18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색

류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-

Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.

영양표시정착화사업(Ⅱ) : 식품참고량설정에 관한 연구 Study on the Establishement of the Reference Amount in Foods

김대병,장영미,김인복,이혜영,장재희,김보영,이정구,김창민,정해랑 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-

본 연구는 영양표시에서 1회분량 및 영양소함량표시의 기준으로 사용되는 "식픔창고량"에 관한 연구를 수행하므로써 합리적이고 일관성있는 영양표시기준 개선을 위한 기초자료로 활용코자 하였다. 이를 위하여 미국 및 캐나다를 중심으로 제외국의 현황 및 식품참고량 설정방법을 조사 ·연구 하으며 제도도입 및 개선 방안을 강구하였파. 또한, 시판 제품의 영양료시현황 및 음료류 둥의 포장단위 등을 피악하여 식품참고량설정을 위한 기초자료로 활용코자 하였다. 앞으로 국민건강 ·영양조사자료의 체계적인 통계분석, 가공식품의 섭취량조사 등을 통하여 우리나라 국민의 1인 1회 섭취량자료의 축적이 선행되어야 할 것이다. The purpose of this ?roject is to study on the reference amounts customarily consumed per eating occasion to improve the nutrition labelling standards. We Performed to study on the methodology to establish the reference amounts on the basis of the review on the advanced counITy's status. And we investigated the packaged unit ofprocessed foods. Further study is needed to establlsh the customarily consumed amount per eating occasionthrough the statistical analysis of nationwide food consumption data. Our results will be helpful information to improve nutrition labelling system in Korea.

산업자재용 폴리에스터 섬유의 강도 향상에 관한 연구

박영신,남영식,정상영,최재호,장기혁,박원호,Park, Young-Shin,Nam, Young-Sik,Jung, Sang-Young,Choi, Jae-Ho,Jang, Ki-Hyuk,Park, Won-Ho 한국섬유공학회 2012 한국섬유공학회지 Vol.49 No.1

In this work, effects of total draw ratio change on the mechanical properties of polyester fibers were studied. The process parameter was a total draw ratio and the draw ratios that were used ranged from 6.6 to 7.0. Tensile properties are determined from the tensile tester, and crystallite parameters from the density measurement and X-ray diffraction were discussed with the different total draw ratios. The tenacity, young's modulus and crystallinity were increased to 10.6 g/d, 123.2 g/d and 42.1%, respectively, with increase in the total draw ratio. The relations between total draw ratio and mechanical properties of high tenacity polyester fiber were discussed.

LaCrO₃후막 소자의 가스에 대한 감지 특성

장재영,박기철,신정호,김정규 慶尙大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.14 No.-

LaCrOa₃ thick-film sensors were fabricated on an alumina substrate by the screen printing method. The sensitivities for gases were investigated by varying the heat treatment temperatures of the films. The sensitivities of LaCrO₃ thick-film for ?? and NH₃ gases were better than those for CO and NO gases. The best condition of heat treatment was 450℃ and the optimal operating temperature of LaCrO₃ thick-film for the highest sensitivity was 400℃. Sensitivities of LaCrO₃ thick-film about at 3000ppm for ?? and NH₃gases were 85% and 95%, respectively.

Wigner 분포 함수를 이용한 위상지연 함수에 대한 연구

장남영,은재정,강호정,최평석 國立 昌原大學校 産業技術硏究所 2000 産技硏論文集 Vol.14 No.-

작은 초점 심도를 갖는 원형 대칭 광시스템에 대하여 Wigner 분포 함수(WDF)를 적용해 얻은 위상 지연 함수와 초점 심도와의 관계를 설명한다. 일반적인 광시스템의 이차원의 원형 개구는 잘알려진 변환식에 의해 일차원 동공 함수로 변환되고 변환된 일차원 동공 함수는 다시 Wigner 함수로 표현된다. 일반적으로 일차원 함수를 Wigner 함수로 변환시키면 2차원 함수가 된다. 초점 심도와 위상 지연 함수와의 관계는 2차원 위상 공간(χ, ζ)으로 표현되는 Wigner 함수를 χ축으로 α만큼 기울이므로써 얻을 수 있다. 여기서 초점 거리 f를 1220mm, 구경이 12.5mm, 사용된 광파장 λ가 633nm일 때 α값에 따른 초점 심도의 변화를 수치해석 한다.

중심점 탐색없는 지문 정합 알고리즘에 관한 연구

장경식,임재영,최영규 한국기술교육대학교 2003 論文集 Vol.10 No.1

We propose a fingerprint matching algorithm that compares distance and included angle sequence among minutiaes with another's. We defined this sequence as minutiae constellation which has a basic unit is distance and included angle sequence among three minutiaes. This algorithm searches nearest minutiae from a minutiae and repeatedly searches nearest minutiae from just before searched minutiae. It doesn't search core and is independent of translation and rotation because matching stage only uses distance and included angle sequence.

전단-스팬비가 작은 고강도 철근콘크리트 보의 진단성능

장일영,최광진,송재호 金烏工科大學校 1993 論文集 Vol.14 No.-

This paper is an experimental study on shear capacity of the high strength R/C beams with a shear span-depth ratio between 1.5 and 2.5 A total of 15 beams was tested to determine diagonal cracking and ultimate shear strength. The major variable are shear span-depth ratio(a/d=1.5, 2.0, 2.5), vertical shear reinforcement ratio?? and concrete compressive strength??. Test results indicate that ACI 318-89 Eq(11-31) generally underestimates shear strength carried by vertical shear reinforcements, and the mode of failure may change from shear tension to shear compression for the beams having higher Vs than 75%, thus the effectiveness of r fy on ultimate shear strength(Vu) decreased.

구강악안면외과에서 의식하진정에 필요한 Midazolam용량에 관한 연구

장재현,김성민,김소희,박영욱 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.3

Conscious sedation is a minimally depressed level of consciousness that retains the patients' ability to maintain the airway continuously and to respond appropriately to physical stimulation and verbal command at any time, produced by a pharmacologic or nonpharmacologic method or a combination thereof. In dental anesthesia, a state of sedation in which the conscious patient is rendered free of fear, apprehension and anxiety through the use of pharmacologic agents. Midazolam is a useful drug of benzodiazepine on minor operation of dentistry. The purpose of this study is to estimate the appropriate dosage protocol of Midazolam to the patient receiving intravenous sedation at the department of oral and maxillofacial surgery. Total subject was fifty-one patients and fifteen patients of this subject were decided to control group that they were not received intravenous sedation. The experimental group was randomly subdivided into two groups and each of those groups was administrated to 0.05 ㎎/㎏ and 0.08 ㎎/㎏ each other. All patients of the subject were surveyed with postoperative one day questionaire to evaluate the level of sedation. We found that the result was statistically significant between the experimental and the control, and so we present the protocol of the department of oral and maxillofacial surgery, Kangnung National University Dental Hospital.

Ionized Calcium 과 Chitosan 정제의 안정성에 관한 연구

장윤정,김현주,김영일,양재헌 又石大學校 1998 論文集 Vol.20 No.-

Recently, chitosan has being fiocused on not only the role of a potential and natural resource with antibacterial or antifungal effect but also the natural controller of releasing of drugs or principle actives. Calcium is one of the most important minerals of human that concerned with the intra-or inter-cellular function. But ionized calcium, prepared from shell through the condition of high temperature, own the antibacterial effects. We prepared the mixed tablet of chitosan and ionized calcium with several additives such as starch paste, ethylcellulose(EC), hydroxypropylmethylcelullose(HPMC) or hydroxyprophylcellulose(HPC). Each formulation with a additive was adopted as a challenger to modify of release profiles of calcium. Finally following both cationic properties, chitosan & ionized calcium, the mucoadhesive effects in the oral cavity are favorable to introduce for chewable tablet. The similar patterns of contents of calcium, disintegration time, hardness, weigth variation were showed following the preparation with each additive. The dissolution profiles of starch paste preparation was more slower than other preparations. It was as the order as HPMC, HPC, EC. The stabilities of tablet of each formulation was creditable in the period of 4 weeks under the condition of 50℃ and 75% of humidity. The contents of calcium, disintegration time, hardness were not changed significantly. Ionized calcium and chitosan mixed tablet may increase the antibacterial effects and the release patterns of calcium could changed successfully by several addives.