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        A Case of Isolated Light Chain Deposition Disease in the Duodenum

        김희준,박은경,이태진,도재혁,차영주,이상재 대한의학회 2012 Journal of Korean medical science Vol.27 No.2

        Light chain deposition disease (LCDD) is a rare disorder associated with a clonal proliferation of plasma cells, which synthesize abnormal monoclonal immunoglobulin light chains. LCDD is characterized by systemic deposition of light chains in various organs, with the kidneys being most commonly affected. There have been few reports of isolated LCDD. We report a rare case of LCDD limited to a duodenal polyp. A 63-yr-old man visited our hospital for health screening without symptoms in 2009. On gastrofiberscopy, a duodenal polyp was observed. The biopsy showed diffuse infiltration by atypical plasma cells, which were positive for kappa-type light chains by immunohistochemistry. While the patient refused further management, we could find no evidence of recurrence until 2 yr after the initial diagnosis. It has been reported that isolated LCDD has relatively good prognosis compared to systemic LCDD. However, treatment for this disease has not been established yet.

      • KCI등재

        도축장 폐수의 수질오염원이 물벼룩에 미치는 생태독성 평가 연구

        김희준,천경호,김민수,윤덕노,원건희,최용,조홍식,유정희,이자영,채수백,지석인 한국환경기술학회 2019 한국환경기술학회지 Vol.20 No.2

        The purpose of this study was to investigate the contamination level of slaughterhouse wastewater by analyzing chemical oxygen demand (CODcr), biochemical oxygen demand (BOD5), total nitrogen (T-N), total organic carbon (TOC), and total suspended solids (TSS) which are water pollutants of slaughterhouse wastewater. Daphnia magna is used to determine ecotoxicity and to correlate with major causes of pollutants and ecotoxicity. The measured values of CODcr, BOD5, TOC and TSS of the influent were very high, up to 8,900 mg/L, 4,600 mg/L, 3,400 mg/L and 1,100 mg/L, respectively. Also, the correlation value of CODcr, BOD5, T-N, TOC and TSS were 0.784, 0.698, 0.688, 0.722, 0.744 and 0.824, respectively. The p-value of CODcr, TOC, TSS and protein was less than 0.01 and BOD5 and T-N were significant between 0.01 and 0.05, suggesting that all six items are closely related to ecotoxicity. Experimental results show that waterborne pollutants can cause toxicity to ecotoxicity using Daphnia magna and contribute to the elimination of ecotoxicity by intensive treatment of highly correlated water pollutants.

      • KCI등재

        Electrospray Ionization Mass Spectrometric Observation of Oligomers in Paal-Knorr Synthesis of 2,5-Dimethyl-1-phenylpyrrole

        김희준,Man-Seog Chun,Jin-Su Song,박소영 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.4

        Electrospray ionization mass spectrometry (ESI MS) was used, along with gas chromatography-mass spectrometry (GC-MS), to monitor Paal-Knorr synthesis of 2,5-dimethyl-1-phenylpyrrole by condensation of aniline with 2,5-hexanedione. In addition to 2,5-dimethyl-1-phenylpyrrole observed as a single spot by TLC, unexpected dimer size compounds were observed by GC-MS. Dimers and trimers were observed by ESI MS. ESI tandem mass spectrometry was used to select plausible structures for the dimer. ESI MS with or without liquid chromatographic separation is useful for observing oligomeric byproducts with low volatility produced in organic reactions.

      • KCI등재

        각막굴절교정렌즈 착용 후 시력의 질 평가

        김희준,이군자 대한시과학회 2015 대한시과학회지 Vol.17 No.2

        목 적: 각막굴절교정렌즈 착용 후 시력의 질 변화를 알아보기 위하여 시력의 질과 객관적 시력을 측정하 고 착용 전과 비교하였다. 방 법: 각막굴절교정렌즈를 처음 처방받은 사람으로 매일 밤에 적어도 8시간 이상 각막굴절교정렌즈를 착용할 수 있으며 굴절이상도가 근시 -6.00 D 이하, 난시 -2.00 D 이하인 45명(85안)을 대상으로 하였다. 굴절검사는 자동굴절검사기를 이용하였고, 시력은 LCD Chart ETDRS를 사용하였다. 시력의 질 평가를 위 해 OQAS(optical quality analysis system II)를 이용하여 MTF(modulation transfer function), Strehl ratio, OSI(objective scattering index)와 객관적 시력 OV(OQAS values)를 측정하였고, 각막굴절교정렌즈 착용 전에는 구면 굴절력과 원주 굴절력을 시험용 안경렌즈로 교정한 후 측정하였다. 검사값은 SPSS 18.0을 이용하여 분석하였으며 유의수준은 p<0.05로 하였다. 결 과: 각막굴절교정렌즈 착용 후 나안시력은 각막굴절교정렌즈 착용 전 0.79±0.24 LogMAR에서 1개월 후 0.03±0.05 LogMAR로 유의하게 개선되었고(p<0.001), OQAS로 측정한 객관적 시력 OV100% 및 OV20%는 렌즈 착용 전 교정시력과 유의한 차이를 보이지 않았으나(p>0.05), OV9%는 착용 전보다 유의하게 저하되었 다(p=0.011). MTF 값과 Strehl ratio는 각막굴절교정렌즈 착용 후 착용 전보다 유의하게 감소하였고 (p<0.05), OSI 값은 유의하게 증가하였다(p<0.05). 결 론: 각막굴절교정렌즈 착용 후 나안시력이 개선되었고 시력의 질을 평가한 MTF cutoff, Strehl ratio 및 OSI 값은 정상 범위 내의 값으로 측정되었으나, 시력의 질은 착용 전보다 저하되고 저대비 객관적시력은 안경렌즈에 의한 교정보다 낮았다. Purpose: To investigate the pre-operative and post-operative objective optical quality after overnight orthokeratology (ortho-k). Methods: Forty five patients (85 eyes) satisfying the inclusion criteria (myopia < -6.00 D, astigmatism < -2.00 D, K-reading: 40.00~47.50 D) were participated for overnight ortho-k. Refraction was performed using auto-refractormeter, and visual acuity was measured using the LCD Chart ETDRS. Objective optical quality measurements were performed using the OQAS (Optical Quality Analysis System II) for MTF (modulation transfer function), Strehl ratio, and OSI (objective scattering index) and OVs (OQAS values) ; OV100%, OV20%, OV9% were measured. Before ortho-k all optical quality measurements were performed after calibration with trial spectacle lenses for the spherical cylindrical correction. Statistical analyses were performed with SPSS 18.0 and p-value less than 0.05 was considered statistically significant. Results: The VA were significantly increased with 0.79±0.24 logMAR, and 0.03±0.05 logMAR at pre, and post 1 month operation (p<0.001). OV100% and OV20% were not difference however, OV9% was significantly decreased. difference in comparison with corrected pre-operative VA (p=0.011). The MTF values Strehl ratio were significantly decreased (p<0.05) and OSI value were significantly increased (p<0.05) after ortho-K. Conclusion: VA was significantly improved and the MTF cutoff and strehl ratio and OSI values were in the normal criteria, after ortho-k however, visual quality is decreased and low contrast objective VA was decreased compared with spectacle lens correction.

      • KCI등재

        그림책을 활용한 즉흥극이 유아의 자기 표현력에 미치는 영향

        김희준 한국영유아교육지원학회 2022 영유아교육지원연구 Vol.7 No.1

        The purpose of this study is to design teaching models of picturebook-based improvisation dramas for five-year-old children and to verify their effect on young children's self-expression ability. The sampling of this study was a total 40 children who are younger than 5 years old, who were divided into test group and control group. The test group underwent expression activity with teaching models of picturebook-based improvisation dramas, while the control group had representation activities after reading same picturebooks. Three times a week during 10 weeks for picturbook reading, the children had read picturebook with the sequence of reading picturebooks. The size of the group being same for both groups. After reading picturebooks, the test group performed pantomimes in the first session each week, role plays in the second session, impromptu or thematic plays in the third session. While, the control group had representation activities related with picturebooks. The result for research questions were as follows. First, picturebook-based improvisation drama activity had a positive effect on young children's expression ability. Secondly, picturebook-based improvisation drama activity had a positive effect on young children's paralinguistic expression ability. As such, teaching models of picturebook-based improvisation dramas had a positive effect on young children’s self-expression ability. This study, highlighting the importance of the boost of young children's self-expression ability, would like to be the groundwork for successive research on teaching models of picturebook-based improvisation dramas for the boost of young children's self-expression ability. 본 연구는 그림책을 활용하여 즉흥극 교수 모형을 구안하여 효과를 살펴보고자 한다. 효과적인 즉흥극을 구성하기 위해 그림책 도구를 사용하여 그림책을 활용한 즉흥극을 구안하였다. 즉흥극 프로그램 효과의 검증을 위한 실험집단 S유치원의 만 5세 유아 20명을 대상으로 10주 기간에 30회의 즉흥극을, 통제집단인 20명의 다른 학급 유아들에게 기존의 그림책 읽기 활동의 표상활동 후 유아의 자기표현력 신장을 위한 효과를 검증하였다. 연구결과로 그림책에 기초한 자기표현력 신장을 위한 즉흥극 활동은 유아의 언어적 표현력, 비언어적 표현력에 유의미한 차이를 보였다.

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