잇솔질 압력에 따른 잇솔강모의 탄력손실도 측정

임선아,서은주,강성귀,성진효 조선대학교 구강생물학연구소 2002 Oral Biology Research (Oral Biol Res) Vol.26 No.2

To investigate the elasticity loss of toothbrush according to the strength of pressure. the shape of brushing plane and the duration of use, thirty toothbrushes of five models were used for this examination among the toothbrushes for adults which have been marketed in the Republic of Korea. After 200g/㎠. 300g/㎠, or 400g/㎠ for 1, 2 or 3 month were loaded on toothbrushes, in rolling method the effect of the duration and strength of pressure and the change of the shape of brushing plane on the elasticity loss of toothbrushes was determined using Toothbrush Stroke Testen(CHUMDAN SYSTEM, Korea). The results are as follows; 1. The elasticity loss of toothbrushes according to 200, 300, or 400g/㎠ pressure was 11.11%, 25.21%, 30.84%, respectively. The elasticity loss of toothbrushes was increased with increasing the strength of the pressure (p<0.001) 2. The elasticity loss of the toothbrushes according to 1, 2, or 3months of the duration of use was in 15.60%, 22.09%, 29.47%, respectively. The elasticity loss of the toothbrushes was increased with increasing the duration of the pressure(p<0.001). 3. The elasticity loss of toothbrushes of convex plane according to 1, 2 or 3 month of the durate of use was 10.36% 18.29% and 24.20% respectively, that of toothbrushes of flat brushing plane according to 1, 2 or 3 months of the duration was 20.08%. 25.87% and 34.74%. respectively. The elasticity loss of the toothbrushes or flat brushing plane was higer than that of convex brushing plane(p<0.05). These results show that the property of the KS is optimal according to the pressure of toothbrushing, the shape of toothbrushos and the duration of toothbrushes using must be checked, and the further studies are needed about that.

둥글레(Polygonatum odoratum) 재분획물이 streptozotocin 유발 당뇨 흰쥐의 인슐린 활성에 미치는 영향 및 급성 독성에 관한 연구

임숙자,윤진선 德成女子大學校 1996 德成女大論文集 Vol.27 No.-

This study was carried out to investigate the hypoglycemic effect of subfractions from BuOH fraction in streptozotocin(STZ)-induced diabetic rats. Sixty male Sprague-Dawley diabetic rats weighing 200-300g were induced diabetes mellitus by the STZ injection(45mg/kg) into the tail vein and were devided into five groups; STZ-congrol, and four experimental groups(subfraction A, B, C and D). All groups were orally administered each subfraction, and normal and STZ-control groups were orally administered each subfraction, and normal and STZ-control groups were orally administered Tween 80 with the same amounts for 14 days. The body weight gain was monitored and the blood levels of glucose and cholesterol were analyzed. The levels of plasma triglyceride, HDL-cholesterol, free fatty acid and aminotransferase activity were determined. The extent of blood glucose decremints in rat of orally administered with subfractions was greater than that found in the STZ-control group. The plasma cholesterol levels were not influenced. The levels of insulin were higher in the subfraction groups compare to STZ-control group. The acute toxicity of BuOH fraction was not observed in the subfraction-administered mouse(5g/kg). Administration of subfractions significantly reduced the blood glucose level, AST/AlT activity and insulin showing the possibility of preventive and therapeutic use to diabetes mellitus

브랜드 인지도와 광고가 콘택트렌즈의 착용감과 가격만족도에 미치는 영향

임동규 ; 신상준 ; 한지선 ; 이익한 ; 김진숙 김천대학교 2016 김천대학교 논문집 Vol.36 No.-

The purpose of this research was to analyze the effects of brand awareness and brand advertising on price satisfaction and comfort in contact lens. We did a survey with 200 university students (85 male, 115 female) who have experience of wearing contact lens from April to May in 2015. The brand awareness of contact lens influences to purchasing intention of contact lens, it effects women more than men. Many respondents(53%) replied that the reliability is the most important elements of the advertising. This survey indicates that there is no statistically significant correlation between the brand awareness and advertisement with price satisfaction in contact lens. Therefore we could confirm they have dissatisfaction for prices of contact lens regardless to brand awareness or advertisement. The brand and advertising dependence group have more comfort of contact lens than non-dependence group when they are long time wear of contact lens. Therefore, there is statistically significant correlation between the brand awareness and advertisement with comfort of contact lens. As a result, brand awareness and reliability of advertising influences to purchasing intention of contact lens. But there is no statistically significant correlation with price satisfaction in contact lens. Whereas, brand awareness and advertisement have a statistically significant correlation with comfort of contact lens.

12-O-Tetradecanoylphorbol-13-Acetate에 의한 HL-60 세포 분화유도중 Vimentin 유전자 전사조절에 대한 AP-1의 역할

임규,김진희,권도원,김승민,이명선,윤경아,손미영,박종일,윤완희,황병두 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-

Purpose: To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay. Materials and Methods: HL-60 cells were grown in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum and antibiotics in a humidified 5% CO_2 at 37℃. Total RNA was prepared by a modification of the method of Karlinsey et al. Northern blot hybridization was performed by the method of Virca et al. EcoRI fragment of pVIM-GEM was used as probe for vimentin mRNA. DNA mobility shift assay was performed by the method of Lim et al. End labeled DNA probe(Upper strand, 5'-CGCTTGATGAGTCAGCCG- 3') for AP-1 binding activity was mixed with nuclear extracts in a 20 μl reaction volume containing 300 mM KCI, 60 mM HEPES, pH 7.9, 25 mM MgCI_2, 1 mM EDTA, 1 mM DTT, 60% glycerol, and 2 ㎍ of poly[dI-dC]. Results: TPA increased vimentin mRNA levels, with maximal stimulation reached at 24 hr. The level of vimentin mRNA was induced in proportion to the concentration of TPA. TPA-induced vimentin mRNA was almost reduced by actinomycin-D pretreatment. TPA-induced stimulation of vimentin gene was completely reduced by staurosporin pretreatment. In DNA mobility shift assay, AP-1 newly appeared at 24 hr during TPA-induced differentiation and was almost not detected after the pretreatment of staurosporin. Conclusions: These results suggest that the induction of vimentin mRNA during TPA-dependent differentiation in HL-60 cells may be mediated by protein kinases C signal transduction and AP-1 is important to transcriptional regulation.

12-O-Tetradecanoylphorbol-13-Acetate에 의한 HL-60 세포 분화유도중 Vimentin 유전자 전사조절에 대한 AP-1의 역할

임규,김진희,권도원,김승민,이명선,윤경아,손미영,박종일,윤완희,황병두 忠南大學校 癌共同硏究所 1998 癌共同硏究所 硏究誌 Vol.2 No.1

Purpose: To gain insight on the role of AP-1 in transcriptional regulation of vimentin gene during differentiation of HL-60 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA), the levels of vimentin mRNA and AP-1 have been investigated with Northern blot hybridization and DNA mobility shift assay. Materials and Methods: HL-60 cells were grown in RPMI 1640 medium supplemented with 10% heat-inactivated fetal calf serum and antibiotics in a humidified 5% CO_(2) at 37°C. Total RNA was prepared by a modification of the method of Karlinsey et al. Northern blot hybridization was performed by the method of Virca et al. EcoRI fragment of pVIM-GEM was used as probe for vimentin mRNA. DNA mobility shift assay was performed by the method of Lim et al. End labeled DNA probe(Upper strand, 5'-CGCTTGATGAGTCAGCCG- 3') for AP-1 binding activity was mixed with nuclear extracts in a 20 μl reaction volume containing 300 mM KC1, 60 mM HEPES, pH 7.9, 25 mM MgCl_(2), 1 mM EDTA, 1 mM DTT, 60% glycerol, and 2μg of poly[dI-dC]. Results: TPA increased vimentin mRNA levels, with maximal stimulation reached at 24 hr. The level of vimentin mRNA was induced in proportion to the concentration of TPA. TPA-induced vimentin mRNA was almost reduced by actinomycin-D pretreatment. TPA-induced stimulation of vimentin gene was completely reduced by staurosporin pretreatment. In DNA mobility shift assay, AP-1 newly appeared at 24 hr during TPA-induced differentiation and was almost not detected after the pretreatment of staurosporin. Conclusions: These results suggest that the induction of vimentin mRNA during TPA-dependent differentiation in HL-60 cells may be mediated by protein kinases C signal transduction and AP-1 is important to transcriptional regulation.

심정지환자에서 epinephrine투여시 혈중 catecholamine의 변화

임경수,황성오,이부수,이강현,이진웅,임종천,김영식,김선만,김 현 대한응급의학회 1995 대한응급의학회지 Vol.6 No.1

Background : Cardiac arrest is a potent stimulus for the release of endogenous catecholamine and high plasma catecholamine concentration has been reported during cardiopulmonary resuscitation(CPR). Few data were present about the clinical effect of high plasma catecholamine and endogenous catecholamine response to exogenous epinephrine administration during CPR. Purpose : This study was designed to evaluate endogenous catecholamine response to cardiac arrest and exogenously administered epinephrine during CPR. Method : In 21 cardiac arrest victims, blood sample for epinephrine and norepinephrine was drawn before and 1 minute after each epinephrine administration during CPR. 1mg of epinephrine was administered immediately after intravenous access and 3 minute interval during CPR. Plasma catecholamines were quantitated by high-performance liquid chromatography. Result : Baseline plasma epinephrine concentraqtion was higher in patients with cardiac arrest than normal controls (985±1627 vs 194±173 pg/ml, p<0.05). Baseline plasma norepinephrine concentration was also elevated in patients with cardiac arrest than normal controls, although statistically insignificnat(1965±4915 vs 360±250 pg/ml). Plasma epinephrine concentration in cardiac arrest patients was significantly elevated after exogenous administration of epinephrine, but its response was blunted after the third does of epinephrine. Plasma norepinephrine concentration in cardiac arrest patients was also elevated, but its response was observed only after the first epinephrine administration. Plasma epinephrine concentration was persistently higher in patients with return of spontaneous circulation (ROSC) than patients without ROSC. there was no significant difference of plasma norepinephrine concentration whether spontaneous circulation was restored or not. Endogenous epinephrine response to exogenous epinephrine was not observed in patients having prolonged arrest time over 20 minutes. Conclusion : Results of this study suggests that significant amount of catecholamine is released by exogenous epinephrine administration in spite of high plasma catecholamine concentration, and degree of endogenous catecholamine response influences resuscitation outcome.

박물관 관람자의 동선특성에 관한 조사

임채진,한선영 홍익대학교 산업디자인 연구소 1999 미술디자인 논문집 Vol.- No.4

The purpose of this study is to analyze the characteristics of exhibition circulation through the movement pattern. It looks into the factors under the influence with the visitor's movement. The method of analysis is statistics of investigation by following after visitors. The viewing behavioral of exhibition based on the time, speed, proportion of appreciation is classified into three types of the profound, the general, the passing viewers. The characteristics of the viewing form of these patterns largely depend on the space elements which are the structure form. And particularly the position of exit, the width of exhibition space and the connection of exhibition space stand out the disparity of the factor of the spatial structure. These three patterns bring about a lot of encounter in the exhibition space according to the difference of these routes consequently. So appropriate to the planning of each pattern can offer visitors to more effective environment of exhibition.

우리나라 논 관개용 지하수 수질 특성

김진호,조광래,임수정,이경자,경기천,엄미정,김희권,김찬용,이영한,이신찬,윤순강 한국환경농학회 2003 한국환경농학회지 Vol.22 No.4

This study was carried out to evaluate the status of the groundwater quality for paddy fields irrigation in Korea. Water samples were collected at 130 sites throughout the country. Samples were collected at three seasons-April, July and October-in 2000. According to our survey, the groundwater was found to be suitable for irrigation purpose. Average EC was shown 0.286 dS/m. Nitrate-nitrogen and Cl^(-) concentration was 5.6 ㎎/L, 32.95 ㎎/L which satisfied the Korean Standards for Irrigation Water. Nitrate-nitrogen concentration in each province was shown as following orders: Jeju (11.17 ㎎/L) > Chungnam (8.16 ㎎/L) > Gyeongbuk (6.64 ㎎/L) > Gyounggi (5.91 ㎎/L) > Chungnam (4.95 ㎎/L) > Gyeongnam (3.91 mgk) > Jeonbuk (3.50 ㎎/L) > Jeonnam (3.27 ㎎/L) > Gangwon (2.91 ㎎/L). The concentration by sampling seasons were October (6.62 ㎎/L) > July (5.88 mg&) > April (4.78㎎/L). As the soil of Jeju Province is usually derived from volcanic ash soils mainly used for upland drops, it may influence the nitrate-nitrogen concentration of groundwater. The amount of rainfall also influence the water quality. But the COD_(Cr), were shown April (3.17㎎/L) > July (2.91 ㎎/L) > October (2.40 ㎎/L), it is highly related in the basal dose of organic matter fertilizers. This study demonstrated that groundwater quality was suitable for irrigation, but continuous monitoring is recommended for agricultural policy and developing OECD agricultural environment indicators.

노인의 구강건강 영향지수에 영향을 미치는 요인

이명선,임선아,김진 朝鮮大學校 統計硏究所 2007 統計硏究所論文誌 Vol.9 No.1

우리나라는 고령화(aged society)로 진입하였으며 고령화속도 또한 매우 빠를 것으로 알려져 있다. 이로 인해 노인문제가 보건사회문제로 대두되고 있고, 삶의 질에 대한 관심이 높아지고 있다. 본 연구는 구강건강관련 삶의 질에 영향을 미치는 요인을 분석하고자 구강건강 관련 삶의 질에 대한 평가를 위해 구강건강관련 삶의 질 지수 중 가장 널리 사용되는 OHIP(Oral Health Impacr Profile)을 이용하였다. 이에 연구 가설을 검증하기 위해서 면접지를 전국의 65세 이상의 노인을 대상으로 직접 면접조사를 실시하였으며 회수된 면접 지를 통해 통계분석을 실시하였다. 먼저 측정도구에 대한 검증을 수행하기 위해 신뢰성 및 면접자간의 일치도를 측정하고 측정도구의 타당도를 검증한 후 인구통계학적 특성, 구강상태, 구강건강상태와 구강건강영향지수의 연관성을 검정하였고 단순 로지스틱 회귀분석과 다변량 로지스틱 회귀분석을 이용하여 완성형과 축약형의 구강건강영향지수에 영향을 미치는 요인을 분석하였다. 분석결과 노인의 하루동안 잇솔질 횟수, 잔존 치아수, 구강 건조증 여부, 구강 상태 만족, 자가 구강 건강 인식, 건강 상태 만족, 구강 진료 필요성 인식이 구강 건강영향지수에 영향을 미치는 요인으로 확인되어 이에 연관된 정책개발, 삶의 질을 향상하기 위한 구강건강증진 프로그램을 개발하거나 국가보건정책수립의 기초자료로 이용하고자 한다.

담즙정체성 간염의 임상적 양상

최선택,은종렬,임상우,김봉준,이헌주,구미진,최준혁 영남대학교 기초/임상의학연구소 2001 Yeungnam University Journal of Medicine Vol.18 No.1

Background: Cholestatic hepatitis is failure of bile to reach the duodenum with hepatocellular damage and no demonstrable obstruction of the major bile ducts. The prognosis is usually good with recovery in less than 4 weeks after withdrawal of the offending drug. However, a prolonged course lasting over 3 months is possible and, in rare cases, progression to ductopenia with development of a vanishing bile duct syndrome occurs. A differential diagnosis with other causes of Chronic liver disease is needed. Materials and Methods: From January 1991 through Jaunary 2000, 14 patients diagnosed as cholestatic hepatitis by liver biopsy were inclouded. The possible causative drug, clinical features, laboatory findings, and progression of cholestatic hepatitis were evaluated. The semiquantitative study of liver lesions was performed by two independent observers. Results: Causes of cholestatic hepatitis are 5 cases of oriental medicine, 3 cases of anti-tuberculosis medication, 1 case of ticlopidine and antibiotics and 4 cases of unknown causes. The clinical features of cholestatic hepatitis were jaundice, itching, urine color change, and general weakness. During 6 to 30 months, LFT of 5 patients showed prolonged elevation. Elevated total cholesterol ≥250 mg/dL in 6 patients, pheripheral blood eosinophilia in 5 patients, auto-antibody positive in 6 patients were observed respectively. The biopsies showed intralobular bilirubinostasis with a mixed portal inflammatory infiltration. Conclusion: In cholestatic hepatitis. durations of abnormal LFT are variable regardless of causative drugs. If cholestatic hepatitis progresses toward chronic course, viral hepatitis, primary biliary cirrhosis, and autoimmune hepatitis should be differentially diagnosed and sequential liver biopsies are needed.