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Hyeon-Ji Yoon,Gyu-Hyeon Park,Yu-Rim Lee,Jeong-Min Lee,Hyun-Lim Ahn,Syng-Ook Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
Hemp (Cannabis sativa L.) seeds have recently been attracting attention as a new high value-added food material due to their excellent nutritional properties, and research on the development of functional food materials and foods using them is actively progressing. The present study was conducted to evaluate the antioxidant properties of hemp seed protein hydrolysates. Protein hydrolysates were prepared from defatted hemp seed powder (HS) by enzymatic hydrolysis using five different proteases (alcalase, bromelain, flavourzyme, neutrase, and papain). As a result of TNBS assay and SDS-PAGE analysis, HS treated with all enzymes except papain showed a high degree of hydrolysis. The total polyphenol content of the protein hydrolysates (<3 kDa) and the RC50 values obtained from two different antioxidant tests showed that the alcalase hydrolysate (HSA) had a relatively high level of antioxidant capacity. In addition, treatment with HSA (100 μg/mL) significantly inhibited linoleic acid peroxidation. These results suggest that hemp seed protein hydrolysates are potential sources of natural antioxidants, and further studies are needed to identify active peptides from HSA.
Ahn, Ji Hyeon,Shin, Myoung Cheol,Park, Joon Ha,Kim, In Hye,Cho, Jeong-Hwi,Lee, Tae-Kyeong,Lee, Jae-Chul,Chen, Bai Hui,Shin, Bich Na,Tae, Hyun-Jin,Park, Jinseu,Choi, Soo Young,Lee, Yun Lyul,Kim, Dae Wo SPANDIDOS PUBLICATIONS 2017 MOLECULAR MEDICINE REPORTS Vol.15 No.6
<P>Therapeutic exercise is an integral component of the rehabilitation of patients who have suffered a stroke. The objective of the present study was to use immunohistochemistry to investigate the effects of post-ischemic exercise on neuronal damage or death and gliosis in the aged gerbil hippocampus following transient cerebral ischemia. Aged gerbils (male; age, 22–24 months) underwent ischemia and were subjected to treadmill exercise for 1 or 4 weeks. Neuronal death was detected in the stratum pyramidale of the hippocampal CA1 region and in the polymorphic layer of the dentate gyrus using cresyl violet and Fluoro-Jade B histofluorescence staining. No significant difference in neuronal death was identified following 1 or 4 weeks of post-ischemic treadmill exercise. However, post-ischemic treadmill exercise affected gliosis (the activation of astrocytes and microglia). Glial fibrillary acidic protein-immunoreactive astrocytes and ionized calcium binding adaptor molecule 1-immunoreactive microglia were activated in the CA1 and polymorphic layer of the dentate gyrus of the group without treadmill exercise. Conversely, 4 weeks of treadmill exercise significantly alleviated ischemia-induced astrocyte and microglial activation; however, 1 week of treadmill exercise did not alleviate gliosis. These findings suggest that long-term post-ischemic treadmill exercise following transient cerebral ischemia does not influence neuronal protection; however, it may effectively alleviate transient cerebral ischemia-induced astrocyte and microglial activation in the aged hippocampus.</P>
AHN, JI HYEON,NOH, YOOHUN,SHIN, BICH NA,KIM, SUNG-SU,PARK, JOON HA,LEE, TAE-KYEONG,SONG, MINAH,KIM, HYUNJUNG,LEE, JAE-CHUL,YONG, JUN-HWAN,KANG, IL JUN,LEE, YUN LYUL,WON, MOO-HO,KIM, JONG DAI SPANDIDOS PUBLICATIONS 2018 MOLECULAR MEDICINE REPORTS Vol.18 No.6
<P> Intermittent fasting has been shown to have neuroprotective effects against transient focal cerebral ischemic insults. However, the effects of intermittent fasting on transient global ischemic insult has not been studied much yet. The present study examined effects of intermittent fasting on endogenous antioxidant enzyme expression levels in the hippocampus and investigated whether the fasting protects neurons 5 days after 5 min of transient global cerebral ischemia. Gerbils were randomly subjected to either ad libitum or alternate?day intermittent fasting for two months and assigned to sham surgery or transient ischemia. Changes of antioxidant enzymes were examined using immunohistochemistry for cytoplasmic superoxide dismutase 1 (SOD1), mitochondrial (SOD2), catalase (CAT), and glutathione peroxidase (GPX). The effects of intermittent fasting on ischemia?induced antioxidant changes, neuronal damage/degeneration and glial activation were examined. The weight of fasting gerbils was not different from that of control gerbils. In controls, SOD1 and GPX immunoreactivities were strong in pyramidal neurons of filed cornu ammonis 1 (CA1). Transient ischemia in controls significantly decreased expressions of SOD1 and GPX in CA1 pyramidal neurons. Intermittent fasting resulted in increased expressions of SOD2 and CAT, not of SOD1 and GPX, in CA1 pyramidal neurons. Nevertheless, CA1 pyramidal neurons were not protected in gerbils subjected to fasting after transient ischemia, and inhibition of glial-cell activation was not observed in the gerbils. In summary, intermittent fasting for two months increased SOD2 and CAT immunoreactivities in hippocampal CA1 pyramidal neurons. However, fasting did not protect the CA1 pyramidal neurons from transient cerebral ischemia. The results of the present study indicate that intermittent fasting may increase certain antioxidants, but not protect neurons from transient global ischemic insult. </P>
Scientific Comparison Study on the Joseon Dynasty Palace Roof Tiles and Modern Handmade Roof Tiles
Ahn, Kyoung Suk,Lee, Min Hye,Kim, Ji Hye,Ha, Ji Hyang,Jang, Won Jin,Kim, Du Hyeon,Jeong, Ji Youn,Han, Min Su The Korean Society Of Conservation Science For Cul 2021 보존과학회지 Vol.37 No.1
The purpose of this study is to scientifically analyze physicochemical characteristics of the roof tiles used for palaces in the Joseon Dynasty which stored in Changdeokgung material storage and Seooreung Jaesil and the modern handmade ones which made by N company to understand the differences between their manufacturing techniques. Through chromaticity, cross-sectional observation, component analysis, and crystal structure analysis, it was possible to confirm the physicochemical properties and fired properties of the roof tile. Roof tiles from the Joseon Dynasty have a wider colorimetric range and higher apparent porosity and water absorption, on average, than the modern roof tiles. The cross section of the Joseon Dynasty roof tiles shows that most clay minerals have not been vitrified, remaining in the form of atypical particles, while the modern roof tiles have denser clay materials. X-ray diffraction analysis identified low-temperature minerals such as micas in Joseon roof tiles but no peak of these minerals was observed in the modern roof tiles, implying that the modern ones are fired at higher temperature than the Joseon ones. Therefore, the modern roof tiles are fired at higher temperature and have higher density than the Joseon ones due to the use of pugmills. The general content of main ingredients was similar between the two. Additionally, the principal component analysis of trace elements in the Joseon roof tiles showed that most samples were from similar areas. It seems that the Joseon roof tiles were manufactured using soils supplied from a specific region at the same timeframe and their consistency in the content of principal components implies that they also have similar mix proportions of clay.
Whole pelvic intensity-modulated radiotherapy for high-risk prostate cancer: a preliminary report
Ji Hyeon Joo,Yeon Joo Kim,Young Seok Kim,Eun Kyung Choi,Jong Hoon Kim,Sang-wook Lee,Si Yeol Song,Sang Min Yoon,Su Ssan Kim,Jin-hong Park,Yuri Jeong,Hanjong Ahn,Choung-Soo Kim,Jae-Lyun Lee,Seung Do Ahn 대한방사선종양학회 2013 Radiation Oncology Journal Vol.31 No.4
Purpose: To assess the clinical efficacy and toxicity of whole pelvic intensity-modulated radiotherapy (WP-IMRT) for high-risk prostate cancer. Materials and Methods: Patients with high-risk prostate cancer treated between 2008 and 2013 were reviewed. The study included patients who had undergone WP-IMRT with image guidance using electronic portal imaging devices and/or cone-beam computed tomography. The endorectal balloon was used in 93% of patients. Patients received either 46 Gy to the whole pelvis plus a boost of up to 76 Gy to the prostate in 2 Gy daily fractions, or 44 Gy to the whole pelvis plus a boost of up to 72.6 Gy to the prostate in 2.2 Gy fractions. Results: The study cohort included 70 patients, of whom 55 (78%) had a Gleason score of 8 to 10 and 50 (71%) had a prostate-specific antigen level > 20 ng/mL. The androgen deprivation therapy was combined in 62 patients. The biochemical failure-free survival rate was 86.7% at 2 years. Acute any grade gastrointestinal (GI) and genitourinary (GU) toxicity rates were 47% and 73%, respectively. The actuarial rate of late grade 2 or worse toxicity at 2 years was 12.9% for GI, and 5.7% for GU with no late grade 4 toxicity. Conclusion: WP-IMRT was well tolerated with no severe acute or late toxicities, resulting in at least similar biochemical control to that of the historic control group with a small field. The long-term efficacy and toxicity will be assessed in the future, and a prospective randomized trial is needed to verify these findings.