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Stereological Analysis on Migration of Human Neural Stem Cells in the Brain of Rats Bearing Glioma
Kim, Jae-Ho,Lee, Jong-Eun,Kim, Seung U.,Cho, Kyung-Gi Oxford University Press 2010 Neurosurgery Vol.66 No.2
<P>OBJECTIVE: The objective of this study was to determine the rate and pattern of NSC migration in the brain and its time course after NSC transplantation. METHODS: We investigated the tropism of HB1.F3 (F3) immortalized human NSCs in rats bearing U373 human glioma in the brain. Rats received an injection of human U373MG malignant glioma cells into the striatum followed by an injection of F3 cells into the contralateral hemisphere 7 days later. We analyzed the numbers, distribution, and migration rate of NSCs using unbiased stereology. RESULTS: Approximately 10% of the injected NSCs migrated into the tumor region by 50 minutes after NSC injection. The number of NSCs in the tumor region increased slowly up to 5 days post-injection and increased significantly up to 15 days post-injection. Changes in tumor volume showed similar patterns. The rate of NSC migration was approximately 175 microm/min. NSCs increased in number approximately 1.7-fold during day 1 in the absence of tumor cell inoculation in vivo. However, the proliferation of NSCs began to decline after 5 days after injection. CONCLUSION: We identified for the first time the rate and pattern of NSC migration to the tumor mass in vivo. These findings may provide useful information with respect to preclinical research of gene therapy for malignant gliomas.</P>
Relativistic Analogue Hidden in Projectile Motion
Lim Jae Hoon,Jung Dong-Won,Kim U-Rae,Cho Sungwoong,Lee Jungil 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.8
We present a four-vector analogue Uμ≡U0,U)=(|V'|,V) that can be directly constructed from the velocity of a projectile. Here, V and V' are the velocities of a projectile at heights h+H and h, respectively. In the non-relativistic regime, the mathematical structure of this four-vector analogue has an exact correspondence to the relativistic counterpart four-velocity uμ=γ(1,β)c of a massive particle. Based on this observation, we illustrate the design of an introductory laboratory experiment to investigate the Lorentz invariance and its covariant nature by measuring the velocity of a projectile. The experiment may help students to acquire a concrete perspective of Lorentz covariance through their own measurements and analyses of a free-fall motion.
이기우,최충돈,조재욱,김충실 한국식품유통학회 2004 食品流通硏究 Vol.21 No.3
This study was carried out to give reference data for peach producers who will be to determine an intention whether or not to select by brix degree and to sell by small package(about 2 kilograms). We developed 2 kilograms?package box. and selled peach indicated in brix degree, then analyzed the effect and consumers'preference degree for the sale. It was confirmed that peach package standard with indicating brix degree by consumers' preference was 2kg as the result of this study. 65% of consumers were satisfied 2kg package box. 18% of them replied to like a little more large size. and 16% of them wanted a little more small size. We expect that there will be the effect of sale by indicating brix degree in the case of 'Vlibaekdo' in the brix degree higher than 13?x being produced in large quantities. We think that it will be desirable for packing house over a village unit not a farm to select and sale by brix degree becase of a farmer meeting more fixed cost than packing house.
하시모토갑상선염에 동반된 골수를 침범한 ( 병기 4E 기 ) 원발성 갑상선 림프종 1 예
이기업,송영기,박중열,김기수,김상희,공경엽,조재근,추윤호,엄완식,지현숙 대한내분비학회 1994 Endocrinology and metabolism Vol.9 No.4
Primary lymphoma of the thyroid is a relatively rare malignant tumor of the thyroid. It is known to be frequently associated with Hashimoto's thyroiditis. In Korea, a few cases of primary lymphoma of the thyroid have been reported and most of these cases were in the stage I E or II E. Recently, we experienced a case of the primary thyroid lymphoma, stage IV E associated with Hashimoto's thyroiditis in a 70-year-old woman who presented with dysphagia and dyspnea due to rapidly enlarging neck mass. She was treated with combination chemotherapy(cyclophosphamide, adriamycin, vincristine and methylprednisolone) and local radiotherapy and achieved partial response with resolution of dysphagia and dyspnea(J Kor Soc Endocrinol 9: 390-394, 1994).
行列多項式 LYAPUNOV 函數 構成에 依한 誘導電動機의 安定度 解析
禹靖仁,李浚柝,文在星 동아대학교 공과대학 부설 한국자원개발연구소 1988 硏究報告 Vol.12 No.2
In this paper, when the steady state values for Multidimensional and Nonlinear Dynamic Models of Space Representations are given, Lyapunov functions of scalar types using matrix quadratic polynomials are constructed by Special Matrix Transformation Techniques and applied to Stability Analysis of Induction Motors. Futhermore, Lyapunov function construction procedures for linear systems can be specified in detail. But, unfortunately, for nonlinear systems, there are no the complete construction techniques. Therefore, in this paper, differently from conventional methods using Linearization obtained from Taylor series expansions about steady state operating points, linear terms and nonlinear ones are invidually separated, and by special matrix transformation techniques, similar Lyapunov function construction procedures such as in the cases of linear systems, are introduced, and are applied to Stability Analysis of induction motor. The hyperspaces of multidimensional stability region, obtained from these techniques, were larger than the obtained ones from conventional linearlization techniques about equilibrium points and were assured to be Lyapunov Asymptotic Stability Region ensuring the stable operation of induction motor.
소화성 궤양에서 삼제 병합 요법의 저용량에 의한 Helicobacter pylori 제균률과 궤양 치유효과
김예리,박봉안,이재동,이종혁,김인숙,박형석,진춘조,김상윤,박의우 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-
Helicobacter pylori is the major cause of histologic chronic gastritis and is strongly associated with peptic ulcer disease, gastric cancer and lymphoma. Several recommendations for the management of the Helicobacter pylori infection have been developed. However, there has been no clear therapeutic regimen for the optimal treatment of Helicobacter pylori infection. This study was desinged to evaluate the eradication rate and the ulcer healing rate of the triple regimen with low-dose clarithromycin(0.5g/day) in peptic ulcer patients. Forty three patients with gastric ulcer(n=15) and duodenal ulcer(n=28) were enrolled. The patients were treated either with omeprazole 20mg b.i.d. amoxicillin 0.5g b.i.d. and clarithromycin 250mg b.i.d. (low-dose regimen group, n=29) or with omeprazole 20mg b.i.d., amoxicillin 1.0g b.i.d. and clarithromycin 0.5g b.i.d.(high-dose regimen group, n= 14) for 2 weeks. After 4 weeks, the patients were evaluated for the eradication of Helicobacter pylori and the healing of ulcer. And gastritis scores according to the Sydney system were evaluated before and after 4 weeks from the end of the triple regimen. There was no significant difference in the eradication rate and the ulcer healing rate between the low-dose regimen group, group and the high-does regimen group. In the low-does regimen group, the mean initial scores of chronic inflammation and activity were decreased after the eradication of Helicobacter pylori. In conclusion, the low-dose triple regimen is as effective as the high-dose triple regimen on the eradication of Helicobacter pylori and the ulcer healing rate in peptic ulcer disease.
크롬계 탄화물의 분포와 형태가 니켈계 합금 600의 염기응력부식에 미치는 영향
김선재,최종호,성진경,김우곤,박순동,이창규,정용환,국일현,Kim, Seon-Jae,Choe, Jong-Ho,Seong, Jin-Gyeong,Kim, U-Gon,Park, Sun-Dong,Lee, Chang-Gyu,Jeong, Yong-Hwan,Guk, Il-Hyeon 한국재료학회 1998 한국재료학회지 Vol.8 No.8
32$0^{\circ}C$, 40%NaOH 용액의 autoclave에서 약 300wppm의 탄소를 함유하고 있는 15Cr-9Fe-balanced Ni 합금 판상시편에 대해 응력부식 저항성을 조사하였다. 부식시편은 $700^{\circ}C$, 100시간 동안의 열처리로 합금내부에 석출될 수 있는 가능한 한 많은 양의 크롬계 탄화물을 석출시킨 후, 다시 재용해에 의해 크롬계 탄화물의 형태를 조절하는 $800^{\circ}C$-$950^{\circ}C$범위의 최종열처리를 시행하고 급냉시킨 다음 U-자형으로 응력을 가하여 준비되었다. 최종열처리 온도가 올라감에 따라 시편들의 입계응력부식균열(IGSCC ) 전파속도는 $900^{\circ}C$까지는 거의 직선적으로 증가하다가 $950^{\circ}C$에서는 $700^{\circ}C$에서 얻은 값보다도 더 낮게 감소하였다. 즉, 크롬계 탄화물이 재용해되어 그 밀도가 감소함에 따라 IGSCC저항성이 감소하다가 완전히 재용해된 $950^{\circ}C$ 열처리 조건에서 오히겨 가장 큰 IGSCC 저항성을 나타내었다. 이와같은 최조열처리 온도에 따른 니켈계 합금 600의 부식거동은 입계에 존재하는 크롬계탄화물의 형태변화 때문이 아니라 입계에서 탄소-크롬계 탄화물-크롬간의 상평형에 의해 이루어지는 탄소의 입계편석량이 크롬계탄화물이 존재할 때에는 열처리 온도에 따라 증가하다가 그것이 완전히 재용해 되었을 때 가장 낮아지기 때문인 것으로 생각된다.
Lee, Juhyun,Lee, Seunghyun,Ryu, Young‐,Jae,Lee, Dohyun,Kim, Sangjune,Seo, Ji‐,Young,Oh, Eunji,Paek, Sun Ha,Kim, Seung U.,Ha, Chang‐,Man,Choi, Se‐,Young,Kim, Kyong‐,Tai John Wiley & Sons, Inc. 2019 Glia Vol.67 No.9
<P><B>Abstract</B></P><P>During postnatal neurodevelopment, excessive synapses must be eliminated by microglia to complete the establishment of neural circuits in the brain. The lack of synaptic regulation by microglia has been implicated in neurodevelopmental disorders such as autism, schizophrenia, and intellectual disability. Here we suggest that vaccinia‐related kinase 2 (VRK2), which is expressed in microglia, may stimulate synaptic elimination by microglia. In VRK2‐deficient mice (VRK2<SUP>KO</SUP>), reduced numbers of presynaptic puncta within microglia were observed. Moreover, the numbers of presynaptic puncta and synapses were abnormally increased in VRK2<SUP>KO</SUP> mice by the second postnatal week. These differences did not persist into adulthood. Even though an increase in the number of synapses was normalized, adult VRK2<SUP>KO</SUP> mice showed behavioral defects in social behaviors, contextual fear memory, and spatial memory.</P><P><B>Main points</B></P><P>VRK2 is specifically expressed in microglia in the brain. The number of presynaptic puncta within microglia was reduced in VRK2<SUP>KO</SUP> mice. Adult VRK2<SUP>KO</SUP> mice displayed several behavioral deficits. </P>