Correlation between skeletal and dental changes after mandibular setback surgery-first orthodontic treatment

Chang-Hoon Rhee,Youn-Kyung Choi,Yong-Il Kim,Seong-Sik Kim,Soo-Byung Park,Woo-Sung Son 대한치과교정학회 2015 대한치과교정학회지 Vol.45 No.2

Objective: To investigate skeletal and dental changes after application of a mandibular setback surgery-first orthodontic treatment approach in cases of skeletal Class III malocclusion. Methods: A retrospective study of 34 patients (23 men, 11 women; mean age, 26.2 ± 6.6 years) with skeletal Class III deformities, who underwent surgery-first orthodontic treatment, was conducted. Skeletal landmarks in the maxilla and mandible at three time points, pre-treatment (T0), immediate-postoperative (T1), and post-treatment (T2), were analyzed using cone-beam computed tomography (CBCT)-generated half-cephalograms. Results: The significant T0 to T1 mandibular changes occurred ?9.24 ± 3.97 mm horizontally. From T1 to T2, the mandible tended to move forward 1.22 ± 2.02 mm, while the condylar position (Cd to Po-perpendicular plane) shifted backward, and the coronoid process (Cp to FH plane) moved vertically. Between T1 and T2, the vertical dimension changed significantly (p < 0.05). Changes in the vertical dimension were significantly correlated to T1 to T2 changes in the Cd to Po-perpendicular plane (r = ?0.671, p = 0.034), and in the Cp to FH plane (r = 0.733, p = 0.016), as well as to T0 to T1 changes in the Cp to Poperpendicular plane (r = 0.758, p = 0.011). Conclusions: Greater alterations in the vertical dimension caused larger post-treatment (T2) stage skeletal changes. Studying the mandibular position in relation to the post-surgical vertical dimension emphasized the integral importance of vertical dimension control and proximal segment management to the success of surgery-first orthodontic treatment.

Long second toe: its nail and skin changes

( Geun-hwi Park ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Nail can be affected by trauma, infection, and systematic disorders. In particular, the toe nails are exposed to the repeated and cumulative minor traumas, which usually result in thickened, splitted, and discolorated nails. Considering these, it can be inferred that the long second toe can be related to various nail and skin changes by repeated minor traumas such as friction in shoes, but the study or report on this topic hasn’t been done yet. Objectives: The purpose of this study was to introduce various nail and skin changes on long second toe. Methods: We analyzed the kinds of nail/skin changes of 50 patients with long second toe, enrolled at Pusan National University Hospitals (Busan and Yangsan) from 2013 to 2018. Results: There was no significant difference in the incidence of left and right toe and toenail, and 7 (14%) patients presented bilateral distribution. The most common nail change on long second toe was melanonychia (23, 46%), followed by subungual hematoma (15, 30%), onycholysis (2, 4%), subungual hyperkeratosis (2, 4%), onychomadesis (1, 2%), and retronychia (1, 2%). The most common skin change was corn (9, 18%), followed by paronychia (2, 4%). Twenty (20/50, 40%) patients also had other toe or toenail changes. Among them, the most common site was big toe/nail (13, 62%), and the most common change was subungual hematoma (8, 42%). Conclusion: Through this study, the dermatologists can recognize and diagnose the nail and skin changes of long second toe.

A Comparative Proteomics Survey of Proteins Responsive to Phosphorous Starvation in Roots of Hydroponically-grown Rice Seedlings

( Sang Gon Kim ),( Yi Ming Wang ),( Chang Hoon Lee ),( Bong Gyu Mun ),( Pil Joo Kim ),( Sang Yeol Lee ),( Yong Chul Kim ),( Kyu Young Kang ),( Randeep Rakwal ),( Ganesh Kumar Agrawal ),( Sun Tae Kim ) 한국응용생명화학회 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.5

Rice takes up phosphorous (P) as major nutrient source for its growth and development when grown under anaerobic water-logged soil conditions. To better understand the underlying mechanisms and to develop potential protein biomarkers of P-starvation, hydroponically-grown rice seedlings in the complete media and phosphorus absence (P-starvation) of phosphorous nutrient solutions were investigated for physiological and proteome changes. The P-starvation manifested significant reduction in root growth in three-week-old seedlings compared to respective complete media. Furthermore, P-starvation also showed increased activity of acid phosphatase in roots of one- and three-week-old seedlings, suggesting that experimental design is suitable for proteomics survey of P-starvation responsive proteins. Two-dimensional gel electrophoresis coupled with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis of total root protein from three-week-old seedlings identified 10 P-starvation responsive protein spots out of 140 high-quality protein spots. Identified 10 proteins were involved in metabolism and defense/stress response. Out of 10, 2 and 8 protein spots were found to be up and down-regulated, respectively. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis of corresponding genes of four randomly selected proteins, including putative glyceraldehydes-3-phophate dehydrogenase (G3PDH, spot R1), S-adenosyl-L-methionine synthetase (SAMS, spot R4), ATP synthase subunit alpha (spot R6), and root-specific pathogenesisrelated protein 10 (PR-10, spot R8), showed that just as protein abundance, these proteins are also regulated at the transcript level. Results suggest identified P-starvation responsive proteins are involved in maintaining nutrient homeostasis and/or associated with changes in root physiology under the absence of P.

Salt and pepper appearance of the skin associated with mixed connective tissue disease

( Sang-hyeon Won ),( Woo-il Kim ),( Min-young Yang ),( Won-ku Lee ),( Tae-wook Kim ),( Sung-min Park ),( Hyun-joo Lee ),( Gun-wook Kim ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byung-soo Kim ),( Moon-bum 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

The salt-and-pepper appearance of skin is composed of salt (vitiligo-like depigmentation) and pepper(perifollicular pigmentation). This characteristic feature can be a clinical clue for the diagnosis of systemic sclerosis. Mixed connective tissue disease(MCTD) is a distinct disease entity with mixed features of systemic lupus erythematosus, systemic sclerosis, myositis and rheumatoid arthritis with high titers of antibodies to U1 small nuclear ribonucleoprotein(U1 snRNP). Therefore, MCTD is known to have a wide spectrum of cutaneous manifestations which may be the presenting signs of the disease. However, there are few reports of pigmentary changes in MCTD. A 51-year old woman presented with variably sized hypopigmented macules along with relative hyperpigmentation of the perifollicular areas. She was diagnosed with MCTD by Raynaud’s phenomenon and high titer anti-RNP corresponding to a speckled antinuclear antibody of 1:1280 in Rheumatology clinic. A biopsy specimen showed dermal sclerosis. Pigment loss and melanophages were observed in the papillary dermis. Hypo- and hyperpigmentation were confirmed histologically by S100 and Fontana-Masson stain. To our knowledge, ‘salt and pepper appearance of the skin’ has rarely been reported in MCTD. The diagnosis of MCTD can be challenging due to its diverse characteristics. Therefore, we suggest that MCTD should be regarded as a differential diagnosis in patient with this pigmentary change.

Underlying representation in geminates: from OT perspective

Sung-Hoon Hong,Chang-Kook Suh 한국음운론학회 2004 음성·음운·형태론 연구 Vol.10 No.1

Hong, Sung-Hoon, and Chang-Kook Suh. 2004. Underlying represen-tation in Geminates: from an OT perspective. Studies in Phonetics, Phonology and Morphology. 10.1. 129.144. This research has examined the status of Underlying Representation (UR) in Optimality Theory focusing on the representation of consonant geminates. For this purpose, we have examined geminate/singleton alternation in Ponapean employing Lexicon Optimization (LO), an algorithm proposed to select a UR among multiple inputs. We have seen that simple application of LO is problematic in singling out a UR for the case of alternation. This leads us to the version of LO that is performed on the paradigms, rather than on an individual forms (Tesar and Smolensky 1996, 2000, Inkelas 1995, 1998). After a thorough implementation of LO, we have found that the URs are simply identical to the input forms; geminate UR for the alternating case and singleton UR for the nonalternating case. Further, it was shown that a unique underlying representation of geminates, regardless of their positions in which they occur, can account for the exceptional geminate behaviors. (Hansung University and Cheonan University)

고양이 소뇌 치상핵 자극에 따른 전경골근의 근전도 변화

성재훈,김문찬,강준기,최창락 대한신경외과학회 1994 Journal of Korean neurosurgical society Vol.23 No.7

Through the use of stereotactic neurosurgical operation, some authors have employed chronic electrical stimulation of the dentate nucleus reduce spasticity and each trial on spastic patients has show marked clinical improvement. We investigated the eletrophysiological changes of cats after stereotactic electrical stimulation of the dentate nucleus to elucidate the possibility of clinical application and to evaluate the clinical results The M-wave is an initial response and the F-wave is a late response in the electromyography of a muscle, which is stimulated by its original controlling nerve itself. There is evidence that the sue of the F-wave is dependent on motor neuron excitability and its amplitude is increased significantly at spastic condition. If such a relationship exists, procedures which are cam& out to relieve spasticity might be exerted to change the F-wave sue and thus it might be possible to use the F-wave as an objective monitor during electrical stimulation of the dentate nucleus. We investigated this possibility in experiments on 10 cats weighing betHieen 27kg and 4.4kg. We studied the change% of M and F waves, recorded in EMG, after stereotactic stimulation to cerebellar dentate nucleus in cats. The results were as follows 1) The change of mean value of M-wave amplitude was not significant(contro1 group, 3591 ± 1029μV stimulation group, 3424± 927μV, 00.05). 2) The mean value of F-wave amplitude was significantly reduced about 56.7% after the dentate stimulation(contro1 p u p , 443.2± 119μV stimulation p u p , 251.3±99.4μV, P<0.05). 3) The F/M ratio also significantly reduced about 56.8% after the dentate stimulation(contro1 group, 12.5±1.9%, stimulation group, 7.1± 1.2%, P<0.05). Our experimental results demonstrated that the dentate stimulation markedly decreased the sue of F-wave amplitude and F/M ratio in the experimental cats and we concluded that theseelectrophysiological changes can be applied as a parameter of clinical evaluation of electrical dentate stimulation for the spasticity.

A Comparative Proteomics Survey of Proteins Responsive to Phosphorous Starvation in Roots of Hydroponically-grown Rice Seedlings

Kim, Sang-Gon,Wang, Yiming,Lee, Chang-Hoon,Mun, Bong-Gyu,Kim, Pil-Joo,Lee, Sang-Yeol,Kim, Yong-Chul,Kang, Kyu-Young,Rakwal, Randeep,Agrawal, Ganesh Kumar,Kim, Sun-Tae The Korean Society for Applied Biological Chemistr 2011 Applied Biological Chemistry (Appl Biol Chem) Vol.54 No.5

Rice takes up phosphorous (P) as major nutrient source for its growth and development when grown under anaerobic water-logged soil conditions. To better understand the underlying mechanisms and to develop potential protein biomarkers of P-starvation, hydroponically-grown rice seedlings in the complete media and phosphorus absence (P-starvation) of phosphorous nutrient solutions were investigated for physiological and proteome changes. The P-starvation manifested significant reduction in root growth in three-week-old seedlings compared to respective complete media. Furthermore, P-starvation also showed increased activity of acid phosphatase in roots of one- and three-week-old seedlings, suggesting that experimental design is suitable for proteomics survey of P-starvation responsive proteins. Two-dimensional gel electrophoresis coupled with matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis of total root protein from three-week-old seedlings identified 10 P-starvation responsive protein spots out of 140 high-quality protein spots. Identified 10 proteins were involved in metabolism and defense/stress response. Out of 10, 2 and 8 protein spots were found to be up- and down-regulated, respectively. Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) analysis of corresponding genes of four randomly selected proteins, including putative glyceraldehydes-3-phophate dehydrogenase (G3PDH, spot R1), S-adenosyl-L-methionine synthetase (SAMS, spot R4), ATP synthase subunit alpha (spot R6), and root-specific pathogenesis-related protein 10 (PR-10, spot R8), showed that just as protein abundance, these proteins are also regulated at the transcript level. Results suggest identified P-starvation responsive proteins are involved in maintaining nutrient homeostasis and/or associated with changes in root physiology under the absence of P.

난소성 장액성 낭선암에 특이한 단백의 분리에 관한 연구

이상훈,장상근,고재경,김두상 한양대학교 의과대학 1992 한양의대 학술지 Vol.12 No.1

In order to correlate changes in the nature of proteins in the serous cystadenocarcinoma tissue of the ovary with those in the cystic fluid and ascitic fluid of patients with the ovarian cancer, proteins in the ovarian tissue, cystic fluid and ascitic fluid of patients with serous cystadenocarcinoma were isolated by a DEAE-cellulose column chromatography and HPLC. (1)Concentrations of protein in the ovarian cancer tissue, cystic fluid and ascitic fluid of patients with serous cystadenocarcinoma were unchanged as compared with those of controls. (2)Proteins in the ovarian tissues were isolated by a DEAE-cellulose column chromatography into 7 peaks in both serous cystadenocarcinoma tissue and control ovarian tissue. The DEAE-peak Ⅲ protein was divided into two parts (peak ?? and ??) in the ovarian cancer, but not in the control, indicating that the DEAE-peak Ⅲ?? was specific to the ovarian cancer. The DEAE-peak Ⅴ common to both serous cystadenocarcinoma tissue and its control was further separated by a HPLC into 4 peaks each. Although the HPLC patterns for proteins of both tissues appeared to be different, presence of proteins specific to the ovarian cancer was not confirmed in the ovarian cancer tissue. (3)Proteins in the ovarian cystic fluid were isolated by a DEAE-cellulose column chromatography into 5 peaks for serous cystadenocarcinoma and 4 peaks for serous cyst as the control of which the peak Ⅳ protein was divided into two parts(peak ?? and ??) in the ovarian cancer, but not in the control. Two protein peaks (DEAE-peak ?? and ??) in the ovarian cancer, but not control. Two protein peaks (DEAE-peak ?? and Ⅷ) were observed to be specific to the ovarian cancer. (4)Proteins in the ascitic fluid were separated by a DEAE-cellulose column chromatography into 7 peaks for the ovarian cancer and 5 peaks for the serous cyst, of which the peak Ⅳ protein was also divided into two parts as in the cystic fluid of the ovarian cancer, but not in the control. Three protein peaks (peak Ⅲ, ?? and Ⅷ) appeared to be specific to the ovarian cancer. These results indicated that concentrations of proteins were unchanged, but the nature of proteins were changed in the cancer tissue, cystic fluid and ascitic fluid of patients with serous cystadenocarcinoma and that proteins specific to the ovarian cancer were present in at least one for the ovarian cancer tissue, two for the cystic fluid and three for the ascitic fluid. The proteins specific to serous cystadenocarcinoma in the cystic and ascitic fluid appeared to be released from the ovarian cancer tissue and could be used as biochemical markers for the cancer.

소아에서 발생한 요추 추간판 탈출증

정창훈(Chang Hoon Jeong),이기행(Kee Haeng Lee),김윤수(Youn Soo Kim),문찬웅(Chan Woong Moon),박일중(Il Jung Park),정상룡(Sang Lyong Jung),김형민(Hyoung Min Kim) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.2

요추 추간판 탈출증은 추간판의 퇴행성 변화가 있는 30-40대에 흔하게 발생한다. 그러나, 추간판의 퇴행성 변화가 없는 소아(12세 이하)에서는 매우 드물며 그 임상증상 및 치료 방법 역시 성인과 차이가 있다. 저자들은 소아에서 발생한 요추 추간판 탈출증 5예를 경험하였기에 이에 대해 분석, 보고하는 바이다. Lumbar intervertebal disc herniation is common in the fourth to fifth decades because the intervertebral disc undergoes degenerative change. However juvenile lumbar intervertebal disc herniation (under 12 years old) is rare because there is no degenerative change, and the clinical symptoms and treatments are different from those of adults. Herein, our experience of five juvenile lumbar intervertebal disc herniation cases are analyzed and reported.

철도 부하의 이동성을 반영한 변전소 정태부하모델링 수립에 대한 연구

창상훈(Sang-Hoon Chang),윤석민(Seok-Min Youn),김정훈(Jung-Hoon Kim) 대한전기학회 2015 전기학회논문지 Vol.64 No.2

Nowadays, it is expected that mobility loads such as electric railways and electric vehicles will be penetrated gradually and affect on the power system stability by their load characteristics. Various researches have been carried out about electric vehicles for the recent decade though the load of electric railway could be forecasted because of the specified path and timetable, is a field with a long historic background. Some precise 5th polynomial equations are required to analyze the power system stability considering mobility load to be increased in the immediate future while the electric railway dispatching simulator uses load models with constant power and constant impedance for the system analysis. In this paper, seasonal urban railway load models are established as the form of 5th polynomial equations and substation load modeling methods are proposed merging railway station load models and general load models. Additionally, load management effects by the load modeling are confirmed through the case studies, in which seasonal load models are developed for Seoul Subway Line No. 2, Gyeongui Line and Airport Railroad and the substation load change is analyzed according to the railway load change.