하악골 절제술후 재이식된 돌결자가골 재이식 : 치험 3례

김 식,김수관,김운규,김수민,류종희,이준길,조경안,김수흥,정태영,여환호 대한악안면성형재건외과학회 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.2

We described three cases of immediate reimplantation of a frozen-thawed autogenous mandible composed of a mixture of iliac bone, marrow, and particulate hydroxyapatite in tumors of the mandible. Acceptable outcomes were obtained in three patients who underwent immediate autogenous mandibular graft reconstruction. The conditions leading to successful outcome of the procedure are also discussed. Reimplantation of frozen autogenous lesioned mandible was performed in three patients with mandibular tumors. Two reimplanted grafts survived without complications following surgery. One case had postoperative infection that resolved with appropriate antibiotic treatment. There were no recurrences of the primary lesions. Satisfactory facial contour after surgery was achieved. These results are most promising, and we believe that, with further refinement, this technique will offer a new and acceptable modality for facial reconstruction in patients with cancer.

품종별 감꽃 동결건조 분말의 유효성분 분석

김준한 ( Jun Han Kim ),박석희 ( Seok Hee Park ),문혜경 ( Hye Gyeong Mun ),이인선 ( In Seon Lee ),김종국 ( Jong Kuk Kim ) 한국식품저장유통학회 ( 구 한국농산물저장유통학회 ) 2006 한국식품저장유통학회지 Vol.13 No.6

감 품종별(도근조생, 고종시, 갑주백목, 차랑, 월하시, 상주둥시)로 감꽃을 개화기에 채취하여 동결건조 분말화한 감꽃분말에 함유된 유효성분을 분석, 비교하였다. 조지방 함량은 도근조생이 57.26%로 가장 높은 값을 보였으며, 유리당 조성은 fructose가 95~310 mg%, glucose는 75~281 mg%, sucrose가 7~28 mg%의 함유량을 나타내었고, 유기산 중 malic acid가 갑주백목(6월4일)에 225 mg%로 가장 많았고, tartaric acid도 189 mg%로 가장 많았다. 유리아미노산 중 hydroxy-L-proline은 월하시에 25.33 mg%, L-citrulline은 상주둥시(5월28일)가 58.83 mg%, L-threonine은 상주둥시(5월28일)가 11.88 mg%로 가장 많았다. 페놀산으로 caffeic acid는 갑주백목(6윌4일)이 1946 μg/100 g, phydroxybenzoic acid는 상주둥시(5월29일)가 417.8 μg/100 g, protocatechuic acid는 갑주백목(6월1일)이 181.1 μg/l00 g으로 가장 많았다. 따라서 감꽃에도 감이나 감잎에 못지않게 유용한 식품성분들과 기능성 성분들이 다량 함유되어 있어 새로운 식품 및 기능성 신소재로서의 가치가 매우 높다고 할 수 있다. This study was carried out to analyze useful components in freeze-dried persimmon flower powder made from six cultivars. The cultivars were Dogunjosang, Kojongsi, Kabjubaekmok, Chalang, Weolhasi and SangjuDungsi. Powder of persimmon flower was prepared by milling after freeze drying at -70℃. Crude lipid was the highest in Dogunjosang (57.26%). Major free sugars of the persimmon flowers were fructose (95~310 mg%), glucose (75~281 mg%)and sucrose (7~28 mg%). Major organic acids were malic acid (225 mg% in Kabjubaekmok (Jun. 4th)) and tartaric acid (189 mg% in Kabjubaekmok (Jun. 4th)). Predominant free amino acids were hydroxy-L-proline(25.33 mg% in Weolhasi), L-citrulline (58.83 mg% in SangjuDungsi (May 28th)) and L-threonine (11.88 mg% in SangjuDungsi (May 28th)). Major phenolic compounds in the persimmon flowers were caffeic acid (1,946 μg/100g in Kabjubaekmok (Jun. 4th)), p-hydroxybenzoic acid(418 μg/100g in SangjuDungsi (May 29th)) and protocatechuic acid(181 μg/100g in Kabjubaekmok(Jun. 1st)). The results suggest that persimmon flowers be potential materials as useful food ingredients.

Metagenomic Analysis of Fungal Communities Inhabiting the Fairy Ring Zone of Tricholoma matsutake

( Miae Kim1 ),( Hyeok Jun Yoon ),( Young Hyun You ),( Ye Eun Kim ),( Ju Ri Woo ),( Yeong Gyo Seo ),( Gyeong Min Lee ),( Young Ja Kim ),( Won Sik Kong ),( Jong Guk Kim ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.10

Tricholoma matsutake, an ectomycorrhiza that has mutual relationships with the rootlet of Pinus denisflora, forms a fruiting body that serves as a valuable food in Asia. However, the artificial culture of this fungus has not been successful. Soil fungi, including T. matsutake, coexist with many other microorganisms and plants; therefore, complex microbial communities have an influence on the fruiting body formation of T. matsutake. Here, we report on the structures of fungal communities associated with the fairy ring of T. matsutake through the pyrosequencing method. Soil samples were collected inside the fairy ring zone, in the fairy ring zone, and outside the fairy ring zone. A total of 37,125 sequencing reads were obtained and 728 to 1,962 operational taxonomic units (OTUs) were observed in the sampling zones. The fairy ring zone had the lowest OTUs and the lowest fungal diversity of all sampling zones. The number of OTUs and fungal taxa inside and outside the fairy ring zone was, respectively, about 2 times and 1.5 times higher than the fairy ring. Taxonomic analysis showed that each sampling zone has different fungal communities. In particular, out of 209 genera total, 6 genera in the fairy ring zone, such as Hemimycena, were uniquely present and 31 genera, such as Mycena, Boletopsis, and Repetophragma, were specifically absent. The results of metagenomic analysis based on the pyrosequencing indicate a decrease of fungal communities in the fairy ring zone and changes of fungal communities depending on the fairy ring growth of T. matsutake.

Case Report : Autosomal Translocation Patient Who Experienced Premature Menopause: A Case Report

( Tae-hee Kim ),( Yesol Kim ),( Do-won Jeong ),( Eun-gyeong Lee ),( Dong-su Jeon ),( Jun-mo Kim3 ) 대한폐경학회 2015 대한폐경학회지 Vol.21 No.2

Premature ovarian failure (POF) is a condition in which the ovarian functions of hormone production and oocyte development become impaired before the typical age for menopause. POF and early menopause are present in a broad spectrum of gonad dysgenesis, from a complete cessation of ovarian function to an intermittent follicle maturation failure. Actually POF has been identified as a genetic entity (especially chromosome X), but data on genetic factors of premature menopause are limited. Until now, several cases revealed that inactivation of X chromosomes has an effect on ages of premature menopause and females with balanced or unbalanced X-autosome translocations can have several reproductive problems. On the other hand, there have been a few data that was caused by autosome-autosome translocation can lead. Therefore we report a relevant case of POF with translocation between chromosomes 1 and 4. She had her first menstrual period at the age of 12, and after 7 years she stopped menstruation. Chromosomal analysis showed 46, XX, t (1;4) (p22.3;q31.3). While evaluating this rare case, we could review various causes (especially genetic factors) of POF. To remind clinicians about this disease, we report a case of POF caused by autosomeautosome translocation with a literature review. (J Menopausal Med 2015;21:112-114)

발달장애유아의 언어행동발달 연구

김춘희,변찬석,서경희,유은정,이효신,전헌선,최성규 大邱大學校 特殊敎育·再活科學硏究所 2000 特殊敎育硏究 Vol.23 No.1

본 논문은 발달장애유아 언어행동발달 컨텐츠 개발에 요구되는 기초연구로써 연구의 이론적 바탕을 확립하고자 하였다. 연구에 사용된 방법은 문헌조사 방법 및 현장 인터뷰기법을 병행하였다. 본 연구의 주된 목적은 크게 3가지로 구분된다. 첫째, 발달장애유아의 가정 내 교육 욕구를 분석하고자 하였다. 둘째, 발달장애유아의 언어발달 양상을 검토하고자 하였다. 세 번째 목적은 유아의 언어행동발달 컨텐츠 구성의 주요 지침을 설정하고자 하였다. 이상의 연구목적에 따른 연구결과를 요약하면 다음 몇 가지로 제시된다. 1.가정 내 부모-유아간 관계형성이 우선 고려 되어야하고, 이에 따른 상호작용은 발달적 애착형성이 가능한 방향으로 정립되어야한다. 2.발달장애유아의 언어행동발달양상을 검토한 결과에 따르면, Piaget는 언어행동발달에 있어 감각운동기적 환경탐색 기능을 강조하고 있고, 이는 현재까지 중요한 유아 발달의 기저로 정착되었다. 따라서, 발달장애유아의 언어행동발달을 위한 컨텐츠 개발 내용에 있어서도 이러한 기저에 충실함이 합리적이다. 3.발달장애유아들에게는 언어행동 양상의 갈래가 크게 운동장애 및 감각결함으로 나누어질 수 있으므로, 이 두 가지 갈래의 각기 다른 특성이 컨텐츠 구성에서 충분히 고려되어야한다. 4.자폐성과 같은 중증 전반적 발달장애 유아를 위한 언어행동발달 컨텐츠 구성에서 특히 고려해야 할 두 가지 요소는 모방행동기능과 반복단순훈련기능 향상으로 결론지을 수 있다. This article planed to establish the theoretical foundations of the research as a basic study needed for developing the contents of verbal(language) behavior development for the infants with developmental disabilities. The methods used in the study was previous literature researches and interviews with subjects. The purposes of the study were divided into three parts. First, it was to analyze the educational needs of the infants with developmental disabilities in home settings. Second, it was to review and discover the language patterns of the infants with developmental disabilities. The third purpose was to devise the major guidelines of their language development's contents. The results of the study were described as the followings. 1.The relationships between the infants with developmental disabilities and their parents and their interactions should move to build the developmental attachments between them. 2.According to the literature findings of their language development patterns, Piaget concentrated on the functions of sensory motor environmental exploring in the language behavior development. The functions have been settled down into the important foundation for the infants' development. Thus, it was resonable that the content's development of the language behaviors for the infants with developmental disabilities should based on the function addressed by Piaget. 3.The language behaviors' patterns of the infants with developmental disabilities generally were classified into motor disabilities and sensory defect(deficiency). Therefore, the two factors should be considered for the constructions of the contents. 4.Constructing the contents of the language behavior developments for the infants with severely pervasive developmental disabilities such as autism, the improvements of two functions, imitative behavior and repetitive simple training should be considered.

GIS를 위한 홍수유출해석에 관한 연구

박준일,함계운,성오경,장영태,김경훈 경상대학교 생산기술연구소 2003 工學硏究院論文集 Vol.19 No.-

In the rainfall-runoff simulation, it is crucial problem to extract the hydrologic topographical factors that are used as the model input parameters. Those factors are drawn out from DEM(Digit a1 Elevation Model) along with GIS(Geographic Information System) techniques represent a wide range of topographical informations. GIS is employed to estimate the parameters and examine application. Also, the results from different GIS data and analysis methods are examined. In the study, spatial data are calculated using WMS(Watershed Modeling System) v.6.1, which is hydrologic analysis software coupled with GIS, and flood analysis is accomplished by HEC-1 included in WMS, and applied to Dukchon River basin. To calculate the effective rainfall CN values of NRCS are used. Clark, Snyder and NRCS methods are selected to derive unit hydrograph respectively. In addition, the characteristics of runoff responses according to the selection of GIS spatial data for NRCS CN, TIN or Grid used to extract hydrologic topographical informations. and the number of partitioning sub-basin are investigated.

광주의 한 이차병원에서 조사한 결핵약제 내성과 관련인자

조준호,김강,최상철,이경록,정종필,고영춘 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.3

연구목적: 우리나라의 결핵약제에 대한 내성은 지속적으로 감소되고 있음에도 불구하고 여전히 적지 않은 환자를 보유하고 있는 상황에서 치료 실패의 중요한 요인이 되고 있다. 이에 결핵 내성률에 영향을 미칠 수 있는 인자들을 파악하고 이에 대한 예방 대책을 수립하는 것이 내성률 발생의 예방에 도움이 될 것으로 사료된다. 이에 저자들은 광주 소재의 한 2차 병원에서 결핵 약제 내성률 및 위험인자로 판단되는 요소들과의 상호관계를 조사하였다. 대상 및 방법: 2005년 3월 부터 2006년 2월 까지 광주 기독 병원 내과에서 치료받은 결핵 환자중 객담 결핵균 배양 검사상 양성으로 판명되어 약제 감수성 검사를 확인할 수 있었던 346명을 대상으로 의무기록, 면담 등을 통한 후향적 조사를 시행 하였다 결과: 346명중 한가지 이상의 약제에 내성을 보인 경우는 150명(43.4%)였고, 다제 내성 결핵은 72명(20.8%)였다. 조사 요인의 유무별로 약제 내성률을 조사하였을 때 흉부 사진의 침범 정도에 따른 약제 내성률 및 다제 내성률은 경증에서 36.3%와 6.2%, 중등도에서 36.1%와 22.6%, 중증에서 61.0%와 35.0%였다. 병변의 공동성 병변 유무에 따른 약제 내성률은 공동이 있는 군에서는 49.8%, 공동이 없는 군에서는 34.0%였다. 과거의 치료력 여부에 따른 약 제 내성률은 치료력이 없는 군에서는 19.7%였고, 치료력이 있는 군에서는 81.2%였다. 항 결핵제 복용의 규칙성 여부에 따른 약제 내성률은 규칙적 복용군은 31.7%, 불규칙적 복용군은 59.7%로 나타났다. 결론: 광주 소재의 한 2차 병원에서 조사한 약제 내성률 및 다제 내성률은 전국 평균치를 훨씬 상회하였다. 한편 과거 치료병력 및 약제의 불규칙 복용은 약제 내성률을 높이는 데에 기여하는 인자가 될 것으로 사료된다. 흉부방사선 사진 상의 폐 침범 정도, 공동성 병변의 존재도 약제 내성률 증가와 관련이 있는 것으로 보이나 보다 정확한 선후관계 분석을 위해서는 추가적인 전향적 연구가 필요하다. Background and objectives: Drug resistance is a major obstacle to the treatment of pulmonary tuberculosis (TB). This study was conducted to determine the prevalence of drug-resistant tuberculosis and its associated factors at a secondary hospital in Gwangju. Materials and Methods: A retrospective one-center analysis was conducted, with 346 pulmonarytuberculosis patients who underwent drug susceptibility tests for M. tuberculosis at Gwangju Christian Hospital from March 2005 to February 2006. Results: The following percentages of subjects were found to be resistant to at least one drug and to have multidrug-resistant tuberculosis (MDR-TB), respectively: 43.4% and 20.8% of all the subjects; according to the severity of the chest X-ray findings, 36.3% and 6.2% in the mild group, 36.1% and 22.6% in the moderate group, and 61.0% and 35.0% in the far- advanced group; according to the presence of a cavitary lesion, 49.8% in the cavitary-lesion group and 34.0% in the noncavitary-lesion group and according to the history of previous tuberculosis treatment, 81.2% in the group who have had treatment and 19.7% in the group who have never had treatment. The resistance rate according to the regularity of antituberculosis drug medication was 31.7% in the regular medication group and 59.7% in the irregular medication group. Conclusion: The drug resistance rate was increased by the history of previous tuberculosis treatment and the irregular medication. As to whether the severity of chest X-ray findings and the presence of cavitary lesions have a correlation with drug resistance, prospective studies are needed for more accurate results.

경남지역 강우량의 분포특성

박준일,함계운,김경훈,장영태 경상대학교 생산기술연구소 2003 工學硏究院論文集 Vol.19 No.-

A rainfall distribution is very complicate owing to topographic influence in Korea. Hence, the variations in the distribution of monthly rainfall are required precise analysis in order to predict a flood control and to secure a sufficient capacity of water. In this study, time series of 32 rain gage stations over Gyeongnam area are examined for a 36-year secular period(1963-2000) and the extent and nature of changes, such as fluctuations, trend and persistence, are investigated. The trend analysis of regional rainfall practised a tendency towards annual rainfall and seasonal rainfall totals in all regions divided into two climatologically homogeneous regions by cluster analysis for annual rainfall series ; namely, Region Ⅰ(gyeongnam's inland area), Region Ⅱ(western mountain & southern coastal area), the periodicity is examined by the power spectrum analysis.

몬테 카를로 시뮬레이션에 의한 지수분포 매개변수 추정법의 통계학적 상호비교

박준일,김중완,김경훈 慶尙大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.12 No.-

In this study. Exponential distribution parameter was estimated by MOM(Method of Moments), PWM(Method of Probability Weighted Moments), MLE(Method of Maximum Likelihood Estimation), ENT(Method of Entropy) and LEAS(Method of Least Squares) for Monte Carlo generated samples. The performance of these estimators was statistically compared, with the objective of identifying the most robust estimator from amongst them.

결핵균항원에 대한 폐결핵환자의 임파구 증식반응에 관한 연구

백태현,김준배,박정규,김화중,조은경,최대경 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

T lymphocytes are thought to play a central role in cell mediated immune response. To study the T lymphocyte proliferative response to purified 30-kDa antigen from Mycobacterium tuberculosis H37Rv, peripheral blood lymphocytes(PBL) isolated from healthy controls and tuberculosis patients were stimulated with the 30-kDa antigen, crude antigen and PHA. Healthy controls and tuberculosis patients were divided into PPD(+), PPD(-) groups and AFB(-), AFB(+) groups, respectively. PBL proliferation were determined by the ^3H-thymidine incorporation assay and MTT colorimetric assay. PBL proliferation with 30-kDa and crude protein antigens measured by both methods were almost identical(r=0.74, p<0.001). The lymphocyte proliferation to 30-kDa antigen and crude antigen were singnificantly increased in PPD(+) healthy controls and tuberculosis patients when compared to those in PPD(-) controls, but response to PHA was no significant difference. Analysis to T cell subsets of proliferated lymphocytes performed by the indirect immunoalkaline phosphatase techniques were no difference between not only healthy controls and patients groups, but also stimulated antigen or PHA, and especially, at all groups, the percentage of T8 cell was higher than that of T4 cell.