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- 저자 : Jae H. Kim (검색결과 789 건)
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한국에서 지역에 따른 Helicobacter pylori 균주 내성
김재연 ( Jae Yeon Kim ),김나영 ( Na Young Kim ),김성중 ( Sung Jung Kim ),백광호 ( Gwang Ho Baik ),김광하 ( Gwang Ha Kim ),김정목 ( Jung Mogg Kim ),남령희 ( Ryoung Hee Nam ),김홍빈 ( Hong Bin Kim ),이동호 ( Dong Ho Lee ),정현채 ( H 대한소화기학회 2011 대한소화기학회지 Vol.57 No.4
Background/Aims: This study was performed to compare the prevalence rates of primary antibiotic resistance in Helicobacter pylori (H. pylori) isolates among different regions of Korea. Methods: H. pylori were isolated from gastric mucosal biopsy specimens of 99 Koreans who lived in Gyeonggi (n=40), Kangwon province (n=40) and Busan (n=19) from April to August in 2008. All the patients had no history of H. pylori eradication therapy. The susceptibilities of the H. pylori isolates to amoxicillin, clarithromycin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin, and moxifloxacin were tested according to the agar dilution method. Results: There was a difference in resistance to clarithromycin in three institutes located among Gyeonggi (32.5%), Kangwon province (12.5%) and Busan (42.1%) by One way ANOVA test (p=0.027) and nonparametric Kruskal Wallis test (p=0.027). However, by post-hoc analysis, there was no statistically significant difference among three regions. Similarly, the other 7 antibiotics (amoxicillin, metronidazole, tetracycline, azithromycin, ciprofloxacin, levofloxacin and moxifloxacin) did not show any significant difference. Conclusions: There was no significant regional difference of the primary antibiotic resistance of H. pylori. However, the included patient number might not be enough for this conclusion demanding further evaluations. (Korean J Gastroenterol 2011;57:221-229)
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New Nonparametric Tests for the Efficiency in Foreign Exchange Markets
Jae H. Kim,Chong Soo Pyun,Osamah M. Al-Khazali 한국재무학회 2010 한국재무학회 학술대회 Vol.2010 No.05
Using Kim’s (2009) wild bootstrapped automatic variance ratio (AVR) test and Kuan and Lee’s (2004) martingale difference sequence (MDS) test, we investigate the random walk (RW) and the martingale hypotheses for the Australian dollar and seven Asian currencies between 1993 and 2008. Our findings are that (i) the hypotheses of RW and MDS are rejected for all eight currencies for the entire study period as well as for the sub-period leading up to the Asian financial crisis in 1997; (ii) for the post-Asian crisis period, only the Australian dollar, Malaysian ringgit, and Korean won behave as weak-form efficient while the rest of five Asian currencies show no discernible improvement toward market efficiency. Our findings have broad policy implications - investors can exploit time-varying movements of the returns of the five currencies which can be identified by technical trading rules for profitable trading.
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Kim, J.Y.,Park, M.C.,Kim, S.B.,Park, H.D.,Lee, J.H.,Kim, Jae-Myeoung Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.8
This study investigated the effects of IGF-I and EGF on the development of blastocysts or hatched blastocysts during the in vitro culture of embryos from immature porcine oocytes. After the in vitro maturation and fertilization of cumulus-oocyte complexes (COCs) and their culture in vitro in PZM3 medium, we examined the embryo development rate for 168 h. When different concentrations of IGF-I (0, 1, 10, 20 ng/ml) were supplemented to fertilized porcine embryos in vitro, there were no significant differences in cleavage rate, blastocyst development rate or blastocyst hatching rate among the treated groups. On the other hand, when different concentrations of EGF (0, 1, 10, 20 ng/ml) were supplemented to the in vitro culture medium, blastocyst development rate was highest in the group in which EGF was not supplemented and, specifically, it was higher than in the 20 ng/ml treatment group (p<0.05). When 10 ng/ml IGF-I and 1 ng/ml EGF were supplemented separately or simultaneously, there were no significant differences among the treated groups in blastocyst hatching rate and the number of cells in each condition. This study demonstrated that the addition of IGF-I and EGF into PZM3 medium did not enhance development of the blastocyst stage and total cell number in blastocysts.
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Kim, Su Jae,Cha, Su Young,Kim, Ji Young,Shin, Jong Moon,Cho, Yong Chan,Lee, Seunghun,Kim, Won-Kyung,Jeong, Se-Young,Yang, Y. S.,Cho, Chae Ryong,Choi, H. W.,Jung, Myung-Hwa,Jun, Byeong-Eog,Kwon, Ki-Yon American Chemical Society 2012 The Journal of Physical Chemistry Part C Vol.116 No.22
<P>There have been many studies of ferromagnetism in ZnCoO, and the results have been controversial. Secondary phases, such as Co oxides and Co metal clusters, in ZnCoO are easily produced during treatment, but the formation conditions are not well understood. We fabricated samples under hydrogen-injection conditions at different heat-treatment temperatures and examined the conditions by using synchrotron X-ray analysis under which Co<SUB>3</SUB>O<SUB>4</SUB> appeared or was transformed into Co metal. We investigated the transforming process of the ferromagnetic origin from intrinsic to extrinsic nature via intermediate region competition by Co–H–Co and Co metal cluster and suggest conditions that induce ferromagnetic spin ordering in ZnCoO due to Co–H–Co complexes through hydrogen mediation.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2012/jpccck.2012.116.issue-22/jp300536w/production/images/medium/jp-2012-00536w_0010.gif'></P>
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Kim, Tae S .,Chung, Su W .,Kim, Seung H .,Kang, Bok Y .,Hwang, Seung Y .,Lee, Jae W . 전남대학교 약품개발연구소 2000 약품개발연구지 Vol.9 No.1
BLK mouse fibroblasts (H-2^b) were genetically engineered to express costimulatory B7.1 and interleukin-2 (BLK/IL2/B7.1). The BLK/IL2/B7.1 cells were then pulsed with an ovalbumin (OVA) epitope as a model antigen (Ag) (BLK/IL2/B7.1/OVA), and tested for the induction of OVA-specific cytotoxic T lymphocytes (CTLs) in C57BL/6 mice (H-2^b). The genetically engineered fibroblasts lacking one or two of three factors (interleukin-2, B7.1, and OVA) were constructed and used as controls. Immunization with the BLK/IL2/B7.1/OVA cells induced strong cytotoxic activities against OVA-expressing EL4 (EG7) tumor cells, but not against other H-2^b tumor cells, such as EL4, C1498 and B16F1 cells. The magnitude of the cytotoxic response in mice with the BLK/IL2/B7.1/OVA cells was significantly higher than the response in mice immunized with any other cell constructs. CD8^+ T cells with OVA-specific cytotoxic activities were predominant in mice immunized with the BLK/IL2/B7.1/OVA cells. Furthermore, immunization with the BLK/IL2/B7.1/OVA cells significantly prolonged the survival of mice, compared with any other cell constructs, when the mice were challenged with EG7 tumor cells at 2 weeks postimmunization. Induction of antitumoral CTL immunity by the BLK/IL2/B7.1/OVA cells was independent of host Ag-presenting cells and of CD4^+ T-cell and natural killer 1.1^+ cell help. These results suggest that fibroblasts can be genetically modified to efficient Ag-presenting cells for the induction of an Ag-specific CTL response.
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TEOS 의 부분가수분해에 의한 실리카 졸의 합성과 유리섬유 제조
양현수,권오현,이재도,노재성,김영호 ( Hyun S . Yang,Oh H . Kwon,Jae D . Lee,Jae S . Rho,Young H . Kim ) 한국공업화학회 1996 공업화학 Vol.7 No.5
본 연구는 [H₂O]/[TEOS]=1.7에서 산촉매를 첨가한 부분가수분해를 행하여 졸을 합성하였다. 최적의 방사성을 갖는 졸을 결정하기 위하여 부분가수분해에 의하여 합성된 졸을 trimethylsilylation하여 안정화시킨 후에 반응시간에 따르는 분자량과 점도의 변화를 관찰하였다. 최적조건하에서 제조된 졸용액에서 용매를 제거한 후 겔섬유를 제조하였고 이를 1,000℃에서 열처리하여 실리카섬유를 제조하였다. 제조된 섬유는 단면적이 원형이며 인장강도는 83±20kg/mm²이었고, 순도는 약 99.997%이었다. At the ratio [H₂O]/[TEOS]=1.7, the silica sol was synthesized by partial hydrolysis in the presence of acid catalyst. After stabilizing the silica sol by trimethylsilylation, the molecular weight and viscosity of the sol obtained at various reaction times were examined to determine a best spinnability of the sol. Gel fibers were prepared from the sol solution after removing solvent in the solution, and the gel fibers were heated at 1,000℃. The prepared silica fibers were in the shape of circular cross-section and their tensile strength and SiO_2 purity were 83±20kg/mm₂and about 99.997%, respectively.
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피부감작성에 있어 Local lymph node의 반응성 연구
이종권,박재현,김형수,정승태,엄준호,황인창,장은정,윤소미,남기택,허용,오혜영 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-
알레르기설 접촉 괴부염은 다양한 화학물질에 의해 유포될 수 있다. 화학물질이 피부 감작성을 알 킬 수 있는지 여부는 전통적으로 기니픽을 사용한 등물모겔이 이용되어 쏜으나, 최근에는 마우스를 이용한 local Iymph node assily tLLNA) 발법 개발이 요구되고 있떠 본 연구는 focal Iymph not assa)·의 시험방법을 개발하고, 감작을 일으키는 기전을 파악하고자 하였다. 콕헝물질로는 패표적 접촉 알러전인 DffCB(2,4-dinitrochlorobenzone), 호홉 알러젠인 fDl(toluene diisocyanate), 약한 알러젠인Cf.(o-kerplcinamaldehl,do:4, 강한 자극물질인 SLS(sodum lauryl sulfate)를 사용하였다. 각 시험물질 2sr4를 적절한 농도로 6-8주령의 암컷 Balb/c 마우스의 귀의 배측에 3일간 도포한 후 5일째에 부검하여 이개림프절, 귀의 변화 등을 관찰하였다. DNCB, TDI를 도포한 마우스의 이개 림프절의 중량은 대조군에 비해 증가하였으며, 고농도의 HCA를 투여한 마우스에서의 림프절 중량도 증가하였다. SLS를 투여한 군의 림프걸치 중량은 저농도에서는 변화가 없었으나, 고농도에서는 중량이 증가하였다. 꼬리정맥에 3H-thymidine을 투여하여 림프절의 증식정도를 파악한 결과, BNCB를 도포한 군에서는 프절의 증식지수(Stimulation 1.Idex, Sl)가 용량별로 20.3, 24.6, 27.5로 관찰되었으며, TDI군에서는 각 19.0, 29.T, 42.3으로 관찰되첬고 HCA군에서는 각각 3.8, 9.7, 19.8로 관찰되었다. sLs군에서는 0.8 3.7, 6.6으로 관찰되었다. 이잖끈 결과 fH-thynudine을 이용한 피부 감작성 평가는 기니픽을 대체할수 있는 방법으로 _평가되었다. 그러나 방사선이용이라는 단점과 강한 자극성물질에서의 위양성 반응이 관찰되어 BrdU(Eromodeoklpuddine) 면역조직차학기법으로 시험한 결과 비방사선법도 이용 가능함을 알 수 있었다. 또는 TDI를 처리한 마우스의 림프절에서 cytoklne의 발현을 RT-PCR로 측정한 결과 IL-2 IL-4, U-10과 INf-r의 mRNA발현이 증가하였으며, HCA를 처리한 경우에는 토-4, IL-10. INf-γ mRNA의 발현이 증가 하였다. 또한 B리CB의 경우에는 U-4의 발현이 증가하였다. 그러나, sLs의 경우에는 IL-?, IL-4, 0--10 과 rNF-r꼭 발현이 증가되지 않았다. 이러한 결과는 LLNA를 이용한 c번okine의 n)교NA발현이 유용싼 측정 지포중 하나가 될 수 있을 것으로 생각되며. 특히 IL-4의 발현정도의 증가는 알레르기 유발성을 평가할 유용한 생체지표의 하나가 될 수 있을 것으로 생각되어진다. Allergic contact dermatitis (skin sensitization) may be caused by a wide variety of chemicals. A murine local lymph node assay(LLNA) has been developed as an alternative to guinea pig models for assessing the contact sensitization potential of chemical. First, the objective of this study was to evaluate allergenecity of chemicals by LLNA. Secondly, we aimed to investigate the possibility of development of non-radio isotopic endpoint for LLNA using immunohistochemistry. Thirdly, we aimed to analyze cytokine mRNA expression of draining lymph node cell in mice exposed to chemical allergen and irritant. In this study, contact allergen, dinitrochlorobenzone (DNCB), respiratory allergen toluene diisocyanate (TDI) and moderate allergen, α-hexylcinnamaldehyde (HCA) were used as positive chemicals and the irritant, sodium lauryl sulfate(SLS) also used as reference chemical. The stimulation index (SI) of lymph node cell in the mice treated with allergens. DNCB, TDI, and HCA were more increased dose-dependently compared to vehicle control by ^(3)H-thymidine uptake. And SI of lymph node cell in strong irritant, SLS were also increased dose-dependently compared to control. The BrdU(Bromodeoxyuridine) LI of lymph node in DNCB and TDI were dramatically increased campared to that of control. However, the LI of lymph node in SLS were not significantly increased compared to vehicle control. This data represents that BrdU LI of lymph node could be one of useful method for screening for irritant and allergen. The expression of IL-2, IL-4, IL-10 and IFN-γ mRNA was increased in draining auricular lymph node cell of the mice treated with TDI by RT-PCR. The level of IL-4, IL-10 and IFN-γmRNA was increased in mice treated with HCA. The expression of IL-4 was increased in lymph node cell of mice treated with DNCB. However, the level of IL-2, IL-4, IL-10 and IFN-γ in lymph node cell of mice treated with SLS was not increased. These results suggest the measurement for increase in level of IL-4 mRNA expression could by one of the method for screening the allergenic potential.
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