자발성 뇌지주막하 출혈 환자에서 최초 뇌실 크기의 임상적 의의

신일영,윤일규,윤석만,도재원,이경석,배학근,최순관,변박장 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

The purpose of this study is to invesetigate the clinical significance of initial enlargement of ventricle in the patients who had aneurysmal SAH. Of the total 821 patients with aneursmal SAH who were registerd in SAH data bank system between 1989-1999, 307 patients who had been already measured in the size of ventricle at the time of admission, were studied retrospectively. The size of ventricle was calculated by bifrontal index. Normal size of ventricle was defined as 30% or less, mild enlargement was defined as 31 to 39%, and moderate enlargement of vertricle was defined as more than 39% in bifrontal index. The sizes of ventricle using bifrontal index were analysed according to the age, sex, blood pressure, consciousness at admission, medical history of hypertension, location of ruptured aneurysm, Fisher's grade on CT(computerized tomography) scan at the time of admission, cerebral vasospasm, intraventricular hemorrhage (IVH), performance of external ventricular drainage (EVD), and prognosis at discherge. Chi-square test and ANONA were used in the statistical evaluation. The results were as follows : 1) Of the 307 patients, 235(76.5%) had a mild to moderate enlargement of ventricle at the time of admission (more than 30% in bifrontal index). 2) The size of ventricle was enlarged according to the increase of age (p<0.05). 3) In the patients who had ruptured aneurysm on anterior cerebral artery, the size of ventricle significantly increased and showed a higher incidence in mild enlargement compared with moderate enlargement of ventricle (p<0.05). 4) The size of ventricle increased in th patients who had IVH and the EVD was more frequently performed in th patients who had the enlarged ventricle associated with IVH (p<0.05). 5) In the patients who had high Fisher's grade, the size of ventricle had a tendency to increase, but there was no statistical significance. 6) In the patients who had poor prognosis, the size of ventricle had a tendency to increase, but there was no statistical significance. Conclusively, the initial size of ventricle was enlarged in th aged patients, ruptured aneurysm on anterior communicating artery, high FIsher's grade, patients associated with IVH. Considering those factors, prediction for the enlargement of ventricle size may help to treat the patients suffering aneurysmal SAH.

산업폐수 슬럿지를 이용한 경량골재 개발에 관한 연구

고영민,이내우,최재욱,우희철,신학기 한국산업안전학회 2002 한국안전학회지 Vol.17 No.1

Among the disposal techniques of inorganic wastewater sludges from industries, most of sludges were dealed with buring underground inefficiently. But we have tried to recycle the resources that exhausted inorganic sludges were properly blended to certain ratioes to make lightweight aggregate, that means manufacturing of it can be possible through blending of various components, drying, sintering, cooling and crushing to certain sizes that are needed by consumers. As disposal method of inorganic wastewater sludge is changed to environmentally fraternative method, this method could be very useful to make lightweight aggregates for decoration of building and the other so many purposes of those usages. That could be economically useful due to expected income for buring costs of ordinary disposal method from industries and sales income after manufacturing it. The second important profit is saving foreign currency from purchasing self-developed lightweight aggregate instead of importing expensive foreign product. This product will be also very impressive to user because of the fraternative lightweight to be composed of apatite structure that is important part of human body.

Pentazocine의 鎭痛效果에 미치는 Diazepam과 Naloxone의 影響

廉英鶴,全普權,申萬鍊 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

In this paper, the analgesia and the change induced by pentazocine of plasma corticosterone level and blood sugar level in mice were assayed, and also the influences of diazepam and naloxone on those effects of pentazocine were studied. The results obtained were summarized as follows; 1. The threshold temperature of pain induction (TTPI) was determined as a index of the response to a painful stimulus using a hotplate. Diazepam 2.5㎎/㎏ and naloxone 1.0 ㎎/㎏ moderately increased TTPI, respectively, and the analgesic effect of pentazocine 3.16㎎/㎏, 10㎎/㎏, or 31.6 ㎎/㎏, showed a log dose-dependent response curve. The response curve to pentazocine was shifted to the right by the pretreatment of naloxone, but it was shifted to the left by the pretreatment of diazepm. 2. Diazepam 5.0㎎/㎏ and pentazocine 30㎎/㎏ significantly increased the plasma corticosterone level. And the increase induced by pentazocine of plasma corticosterone was not suppressed by the pretreatment of naloxone but by the pretreatment of diazepam. 3. Diazepam 5.0㎎/㎏ and pentazocine 30㎎/㎏ transiently increaesd the blood sugar level, and the increase induced by pentazocine was not affected by the pretreatment of either naloxone or diazepam. This study suggests that the pentazocine receptor to increase the plasma corticosterone level is different from that to induce the pentazocine analgesia.

다기관 기능부전을 초래한 치명적인 삼일열 말라리아 증례

박상원,김동우,박주원,이순일,신영학,김의종,오명돈,최강원 대한감염학회 2005 감염과 화학요법 Vol.37 No.2

삼일열 말라리아는 국내에서 재유행하고 있는 감염질환으로, 일반적으로 양성의 임상경과를 거친다. 저자들은 특이한 질병력이 없이 건강하였던 젊은 성인이 국내에서 삼일열 말라리아에 걸린 후 다기관기능부전과 폐출혈으로 사망한 증례를 경험하였다. 환자의 중증 임상경과를 설명할 만한 특이한 인자가 발견되지 않았다. Vivax malaria is a re-emerging infectious disease in Korea with cumulating 19,416 cases as of December 2003 since 1993. Vivax malaria is generally a benign disease with few severe complications. Even in the worldwide literature, there are only small number of case reports on severe complications. We experienced a fatal vivax malaria in a previously healthy young adult with severe multi-organ failure and fatal massive pulmonary hemorrhage. The patient presented with abdominal pain and shock. There were splenic hemorrhage, disseminated intravascular coagulation, oliguric acute renal failure requiring dialysis, and pulmonary hemorrhage leading the patient finally to death. The initial parasitemia was 2,046/μL. Thin smear and PCR revealed only Plasmodium Vivax. There was no explainable cause of death except for the only serological suggestion of Mycoplasma pneumoniae infection without correlating clinical evidence. This is a first case of fatal vivax malaria in Korea since its re-emergence in 1993. Further case monitoring is needed to define whether this is a index case or an isolated one.

Calibration of HEPD on KOMPSAT-1 Using the KCCH Cyclotron

Shin, Young-Hoon,Rhee, Jin-Geun,Min, Kyoung-Wook,Lee, Chun-Sik,Lee, Ju-Hahn,Kwon, Young-Kwan,Kim, Jong-Chan,Ha, Jang-Ho,Park, Se-Hwan,Lee, Chang-Hack,Park, H.S.,Kim, Young-Kyun,Chai, Jong-Seo,Kim, Yu- The Korean Society of Remote Sensing 1999 大韓遠隔探査學會誌 Vol.15 No.4

Space Physics Sensor (SPS) on-board the KOMPSAT-1 consists of the High Energy Particle Detector (HEPD) and the Ionospheric Measurement Sensor (IMS). The HEPD is to characterize the low altitude high energy particle environment and the effects on the microelectronics due to these high energy particles. It is composed of four sensors: Proton and Electron Spectrometer(PES), Linear Energy Transfer Spectrometer (LET), Total Dose Monitor (TDM), and Single Event Monitor (SEM). 35 MeV proton beam from the medical KCCH cyclotron, at Korea Cancer Center Hospital in Seoul, is used to calibrate the PES. Primary proton beam of 35MeV scattered by polypropylene target is converted to various energy protons according to the elastic collision kinematics. In this calibration, the threshold level of the proton in the PES can be determined and the energy ranges of PES channels are also calibrated.

Calibration of HEPD on KOMPSAT-1 Using the KCCH Cyclotron

Young Hoon Shin,Jin Geun Rhee,Kyoung Wook Min,Chun Sik Lee,Ju Hahn Lee,Young Kwan Kwon,Jong Chan Kim,Jang Ho Ha,Se Hwan Park,Chang Hack Lee,H. S. Park,Young Kyun Kim,Jong Seo Chai 大韓遠隔探査學會 1999 大韓遠隔探査學會誌 Vol.15 No.4

Space Physics Sensor (SPS) on-board the KOMPSAT-1 consists of the High Energy Particle Detector (HEPD) and the lonospheric Measurement Sensor (IMS). The HEPD is to characterize the low altitude high energy particle environment and the effects on the microelectronics due to these high energy particles. It is composed of four sensors: Proton and Electron Spectrometer(PES), Linear Energy Transfer Spectrometer (LET), Total Dose Monitor (TDM), and Single Event Monitor (SEM). 35 MeV proton beam from the medical KCCH cyclotron, at Korea Cancer Center Hospital in Seoul, is used to calibrate the PES. Primary proton beam of 35MeV scattered by polypropylene target is converted to various energy protons according to the elastic collision kinematics. In this calibration, the threshold level of the proton in the PES can be determined and the energy ranges of PES channels are also calibrated.

Calibration of HEPD on KOMPSAT-1 Using the KCCH Cyclotron

Shin, Young Hoon,Rhee, Jin Geun,Min, Kyoung Wook,Lee, Chun Sik,Lee, Ju Hahn,Kwon, Young Kwan,Kim, Jong Chan,Ha, Jang Ho,Park, Se Hwan,Lee, Chang Hack,Park, H. S.,Kim, Yong Kyun,Chai, Jong Seo,Kim, Yu 대한원격탐사학회 1999 International Symposium on Remote Sensing Vol.15 No.1

Space Physics Sensor (SPS) on-board the KOMPSAT-1 consists of the High Energy Particle Detector (HEPD) and the Ionospheric Measurement Sensor (IMS). The HEPD is to characterize the low altitude high energy particle environment and the effects on the microelectronics due to these high energy particles. It is composed of four sensors: Proton and Electron Spectrometer(PES), Linear Energy Transfer Spectrometer (LET), Total Dose Monitor (TDM), and Single Event Monitor (SEM). 35MeV proton beam from the medical KCCH cyclotron, at Korea Cancer Center Hospital in Seoul, is used to calibrate the PES. Primary proton beam of 35MeV scattered by polypropylene target is converted to various energy protons according to the elastic collision kinematics. In this calibration, the threshold level of the proton in the PES can be determined and the energy ranges of PES channels are also calibrated.

Insecticide Susceptibilities of Anopheles sinensis (Diptera: Culicidae) Larvae from Paju-shi, Korea

Shin, E-Hyun,Park, Young-In,Lee, Hee-Il,Lee, Won-Ja,Shin, Young-Hack,Shim, Jae-Chul 한국곤충학회 2003 Entomological Research Vol.33 No.1

A study was conducted to determine the susceptibility of Anopheles sinensis larvae, malaria vector, from Paju-shi(Gyonggi-do) to 24 pesticides including 11 pyrethroids, 11 organophosphates, 1 pyrazole analogue and another pesticide. The mosquito larvae showed the most highly susceptible to chlorfenapyr with $LC_{50}$ of 0.0063 ppm followed by spinosad, temephos, fenthion and beta-cyfluthrin with 0.03, 0.0366, 0.0367 and 0.0998 ppm, respectively, and fluvalinate (> 128 ppm) was the least susceptible. Also, 11 pesticides of them were compared with Goyang strain(Gyonggi-do) of data 1992. The development of resistance was noticed to cypermethrin and permethrin as much of 73.59 and 6.23 folds at $LC_{50}$, respectively, and also fluvalinate was showed high resistance development. In generally, the pyrethroid insecticides were showed higher development of resistance than organophosphorus insecticides.

수종의 생약추출물이 PC12 Cells 중의 Dopamine 함량 변화에 미치는 영향

신정수,김영호,배기환,김학성,이명구 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-

The effects of MeOH extracts of ninety kinds of medicinal herbs on dopamine content in PC12 cells were investigated. Among them, the MeOH extracts at a concentration of 40㎍/ml of Symplocarpus renifolius, Adenocaulon himalaicum and Mosla punctulata decreased 38.5~60.0% of dopamine content. Tyrosine hydroxylase, the rate-limiting enzyme of the catecholamine biosynthesis, was inhibited by the treatment of the MeOH extracts of Symplocarpus renifolius, Adenocaulon himalaicum and Mosla punctulata (19.9~31.3% inhibition at 40㎍/ml). These results suggested that these bioactive herbal medicines exhibited partially an inhibitory effect on dopamine biosynthesis by the reduction of tyrosine hydroxylase activity in PC12 cells.

Salmonella typhi Salmonella typhimurium 및 Salmonella enteritidis의 항균제 감수성(1997)

신영학,유정식,김기상,정동준,오경수,이점규,이상원,이근영,박미선,이복권,김호훈 대한화학요법학회 1998 대한화학요법학회지 Vol.16 No.3

목적 : 국내에서 토착화 발생하여 공중보건학상 중요관리 대상 병원체인 장티푸스균과 최근 범세계적 유행추세를 보이고 있으며 우리나라에서도 급속히 증가추세를 보이고 있는 세균성 식중독의 원인균인 S. Enteritidis 및 S. Typhimurium을 대상으로 시험관내 항균제 감수성시험을 실시하여 항균제 내성양상을 파악하고자 하였다. 방법 : 1997년 1월부터 12월사이 전국 16개 시도 보건 환경 연구원 및 일부 종합병원으로부터 수집 동정한 장티푸스균 79주, S. Enteritidis 114주 및 S. Typhimurium 83주를 대상으로 미량 액체 희석 법으로 최소 발육 억제농도를 측정하고, break Point를 적용 내성양상을 분석하였다. 사용한 항균제는 β-lactam계 항균제로 ampicillin, amoxacillin, carbenicillin, cefoxitin, cephalothin, ceftriaxone, timentin(ticarcillin/clavulanic acid)을, aminoglycoside계로 streptomycin, amikacin, gentamicin, kanamycin을, quinolone계로 ciprofloxacin을 기타 tetracycline, nalidixic acid, chloramphenicol, trimethoprim, trim e th oprim/sulfamethoxazole등 총 17종 이었다. 결과 : 17종의 항균제중 1 종 이상의 항균제에 내성을 지니고 있는 균주가 장티푸스균 79주 중 15주 (19.0%), S. Enteritidis 114주중 14주(12.3%) 그리고 S. Typhimurium 83주 중 67주(80.7%) 였다. 시험에 공시된 살모넬라균종에 대해 전체적으로 tetracycline 및 페니린계의 항생제에 대한 내성균 검출빈도가 높았다. 다만 장티프스균의 경우 chloramphenicol 내성균주가 12주(15.2%) 검출되었으며, S. Typhimurium은 Streptomycin 내성 균주가 37주 (44.5%) 검출되어 높은 내성율을 보였다. 3균종 모두에서 ceftriaxone 및 ciprofloxacine 에 내성을 보이지 않았다. 다제내성 양성을 보면 장티프스균은 한가지 이상의 균제에 대해 내성을 나타낼 15주 중 10균주가 tetracycline, chloramphenicol, ampicillin, 및 trimethoprim등 4종 이상의 항균제에 대해 내성을 갖는 다제 내성 균주로 전체 내성균의 66.7%를 차치하였고 특히 9종의 항균제에 내성을 갖는 균이 3주, 8종의 항균제에 내성을 갖는 균이 5주나 검출되었다. S. Enteritidis균의 다계 내성 양상은 gentamycin을 비롯한 8종의 항균제에 내성을 지닌 균주가 1주 있었으며 4종이상의 항균제에 내성을 갖는 다제내성균이 6주로 내성균의 42.8%를 차지하였다. 주로 tetracycline과 페니실린계 항생제에 동시에 내성을 갖는 것으로 나타났다. S. Typhimurium의 다제내성양상은 tetracycline 및 streptomycin 등 2종의 항생제에 내성을 가진 형이 25주로 가장 많았으며, tetracycline 과 페니실린계 항생제에 동시에 내성을 나타내는 경우도 많았다. 또한 4종 이상의 항균제에 내성을 갖는 다제 내성균이 29주로 내성균의 43.3%를 차지했으며, S. Typhimurium DT104 주와 유사한 항균제 내성 양상을 나타내는 균주도 확인되었다. 결론 : 국내에서 분리된 장티푸스균, S. Enteritidis 및 S. Typhimurium 감수성 시험 결과 항균제 내성이 현재까지 일반적인 항균제에 국한되어 있으나 S. Typhimurium DT104주와 유사한 항균제 내성 양상을 보이는 균주가 확인되었고 과거에는 분리 보고가 흔하지 않았던 4종이상의 항균제에 내성을 지닌 장티푸스균이 다수 검출되었으므로 항균치료제 선택에 신중을 기함은 물론 내성균주 감시를 체계적이고 지속적으로 실시하여야 할 것으로 사료된다. Background : Salmonella Typhi, an endemic in Korea, S. Enteritidis and S. Typhimurium, major organisms of bacterial food poisoning, which have been responsible for numerous outbreak in the m7orld including Korea currently are important organisms to be in control. At this point, to understand current antimicrobial resistance of the three Salmonella serovars in Korea, we conducted in vitro susceptibility studies to 17 antimicrobial agents. Methods : We tested antimicrobial susceptibility by a microbroth dilution method. The target organisms are 79 isolates of S. Typhi, 114 isolates of S. Enteritidis, and 83 isolates of S. Typhimurium collected on January through December 1997 in Korea. Results : The resistance rates to one or more antimicrobial agents are 19.0%(15/79 isolates) for S. Typhi, 12.3% (14/114 isolates) for S. Enteritidis, and 80.7% (67/83 isolates) for S. Typhimurium. Grossly, the organisms' resistance rates to tetracycline and penicillins are higher than that of other agents with two exceptions : 15.2% to chloramphenicol (12/79 isolates) for S. Typhi and 44.6% to streptomycin (37/83 isolates) for S. Typhimurium. Multi-drug resistant (MDR) strains to four or more antimicrobial agents among the resistant organisms are quite high: 66.7% (10/15 isolates), 42.8% (6/14 isolates), and 43.3% (29/67 isolate) for S. Typhi, S. Enteritidis, and S. Typhimurim, respectively. Conclusion : From this investigatron, we found that the MDR strains of S. Typhi, S. Enteritidis, and S. Typhimurim have increased than previous studies. It implies that limitation of unnecessary use of drugs is very important. in order to maintain the efficacy of drugs.