서울의 Penicillinase Producing Neisseria Gonorrhoeae 발생빈도(1994)

김재홍,안진균,정성재,김영태,김중환,김시영,이석종,이홍렬,서호석,김경훈,권혁진,정우권,고우석,이용석,안필수,오준규,오용섭 대한화학요법학회 1996 대한화학요법학회지 Vol.14 No.1

Background : In recent years gonorrhoea has been panendemic and remains one of the most common Sexually Transmitted Diseases in the world, especially in developing countries. Objective & Method : For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria Gonorrhoeae(PPNG), Ive have been trying to study the patients who have visited the VD Clinic of Choong-Ku Public Health Center in Seoul since 1980 by means of the chromogenic cephalosporin method. Results : In 1994, 168 strains of N. gonorrhoeae were isolated, among which 109 (64,9% ) were PPNG. Conclustion : Our results suggests that the prevalence of PPNG in Seoul is still increasing.

Graphene: Position‐ and Morphology‐Controlled ZnO Nanostructures Grown on Graphene Layers (Adv. Mater. 41/2012)

Kim, Yong‐,Jin,Yoo, Hyobin,Lee, Chul‐,Ho,Park, Jun Beom,Baek, Hyeonjun,Kim, Miyoung,Yi, Gyu‐,Chul WILEY‐VCH Verlag 2012 Advanced Materials Vol.24 No.41

<P>On page 5565, Gyu‐Chul Yi and co‐workers grow position‐ and morphology‐controlled ZnO nanowalls in prescribed positions on graphene layers. The nanowalls are grown to produce a variety of shapes from simple circles to text at the microscale. The selective growth of high quality ZnO nanowalls is investigated by electron microscopy and optical spectroscopy. The hybrid nanostructure can be exploited to fabricate various nanodevices including microarrays of nanotube LEDs. </P>

관동맥질환에서 저밀도 지단백 입자 크기의 분포

임효영,김인숙,승기배,강동헌,전두수,장기육,박준철,이수영,홍순조,최규보 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.8

다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

결핵성 중이염의 임상적 고찰

박병원,조우령,석상렬,김서규,김명구,권오준,김병헌 대한이비인후과학회 1999 대한이비인후과학회지 두경부외과학 Vol.42 No.8

임신중 알코올 섭취에 의한 기형 유발기전에 관한 연구

김소희,김순선,이규식,손경희,곽승준,채수영,안상미,허만욱,박귀례 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

임신중에 만성적으로 음주한 산모의 태아는 중추신경계 손상으로 인한 특징적인 이상증상인 소두증 정신발육장애 등 태아 알코을 증후군(fetal alcoho3 syndrome, F,LSB이 나타나는 것으로 알려져 있으냐 분자생물학적 측면에서의 유발기전은 명확하게 밝혀져 있지 않다. 든 연구예서는 in vitro 단기 발생독성시험법 중 하나인 전배자배양댑을 사용하여 랫드 배자의 )1관 발생기에 알코을 및 알코올의 주 군사 체인 아세트알데히드를 처리하여 기형 유발 여부를 관찰하였다. 또한 이들 물질의 기형 유발 기전을 규명하고자 microarray 깡법으로 발현이 변화되는 유전자를 검색하였으며, 알코을 처리로 발현이 변후 되는 유전자의 정확한 확인을 위하여 northern blot analysis 실시 중이다. 임신 9.5일의 랫드 배자에 0.1, 0.5, 1.0% 에란올을 처리하였을 때 성장부진, 뒤틀리거나 꼬렬라진 꼬리, open caudal neura tube, open neural tube, 불완전찬 반전, 불규칙적이고 비정상적인 체절과 짧은 꼬리 등의 이상이 나티났다. 임신 9.5일의 랫드 배자에 Sr10-4, 8.3×10-4, 2.SxIO-3% 아세트알데히드를 처리시 래antois caudal neura3 tube의 발달저해, somite 수 감소, 꺽인 꼬리 등의 이상이 나타났다. Control과 에탄을 처리한 배자로부터 total RNA를 추출하고 poll· A--RNA를 분리한 후, reverse transcriptase를 사용하여 C?3 혹은 Cl·5 형광염료로 tag된 nucleotide로 표지된 probe를 만들어 등량을 시판중인 'toxicotogy chip'의 틴991개의 CDNA 형태의 유전자와 hybr겨iaation시켰다. 에탄을 처리에 의해 'serum deprivation response' gene등의 발현이 유도되었으며, 'rat transcription factor MaflmRNA'등의 발현은 저해되었다. It is reported that alcohol drinking by pregnant mothers often leads to abnormal fetal development including fetal alcohol syndrome(FAS) in both humans and experimental animals. The FAS is characterized by prenatal and postnatal growth retardation, distinct craniofacial dysmorphology, and central nervous system dysfunctions such as mental retardation. However, molecular mechanisms for FAS is not completely elucidated as yet. In this study, developmental toxicity of ethanol and its metabolite, acetaldehyde were evaluated using whole embryo culture. In addition genes inducing FAS were investigated by the technique of cDNA microarray. Embryos treated with ethanol showed growth retardation, abnormal tail torsion, open neural tube, open caudal neural tube and abnormal somite at concentrations of 0.1∼0.5%. Also embryos treated with acetaldehyde showed growth retardation including allantois, open caudal neural tube, reduction number of somite and abnormal tail torsion at concertrations of 5×10^(-4)∼2.5×10^(-3)%. RNAs from embryos of control and ethanol treatment were reverse transcribed into cDNA tagged with Cy3 or Cy5 and hybridized with cDNA probe of rat in 'toxicology chip'. Ethanol 0.5% treatment resulted in alteration in expression of several genes including 'serum deprivation response', 'Cide-b' and 'check point suppressor 1'. Northern blot analysis is conducted for identification of genes related to FAS.

大邱地域 中小企業의 效率的인 技術開發 方案에 관한 硏究

全瑨文,張晩植,尹在坤,金圭昌,李栽燁,朴筍植,黃建夏 효성여자대학교 산업경영연구소 1988 경영경제 Vol.5 No.-

For modern business firms, the most important factor in determining comprtitiveness of a firm is technology, rather than capital. Technogical innovation is a driving force to develop an economy and is essential in growth and/or survival of a business firm. Following studies concerned with this subject, small business firms seem to be more efficient in technological innovation and developing new technology in several respects. Espercially in the new technology based industries, the small business firms have several advantages in technological innovation. In this study, we tried to show how to plan a technology development strategy in relation to management strategy when small business of theoretical and empirical study, we aimed to show the way to efficient management and procedure of technological innovation. For the research methodology, we firstly reviewed and analyzed current and previous studies about technological innovation strategy, efficient management, and selection of R&D projects. Secondly, the results of this theoretical study was examined empirically. The empirical study contains 153 questionaires and 30 interviews for business firms of this area. In addition, for the evaluation criteria for the selection of R&D projects, we sent questionaires to 60 professors who teaches R&D OR in university or college level. The result of these questionaires was analyzed and compared with that of the business firms of this area. The result of this empirical study shows that top management of small business firms should notice the importance of technological innovation and try to stimulate R&D activity. For the evaluation criteria for R&D projection, the criteria which could reduce the possibility of future uncertainty, maximize profit, and he suited for the situation of the business firm, should be established.

표백에 의한 라디에타소나무의 청변 제거

김규혁,김형준,나종범,김재진 한국목재공학회 2003 목재공학 Vol.31 No.1

본 연구는 라디에타소나무 제재목의 균 변색을 제거하기 위한 표백처리의 사용 가능성을 조사하기 위하여 수행하였다. 염소계 표백제인 아염소산나트륨과 차아염소산나트륨은 표백조건(약제농도, 처리온도, 처리시간)의 조절에 따라 만족할만한 변색제거 효과를 얻을 수 있었다. 비염소계 표백제인 과산화수소는 표백조건의 조절만으로는 변색제거가 불가능하였으나 규산나트륨과 수산화나트륨을 활성제로 첨가하는 경우에는 염소계 표백제보다 탁월한 변색제거 효과를 나타내었다. 그러나 활성제 첨가에 따라 재색의 녹색화 문제가 발생하였는데, 앞으로 이러한 문제점을 해결하기 위한 연구가 진행되어야 할 것이다. 또한, 앞으로 본 연구를 통해 개발된 변색제거방법의 현장 적용을 후속 연구도 필요하다고 본다. The feasibility of using bleaching treatments for removing fungal stain was evaluated on heavily stained raiadta pine sapwood. Sodium chlorite and sodium hypochlorite appeared to destain fungal discoloration by providing proper treatment conditions (chemical concentration, treatment temperature, and treatment time), while hydrogen peroxide did not remove fungal stain under the bleaching regimes evaluated. The addition of sodium silicate and sodium hydroxide in the hydrogen peroxide solution as a buffer could remove fungal discoloration completely:; however, the color of wood surface turned faint green after bleaching, thereby reducing the lightness of bleached samples. The results suggest that hydrogen peroxide bleaching could be a feasible method for removing fungal discoloration of stained radiata pine sapwood, although further research is needed to solve the problem of color change after bleaching Also, further tests under field conditions are recommended.

장기간의 저항성운동이 각ㆍ완근력 및 호흡순환능력에 미치는 영향

김영준,박태열,최규환 東亞大學校附設스포츠科學硏究所 1999 스포츠科學硏究論文集 Vol.17 No.-

The purpose of this study was to investigate the distribution of the physical girth, muscular strength, Oxygen Consumption and pulmonary capacity by resistance Training. The subjects of this study were consisted with 10 adult males. The circuit of 10stations performed on 3 circuits, 3day/week. The subjects exercised at 60-70% of 1-RM, executing as many repetition as possible in 30sec, followed by 15sec rest as the subject moved to the rest station the training program. The result were as follow: 1. After resistance training was increases significantly in girth of upper arm, thigh, lower thigh. 2. After resistance training was increased significantly in grip strength, back strength, arm strength, leg strength. 3. After resistance training was increased significantly in HRmax, VEmax, but non-significantly VO₂max. It was concluded that resistance training are a good general conditioning activity, attends to more than one component of fitness.

무기고분자응집제를 이용한 조류의 응집제거

김규동,최영균,김희준,곽종운,정태학 대한상하수도학회 2002 상하수도학회지 Vol.16 No.5

An Experimental study was conducted for the removal of algae using various inorganic coagulants. Cultivation of algae, investigation of turbidity and chlorophyll-a removal efficiency according to the dosage of coagulants were conducted in series using a jar-tester in this study. Alum, PAC (Polyaluminum chloride), PAC-2 (Concentrated Polyaluminum chloride), PAC-Ca (PAC with Ca), PFC (Polyferricchloride) and PACS (Polyaluminum chlorinate silicate) with various SiO_2 content were used as coagulants. Algae grew up to about 1,500㎍ chlorophyll-a/l in 30 days. Cultivated algae was diluted to 150㎍ chlorophyll-a/l for the laboratory experiment. Decrease of pH was the lowest when PACS-5 was used as a coagulant, while it was the highest when PAC was used. Host of the coagulants showed high turbidity removal rate when the dosage was 1-3 mg Al/l. PFC showed stable turbidity removal efficiency and 80% of removal efficiency could be obtained when the dosage was 1.34 mg Fe/l. Among the coagulants, PACSs showed relatively higher removal efficiency of chlorophyll-a and it was the highest when PACS-5 was used. It means that inorganic coagulant including silicate is more advantageous in the removal of algae, and appropriate content of silicate on the basis of molar ratio of Al to Si is an important factor affecting the stability and settleability of the alum floc.