Intraocular Lens Power Calculation Using IOLMaster and Various Formulas in Short Eyes

노영래,이상목,한영근,김미금,위원량,이진학 대한안과학회 2011 Korean Journal of Ophthalmology Vol.25 No.3

Intraocular Lens Power Calculation Using IOLMaster and Various Formulas in Short Eyes

Foveal Thickness between Stratus and Spectralis Optical Coherence Tomography in Retinal Diseases

노영래,박규형,우세준 대한안과학회 2013 Korean Journal of Ophthalmology Vol.27 No.4

Purpose: To compare the foveal thickness (FT) parameters measured by Stratus optical coherence tomography (OCT) and Spectralis OCT in various retinal diseases and to construct conversion formulas between the two types of OCT devices. Methods: We examined 366 consecutive patients (475 eyes) with retinal diseases and 13 normal controls (13eyes). The patients were categorized into eight retinal disease groups. The mean amount and distribution of foveal thickness differences (FTD) measured by Stratus and Spectralis OCT were determined, and conversion formulas were constructed for Stratus OCT FT from Spectralis OCT FT for each retinal disease group. Results: Among retinal diseases, the mean FTD was significantly larger in exudative age-related macular degeneration (AMD) patients (mean ± SD, 94.0 ± 55.0 μm) compared to normal subjects (66.2 ± 11.7 μm; p <0.0001). The proportion of eyes with a mean FTD outside 1.96 standard deviations of normal subject FTD was greatest in the exudative AMD (50.0%) group and smallest in the macular hole (18.2%) group. The predicted FTs obtained through the conversion formulas showed lower variance than the actual FTD values, especially in the exudative AMD group. The prediction line for exudative AMD deviated most from that of normal subjects. Conclusions: FTD shows diverse values and variances among various retinal diseases, especially in exudative AMD, which indicates that Stratus OCT FT cannot be predicted from Spectralis OCT FT by FTD value alone. We constructed statistically significant conversion formulas, which provided more reliable methods to predict Stratus OCT-measured FT from Spectralis OCT measurements for different retinal disease groups.

만성기침에 대한 보조제제로써 청인(淸咽)트로키 복합투여의 임상적 유효성 평가

노영래,최준용,이성헌,김재환,정희재,정승기,Roh, Young-Lae,Choi, Jun-Yong,Lee, Sung-Hun,Kim, Jae-Hwan,Jung, Hee-Jae,Jung, Sung-Ki 대한한방내과학회 2008 大韓韓方內科學會誌 Vol.29 No.3

Objectives : We designed this study to evaluate the effectiveness of Chungin-troche(CIT) preparation as an adjunctive medicine to a herbal extract of Chungsangboha-tanggagambang(CSBH). Methods : A paralled, comparative study of CSBH+CIT and CSBH was conducted on 42 patients of chronic cough who attended Division of Allergy, Immune & Respiratory System, Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University between December, 2007 and June, 2008. The treatment in each group lasted for two weeks. Patients were asked to fill in the Leicester Cough Questionnaire (LCQ) before and after administration of each treatment legimen. Results : 42 patients completed the trial and no adverse effects were reported. Both CSBH +CIT group and CSBH group showed statistical significant improvement in total LCQ score after 2 weeks from baseline. Social domain score and total score in patients taking CSBH+CIT showed a statistical significant increase compared to those scores in CSBH patients. Conclusion : CSBH+CIT compositive preparation and CSBH separate preparation appeared to have some benefits in the treatment of chronic cough. However, additional CIT preparation to CSBH can improve social domain in LCQ of chronic cough patients.

백내장 수술 후 발생하는 안구건조증의 임상양상 및 영향을 미치는 요인에 대한 분석

노영래,이상목,한영근,김미금,위원량,이진학,Young Rae Roh,Sang Mok Lee,Young Keun Han,Mee Kum Kim,Won Ryang Wee,Jin Hak Lee 대한안과학회 2011 대한안과학회지 Vol.52 No.9

Purpose: To evaluate the changes in the clinical signs and symptoms of dry eye syndrome before and after cataract surgery according to the main incision location and the type of artificial tears. Methods: Twenty-four eyes of 17 patients who underwent phacoemulsification and posterior chamber lens insertion from May 2009 to July 2009 were enrolled in the present study prospectively. The main incision location (temporal or superior incision) was determined according to the axis of astigmatism and the postoperative artificial tears (sodium hyaluronate with or without preservatives) were determined randomly. The tear film break-up time (TF-BUT), Schirmer test, esthesiometer, corneal surface grading with Oxford system and ocular surface disease index (OSDI) questionnaire before and 1, 2 and 6 months after surgery were evaluated. The corneal nerve was also analyzed using corneal confocal microscopy (Confoscan 4, Nidek, Italy) before, and 1 and 6 months after surgery. Results: The TF-BUT was significantly longer (<em>p</em> = 0.010) and the OSDI score was significantly lower (<em>p</em> = 0.007) in the patient group with preservative-free sodium hyaluronate than the group with sodium hyaluronate containing preservatives at 6 months after cataract surgery. There were no statistically significant differences according to the main incision location in the sodium hyaluronate without preservatives group. Conclusions: Symptoms and several signs of dry eye syndrome triggered by cataract surgery decreased with preservative- free artificial tears compared to tears with preservatives. J Korean Ophthalmol Soc 2011;52(9):1030-1038

망막 낭포가 동반된 코우츠병 환아 1예

노영래,김정훈,유영석 대한안과학회 2010 대한안과학회지 Vol.51 No.3

Purpose: To report a case of laser photocoagulation treatment for the patient of Coats’ disease accompanying a retinal macrocyst. Case summary: A three-year-old boy visited the hospital whose chief complaint was visual acuity decrease of his left eye. Fundus examination showed macular scar, foveal hard exudates and inferior retinal cystic lesion in his left eye. Two months later, examination under anesthesia (EUA) and fluorescein angiography (FAG) was performed. The results revealed inferior retinal macrocyst, nasal avascular retina and telangiectasia around the retinal macrocyst. Laser photocoagulation was performed around the retinal macrocyst and at the nasal avascular retina. One year after the laser photocoagulation, retinal macrocyst did not further progress and the retina was stabilized. Conclusions: Laser photocoagulation was done around the retinal macrocyst and at the nasal avascular retina of the Coats’ disease accompanying a retinal macrocyst and the lesions did not further progress and the retina was stabilized. J Korean Ophthalmol Soc 2010;51(3):453-457

연령대에 따른 망막신경섬유층결손의 양상 분석

노영래,권지원,한영근,위원량,이진학,박기호.Young Rae Roh. MD. Ji Won Kwon. MD. PhD.. Young Keun Han. MD. PhD.. Won Ryang Wee. MD. PhD.. Jin Hak Lee. MD. PhD... Ki Ho Park. MD. PhD. 대한안과학회 2011 대한안과학회지 Vol.52 No.2

Purpose: To compare the detection rate of the patients with retinal nerve fiber layer (RNFL) defect and the amount of RNFL defect according to the patients’ age. Methods: Retrospective chart reviews of 22,811 subjects, who visited the health care center from January 2009 to December 2009 were performed. The detection rate, location and average amount of RNFL defect and the proportions of the patients who were diagnosed with glaucoma through Humphrey visual field (HVF) test or determined as a glaucomatous optic disc were compared according to the patients’ age. Results: The proportions of the patients whose RNFL defect were detected was highest in the patients 60 years old or older (2.3%) and was statistically significant (p = 0.012). However, there was no significant difference among the other age groups (under 40 years: 1.7%, 40 thru 49 years: 1.5%, 50 thru 59 years: 2.0%). The proportions of the patients who were determined as glaucoma through the HVF test or glaucomatous optic disc were also highest in the patients 60 years old or older (1.4%), however, there was no statistically significant difference (p = 0.070) among the age groups (under 40 years: 1.1%, 40 thru 49 years: 0.9%, 50 thru 59 years: 1.2%). Conclusions: The RNFL defect is likely to be detected in subjects less than 40 years of age and the detection rate is similar to subjects in their 40’s and 50’s. The use of fundus photography to detect RNFL defect in a health care center is recommended in subjects under 40 years of age. J Korean Ophthalmol Soc 2011;52(2):210-215

소비자의 환경의식 , 재활용의식과 재활용행동에 관한 연구 - 미혼취업여성의 사장의복을 중심으로 -

노영래(Young Lae Roh),김시월(Si Wuel Kim) 대한가정학회 2002 Human Ecology Research(HER) Vol.40 No.1

열성경련 플러스에서 SCN1B 유전자의 돌연변이

노영래(Young-Nae Roh),신미영(Mi-Young Shin),김영훈(Young-Hoon Kim),고영선(Young Sun Ko),김진모(Jinmo Kim),김홍태(Hongtae Kim),김흥동(Heung Dong Kim),황경태(Kyung-Tai Whang),이권행(Kweon-Haeng Lee) 대한소아신경학회 2002 대한소아신경학회지 Vol.10 No.2

목 적 : 열성경련은 6세 이하 소아의 2-5%에서 경험하는 비교적 흔한 질환이다. 열성경련을 경험한 소아의 일부는 나중에 비열성경련성질환과 간질로 발전한다. 열성경련플러스(generalized epilepsy with febrile seizure plus, GEFS+)는 열성경련과 다양한 정도의 전신발작 등 이질적은 표현형을 가진 중요한 유전학적간질증후군이다. GEFS+ 관련 유전자는 염색체 19q13.1에 존재하며, voltage-gated sodium channel β1 subunit(SCN1B) 유전자 exon 3내 387 C→G DNA돌연변이와 관련되었다고 보고되었다. 저자들은 단순 열성경련 및 GEFS+로 진단받은 환아를 대상으로 SCN1B 유전자의 돌연변이 여부를 알아보기 위하여 본 연구를 시행하였다. 방 법 : GEFS+로 진단받은 환아 18명과 단순열성경련 환아 13명 등 가족력이 있는 열성경련환아 31명을 대상으로 하여 SCN1B 유전자의 돌연변이를 선별하였다. 5개의 SCN1B exon을 증폭하기 위한 primer쌍은 Neurology Web 사이트에 올려진 Wallace등의 자료에 얻었다. 모든 exon을 PCR로 증폭하였고 증폭된 유전자는 단계적으로 염기서열을 분석하였으며 단일가닥구조다형성(Single-Stranded DNA Conformational Polymor-phism, SSCP) 분석을 8% polyacrylamide gel을 사용하여 수행하였다. 결 과 ; 연령 분포를 보면 10세 미만 24명(77%), 10세에서 14세 미만 3명(10%), 14세 이상 4명(13%)이었다. 남녀비는 0.55였다. GEFS+ 환아의 간질발작 양상으로는 전신 강직-간대발작 14(88%), 근간대발작 1명(6%), 탈력발작 1명(6%)이었다. 뇌파소견ㄴ은 정상 11명(78%), generalized spike wave 5명(28%), diffuse slowing 2명(11%)이었다. 염기서열분석고 SSPC 분석을 통한 본 연구에서는 GEFS+군 2례에서 SCN1B 유전자 exon 3내 DNA 돌연변이를 관찰할 수 있었다. 2례에서 모두 SCN1B 유전자 exon 3내 224 G와 225 C 사이에 염기 C가 추가되어 있는 돌연변이였다. 돌연변이를 나타낸 2례는 다른 가족에서 발생한 경우이다. 결 론 : 저자들은 가족이 다른 두명의 GEFS+ 환아에서 SCN1B 유전자의 새로운 돌연변이를 확인할 수 있었다. Purpose : Febrile seizures affect 2-5% of all children younger than 6 years olf. A small proportion of children with febrile seizures later develop epilepsy. Generalized epilepsy with febrile seizures plus(GEFS+) is an important childhood genetic epilepsy syndrome with heterogeneous phenotypes, including febrile seizures(FS) and generalized epilepsies of variable severity. It was reported that the gene locus for GEFS+ exists in the chromosome 19q13.1, and has relationship with a 387 C→G mutation in the voltage-gated sodium channel β1 subunit(SCN1B) gene. This study is to determine whether there are mutations in children with GEFS+ and FS. Methods : Eighteen GEFS+ and thirteen FS patients were screened for mutations in the sodium channel beta-subunits SCN1B. The primer pairs used to amplify the exons of SCN1B are given in the supplementary data on the Neurology web site. All exons were amplified by PCR and PCR products were subsequently sequenced. Single-stranded conformation polymorphism(SSCP) was carried out using 8% polyacrylamide gel. Results : Twenty four patients(77%) were younger than 10 years old, three(10%) were between 10 and 14 years old, and four(13%) older than 14 years old. The ratio of female to male was 0.55:1.0 In phenotypes of GEFS+, fourteen patients(88%) had generalized tonic-clonic seizures, one patient(6%) myoclonic seizures and one patient(6%) atonic seizures. In EEG findings of GEFS+, eleven(78%) patients had normal findings, five(28%) patients generalized spike waves and two patients(11%) diffuse slowings. In sequencing and SSCP of PCR products, we could observe added C mutations between 224G and 225C of exon 3 in two unrelated patients with GEFS+. Conclusion : We proved the existence of a new mutation of SCN1B in two unrelated patients with GEFS+.

DRAM 기술에서 구리에 대한 Pt/Ti, Ni/Ti의 확산 방지막 특성에 관한 연구

노영래(Young-Rae Noh),김윤장(Youn-Jang Kim),장성근(Sung-Keun Chang) 대한전기학회 2001 대한전기학회 학술대회 논문집 Vol.2001 No.11

영업점 감시 특성과 목표설정의 톱니현상

이상철,노영래 한국회계정책학회 2022 회계와 정책연구 Vol.27 No.3

[연구목적]영업점 관리자에 대한 본사 경영자의 감시 특성으로 영업점의 총자산 규모, 영업점 등급 및 영업점 등급변경을 선정하고, 이러한 본사 경영자의 영업점 감시 특성이 목표설정의 톱니현상에 미치는 효과를 검증하였다. [연구방법]2015년부터 2019년까지 5년간 국내 한 금융투자회사 영업점의 성과목표 및 평가 자료를 분석하였다. Leone and Rock(2002)과 Aranda et al.(2014)의 연구에 기초하여 본사 경영자의 영업점 감시 특성이 톱니현상에 미치는 효과를 검증하기 위한 모형을 설정하고, 회귀분석을 통해 모형을 검증하였다. [연구결과]당기 성과와 목표의 차이는 차기와 당기의 예산목표 차이에 유의적인 양(+)의 영향을 미치는 것으로 나타나, 톱니현상의 존재를 확인하였다. 그러나 영업점이 성과목표를 달성하지 못한 경우와 달성한 경우, 톱니현상의 차이는 나타나지 않았다. 본사 경영자의 영업점 감시 특성이 목표설정의 톱니현상에 미치는 효과를 검증한 결과, 영업점의 총자산 규모가 크면, 톱니현상은 감소하는 것으로 나타났다. 영업점 등급이 높은 경우에는 낮은 경우보다, 톱니현상이 작게 나타났다. 영업점 등급이 변경된 경우에는 변경되지 않은 경우보다, 톱니현상이 작게 나타났다. 본 연구의 검증결과는 영업점 관리자에 대한 본사 경영자의 감시가 강화되는 경우, 톱니현상이 감소된다는 것을 의미한다. [정책적 시사점]본사 경영자가 영업점 관리자에 대한 감시를 강화하면 본사 경영자와 영업점 관리자 사이에 존재하는 정보비대칭이 감소되기 때문에, 미래 목표설정 과정에서 영업점의 현재 성과정보를 활용할 필요성이 낮아진다는 것을 의미한다. 따라서 본 연구결과는 예산 편성을 위한 목표설정 과정에 영향을 미치는 요인을 파악하여 통제시스템을 구축하기 위한 근거를 제시한다는 측면에서 정책적 의의가 있다. [Purpose]Analyzing data on target setting and performance evaluation from a securities firm in Korea, we empirically test whether target ratcheting occurs. We also examine whether such target ratcheting depends on monitoring characteristics for branches of the securities firm. [Methodology]Using 242 branch-year data of the securities company from 2015 to 2019, we perform ordinary least square regression to test the research hypotheses. [Findings]We find evidence that current year performance relative to target has significantly positive effect on increase in next year sales target. However, we fail to find that the relationship between target change and performance is higher when previous performance falls short of target. These test result implies that the target ratcheting occurs but the asymmetric pattern of target ratcheting does not occur. We present evidence that as the assets for branches grow, the relationship between target changes and performance decreases. In addition, we find evidence that the relationship between target changes and performance in branches with high status is lower than that in low status branches. Moreover, we show that the association between target changes and performance in branches changed status is lower than that in branches unchanged status. [Policy Implications]These findings provide the empirical evidence on target ratcheting and the monitoring characteristics for branches affecting target ratcheting. This study can not only provide additional empirical evidence on target ratcheting, but also present new determinants affecting target ratcheting. Therefore, the study helps practitioners to understand the determinants affecting target setting and to develop control mechanism in target setting process.