인자에 대한 교육을 받은 적이 없다고 응답했다. 전체 응답자의 35.7%가 유해인자에 폭로시 보호 장비를 착용하지 않는다고 응답했고 주기적인(격년) 건강진단은 48.6%에서 받는 것으로 조사되었다. 근무부서의 환기상태는 7.2%만이 좋은 편이라고 응답했다. 이상에서 살펴본 바와 같이 병원근무자들이 여러 가지 유해환경에 노출되고 있고 또, 이로 인해 발생할 수 있는 건강장해에 대한 예방대책이 소홀한 것으로 나타나 병원의 작업환경측정의 시행이 필요하고 이 결과를 바탕으로 병원근무자들에 대한 특수건강진단 적용여부를 결정해야 할 것이다. This study was performed to decide the possibility of special health examination to the hospital employees. We carried out questionnaire survey for 830 subjects at 2 general hospitals located in Pusan city. The summary of this study are as follows. 1. Above 10% of total hospital employees were replied that they exposed to 16 hazard items, such as dust, noise, stress and etc. Among them, over 50% of hospital employees exposed to dust(69.8%), noise(52.3%), stress(60.1%). And hospital employees exposed to alcoholic disinfectant(41.3%), radiation(34.6%), drug(33.3%), VDT(25.2%), and aldehyde(18.7%) also. 2. 63% of the hospital employees replied that there were hazardous factors in hospital environments, and 80% insisted the necessity for hospital environment measuring. 35.7% of respondents replied that they had never taken the education about hazardous factors. 35.7% of the total respondents answered that they didn't use protective equipment when exposed to hazardous factors. And 48.6% answered they took periodic health examination. Only 7.2% replied that ventilation condition of office room was proper. As shown in above results, hospital employees are exposed to various hazards, and turn out neglecting to health problems caused these hazardous factors. So at first, it is necessary to measuring hospital working environment, and then will be decided the possibility of special health examination to the hospital employees.

電子商去來에서의 消費者保護를 위한 法的 問題點에 대한 考察 : 電子認證과 電子署名을 중심으로

남경두,이수진 건국대학교 경제경영연구소 2000 商經硏究 Vol.25 No.1

Electronic certification and electronic signature issues are a vital concern for developing electronic commerce, and a number of initiatives are underway in both the public and private sectors to ensure that businesses and consumers can engage in secure and reliable electronic communications and transactions in the global networked society. In recent years OECD Member countries have undertaken to develop and iMplement may create obstacles to the evolution of national and global information and communications networks and hinder the development of electronic commerce. Both governments and the private sector have recognized the need for international collaboration to develop and efficient and secure information infrastructure. This paper in this area has focused on electronic authentication and signature issues in order to protect consumers. The paper concludes that electronic authentication and signature consensus about specific policy and regulatory issues related to information and communications networks and technologies, including electronic authentication and electronic signature.

골수구성 백혈병 환자에게 발생한 결핵성 림프절염

이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5

혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.

Letrozole에 반응을 보인 다발성 폐전이를 동반한 저도 자궁내막 기저육종 1례

이남수,원종호,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Low-grade endometrial stromal sarcoma is generally an indolent tumor rich in estrogen and progesterone receptors. Objective responses to hormonal therapy, most commonly with megestrol acetate, have been reported. The patient is a 50-year-old woman who presented with low-grade endometrial stromal sarcoma confined to the vagina in 1992 and was treated with local excision. Approximately 4 years later, the patient had recurrent right ovarian and ileal mass treated with right oophorectomy and segmental resection of ileum. In 2002, multiple lung metastatic lesions were discovered and treated with megestrol acetate. But megestrol acetate showed no response during the period. Letrozole was then given at a daily dose of 2.5 ㎎ with partial response for a duration of 10 months. Letrozole at a daily dose of 2.5 ㎎ may be effective in low-grade endometrial stromal sarcoma.

Mastoparan B의 항균 활성 및 용혈 작용에 미치는 소수성도와 양친매성의 영향

이봉헌,김광호,장태식,박남규,박장수,강신원 부산대학교 유전공학연구소 1998 분자생물학 연구보 Vol.14 No.-

Tetradecapeptide인 Mastoparan B(MP B)와 이의〔Ala〕-MP B유도체들을 합성하고 항균 활성 및 용혈 작용을 측정하여 MP B의 활성에 미치는 소수성도(hydrophobicity)와 양친매성(amphiphilicity)의 영향을 비교하였다. 그 결과 MP B와 소수성도가 MP B 보다 큰〔Ala^2〕-,〔Ala^4〕-MP B유도체가 큰 항균 활성을 나타내었으며, 소수성도가 MP B보다 작은〔Ala^6〕-MP B유도체의 활성은 MP B와 비슷하거나 작게 나타나 소수성도가 큰 유도체일수록 항균활성을 크게 나타내었다. 그러나 MP B보다 소수성도가 큰 유도체인〔Ala^9〕-MP B는 Ala에 의한 Trp의 치환때문에 MP B보다 작은 활성을 나타내었다.용혈 활성 측정 결과 MP B보다 소수성도가 큰〔Ala^2〕-,〔Ala^4〕-MP B유도체가 각각100.0%와 69.4%로써 용혈 작용을 크게 나타냈으나, 소수성도가 작은〔Ala^6〕-MP B유도체는 6.1%로써 가장 작은 용혈 작용을 나타내었고 Trp대신 Ala으로 치환한 소수성도가 큰 유도체인〔Ala^9〕-MP B는 MP B보다 작은 26.0%의 용혈 작용을 나타내었다. 그러므로 용혈 작용은 소수성도가 클수록 증가하였으며 양친매성이 활성에 미치는 영향은 적었다. Tetradecapeptide.Mastoparan B(MP B)and its〔Ala^2 〕-,〔Ala^4〕-,〔Ala^6〕-,〔Ala^9〕-MP Bderivatives were synthesized, and then their antibacterical and hemolitic were to examine the effect of hydrophobicity and ampiphilicity on the MP B-induced those activities. MP B and more hydrophobic〔Ala^2 〕-,〔Ala^4〕-MP B showed stronger antibacterical activity and less hydrophobic〔Ala^6〕-MP B than MP B did similar or weaker activity, so more hydrophobic〔Ala〕-MP B derivative had stronger activity. But more hydrophobic〔Ala^9〕-MP B than MP B showed weaker activity because of its Trp subsitution by Ala. On the other hand,〔Ala^2 〕-and〔Ala^4〕-MP B showed 100.0% and 69.4% hemoiytic activity, but〔Ala^6〕-MP B did the weakwst activity(6.1%)and〔Ala^9〕-MP B, weaker activity(26.0%) than MP B.Therefore, more hydrophobic〔Ala〕-MP B derviative had stronger activity and the effect of ampiphilicity on the activity was weak.

친환경농업 시범마을에 대한 환경영향평가

이남종,고병구,노기안,한민수,김민경,곽한강,박문희 한국환경농학회 2003 한국환경농학회지 Vol.22 No.4

1999년부터 2001년까지 3년간 친환경농업 시범마을에 적용되고 있는 INM (Integrated Nutrient Management) and IPM (Integrated Pest Management) 실천에 따른 추진효과를 분석하기 위하여 시범마을로 지정된 옥천과 양평지역의 농가 포장에서 시비량, 양분유실 및 생태계 변화 등을 조사 분석하였다. 3요소 시비량은 토양검정시비로 인하여 농가관행시비와 비교하여 28.6~39.4% 절감할 수 있었으며, 쌀 수량도 시비량이 비교적 적은 토양검정 시비구에서 3~10% 증수하였다. 영농기간동안 토양 침투수중 NO₃-N 농도는 농가관행 시비구 2.9 ㎎/L에 비하여 토양검정 시비구는 1.5 ㎎/L로 감소하였으며, 시범마을 논으로 유입되는 관개수의 COD, NH₄-N, NO₃-N 농도는 각각 15.0, 0.67, 1.39 ㎎/L, 시범마을 논에서 배출된 용수는 각각 12.4, 0.29, 2.42 ㎎g/L로 감소되는 경향이었다. 처리별 수서곤충, 환형동물, 패류 및 감각류 등의 개체수는 농가관행구 100에 대하여 토양검정 시비구 293, 토양검정과 개량제 혼용구 276, 무비구 90으로 토양검정 시비구에서 많았으며 수서 무척추 동물은 관행농업을 수행하고 있는 지역을 100으로 볼 때 친환경농업마을은 242와 443으로 INM과 IPM을 실천하는 시범마을에서 생물종이 다양하고 그 개체수가 많은 것으로 나타났다. 친환경농업 시범마을 조성 후 작물 추천시비량 준수와 적기 예찰을 통하여 필요이상 사용되는 비료와 농약을 절감하여 생태계의 개선과 토양이 건전화된 것으로 평가되었다. In order to preserve the soundness of ago-ecosystem and products safety in agriculture, this study was evaluated environmental impact in relation to the INM (Integrated Nutrient Management) and IPM (Integrated Pest Management) at paddy fields at Ok-Chun and Yang-Pyung region. By introduction of INM with the application of BB(bulk-blanded) fertilizer based on soil analysis and EM, the application rate of fertilizer was reduced to about 28.6-39.4% and the yield of brown rice was increased to about 3-10% compared to conventional practices. The concentrations of COD, NH4-N, and NO3-N in irrigation water flowed to the environmental-friendly agriculture practices were 15.0, 0.67, and 1.39 ㎎/L, respectively. The concentrations of COD, NH₄-N, and NO₃-N from paddy fields in drainage water were 12.4, 0.29, and 2.42 ㎎/L, respectively. The total number of the freshwater invertebrates was higher in field treated with fektilhtion by prescription with soil testing. Also, the population density of aquatic insects was higher than the other fields at both demonstration villages. In conclusion, it was possible to reduce the amount of fertilizer and agricultural chemicals application, and increase the yield of rice by application of the environmental-friendly agriculture practices.

주간보호시설과 재가 치매노인 주간호자의 삶의 만족과 부담감

이수진,박호란,,김남초 노인간호학회 2005 노인간호학회지 Vol.7 No.1

Purpose: To investigate the level of life satisfaction and burden for primary caregivers of patients with dementia in day care centers and in their homes. Method: From August to September 2003, 56 caregivers of patients with dementia in day care centers and 54 caregivers in their homes were surveyed through three questionnaires: Life Satisfaction Index-Z and Korean Dementia Caregiver Burden. Result: Life satisfaction of caregivers in day care centers was significantly higher than that of caregivers in their homes(p<.005). Also, the sense of burden of caregivers in day care centers was significantly lower than that of caregivers in their homes(p<.005). Caregivers in day care centers showed significantly lower levels in four subdimensions of burden than those of caregivers in their homes. The level of life satisfaction of caregivers in day care centers and in their homes were also negatively correlated with the sense of burden(p<.005, p<.005). Conclusion: Using day care centers for patients with dementia will be a good way to take care of them because their primary caregivers can have more rest time and less burden. Therefore, using day care centers for patients with dementia should be recommended and the number of the facility should be increased nationwide.