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Ciprofloxacin 제제의 생물학적 동등성에 관한 연구
최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1
국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.
박원종,유성근,신경철,정진홍,이관호 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2
Varicella is a contagious infection in childhood disease typically affecting children aged 2-8 years and usually follows benign outcome. In the adult, clinical presentation is more severe and more commonly associated with complications. Varicella pneumonia, although rare, is a potentially life-threatening complication that should be suspected in any adult with varicella and respiratory symptoms. We report a case of varicella pneumonia in immunocompetent patient. The characteristics radiographic findings consisted of diffuse scattered coarse nodular infiltrations, less than 1cm sized, with ground glass opacity and consolidation in both lung fields. The patients was started on intravenous acyclovir. The chest radiograph performed 2 weeks later showed complete resolution of the pulmonary lesions.
( Yu-kyeong Shin ),( Shiva Ram Bhandari ),( Yong-hyeon Kim ),( Jung-su Jo ),( Ji-hyeon Kim ),( Jun-gu Lee ) 한국농업기계학회 2019 한국농업기계학회 학술발표논문집 Vol.24 No.1
Nursery management is generally performed by the manager's visual judgment and experience which may be different depending upon the person leading an insufficient management method for the production of the uniform seedlings. To overcome this situation, this study was performed by the classified chlorophyll fluorescence technique which was not judged by visual inspection according to the moisture content in medium and monitored to supplement water management technology. Grafted watermelon seedlings after six days of grafting were first irrigated sufficiently and grown for two days without irrigation. The seedlings were then classified into different six groups depending upon the soil water content from sufficient (I) to severe water stress (V) using the moisture content sensor. Furthermore, the seedlings with the lowest soil water content (I) were grown until 4 days with and without irrigation progressively for the recovery test. Then the chlorophyll fluorescence imaging system was used to assess the different fluorescence parameters; maximum quantum yield (Fv/Fm), the maximum fluorescence at P level without saturation (Fp), non-photochemical quenching (NPQ), a decrease of fluorescence ratio (Rfd), photochemical quenching (qP) and effective quantum yield of photochemical energy conversion in PSII (φPSII) to understand the effect of water stress. Fv/Fm, Fp, NPQ and Rfd decreased with the increase in water stress level. The lowest value was found on the 4th day of the water stress treatment with the highest decrement in Fp and Rfd. While other parameters (qP and φPSII) were not significantly affected at different soil water level. In contrast, all the parameters were significantly decreased at the progressive severe water stress condition. Fv/Fm, qP, NPQ, and φPSII were fully recovered when recovering through irrigation after severe water stress while the Fp and Rfd were recovered at a certain level only. In conclusion, the chlorophyll fluorescence parameters; Fp and Rfd can be preferred to monitor the water stress level in grafted watermelon seedlings.
Yu Kyeong Shin,Shiva Ram Bhandari,Jae Woo Song,Myeong-Cheoul Cho,Eun Young Yang,Yul Kyun Ahn,Indeok Hwang,Jun Gu Lee 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
To detect the injury caused by the low temperature in tomato seedlings, one scion (Dafnis) and three stock (B-blocking, BKO, and Spider) cultivars of tomato were used in this study, and their growth performance as well as chlorophyll fluorescence (CF) parameters were evaluated. For this, the seedlings at three-leaf stage were brought from seedling farm and grown under warm white LED (220 ± 10 μmol·m<SUP>-2</SUP>·s<SUP>-1</SUP>) in a constant environmental condition [temperature (24/20°C), and light period 14/10 h (day/night)] for 3 days for acclimatization to the new environment. Then, the seedlings were grown under the three temperature levels [control: 24/20°C (day/night), Low I: 16/12°C, and Low II: 8/4°C] in a closed and controlled plant production system for 6 days. Both the CF and growth parameters (number of leaves, height, fresh and dry weight of shoot, and diameter) were measured 2-day interval during the experiment. Among the CF parameters, minimal chlorophyll fluorescence intensity measured in the dark-adapted state (Fo), maximal chlorophyll fluorescence intensity measured in the dark-adapted state during the application of a saturating pulse of light (Fm), and maximum quantum yield of PSII photochemistry measured in the dark-adapted state (Fv/Fm) showed significant changes in both the low temperature treatments compared to the control during the progressive treatment time. Also, non-photochemical quenching (NPQ) and the ratio of the fluorescence decrease (Rfd) were influenced significantly. In particular, all the three stock cultivars exhibited significant differences in photochemical quenching of variable fluorescence based on the puddle model of PSII (qP). Overall growth performance was also affected significantly showing reduced growth rate, curling of leaves and nodes, and yellow leaf color. The selected CF parameters; Fo, Fm, Fv/Fm, NPQ, and Rfd could be used to detected low temperature stress in tomato seedlings.
Effect of High-Temperature in Photosystem II of Scion and Stock Commercial Tomato Cultivars
Yu Kyeong Shin,Shiva Ram Bhandari,Jae Woo Song,Myeong-Cheoul Cho,Eun Young Yang,Yul Kyun Ahn,Indeok Hwang,Jun Gu Lee 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
This study was conducted to evaluate the chlorophyll fluorescence (CF) as well as growth performance for the detection of high-temperature treatment in the seedlings of one scion (Dafnis) and three stock cultivars of tomato (B-blocking, BKO, and Spider). Tomato seedlings at three-leaf stage were brought from seedling farm, and grown under warm white LED (220 ± 10 μmol·m<SUP>-2</SUP>·s<SUP>-1</SUP>) in a closed chamber having temperature (24/20°C), and light period 14/10 h (day/night) for 3 days. The seedlings were then grown under the three temperature levels [control: 24/20°C (day/night), High I: 32/28°C, and High II: 40/36°C] in a controlled condition for 6 days. Both the CF and growth parameters (number of leaves, height, fresh and dry weight of shoot, and diameter) were measured at 2-day interval during the experiment. Overall chlorophyll fluorescence kinetic in both the scion and stock cultivars was decreased in both High I and II treatment. Among the CF parameters, non-photochemical quenching (NPQ) and the ratio of the fluorescence decrease (Rfd) were the most influenced parameters showing significant decrement in both the high temperature treatments compared to the control during the progressive treatment time. In particular, the large stock varieties; B-blocking and BKO showed significant differences in effective quantum yield of photochemical energy conversion in PSII [Y(PSII)] and photochemical quenching of variable fluorescence based on the puddle model of PSII (qP) compared to Dafnis cultivar. Tomato seedlings exposed to high temperature showed straight leaf with dark in color, and reduced plant height and weight. The overall results showed that Y(PSII), qP, NPQ, and Rfd could be used to identify high temperature stress in tomato seedlings.