건설공사현장의 안전관리에 관한 연구

정남선,주승완,윤선호 서강정보대학 1999 산업과학연구 Vol.1 No.-

To live in good health is man's earnest wish. The degree of exposure to danger is deepened with the improvement of people's standard of living. Under the current situation where there increases the national demand for safety and health improvement, the sense of responsibility for safety security should be emphasized and be practised in industrial fields, homes, schools, and offices in order to strengthen the national infrastructure for the prevention of disaster and to prevent the safety accident effectively. The frequent disasters of falling in construction fields is primarily due to the lack of safety consciousness and knowledge of both proprietors and laborers, which resulted in the qualitative lowering of work and safety accidents. To prevent disasters, safety security is required through the consolidation of standards for safety equipment and structure installment. The highest frequency of disaster is found at the processing rate of 61~100%. Therefore this study has tried to make safe and comfortable working environment, and to construct better workplace which secures the safety and health of workers by tracing the causes of accident, taking the preventive measure, analyzing the cause of disaster with the statistical date of construction related to disaster, and suggesting the improvement methods, in order to reduce the loss of lives and properties.

랫드 배양배아에서 ginsenosides가 superoxide dismutase 유전자 발현에 미치는 영향

김재승, 이세라, 김연, 연정민, 백인정, 안병우, 김윤배, 이범준, 윤영원, 남상윤 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

동맥경화에 의한 하지 허혈증 환자에서 Subintimal Angioplasty의 효과 : 단기 추적 결과를중심으로

윤상섭,허윤정,최승혜,박종경,이성,송경섭 대한혈관외과학회 2003 Vascular Specialist International Vol.19 No.2

복극전해조를 이용한 사진폐액 중에 함유된 은제거

윤철종,박정호,임찬섭,박승조 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.2

This study was on the removal of silver ion containing photographic wastewater by BPBE cell. The experiments were performed at different voltage. electrolytic time and pH. When we inverstigated with silver removal efficiency, current efficiency and power efficiency at pH 4, 7, 9, thoese were indicatec most superior values in pH 9. And for the conditions of pH 9, l000mg-Ag/L, 3V, thoese were 93%. 40.4%, 0.54g-Ag/W .hr respectively.

쌍각자궁에서 4회 반복유산 후 만삭 둔위 분만 1예

홍정의,김윤숙,최승도,선우재근,배동한 순천향의학연구소 2008 Journal of Soonchunhyang Medical Science Vol.14 No.2S

..

치료저항 정신분열병환자에서 Clozapine의 효과 및 안전성

지익성,김영희,신석철,왕성근,신윤오,이선우,김정란 충남대학교 의학연구소 2001 충남의대잡지 Vol.28 No.2

In order to assess the efficacy and safety of clozapine, 50 in-patients with treatment-resistanat schizophrenia were evaluated using PANSS(Positive and Negative Symptome Scale for Schizophrenia), CGI(Clinical Global Impression), AMS(Abnormal Involuntary Movement Scale), Adverse Event-Somatic Symptoms, Neurological Rating Scale for EPS before and during treatment. Mean daily dosage of clozapine was 344.15±123.43mg at 12th week. A clinically significant improvement in positive, negative, and general psychopathology was noted as early as week 2 through 12 week. The tolerability of clozapine was generally found to be good. Drowsiness/sleepiness, Hypersalivation, and Constipation were the most common side effects. There was no neutropenia, and 3 patients suffered from seizures. These results suggest that clozapine is worth considering for the treatment-resistant patients

수술실 손 소독제의 종류에 따른 균주 수의 변화

홍성윤,김정민,김소영,이수정,오은실,양서인,김화실,김남초 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: The present study purposed to compare the hand washing effect of 7.5% powidone-iodine, which is used in the operation room of C university hospital in Seoul, with that of Ethyl alcohol-CHG mixture recommended by the US Association of Operating Room Nurses (2002) and to adopt a more effective hand disinfectant. Method: In a quasi-experimental design, 48 medical staff who participated in operations during the period from November 2004 to February 2005 had hand washing using the two kinds of hand disinfectants: 7.5% povidone-iodine and the ethyl alcohol-CHG mixture. Their palms were swabbed and cultured just after hand washing and again after taking dff sterile gloves after the operation. The number of colonies from the two occasions were counted and compared. Result: The number of general bacillus increased significantly in the group using 7.5% povidone-iodine compared to that in the group using the ethyl alcohol-CHG mixture. The number of general bacillus increased signficantly in doctors compared to that in nurses. The factors affecting the increase of the number of general bacillus were disinfectants and medical personnel. The number of general bacillus was expected to increase 9.41 times with 7.5% povidone-iodine than with the ethyl alcohol-CHG mixture and 14.87 times in doctors than in nurses. Conclusion: This study shows that the ethyl alcogol-CHG mixture has a stronger hand disinfection effect than 7.5% povidone iodine. Thus we need to change the hand disinfectant used in operating rooms as soon as possible in order to minimize the infection of wounds resulting from operations.

폴리카프로락톤 매트릭스로부터 세파드록실의 방출에 미치는 BSA의 영향

김승렬,정연진,김영미,이치호,김대덕 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.5

In order to investigate the effect of bovine serum albumin (BSA), as a pore former, on the controlled release of an antibiotic from a biodegradable polymeric device, polycaprolactone (PCL)-cefadroxil matrices were prepared by the solvent casting method. The amount of cefadroxil released from various formulations at 37℃ was measured by HPLC. The duration of antimicrobial activity of matrices against S. aureus was evaluated by measuring the diameters of the inhibition zone. The morphology of the matrices was investigated by scanning electron microscopy (SEM). The release rate and extent of cefadroxil from PCL matrix increased as the loading dose and particle size of BSA/cefadroxil mixture powder increased. Cefadroxil released from the matrix exhibited antibacterial activity for up to 4 days. SEM of the cross-section of matrix showed the typical channel formation after 3 days of release study. Thus, a biodegradable polymeric matrix loaded with antibiotic/BSA mixture can effectively prevent bacterial infection on its surface, thereby bringing about an enhancement of biocompatibility of biomaterials.

설측 복합레진 색상이 치아 순측 색상에 미치는 영향

문승희,박수정,조현구,황윤찬,오원만,황인남 大韓齒科保存學會 2009 Restorative Dentistry & Endodontics Vol.34 No.4

본 연구는 순면 잔존 치질의 두께와 후방 복합레진의 색상이 최종 수복된 치아표면의 색상에 미치는 영향을 알아보고자 시행하였다. 배경판으로 사용될 복합레진은 Filtek Supreme (3M ESPE, St. Paul, U.S,A.)의 Al, A2, A6D, Bl, B2, B3,C1, C2 C6D를 선택하였다. 배경판으로 사용될 복합레진 시편은 직경 10 mm, 두께 4.5 mm로 각 shade당 한 개씩 제작하였다. 순면 잔존 치질은 상악 중절치 치관의 순면을 제외한 나머지 부위를 아크릴릭 레진을 이용하여 매몰 후 저속의 Diamond Wheel Saw (Isomet ; Buehler Ltd, Lake Bluff, U.S.A.)를 이용하여 주수 하에 순면으로부터 2.5 mm 두께로 절단하였다. 절단된 상아질측 표면을 2000번 사포로 연마하여 2.2 mm 두께의 시편을 얻었다. 분광광도계 Spectrolino^(Ⓡ) (Serial No. 3257-18522, GretagMacbeth, Regensdorf, Switzerland)를 이용하여 치아시편을 9개의 복합레진 시편위에 접촉면에 수분이 있는 상태로 위치시켜 치아 순면색상을 측정하였다. 그 후, 치아시편의 상아질 측면을 1.0 mm까지 0.3 mm 간격으로 연마하면서 복합레진 시편위에 위치시켜 동일한 방법으로 색상을 측정하였다. 모든 시편에서 L^(*)값과 b^(*)값은 배경색에 무관하게 치아시편의 두께가 두꺼워질수록 증가하는 양상을 보였으나(p <0.05), a^(*)값은 배경색에 무관하게 두께에 따른 유의한 차이를 보이지 않았다. In this study we evaluated the influence of both the thickness of residual enamel and the color of the composite resins applied to lingual surface on the labial surface color. Background plates were made by randomly (Al, A2, A6D, Bl, B2, B3, Cl, C2, C6D) selected colors of Filtek Supreme (3M ESPE, St. Paul, U.S.A.) composite resin. Crown portion of 9 maxillary central incisors were cut off and embedded with acrylic resin except labial surface. Samples of average thickness of 2.2 mm were obtained after cutting it in a thickness of 2.5 mm from the labial surface and sandpaper polish. The shade of composite resin background was measured using Spectrophotometer (Spectrolino^(Ⓡ), GretagMacbeth, Regensdorf, Switzerland). And CIE L^(*)a^(*)b^(*) value of 2.2 mm thickness tooth samples were measured on the 9 composite resin backgrounds. And then, the cutting side of tooth samples was ground to the extent of 1.9 mm, 1.6 mm, 1.3 mm, 1.0 mm and placed on composite resin backgrounds and measured L^(*)a^(*)b^(*) values with the same method. In all samples, L^(*) value and b^(*) value seemed to have a tendency of decreasing as thickness of tooth sample becomes thinner regardless of background colors (p < 0.05). But, a^(*) value didn't show the significant differences depending on the thickness.

Dopamine Transporter Gene의 다형성과 알코올 의존증의 관련

최윤정,방승규,김정진,도규영,백인호 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 도파민계는 알코올 추구와 같은 알코올 의존증과 관련된 행동에 중요한 역할을 한다. Dopamine transporter(DAT1)는 신경연접부위에서 도파민 재흡수에 관여하여 도파민 활성을 종결시키는 물질로 알려져 있다. 그러므로, DAT1 유전자가 알코올 의존증에 대한 감수성에 영향을 줄 수 있다. DAT1 유전자는 다형성을 보이는 반복된 40개의 염기서열(VNTR)을 갖는다. 본 연구에서는 DAT1 유전자 다형성과 알코올 의존증 및 알코올 의존증의 임상변인과의 관련성에 대하여 알아보았다. 방 법 : 알코올 의존증 환자 94명과 정상대조군 113명을 대상으로 말초혈액을 채취하여 분리된 DNA의 DAT1 유전자를 DNA 중합효소연쇄반응으로 증폭하였다. 증폭된 산물을 15% polyacrylamide gel에서 전기영동하여 나타나는 띠의 크기에 따라 유전자형을 구분하였다. 자료의 통계적 처리는 Fisher's exact test, oneway ANOVA를 사용하였다. 결 과 : 환자군과 정상대조군의 유전자형은 모두 Hardy-Weinberg equilibrium의 예상치와 유의한 차이가 없었다. 대립유전자는 7 repeats, 9 repeats, 10 repeats, 11 repeats의 4가지 종류로 구분되었고, 유전자형은 7/7 repeats, 7/10 repeats, 9/10 repeats, 10/10 repeats, 10/11 repeats의 5가지 형태를 보였다. 환자군과 대조군간에 DAT1 유전자형 및 대립유전자 빈도는 유의한 차이가 없었고, DAT1 유전자형에 따른 음주 시작 연령, 알코올 의존증의 발병 연령 및 잠복기간에서도 차이가 없었다. 알코올 의존증의 가족력이 있는 환자군과 없는 환자군은 DAT1 유전자형의 빈도에서 차이가 있는 경향을 보였고(χ²=6.912, p=0.081), DAT1 대립유전자의 빈도에서도 유의한 차이가 있었으며(χ²=10.193, p=0.008), lambda값은 0.046였다. 결 론 : DAT1 유전자의 다형성이 알코올 의존증의 유전적 소인이 될 가능성은 적은 것으로 보이나, 알코올 의존증의 가족내 유전과는 관련있을 것으로 시사된다. Objectives : Alcoholism is known to be a heritable disease. It has been hypothesized that dopaminergic systems play an important heritable role in human behavor related to alcohol dependence, such as alcohol seeking. Therefore, genes involved in this pathway, including dopamine transporter(DAT1), which is responsible for taking released dopamine back up into presynaptic terminals and terminating dopaminergic activity, are potential candidate that may affect susceptibility to alcoholism. Analysis of a 40-base pair(bp) repeat(VNTR) in the 3' untranslated region of the DAT1 gene revealed variable number of the repeat ranging from 3 to 11 copies. Therefore, in the present study, we examined the association between alcoholism and VNTR polymorphism of DAT1. Methods : Genomic DNA analysis with polymerase chain reaction(PCR) was used to identify the presence of a VNTR polymorphism. It was carried out within a group of 94 alcoholic patients and 113 normal controls. Results : 1) There were no significant differences in allelic or genotype frequencies between the group of alcoholic patients and controls. 2) There were no significant differences in the first drinking age, onset age and latency of alcoholism according to DAT1 genotypes. 3) There was a significant difference in allelic frequencies between alcoholics with family history and those without family history. Conclusions : These results suggested that VNTR polymorphism of DAT1 is unlikely to be a factor in the genetic etiology of alcoholism, but might be related to familial transmission of alcoholism.