캔음료중 epichlorohydrin 의분석법에 관한 연구

이광호,곽인신,최재천,전대훈,김형일,강경모,최병희,김귀정,이철원 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

캔식품중에 잔류하는 epichlorohydrin을 분석하기 위한 pu링e & trap-Cc/uf통D 분석법을 확립하여 캔의 lacauer 코팅제에서 식품으로 이행되어 잔류하는 epichtorohydfn을 측정하고, 식품유사용매에 의한 용출시험을 통해 일일추정섭취량을 산출하였다. epichlorohydrin의 검량선은 y=0.0006x+0.OO6?(R큰0.9983)의 직선성·라 0.05#ga의 검출한계를 나타내었다. 각종 음료 및 식품유사용매에 일정량의 epichlorohydrin을 첨가한 후 분석하였을 때 회수을은 72~91%였으며, 실제 시판되는 f5건의 캔음료 중 잔류하는 epichlorohydrin을 측정한 결과 모든 캔음료에서 검출한계(0.1#94) 이하였다. 제관업체에서 구입한 modifed epoxy, epoxy phenolic, vinyl organosol, epoxy phenol ester 등의 BADGE(bisphenol A diglycidyt ether)형 에폭시수지로 lacquer 코팅된 식품용 캔에 식품윤사용매인 10% 또는 95% 에탄올을 층L진한 후 90~121'c의 드라이오븐에서 30분~2시간동안 용출시켰을 패 캔의 lacquer 코팅재에서 식품유사용매로 이행되는 epichBorollydirn은 코팅재질, 그리고 가열온도 및 시간에 문관하게 모든 캔에서 검출한계(0.4#ga)이하 였다. 위의 용출결과를 FD.f_의 "Recommendation for Chemistry Data for Indirect Food Additive Petition" 윽 일일추정섭취량 산출법에 적용하여 얻은 epichtorohydrin의 일딜추정 섭 취 량은 0.2r조persorday이하였다. A sensitive ana1?~7tical method based on gas cl)romatogFapy~mass spectrometry with a selected ion monitoring (GE/hfS-Slhf) and the purge-and-trap concentrator ))·asdeveloped for determining ot'epicillorohydrin in canr;ed be)#erages coated with eporl· resin. Thecalibration rurve in the ranre of 0.j ~50nr had'correlation coefficient of 0.9983 and detection limit of 0.Osrga. Recoveries of epichlorohydrin spiked to beverages were in the range of 72 ~91% with detection limits of 0.1 #ga. fn survey of epichlorohydff in twenty commercialcanned beverage samples, epichlorohydrin was not found in all the samples with the detectionlimit of 0.1 r9a. In migration test of various cans coated with BADGE-based coating cans;modifed epoxy, epoxy phenolic, vinyl organosol, epox?· phenol ester were exposed to the foodsimulants of 10% ethanol and 95% ethanol. flfo delectable epichlorohydrin migrated to foodsiHulants was found in aTl the cars with detection Jimit of 0.4 #9/L. Using the miEration data,along uTith the applicstion of food and beverage cans complied with FDA's "Recommendationfor Chemlstry Data f,3r Indirect Food Additive Petition" , the potential dietary exposure toepichlorohydrin was estlmated to be under 0.2rf/person/day.

절개선을 활용한 직물의 신장변화에 관한 연구

이정숙,성수광,이인아 한국의류산업학회 2002 한국의류산업학회지 Vol.4 No.3

To propose a basic material that can improve the crumples in the knee area and can be applied as an element of garment design, the present study examined the elongation rates of the samples by differentiating the number of cutting lines according to the direction of the fabric, and then determined the puckering phenomenon by judging the conditions of the seams based on the looks of seam lines after bi-axil elongation. After the subjective evaluation on the knee areas of both the standard and modified trousers, the following conclusion was drawn : The elongation rates of the samples are: warp (3.98%)<warp1 (4.29%)<weft1 (5.30%)<weft (5.82%)<warp2 (5.68%)<bias (6.96%)<weft2 (8.64%). The samples in the warp direction: as the cutting lines increase, the elongation rate grows by 1.4%. The elongation rates of the samples in the weft direction: the sample with one cutting line has 0.52% lower rate than that in the weft direction without cutting line; that with two cutting lines has 1.68% higher rate than that running on the bias. The subjective evaluation on the knee areas: the subjects wearing the standard trousers feel more comfortable when sitting on a chair (0.2) >cross-legged (-0.2) > squatting down (-0.4); those in the modified trousers feel more comfortable when sitting on a chair (0.2) > cross-legged (0)> squatting down (-0.6). In the cross-legged posture, the modified trousers (0) has higher scores in the subjective evaluation than the standard ones (-0.2). The evaluation on the looks of needleworks in the samples with cutting lines along the direction of the fabric: weft2 (5.0)<weft1 (4.8)<warp1 (3.8)<warp2 (2.8).

토끼 수막염 모델을 이용한 다제내성 폐렴구균에 대한 Meropenem의 치료 효과

김신우,진정화,강수정,정숙인,김연숙,기현균,김춘관,이혁,김성민,백경란,송재훈 대한화학요법학회 2001 대한화학요법학회지 Vol.19 No.1

목적 : 다제내성 폐렴구균에 의한 수막염은 기존과 단일 항생제로는 근치가 어려워 ceftriaxone과 vancomycin 혹은 rifampin의 병용요법이 권유되고 있다. 다제내성 폐렴구균에 사용할 수 있는 다른 약제 중 meropenem은 시험관내 폐렴구균에 대한 항균력이 좋고 경련 등의 중추신경계 부작용이 거의 없어 다제내성 폐렴구균에 의한 수막염의 치료에 이용할 수 있을 것으로 기대되나 이에 대한 자료가 매우 부족한 상태이다. 이에 연자 등은 meropenem과 meropenem+vancomycin의 병용요법이 다제내성 폐렴구균 수막염의 치료에 효과가 있는지를 토끼 수막염 동물 모델을 이용하여 검증하고자 하였다. 방법 : 인체에서 수막염을 일으킨 다제내성 폐렴구균 균주(penicillin MIC 2, ceftriaxone MIC 4, meropenem MIC 0.5㎍/㎖)를 토끼 척수강 내에 직접 주입하여 수막염을 유발한 후 ceftriaxone, vancomycin, rifampin, meropenem의 단일 항균요법, ceftriaxone+vancomycin, ceftriaxone+rifampin, meropenem+vancomycin의 병용요법 간에 치료 효과의 차이를 비교 하였다. 각 치료군은 6 마리의 토끼를 대상으로 하였다. 각각의 항생제는 5 시간 간격으로 2번 정주하였으며, ceftriaxone은 1회 투여하였다. 균주 주입 후 각 치료군이 토끼에서 치료 후 0, 5, 10, 24 시간에 척수액을 채취하여 균주의 수를 측정하여 24시간째의 살균 여부를 최종 치료 효과로 판정하였다. 결과 : meropenem 단독 요법은 10시간째에 모든 균주를 살균하였으나 24시간 째에 다시 균의 성장이 관찰되었으며, meropenem+vancomycin의 병용요법은 단독 약제보다 우수한 살균효과를 보였으나 상승작용은 없었다. 결론 : meropenem+vancomycin의 병용요법은 기존의 ceftriaxone+vancomycin보다 24시간째에 더 큰 균의 감소 경향을 보여(P=0.054) 임상에서 사용이 가능할 것으로 기대되며 향후 실제 수막염 환자에서의 임상효과를 증명하는 연구가 필요할 것으로 생각된다. Background : Because antimicrobial monotherapy for pneumococcal meningitis caused by penicillin-resistant strains is not satisfactory, ceftriaxone+vancomycin [C+V] or ceftriaxone+rifampin [C+R] regimens are recommended. Meropenern [M] is one of the monotherapy options for penicillin-resistant pneumococcal meningitis due to good in-vitro activity against pneumococci and rare adverse reactions in CNS. But there have been few reports in the efficacy of meropenern against pneumococcal meningitis. We evaluated therapeutic efficacy of the meropenern and meropenem+vancomycin in a rabbit model of meningitis caused by penicillin-resistant S. pneumoniae (PRSP). Methods : Meningitis was induced by intracistemal inoculation of a pneumococcal strain isolated from a patient with meningitis (MIC; penicillin 2, ceftriaxone 4, meropenem 0.5 g/㎖). Bacterial concentrations in the CSF were measured at 0, 5, 10, and 24 h after therapy was started. Therapeutic efficacy was evaluated by the final bacterial concentration in the CSF at 24 h. Results : C+V cleared the CSF at 10 h, but regrowth of bacteria was noted at 24 h. Meropenem monotherapy resulted in sterilization at 10 h but regrowth at 24 h. M+V was superior to M or V monotherapy but did not show synergism. Therapeutic efficacy of M+V was at least equal or superior to that of C+V (P = 0.054). Conclusion : Meropenem+vancomycin regimen could be one of the useful options in the treatment of PRSP meningitis. Clinical trials to evaluate the M or M +V are warranted in the future.

무선 센서 네트워크에서 효율적인 집계 질의 처리

김정준,신인수,이기영,한기준,Kim, Joung-Joon,Shin, In-Su,Lee, Ki-Young,Han, Ki-Joon 한국공간정보학회 2011 한국공간정보학회지 Vol.19 No.3

최근 무선 센서 네트워크에서 센서로부터 원하는 데이타를 가져오는 네트워크 내 집계 질의처리 기법에 대한 연구가 활발히 진행되고 있다. 기존의 대표적인 네트워크 내 집계 질의 처리 기법들은 집계 질의 처리를 위해 라우팅 알고리즘과 데이타 구조를 제안하고 있다. 그러나 이러한 기법들은 센서 노드들의 에너지 소모가 크고, 질의 처리 결과 정확도가 떨어지고, 또한 질의 처리 시간이 오래 걸리는 문제점들을 가지고 있다. 본 논문에서는 이러한 기존 집계 질의 처리 기법들의 문제점을 해결하고 무선 센서 네트워크에서 보다 효율적인 집계 질의 처리를 위해 BPA(Bucket-based Parallel Aggregation)를 제시하였다. BPA는 질의 영역을 센서 노드 분포에 따라 쿼드 트리로 구성하여 집계 질의를 병렬로 처리하고, 각 센서 노드로 하여금 데이타를 이중 전송하게 함으로써 전송 오류로 인한 데이타 손실을 줄인다. 또한, BPA는 집계 질의 처리시 버켓 기반의 데이타 구조를 이용하고 이러한 버켓 데이타 구조를 버켓내 데이타 개수에 따라 적응적으로 분할 및 합병한다. 특히 버켓내 데이타 크기를 줄이기 위해 데이타를 압축하고 데이타 전송 횟수를 줄이기 위해 필터링을 수행한다. 마지막으로 센서 데이타를 이용한 다양한 실험을 통해 본 논문에서 제안하는 BPA의 우수성을 입증하였다. Recently as efficient processing of aggregate queries for fetching desired data from sensors has been recognized as a crucial part, in-network aggregate query processing techniques are studied intensively in wireless sensor networks. Existing representative in-network aggregate query processing techniques propose routing algorithms and data structures for processing aggregate queries. However, these aggregate query processing techniques have problems such as high energy consumption in sensor nodes, low accuracy of query processing results, and long query processing time. In order to solve these problems and to enhance the efficiency of aggregate query processing in wireless sensor networks, this paper proposes Bucket-based Parallel Aggregation(BPA). BPA divides a query region into several cells according to the distribution of sensor nodes and builds a Quad-tree, and then processes aggregate queries in parallel for each cell region according to routing. And it sends data in duplicate by removing redundant data, which, in turn, enhances the accuracy of query processing results. Also, BPA uses a bucket-based data structure in aggregate query processing, and divides and conquers the bucket data structure adaptively according to the number of data in the bucket. In addition, BPA compresses data in order to reduce the size of data in the bucket and performs data transmission filtering when each sensor node sends data. Finally, in this paper, we prove its superiority through various experiments using sensor data.

고려 엉겅퀴(Cirsium setidens Nakai) 잎 조직을 이용한 callus 배양 및 항산화 활성 검증

박정훈,심예지,박기임,이인순,문혜연 대구대학교 특수교육재활과학연구소 2010 産業技術硏究 Vol.21 No.1

We described the effects of antioxidant activity on the extracts of tissue and callus formation by Cirsium setidens Nakai. The callus culture were induced from leaf tissue of Cirsium setidens in both MS and B5 medium with IAA or/and kinetin (0∼5.0 ㎎/ℓ). As medium for callus culture induced from Cirsium setidens, B5 medium showed better condition than MS media. MS medium brought to decrease callus differentiation after formation, on the other hand B5 medium induced to accelerate callus differentiation. Among phytohormones is required 0.5 ㎎/ℓ of IAA and between 2.0 ㎎/ℓ and 1.0 ㎎/ℓ of Kinetin for formation of callus. In order to extract functional material from natural leaf and callus tissue of Cirsium setidens used distilled water and 75% ethanol as solvent and those extract used to determine antioxidant activity as alpha-diphenyl-2-picryl-hydrozyl (DPPH) radicals scavenging effect and TBA(thiobarbituric acid) activity. In result, the effect of DPPH and TBA had high activity more natural leaf extract than callus tissue and 75% ethanol was solvent better than distilled water. The 75% ethanol extract of natural leaf showed an excellent antioxidant activity because that particularly had highest concentration of vitamin C and total phenol among those extracts

대학생들의 가족가치관

박인숙,이정애 충남대학교 간호과학연구소 2003 충남대 간호학술지 Vol.6 No.1

Purpose: When family values of university students studying investigation family values of university students grasp and achieves family nursing to nursing subject persons, tried to help in promotion of family comprehension Method : Two instruments were used to measure family value. The modified form of general family value scale was 18 items with a 5 point of Likert response format( Cronbach's alpha= .86) and Patient circumstance family value scale was consisted of 18 items with a 5 point of Likert response format( Cronbach's alpha= .77). The subjects of this study were 512 undergraduate students, living in Daejeon, Chungnam, or Jeonbuk, during the period from May to June , 2002. Data used for analysis were 480 except insincere response. Result : General family values were(or value was) the highest, 'It's essential to hold the ceremony to respect their forefathers(3.93)', and 'It's not impossible for man to have extramarital relationship(1.64) was the lowest. Patient circumstance family values were the (or) value was the highest. 'The parents need to talk to each other more often to overcome difficulties(4.66)' and 'The parents can have conflicts in decision making when their parents is sick(3.32) were the lowest. The General family value was significantly different by current resident, grand-parents' visit degree, age and sex. Patient circumstance family values was significantly different by parents' survival, grand-parents' visit degree and residence.

接觸材를 利用한 糞尿의 好氣性 消化에 있어서 窒素除去에 關한 硏究

朴魯參,李曾錫,徐正仁 慶一大學校 1987 論文集 Vol.3 No.1

Nitrogen removal is gathering strength as a major problem seriously in wastewater treatments. This study, therefore, was carried out in a semi-batch and in an aerobic digestion process by using contacting material (plasticnet) with night soil to contrast and analyse the efficienties of nitrofication and denitrofication, removal rate of T-N for three digestion tanks which were different in experiment condition. Briefly describing the digestion tanks erected for this research, they are stated below; a) A digestion tank was unsubmerged any material operated at air volume of mixed liquor 1ℓ air/min. b) B, C digestion tanks were submerged plastic net as a contacting material opereated at air volume of mixed of liquor 1ℓ per 1ℓair/min, 0.5L air/min. the result of this research indicated that over 98% T-N was removed for C digestion tank.

관절염 환자의 민속요법이용 형태

은영,강현숙,이은옥,이인숙,이종수 서울대학교 간호대학 간호과학연구소 1997 간호학 논문집 Vol.11 No.1

This sty was undertaken to explore the utilization patterns of medical treatment and herb medicine in patients with arthrits. The data were collected from 995 patients who were registered either in a center of rheumatology or resided in community with arthritis. The data were analyzed by percentile, t-test and chi-square test using SAS PC program. The results of this study were as follows; 1. According to characteristics of sample-population, mean age was 57.7 years, duration of arthritis 9.7 years and mean duration of pain 2.4 hours per day at present. 2. First diagnosis was identified at department of orthopedic surgery or local clinic. But 85.2% of patients have transferred to the center of reumatology currently. But ironically over 70% of patients experienced the herb treatment and herb treatment had hern medicine simultaneous with medical treatment. This indicated that they were shopping around of treatment during the first one year. 3. Mean cost of medical treatment was 67,400 won, while they payed to herb medicine as much as two or three times. The utilization rate of herb medicine was 36.5% of patients per one year. Costs of herb-treatment were 182,000 Won and herb medicine was 36.6% of patients per one year. Costs of herb -treatment were 182,000 Won and herb medicine 149,100 Won. 4. Eighty point six percent of patients were experienced herb medicine during life-time. One hundred and seventy four kinds herb medicine were found to be used by patients, most of which were nutrients, muscle relaxants, andtiphlogistics and analgesics. Thirty two point six percent of users recognized that herb medicine were effective but 51.7% did not. In conclusion, arthritis patients have been experienced various kinds of drug and remedies for treatment. And they wasted their limited medical and economical resources on these unresonable remedies. Therefore, they should be guided for wise decision about treatment. Futher studies in nursing will be required to explore the value system of patients about herb medicine, the determinant factors of shopping-around patterns of treatment, and the coping mechanism for chronic pain or aggravating symptom.

충주 지역에서 10년간 급성심근경색의 임상관찰에 대한 연구

박봉안,류하근,이종혁,김인숙,류주성,유재등,이용구,문언수,김형수 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

Background: The current treatments of acute myocardial infarct(AMI) Include noninvasive method using thrombolytics and invasive methods such as primary percutaneous transluminal coronary angioplasty(PTCA) and coronary artery bypass graft(CABG)surgery. Although there are many studies comparing the effectiveness of noninvasive and invasive methods, when large clinical centers, 20% of totar hospitals, were excluded, most middle-sized hospitals lacked personnels and facilities for the invasive methods. Thus they opted for the noninvasive methods. Therefore, in this study, the clinical characteristics of AMI patients and the results of thrombolytic & conservative treatment were observed. Method: 137 patients with acute myocardial infarct, who visited KonKuk University Medical Center, ChoongJu Hospital during Sept. 1990 to Sept. 1999 were analysed retrospectively using medical records. Result: The sexual compositions of patients were 63.5% male, and 36.5% female. The mean age for male patients were 56±12.9, and for female patients 68.7±9.6 (p<0.05). The mean age for female patients was significantly older than male patients. The patients in the thrombolytic treatment group had mortality rate of 6.25% which is lower than that of the conservative treatment group at 12% (p>0.05). Conclusion: Although in our study, small number of acute myocardial infarct patients caused the statistical insignificance, rapid revascularization by thrombolytic therapy within 6 hours of onset of symptoms improved mortality rate and early ambulation. And we had good results on AMI with thrombolytic agent in ChungJu including near rural area as primary emergency hospital. Therefore a prospective research with greater number of subjects is needed to develop better treatments for AMI.

소화성 궤양에서 삼제 병합 요법의 저용량에 의한 Helicobacter pylori 제균률과 궤양 치유효과

김예리,박봉안,이재동,이종혁,김인숙,박형석,진춘조,김상윤,박의우 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Helicobacter pylori is the major cause of histologic chronic gastritis and is strongly associated with peptic ulcer disease, gastric cancer and lymphoma. Several recommendations for the management of the Helicobacter pylori infection have been developed. However, there has been no clear therapeutic regimen for the optimal treatment of Helicobacter pylori infection. This study was desinged to evaluate the eradication rate and the ulcer healing rate of the triple regimen with low-dose clarithromycin(0.5g/day) in peptic ulcer patients. Forty three patients with gastric ulcer(n=15) and duodenal ulcer(n=28) were enrolled. The patients were treated either with omeprazole 20mg b.i.d. amoxicillin 0.5g b.i.d. and clarithromycin 250mg b.i.d. (low-dose regimen group, n=29) or with omeprazole 20mg b.i.d., amoxicillin 1.0g b.i.d. and clarithromycin 0.5g b.i.d.(high-dose regimen group, n= 14) for 2 weeks. After 4 weeks, the patients were evaluated for the eradication of Helicobacter pylori and the healing of ulcer. And gastritis scores according to the Sydney system were evaluated before and after 4 weeks from the end of the triple regimen. There was no significant difference in the eradication rate and the ulcer healing rate between the low-dose regimen group, group and the high-does regimen group. In the low-does regimen group, the mean initial scores of chronic inflammation and activity were decreased after the eradication of Helicobacter pylori. In conclusion, the low-dose triple regimen is as effective as the high-dose triple regimen on the eradication of Helicobacter pylori and the ulcer healing rate in peptic ulcer disease.