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Eunji Kwak,Honggyun Kim,SangYoon Lee,Yoon Jung Lee,Hayeong Jeong,Youngjae Cho,Mi-Jung Choi 한국산업식품공학회 2018 학술대회 및 심포지엄 Vol.2018 No.04
This study was performed to analyze a saltiness enhancement at the same salt content through multiple emulsion. We compared the samples with different conditions to determine the optimum stability conditions of water-in-oil through layer separation rate, microscopic observation and size analysis. Four electrolytes such as NaCl, KCl, MgCl2, and CaCl2 were used and agar contents ranged from 0 to 1% were experimented at different volume ratios including 5:5, 4:6, 3:7, 2:8, and 1:9 of water and oil. As a result of this study, the droplet size according to the electrolyte type did not show significant differences (p<0.05). Therefore, KCl was used to facilitate in-body excretion of NaCl in the outer water phase, and corn oil containing 8%(w/w) polyglycerol polyricinoleate was used as oil phase. When the volume ratio of water and oil was 3:7, 2:8, and 1:9, the layer separation rate was relatively slow and droplet size was also small. It reveals that the particle size becomes smaller as the water volume ratio decreases. However, considering the amount of water to be stored and eluted on the inner water, appropriate volume ratio of water and oil should be adopted to 3: 7. At Microscopic observation depending on agar concentrations, small particle size appeared at 0.2% and 0.4% agars. When the water and oil ratio was fixed at 3:7, the particle size was measured at 0.2% and 0.4% agar using a zeta sizer. In conclusion, the droplet size of 0.2% agar was smaller than 0.4%. Therefore, the most stable water-in-oil emulsion was obtained with 0.2% agar, when water to oil ratio was 3:7.
Kwak, Jinyoung,Choi, One,Sim, Eunji,Lee, Sang-Yup The Royal Society of Chemistry 2015 The Analyst Vol.140 No.15
<P>Quenching of a fluorophore is significantly influenced by the molecular structure of the quencher. In this study, photoluminescence quenching by nitroaromatic compounds was evaluated to assess the molecular interaction between nitroaromatic molecules and the photoluminescent tyrosyl bolaamphiphile self-assembly, a nanoscale optical photoluminescent probe. Both the aromatic structure and hydrophilic functional groups of the nitroaromatic quencher molecules significantly enhanced the binding of quencher molecules to the photoluminescent probe. UV-vis spectroscopy supported the non-covalent molecular association of aromatic stacking, which significantly increased the quenching efficiency compared to an aliphatic compound. The hydrophilic groups of the nitroaromatic compounds also enhanced the photoluminescence quenching, because of the hydrophilic nature of the phenol moiety. Energy levels of the photoluminescent probe and quencher molecules, along with molecular interactions, were investigated to explain the quenching mechanism. Density functional theory (DFT) calculation was performed to provide the energy levels and charge density of the nitroaromatic compounds. The information presented in this study regarding the structural effect of a quencher molecule on the photoluminescence quenching of the photoluminescent probe will be useful in designing binding motifs of future photoluminescent probes.</P> <P>Graphic Abstract</P><P>Quenching effects of the aromatic stacking and hydrophilic interactions between nitroaromatic compounds and a fluorophore with phenolic groups were investigated. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c5an00517e'> </P>
Kwak, Mi-Kyung,Yang, Kyung-Min,Park, Jinah,Lee, Siyoung,Park, Yuna,Hong, Eunji,Sun, Eun Jin,An, Haein,Park, Sujin,Pang, Kyoungwha,Lee, Jihee,Kang, Jin Muk,Kim, Pyunggang,Ooshima, Akira,Kim, Seong-Jin Elsevier 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>Smad3 linker phosphorylation is a candidate target for several kinases that play important roles in cancer cell initiation, proliferation and progression. Also, Smad3 is an essential intracellular mediator of TGF-β1-induced transcriptional responses during carcinogenesis. Therefore, it is highly advantageous to identify and develop inhibitors targeting Smad3 linker phosphorylation for the treatment of cancers. Galangin (3,5,7-trihydroxyflavone) has been known to be an active flavonoid showing a cytotoxic effect on several cancer cells. However, the mechanism of action of galangin in various cancers remains unclear, and there has been no report concerning regulation of Smad3 phosphorylation by galangin. In the present study, we show that galangin significantly induced apoptosis and inhibited cell proliferation in the presence of TGF-β1 in both human prostate and pancreatic cancer cell lines. Particularly, galangin effectively inhibits phosphorylation of the Thr-179 site at Smad3 linker region through suppression of CDK4 phosphorylation. Thus, galangin can be a promising candidate as a selective inhibitor to suppress phosphorylation of Smad3 linker region.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Galangin significantly induced apoptosis in the presence of TGF-β1. </LI> <LI> Galangin inhibits phosphorylation of the Thr-179 site at the Smad3 linker region. </LI> <LI> Galangin suppresses CDK4-mediated Smad3 linker phosphorylation. </LI> </UL> </P>
SNS 사용이 사회적 이벤트 참여 및 그 연관행동에 미치는 영향 연구
곽진솔(Kwak,Jinsol),김은지(Kim,Eunji),권오병(Kwon,Ohbyung) 한국IT서비스학회 2014 한국IT서비스학회 학술대회 논문집 Vol.2014 No.추계
대형 사회적 이벤트 참여에 SNS가 미치는 영향은 SNS업체 및 SNS를 마케팅 수단으로 활용하는 기업에게 주는 시사점이 크다. 특히 이벤트 참여 후 후속 행동(연관구매, WOM 등)은 관련 사회 이벤트의 효과에 대한 정확한 측정과 밀접한 관련이 있다. 최근 SNS를 활용한 IT기반서비스를 통한 이벤트 수용 연구가 이루어지고 있지만 영향을 미치는 요인과 특히 연관행동으로 이어지는 파급효과에 대한 연구는 거의 존재하지 않는다. 더구나 후속 행동으로 이어지는 것까지도 SNS가 미 치는 영향이 있는지는 그 중요성에도 불구하고 거의 다루어지지 않았다. 따라서 본 논문의 목적은 실증분석을 통해 SNS의 게시글의 특성이 연관활동 수용에 어떻게 얼마나 영향을 미치는지를 이해하는 것이다.
곽새라(Kwak, Saera),강은지(Kang, Eunji) 한국중동학회 2021 韓國 中東 學會 論叢 Vol.41 No.3
The purpose of this paper is to analyze the morphological-semantic changes of Persian kinship terms from a diachronic point of view, and also to analyze cultural characteristics of Persian society which are revealed in Persian kinship terms. To examine those features, we sort out the kinship terms from version B and C of Hui-hui-guan-yi-yu, which are assumed to be published between 15th century and 17th century, and compare these terms with the terms in Iranian and Dari Persian. By doing so, we found the morphological changes as well as semantic changes. Moreover, we concluded that the paternal-centered vocabulary list reflects the paternal-centered culture of Persian-speaking societies, and that the family-centered culture influenced the diversity of Persian kinship terms.
Misook Kim,Eunji Kim,Han Sub Kwak,Yoonhwa Jeong 한국영양학회 2014 Nutrition Research and Practice Vol.8 No.5
BACKGROUND/OBJECTIVES: We investigated total 26 ingredients of Saengshik which will be commercially produced as an anti-diabetic dietary supplement. SUBJECTS/METHODS: Thirteen vegetables, nine cereals, three legumes and one seed were extracted with aqueous ethanol for 2 h at 60°C, and evaluated for their inhibitory effects against α-amylase and α-glucosidase and for total phenolic and flavonoid contents. RESULTS: All ingredients inhibited α-amylase activity except cabbage. Strong inhibitory activity of α-amylase was observed in leek, black rice, angelica and barley compared with acarbose as a positive control. Stronger inhibition of α-glucosidase activity was found in small water dropwort, radish leaves, sorghum and cabbage than acarbose. All Saengshik ingredients suppressed α-glucosidase activity in the range of 0.3-60.5%. Most ingredients contained total phenols which were in the range of 1.2-229.4 mg gallic acid equivalent/g dried extract. But, total phenolic contents were not observed in carrot, pumpkin and radish. All ingredients contained flavonoid in the range of 11.6-380.7 mg catechin equivalent/g dried extract. CONCLUSIONS: Our results demonstrate that Saengshik containing these ingredients would be an effective dietary supplement for diabetes.