Duplication 9p Syndrome 1례

이미경,노영래,김영훈,백청순,신미경,이진,장필상,김진택,이권행,황경태 대한소아과학회 2002 小兒科 Vol.45 No.9

1-Chloro-1-phenyl-2-carboethoxy-2-cyanoethene 유도체에 대한 thioglycolic acid 치환제의 합성

이영행,이채호,이갑상,이만구 圓光大學校 1984 論文集 Vol.18 No.2

The substitution products of thioglycolic acid to the derivatives of 1-chloro-1-phenyl-2-carboethoxy-e-cyano ethene synthesized 1-Chloro-1-phenyl-2-carboethoxy-2-cyanoethene [Ⅴ], 1-chloro-10(4-chlorophenyl)-2-carboethoxy-2-cyanoethene[Ⅳ] and 1-chloro-1-(4-methoxyphenyl)-2-carboethoxy-2-cyanoethene[Ⅶ] undergo substitution reactions with thioglycolic acid to form s-[(1-phenyl-2-carboethoxy-2-cyano) ethenyl]-thioglycolic acid s-[(1-(4-chlorophenyl)-2-carboethoxy-e-cyano] ethenyl]-thioglycolic acid and s-[1-(4-methoxyphenyl)-2-carboethoxy-2-cyano] ethenyl]-thioglycolic acid, respectively. The structure of products were identified by elemental analysis, potentiometric titration, infrared and nmr spectra.

Diethyl 3,4,5, - Trimethoxybenzylmalonate의 새로운 합성법

李茶浩,李英行,李晩求,蔡奎允 圓光大學校 1984 論文集 Vol.18 No.2

3,4,5 - Trimethoxybenjoyl chloride 와 diethyl malonate를 축합시키고 이어서 염소화반응 및 수소화반응에 의하여 70%의 수득률로서 diethyl 3,4,5 - trimethoxybenzylmalonate를 얻었다. direct condensation of 3,4,5 - trimethoxybenzoyl chloried with diethyl malonate followed by chlorination and hydrogenation afforded diethyl 3,4,5 - trimethoxybenzylmalonate in 70% overall yield.

미나리의 성분 특성

이형재,김용두,정현숙 順天大學校 師範大學 附屬 科學敎育硏究所 1994 科學과 敎育 Vol.2 No.-

미나리는 독특한 풍미 및 색깔을 지니고 질감과 영양이 뛰어나서 그 이용이 증가되고 있으나, 아직 연구가 미흡한 점을 주시하여 보다 나은 미나리의 활용을 위한 과학적 기초 자료를 얻고자, 미나리의 성분 특성 및 열처리와 냉각방법을 달리하여 ascorbic acid와 시각적 기호도에 영향을 미치는 chlorophyll의 변화를 검토하였는데 그 결과를 요약하면 다음과 같다. 무기성분은 칼륨과 칼슘의 함량이 높았고 줄기보다 잎에서의 함량이 높아 약 1.0-3.4 배의 차이를 나타냈다. 총 아미노산 함량은 줄기와 잎에서 각각 2139.50mg%, 3031.27mg% 였으며 잎의 함량이 줄기보다 1.42배 높았고 총 아미노산에 대한 필수 아미노산의 비율은 줄기가 37.14%, 잎이 37.71%로 나타났다. 확인된 아미노산은 16종이었으며 각 아미노산의 함량은 줄기에서 aspartic acid와 arginine이 주요 구성 아미노산으로 전체의 22.08%를 차지하였고 lysine > histidine > glutamic acid 순으로 함량이 많았으며 잎의 경우는 glutamic acid, arginine이 주요 구성 아미노산으로 18.93%를 나타냈고, aspartic acid > leucine> lysine의 순으로 함유되었으며, 이는 줄기의 주요 아미노산의 함량과 차이를 나타냈다. 줄기와 잎에서 ascorbic acid 함량은 각각 7.60mg%, 8.72mg%였으며 cholrophyll의 함량은 각각 16.33mg/g, 34.83mg/g로 잎부위가 줄기부위보다 높았다. 열처리 방법에 따라서 ascorbic acid 보유율은 microwave 열처리에서 가장 높았고 1000㎖식염수(1%) > 1000㎖ >500㎖ 순이었으며, chlorophyll 보유율은 1000㎖ 식염수 (1%) >microwave > 1000㎖ > 500㎖ 순으로 높았다. 냉각 방법에서도 실온 방치 냉각보다 냉수 냉각이 훨씬 더 높은 ascorbic acid, chlorophyll 보유율을 보였다. The use of the waterdropwort(Oenanthe javanica DC) as both health food and taste food tends to increase, while the researches on it have not been sufficiently made. For the purpose of obtaining the scientific, basic data for the better use of the water dropwort, the present thesis deals with the researches on the changes in the water dropwort : the ascorbic acid and chlorophyll change depending upon the varied heating and cooling methods which influence visual taste. The research results are as follows. The water dropwort contained greater amount of minerals such as K and Ca, and the leaf had 1.0-3.4 times as much content as the stem. The total amino acid content was 2139.50 mg% in the leaf -1.42 times more in the leaf than in the stem. The ratio of essential amino acid to the total amino acid was 37.14% in the stem and 37.71% in the leaf. 16 different kinds of amino acid were detected from the water dropwort. Aspartic acid and arginine were the major amino in the stem, representing 22.08% of the total, and the content was in the order of lysine, histidine, glutamic acid. Glutamic acid and arginine were the major amino acid in the leaf, representing 18.93% of the total, and the content was in the order of aspartic acid, leucine, lysine. The content of ascorbic acid was 7.60 mg% in the stem and 8.72 mg% in the leaf. The content of chlorophyll was 16.33 mg/g in the stem and 34.83 mg/g in the leaf. When the water dropwort was heated, the retention rate of ascorbic acid was the highest in the case of microwave heating method, and the rate was high in the order of 1000㎖(1% NaCl)>1000㎖>500㎖. The retention rate of chlorophyll was high in the order of 1000㎖(1%NaCl)>microwave>1000㎖>500㎖. When the water dropwort was cooled, the retention rate of ascorbic acid and chlorophyll was higher in the cool water cooling than in the room temperature cooling.

L-N-Benzylaspartic acid의 선택적 에스테르화 반응

이채호,김일광,박승화,이영행,정봉영 圓光大學校 基礎自然科學硏究所 1987 基礎科學硏究誌 Vol.6 No.1

Selective esterification and synthesis of L-N-benzylaspartic acid from L-aspartic acid are described. L-Aspartic acid was transformed into dibenzyl L-asparate p-toluenesulfonate, which was treated with sodium bicarbonate to afford dibenazyl L-asparate. Formation of Schiff base of dibenayl ester with benzaldehyde and subsequent hydrogenation-dehydrogenation of the Schiff base produced L-N-benaylaspartic acid. L-N-Benaylaspartic adcid was transformed into L-N-benzylaspartic anhydride hydrogen bromide, which was treated with methyl alcohol and benzyl alcohol to afford a-methyl and a-benzyl L-N-benzylaspartate and L-N-benaylaspartic acid was transformed into L-N-benaylaspartic acid copper(Ⅱ) salt, which was treated with N,N,N,N-tetramethylguanidine and benzyl bromide to afford β-benzylaspartate

Moclobemide의 항우울 효과에 대한 평가

이귀행,박민철,노승호,백영석,이상열,김재현 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

Eighteen patients took Moclobemide for 6 weeks, who had been diagnosed as major depression based on DSM-Ⅲ-R and had had more than 16 points on the Hamilton Depression Rating Scale. After medication of Moclobemide, they were evaluated by the Hamilton Depression Rating Scale and in terms of sleep, vigilance, performance, social interactions and drive. The results were as follows ; 1. The average dosage of Moclobemide was 400±89 ㎎. 2. Antidepressant effect were checked on the all items of the Hamilton Depression Rating Scale and prominent on the items of work and activities, insomnia, suicide, somatic symptoms. 3 There were obvious changes of the antidepressive effect by the evaluation of the doctors and patients at 4 weeks after the medication of Moclobemide. 4. In the patients, 61% had positive effects on the sleep. 94% no negative effects on the vigilance. Nobody has negative effects on the social interactions and drive. 5. Side effects or physical disturbances induced by Moclobemide were not found. According to these results, it seemed that Moclobemide had clear antidepressant effects, few negative effects on the life of day time, positive effects on the sleep and somatic symptoms.

인슐린의존형 당뇨병환자에서 임신중 병발한 당뇨병성 케톤산증 1예

이성근,신영구,이성규,정윤석,이관우,김현만,김행수 아주대학교 1997 아주의학 Vol.2 No.2

저자등은 인슐린의존형 당뇨병환자에서 임신중에 병발한 당뇨병성 케톤산증을 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. IDDM is an autoimmune disease resulted from beta cell destruction and insulin deficiency, and developed mostly in children and puberty. Ketoaddosis remains one of the most senous complications that can occur in the pregnant diabetic. A 26-year-old woman, gravida 1, para 0, was admitted at 32 weeks gestation because of fever lasted for 6 days. She had been treated with insulin pump during the pregnancy. Blood sugar was well controlled before admission, and the etiology of her ketoacidosis was urinary tract infection and no insulin-intake. DKA was treated with fluids and intravenous insulin. Urinary tract infection was treated with antibiotics, based on culture test. Healthy newbom was later delivered by cesarean section due to fetal distress. We experienced a case of DKA in pregnant woman and report it with a review on literature.

N-Isoprophyliminotriphenylphosphorane과 Benzaldehyde 유도체와 반응

李英行,李晩求,金基炫 圓光大學校 基礎自然科學硏究所 1986 基礎科學硏究誌 Vol.5 No.2

The reactions of N- sopropyliminotriphenylphosphorane with benzaldehyde derivatives were investigated by GC. The reaction were completed within 8hours at an approximate reaction condition. The reactivity of benzaldehyde was in order, Ar=p-NO_2>p-Cl>p-Br>H>p-CH_3>p-CH_3O> and Ar=p-C_2H_5O, consistant with the Wittig mechanism. The reactivity of iminophosphorane increased with the change of reaction solvent from benzene to ethanol.

새로운 의약품의 합성에 관한 연구 : 6-Thiocyanopenicillanic Acid 유도체의 합성

李英行,李寀浩,崔元植 원광대학교기초자연과학연구소 1992 基礎科學硏究誌 Vol.11 No.3

6-Aminopenicillanic acid의 diazo화 반응과 sodium thiocyanate와 반응으로 새로운 β-lactam 화합물인 6-thiocyanopenicillanic acid(1a)를 합성하고 p-nitrobenzyl bromide, chloromelthylpivalate 및 1-chlorodiethylcarbonate들과의 반응에 의해 각각에 해당하는 ester(1b~d)를 합성하였다. A new β-lactam compound, 6-thiocyanopenicillanic acid(1a) was prepared by the reaction of diawnium salt of 6-aminopenicillanic acid with sodium thiocyanate. Reaction of 6-thiocyanopenicillanic acid(la) with p-nitrobenzyl bromide, chloromethylpivalate and l-chlorodiethylcarbonate, respectively, afforded the corresponding esters(1b~d).

Riboflavin Tetrabutyrate의 합성에 관한 연구

李英行,李鍾律,李寀浩 圓光大學校 基礎自然科學硏究所 1983 基礎科學硏究誌 Vol.2 No.1

Riboflavin(Vitamin B_2) is a component of two closely related coenzymes, flavin mononucleotide(FMN) and flavin adenine dinucleotide(FAD). Riboflavin tetrabutyrate is more fat-soluble than riboflavin, which is highly absorbed in vivo. and hydrolysed to give riboflavin. Riboflavin tetrabutyrate has always been synthesized by general method of ester. But the use of DMAP was found be very effective for esterification of riboflavin with butyric acid.