주요우울증에 대한 Milnacipran의 효과 및 안정성 : Fluoxetine과의 비교

이민수,함병주,기백석,김정범,연병길,오강섭,오병훈,이철,정한용,지익성,최병무,백인호 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.4

Objectives : This 6-week, open label randomized, multicenter study was conducted to evaluate the antidepressant effect and safety of milnacipran and fluoxetine in patients with major depression. Methods : The study was done in patients with major depression diagnosed by DSM-IV who score ≥17 in 17 items Hamilton Rating Scale for Depression (17-item HAM-D) and score ≥25 in Montgomery and Asberg Depression Rating Scale (MADRS). A total of 87 patients were randomized to milnacipran group and fluoxetine group. In cases of the patients taking other antidepressants, 6 weeks of each medication was administered after 7 days of drug excretion period. The evaluation was done using 17 item HAM-D, MADRS, Clinical Global Impression Scale (CGI), and COVI scale after baseline, 1 week, 2 weeks, 4 weeks, and 6 weeks. The side effects that had occurred during the period of our study were put in records by developed/disappeared time, severities, incidences, managements and results. Results : A total of 87 patients were enrolled. 70 (mitnacipran group 39 ; fluoxetine group 31) of them were included for the 6 weeks of research and 17 of them dropped out with in the first week, not due to adverse reactions or deficiency of effects. Total 17 item HAM-D scores, total points of MADRS, and CGI showed significant decrease after 1 week in each treatment group and continued decrease after 2 weeks and 4, 6 weeks. But there was no difference between milnacipran group and fluoxetine group in the antidepressant effect. There were no significant changes in vital sign, CBC, chemistry, and EKG in each treatment group. The commonly reported side elfects of minlacipran were nausea (25.0%), headache (10.7%), vomiting (7.1%),constipation (7.1%), dizziness (7.1%) and those of fluoxetne were GI trouble (11.1%), diarrhea (11.1%), insomnia (11.1%),agitation (5.6%), and dizziness (5.6%). Conclusion : Milnacipran was effective for the improvement of depressive symptoms and was well tolerated and safe in patients with depression.

Comparison of efficacy and safety of milnacipran and fluoxetine in Korean patients with major depression

Lee, Min-Soo,Ham, Byung Joo,Kee, Baik Seok,Kim, Jung‐,Bum,Yeon, Byeong Kil,Oh, Kang‐,Seob,Oh, Byoung Hoon,Lee, Chul,Jung, Han Yong,Chee, Ik‐,Seung,Choe, Byeong Moo,Paik, In Ho Informa UK (Librapharm) 2005 Current medical research and opinion Vol.21 No.9

<P>OBJECT: To compare efficacy and safety of milnacipran and fluoxetine in a population of Korean patients with major depression. RESEARCH DESIGN AND METHODS: The design was a multi-centre, randomised, comparative clinical study. Patients with major depression (DSM-IV diagnostic criteria) scoring over 17 points on the 17-item Hamilton Depression Scale (HAM-D) and over 21 points on the Montgomery-Asberg Depression Rating Scale (MADRS) were recruited and randomised to receive milnacipran (50 mg/day increasing after 1 week to 100 mg/day) or fluoxetine (20 mg/day) for 6 weeks. All previous medication was stopped at least 7 days before entry into the study. Patients were evaluated (HAM-D, MADRS and clinical global impression scale, CGI) at baseline and after 1, 2, 4 and 6 weeks of treatment. All adverse events which developed during the study period were recorded. RESULTS: 70 patients (milnacipran 39; fluoxetine 31) were included in the study. Total score on both HAM-D, MADRS and CGI decreased significantly in both groups after 1 week and continued to decrease throughout the study. There was no significant difference between the two groups for any measurement at any time point. Both antidepressants were well tolerated. In the milnacipran group, 13 patients reported 28 adverse reactions, and in the fluoxetine group 11 patients reported 18 adverse reactions. Two patients discontinued due to adverse events in the milnacipran group and three in the fluoxetine group. There were no clinically significant modifications in vital signs, routine blood laboratory tests, biochemistry or ECG throughout the study. Nausea and headache were the most frequently reported adverse events with milnacipran while digestive disturbances, diarrhoea and insomnia were more common with fluoxetine. CONCLUSION: Milnacipran, like fluoxetine, was found to be effective and well tolerated for the treatment of major depression in this population of depressed Korean patients. Principal limitations of the study were its open design, its small sample size and its relatively short duration.</P>

Development of an anaerobic threshold (HRLT, HRVT) estimation equation using the heart rate threshold (HRT) during the treadmill incremental exercise test

( Joo-ho Ham ),( Hun-young Park ),( Youn-ho Kim ),( Sang-kon Bae ),( Byung-hoon Ko ),( Sang-seok Nam ) 한국운동영양학회 2017 Physical Activity and Nutrition (Phys Act Nutr) Vol.21 No.3

[Purpose] The purpose of this study was to develop a regression model to estimate the heart rate at the lactate threshold (HR<sub>LT<sub>) and the heart rate at the ventilatory threshold (HR_VT) using the heart rate threshold (HRT), and to test the validity of the regression model. [Methods] We performed a graded exercise test with a treadmill in 220 normal individuals (men: 112, women: 108) aged 20-59 years. HRT, HR<sub>LT<sub>, and HR<sub>VT<sub> were measured in all subjects. A regression model was developed to estimate HR<sub>LT<sub> and HR<sub>VT<sub> using HRT with 70% of the data (men: 79, women: 76) through randomization (7:3), with the Bernoulli trial. The validity of the regression model developed with the remaining 30% of the data (men: 33, women: 32) was also examined. [Results] Based on the regression coefficient, we found that the independent variable HRT was a significant variable in all regression models. The adjusted R² of the developed regression models averaged about 70%, and the standard error of estimation of the validity test results was 11 bpm, which is similar to that of the developed model. [Conclusion] These results suggest that HRT is a useful parameter for predicting HR<sub>LT<sub> and HR<sub>VT<sub>.

ABSTRACTS ; GROWTH SUPPRESSION OF HEPATOMA CELL LINES BY TRANSDUCTION OF WILD - TYPE P53 ADENOVIRUS

Joo Ho Tai,Chang Min Kim,Kee Ho Lee,Yong Ho Ham,Yoon Jeong Choe,Hoon Cha,Pyeong Uk Park,Key H . Kim,Choon Taek Lee 생화학분자생물학회(구 한국생화학분자생물학회) 1995 추계학술대회집 Vol.- No.-

다양한 식물들을 이용한 Staphylococcus aureus, Listeria monocytogens, Mannhemia haemolytica 및 Salmonella gallinarum 항균 추출물 탐색

Ham Young-Joo,Yang Jin-Ho,Na Chong-Sam 한국유기농업학회 2013 韓國有機農業學會誌 Vol.21 No.1

Antibacterial activity is an important feature for the development of antibiotics alternatives. Plant extract is considered as a promising alternative for organic farming. In this study, a total of 11 plants were extracted using ethanol to determine their antibacterial activities against to Staphylococcus aureus, Listeria monocytogens, Mannheimia haemolytica and Salmonella gallinarum. The synergistic interaction among plant extracts was also investigated. Plants used in this study were Carthamus nctoricus L. (pA), Poncirus trifollata Raf. (pB), Scutellaria balcalensis Georgi (pC) Prunus sargentii (pD), Cucurbita moschata DUCH Leaf (pE), Allium cepa L. peel (pF) Portulaca oleracea L. (pG), Xanthium strumarium L. (pH), Duchesnea chrysantha (pI), Cudrania tricuspidata (pJ) and Juniperus chinensis L. (pK). The pB and pA had the most broad antibacterial spectrum and the highest activity against to Staph. aureus among plant extract, respectively. In the synergistic interaction, the mixtures of pA and pC as well as pA and pF had batter antibacterial activity against to Staph. Aureus compared with other mixtures.

Case Reports : A Synonymous Genetic Alteration of LMX1Bin a Family with Nail-Patella Syndrome

Joo Ho Ham,Seok Joon Shin,Kyu Re Joo,Sung Min Park,Hye Young Sung,Joong Seok Kim,Jin Soo Choi,Yeong Jin Choi,Ho Cheol Song,Eui Jin Choi 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.3

The gene responsible for nail-patella syndrome, LMX1B, has recently been identified on chromosome 9q. Here we present a patient with nail-patella syndrome and an autosomal dominant pattern of inheritance. A 17-year-old girl visited our clinic for the evaluation and treatment of proteinuria. She had dystrophic nails, palpable iliac horns, and hypoplastic patellae. Electron microscopy of a renal biopsy showed irregular thickening of the glomerular basement membrane. A family history over three generations revealed five affected family members. Genetic analysis found a change of TCG to TCC, resulting in a synonymous alteration at codon 219 in exon 4 of the LMX1B gene in two affected family members. The same alteration was not detected in an unaffected family member. This is the first report of familial nail-patella syndrome associated with an LMX1B in Korea mutation, However, we can not completely rule out the possibility that the G-to-C change may be a single nucleotide polymorphism as this genetic mutation cause no alteration in amino acid sequence of LMX1B. (Korean J Intern Med 2009;24:274-278)

3,000 m 상당고도의 저압,저산소 환경에서 4주간의 간헐적인 스프린트 훈련이 무산소성 에너지대사와 운동수행능력에 미치는 영향

함주호 ( Joo Ho Ham ),남상석 ( Sang Seok Nam ),박훈영 ( Hun Yuong Park ),선우섭 ( Oo Sub Sun ) 한국운동생리학회(구 한국운동과학회) 2011 운동과학 Vol.20 No.4

함주호, 남상석, 박훈영, 선우 섭. 3,000 m 상당고도 저압·저산소 환경에서 4주간의 간헐적인 스프린트 훈련이 무산소성 에너지대사와 운동수행능력에 미치는 영향. 운동과학, 제20권 4호 461-474, 2011. 본 연구는 3,000 m 상당고도와 평지에서 간헐적인 스프린트 훈련이 무산소성 에너지대사와 운동수행능력에 미치는 영향을 cross-over study로 비교한 것이다. 연구의 대상자들은 체육전공 남자 대학생 14명으로, 트레드밀 달리기를 경사도 10%, 스피드 15~17 km/hr의 운동 강도로 4주간, 주 3회, 30초×10세트, 세트 간 휴식은 2분으로 하였으며, 3,000 m 상당고도(526 mmHg)와 평지(760 mmHg)에서, 각각 1차 트레이닝을 실시한 후 8주간의 휴식기를 거친 후 2차 트레이닝을 실시하였다. 그 결과 체중과 근육량은 3,000 m 상당고도 트레이닝 후에 유의하게 감소하였다. CPK는 두 조건 모두 트레이닝 후에 유의한 변화가 없었으나, LDH는 3,000 m 상당고도 트레이닝 후에 고강도 운동직후와 회복 5분에 유의하게 감소하였다. 혈중산소운반능력은 두 조건 모두 트레이닝 후에 유의한 변화가 없었다. EPOC는 평지 및 3,000 m 상당고도 트레이닝 후에 유의하게 증가하였다. 무산소성 파워는 3,000 m 상당고도 트레이닝 후에 유의하게 증가 하였다. 하지근 등속성 근력은 평지 트레이닝 후에 유의하게 증가 하였으나, 3,000 m 상당고도 트레이닝 후에는 유의하게 감소하였다. 100 m time trial은 3,000 m 상당고도 트레이닝 후에 유의하게 감소하였으나, 400 m time trial은 두 조건 모두 유의한 변화가 없었다. Ham, J. H., Nam, S. S., Park, H. Y., Sunoo, S. Effects of 4 weeks intermittent sprint training on anaerobic energy metabolites and performance in hypobaric hypoxic condition, equivalent to an altitude of 3,000 m. Exercise Science. 20(4): 461-474, 2011. The study was designed to investigate the effects of intermittent sprint training in hypobaric hypoxic condition, equivalent to an altitude of 3,000 m and sea level on anaerobic energy metabolism and performance. Fourteen college male students majoring sports volunteered to participate in this research. Running grade, speed, time, repetition time, and interval between running were 10 percent, 15-17 km/hr, 30 seconds, 10 times, 2 minutes respectively. Training period was 4 weeks. They took 8 weeks rest after first training (4 weeks) in 3,000 m simulated altitude and sea level. Also second training practiced 4 weeks in that order (a cross-over study). The results of this study were as follows. Weight and muscle mass were significantly decreased after 3,000 m simulated altitude training. CPK was not significantly changed after 3,000 m simulated altitude and sea level training. LDH was significantly decreased immediately after exercise and recovery 5 minutes after 3,000 m simulated altitude training. Oxygen transporting capacity of the blood was not significantly changed after 3,000m simulated altitude and sea level training. EPOC was significantly increased after 3,000 m simulated altitude and sea level training. Anaerobic power was significantly increased after 3,000 m simulated altitude training. Leg isokinetic muscular strength was significantly increased after sea level training. But it was significantly decreased after 3,000 m simulated altitude training. 100 m time trial was significantly decreased after 3,000 m simulated altitude training. But 400 m time trial was not significantly changed in two groups. We have demonstrated that weight, muscle mass and 100 m time trial was significantly changed by 4 weeks of intermittent sprint training in hypobaric hypoxic condition, equivalent to an altitude of 3,000 m, whereas the other physiological parameters was not significantly changed in two groups.

ABSTRACTS ; ROLE OF WAF1 / CIP 1 EXPRESSION IN HUMAN HEPATOCELLULAR CARCINOMA CELL LINE DURING WILD TYPE - P53 MEDIATED APOPOSIS : IMPLICATIONS IN LOW LEVEL EXPRESSION OF WAF1 / CIP1 IN HUMAN HEPATOCELLULAR CARCINOMA TISSUES

Kee Ho Lee,Keun Cheol Kim,Yu Jin Jung,Choon Taek Lee,Sook Hyang Jung,Dong Uk Choi,Joo Ho Tai,Se Chang Kwon,Yong Ho Ham,Hee Chung Kwon,Yoon Jeong Choe,Chang Min Kim 생화학분자생물학회(구 한국생화학분자생물학회) 1995 추계학술대회집 Vol.- No.-

가상대장내시경검사를 이용해 진단한 장관포상기종 1예

함주호 ( Joo Ho Ham ),김태호 ( Tae Ho Kim ),한석원 ( Sok Won Han ),조근종 ( Keun Jong Cho ),최선욱 ( Son Ook Choi ),백정선 ( Jung Sun Pack ),양성은 ( Seong Eun Yang ),김상희 ( Sang Hee Kim ),양승아 ( Seung Ah Yang ),이윤정 ( Yune 대한소화기학회 2007 대한소화기학회지 Vol.50 No.5

Pneumatosis cystoides intestinalis (PCI) is a rare condition characterized by multiple gas filled cysts in the intestinal wall. The diagnosis of PCI is usually made by colonoscopy, histology, or radiologic findings. We report a case of PCI in a 35-year-old man. The patient initially complained of watery diarrhea and abdominal bloating for 2 weeks. Simple abdominal X-ray demonstrated numerous, small, round, air densities on the right upper abdomen along the ascending and proximal transverse colon. Colonoscopy revealed numerous, 5-20 mm sized, sessile poly-poid, balloon-like distended, protruding subepithelial masses covered with normal colonic mucosa from cecum to proximal transverse colon. We performed a CT colonoscopy and confirmed PCI with multiple air-filled cystic masses along the colonic wall from cecum to proximal transverse colon. The patient was treated with antibiotics and oxygen inhalation for 2 weeks. Follow-up CT colonoscopy revealed marked regression in the number and size of the air-filled cystic masses. Herein, we report the first case of the PCI in Korea diagnosed by CT colonoscopy. Follow-up evaluation with CT colonoscopy was performed after the treatment of the PCI. CT colonoscopy is a useful non-invasive diagnostic tool for the diagnosis of pneumatosis cystoides intestinalis. (Korean J Gastroenterol 2007;50:334-339)

성인 위 배출구 폐쇄의 임상 양상의 변화 및 내시경술의 의의

김은주,이석호,김홍수,이문호,김선주,정일권,박상홈,함정호 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.2

Background/Aims: The causes of gastric outlet obstruction (GOO) have changed from peptic ulcer disease (PUD) to malignant diseases in recent years. The aims of this study are to determine the relative incidence of malignany and other causative diseases, and to consider therapeutic and diagnostic usefulness of endoscopy. Methods: 95 patients with GOO who diagnosed by radiologic and endoscopic examination or surgery were reviewed by causative diseases, clinical features, endoscopic findings and outcome of treatment. Results: 1) The mean age was 57.5 years (M: F=2.4: 1). 2) The causative diseases were gastric or duodenal malignancy (56.8%), complication of PUD (39.2%), and biliary and pancreatic disease (4,2%). 3) Malignancy was diagnosed by upper gastrointestinal (UGI) endoscopy in 95.8%; obstruction by complication of PUD was detected by endoscopy in 100%. 4) The most common endoscopic type of malignancy was Borrman type 3 (84.8%) and the most common benign lesions were duodenal or pyloric ulcer (94.5o). 5) The managements of malignancy were operation (53.5%), endoscopic stenting (18.5%), and conservative treatment (38.8%). The complications of PUD were treated by anti-ulcer medication (S5.3%), endoscopic dilatation (4.8%) and operation (13.6%). Conclusions: The main causes of GOO are changed to malignancy in recent 5 years. Endoscopy is useful to detect the various causes of GOO, and necessary procedure to decide the method of their management.