Hematologic and hemodynamic findings during hemodialysis in 13 beagle dogs

Chang-Moo Ji, Hae-Won Jung, Hyo-Mi Jang, Jong-Hyun Moon, Dong-In Jung 충북대학교 동물의학연구소 2014 Journal of Biomedical and Translational Research Vol.15 No.2

Hemodialysis is an effective therapy for renal failure in veterinary practice. To evaluate hematologic and hemodynamic changes during hemodialysis, 13 dogs were treated with hemodialysis, after which complete blood cell counts (CBC), serum chemistry, and mean systolic blood pressure were analyzed. For CBC, white blood cells (WBC) and platelets underwent significant changes. In serum chemistry, there were significant differences in blood urea nitrogen (BUN), creatinine, total protein, albumin, globulin, amylase, calcium, potassium, and phosphorus contents. Further, mean systolic blood pressure suddenly increased in early hemodialysis and decreased significantly thereafter. During hemodialysis, adverse effects were observed in some dogs as follows: bleeding (1 dog), anemia (2 dogs), leukopenia (8 dogs), thrombocytopenia (2 dogs), and hypotension (1 dog). This study demonstrates hematologic and hemodynamic effects during hemodialysis as well as complications similar to human medicine. Before applying the commercialized human hemodialysis system to canine renal failure patients, we monitored hematologic and hemodynamic findings during hemodialysis in healthy beagle dogs.

내생경제성장모형에서 교육의 역할 추정

장창원 한국직업능력개발원 1998 직업능력개발연구 Vol.1 No.1

ABSTRACTEndogenous growth in East Asia is seen in this thesis to be results of an interaction between the expansion of education with the diffusion of capacities to adapt and use more productive technologies. These human resource capacities in the labor force have been essential and aided the export-oriented growth strategies that each of these nations have pursued.The main theme of this paper was to investigate the role of education as a source of economic growth in Korea. In this study, first, the objective mode was built by extending neoclassical Solow growth theory.Second, the capital deepening typical of an endogenous economic per-capita growth model was developed empirically for seven East-Asian economies as for the medium term, during 1965 ~ 1989. And then we found the meaning of coefficients of growth factors, direct relative contribution of each input to per-capita growth in seven East-Asian countries, relative indirect contribution of education to per-capita growth in Korea, accounting for difference due to accumulation in Korea.The indirect relative contributions of secondary and higher education and R & D to per-capita growth change the results somewhat. Secondary education is still the largest single contributor 65 percent of predicted growth is due to secondary school enrollment in Korea. Primary education comes second with 36.2 percent and followed by higher education at 4.7 percent. Physical investment gives 24.9 percent and unimproved raw labor contributes only 6.6 percent.The productivity of education is given prime importance in modem per-capita growth models. These models also accommodate endogenous technological change leading to increasing return to scale. The effects of education on per-capita growth are seen in three ways: (1) through the increased educational attainment as the labor force increases their skills and hence their productivity, (2) through the contribution of investment in higher education to the conduct of R & D, and the training of R & D demand for firms as endogenous technical change, and (3) through the ability to transfer the technology from more advanced countries, as well as to learn and adapt to new technologies on the job.

Safety of a Traditional Korean Medicine, Cheonggan extracts (CGX)

Jang-Woo Shin,Jung-Hyo Cho,Dong-Seok Seo,Nak-Won Sung,Min Kwon,Chang-Gue Son 대한한의학회 2009 대한한의학회지 Vol.30 No.6

우리나라 4년제 대학졸업자의 직업교육훈련 성과분석 : 교육투자수익률 추정을 중심으로 With The Estimation for The Rate of Return to investment in Education

장창원,이지연 한국직업능력개발원 1999 직업능력개발연구 Vol.2 No.1

ABSTRACTThe purpose of this study was to provide the practical policy suggestions for the re-vitalization of vocational education and training at the higher level of education. For the purpose, data from ^P Earning Structure Basic Statistics Survey Reportj was re-analyzed with such variables as educational level, gender, individual who have or not a qualification, and the kinds of qualification. Jacob Mincer earnings function was used to explain and predict the differences between groups on the suggested variables by estimating the rate of return to investment in education.The empirical estimation of the rate of return to investment in education was concluded that adults with higher levels of education (Bachelor's degree : 15.8%) were more likely to have a high wages in the labor market than those with less education (High school graduate : 8.6%, Associate degree:11.7%). For the rate of return to investment by education level for those who have a qualification, 13.8 percent was shown to adults with a bachelor's degree, compared with 10.3 percent of persons with associate degree, and 7.4 percent of persons with high school graduate. In contrast, for those who have a non-qualification, 14.9 percent was shown to adults with a bachelor's degree compared with 10.7 percent of persons with associate degree, and 7.4 percent of persons with high school graduate.The rate of return to investment in education for adults who have a non-qualification with bachelor's degrees were 1.1 percent higher than the persons who have a qualification with similar levels of education. This results show the evidence that persons with lower levels of educational attainment were more likely to have a lower wages in the labor market than those who had a higher levels of educational attainment. Futhermore, persons who have a non-qualification with higher levels of educational attainment were more likely to have a higher wages in the labor market compared with persons who have a qualification with higher levels of educational attainment. This result revealed that acquirement of qualification is not important issue to judge the performance of the vocational education and training nor standard for employability for entering labor market. Statistics on educational attainment of the entire population show that graduation from university is not simply an academic honour. Educational attainment reflects admission to a particular position in society and influences even job opportunities. His or her own employability by acquirement of qualification does not value in our society. Most business and industry differentiate between those jobs which require a university degree, regardless of qualifications or skills, and those that do not. Regardless of his or her ability, social status as determined by university graduation, has become more important than employability.For making a change from the degree-oriented toward person's ability-oriented valued society, vocational education and training at the higher level of education must emphasis in a new direction. Followings are the summary policy suggestions for the re-vitalizing vocational education and training at the university, where is the place for development of workforce and for preparing world of work.1) Most Korean youth want to go to four-year university after high school. The percentage of high school graduates who indicated plans to enter a four-year university increased to "get a better job" and "make more money". However, a large percentage of graduates from four year universities have a significant problem finding employment. Higher level of education must play a important role to make students as a employable person during their 4 year of campus life. Thus, vocational education and training must emphasis at the university level with changing curriculum structure.2) Curriculum at the higher level of education of the 21century may focus more on helping students transferable workplace competencies and advanced work-related technology in a variety method rather than a simple theoritical knowledge delivery in one way communication teaching structure.3) Changes in qualification system may emphasis more on workplace readiness and assessment process with collaborative partnership with business/industry and university.4) Much attention must directed to the role and responsibility of 4-year university in creating and disseminating the practical and advanced knowledge and technology for those who can meaningful transfer university to work beyond Bachelor's degree only.

출산에 따른 그레이브스병의 재발 및 관련이자

임창훈,최현아,한승석,김해성,이창욱,정호연,한기옥,장학철,박원근,윤현구,한인권 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Pregnancy affects the course of Graves' Disease (GD), and patients who initially maintain euthyroid function into their middle trimester with minimum doses of antithyroid drugs become exacerbated after delivery. Even patients who are completely cured, requiring no treatment during pregnancy, can relapse after delivery. In this study, we examined the postpartum changes in the thyroid functions of patients with GD, and attempted to determine the factors contributing to these changes. Methods: The study subjects were recruited from pregnant women visiting our outpatient clinic for routine prenatal evaluations. 45 women previously diagnosed with GD, who had been treated and cured with hyperthyroidism, and were no longer taking any thyroid medications, were evaluated for 1 year post delivery. Results: Among 45 patients, 20 (44.4%) developed thyroid disorders following delivery. Postpartum thyroiditis (PPT) developed in 8 patients (17.8%), and GD developed in 12 (26.0%). The onset of the PPT disease 3.1 ± 1.4 months following delivery, which was significantly earlier than the 6.7 ± 2.7 months required for the post delivery onset of GD (p=0.003). The TBII values, measured during the thyrotoxic state in each womaen, were negative in women with PPT and positive in 71.4% of women with GD (p=0.030). The duration of treatment for hyperthyroidism prior or pregnancy, the number of recurrences, and the time interval without treatment, were not associated with the development of postpartum thyroid disorders. Whereas, the mean number of past pregnancies for women who developed PPT was 3.9 ± 2.1, and was significantly higher than the 2.2 ± 1.7 for women developing no thyroid dysfunctions (p=0.044). In 13 women their initial onset of GD occurred within one year postpartum, 7 (53.8%) having had a recurrence, which was significantly higher than in women whose disease onset occurred unrelated to delivery (5 of 32 women: 15.6%). Conclusion: Women with GD developed postpartum thyroid dysfunctions in 44.4% of cases. Women whose initial disease onset occurred within one year postpartum had higher recurrences of GD, and women who developed PPT had a history of higher gravidity compared to the euthyroid women postpartum. Therefore, if women with GD develop postpartum thyroid dysfunctions, the diagnosis should be made, and a treatment modality planned, following careful considerations of the patients' past obstetric history, changes in clinical manifestations and the TBII values

Safety of a Traditional Korean Medicine, Cheonggan extracts (CGX): A 2-week Single-dose Toxicity Study in SD Rats and Beagle Dogs

Shin, Jang-Woo,Cho, Jung-Hyo,Seo, Dong-Seok,Sung, Nak-Won,Kwon, Min,Son, Chang-Gue The Society of Korean Medicine 2009 대한한의학회지 Vol.30 No.6

Objectives: To evaluate the acute toxic effects and approximate lethal dose of Cheonggan extracts (CGX) in SD rats and beagle dogs. Methods: Male and female rats were divided into 4 groups (Control, CGX 1250, CGX 2500, CGX 5000) respectively and male and female dogs were divided into two groups respectively (Control, CGX 5000) respectively. A single oral dose of CGX was treated to the rats and dogs. Mortality, signs of gross toxicity, and behavioral changes were observed over 14 days. All animals were observed every hour for 4 hours after administration and once a day thereafter for 14 days. Body weights were determined at $0_{th}$, $7_{th}$, and $14_{th}$ days. All surviving animals were sacrificed and necrotized. Major organs were inspected visually for gross findings. Results: No animals died in any of the groups during the experimental period (2 weeks), rats or dogs. Body weights of rats and dogs during the experiment continuously increased in all groups but there was no significant change. No abnormal clinical signs were observed for 2 weeks after a single administration of CGX in any dose group of CGX, rats or dogs. No abnormal findings in major organs were observed in any group of rats or dogs. Conclusion: CGX does not have acute toxic effects in rats or dogs. Therefore, an approximate lethal dose is assumed to exceed 5000 mg/kg in both rats and dogs.

A Multicenter Analysis of Clinical Features and Long-Term Outcomes of POEMS Syndrome in Korea

Kook Hye Won,Jang Ji Eun,Min Chang-Ki,Yoon Dok Hyun,Kim Kihyun,Bang Soo-Mee,Park Yong,Lee Jae Hoon,Yoon Sung-Soo,Kim Jin Seok 대한의학회 2024 Journal of Korean medical science Vol.39 No.2

Background: POEMS syndrome is a rare form of plasma cell dyscrasia characterized by polyneuropathy, organomegaly, endocrinopathy, monoclonal proteins, and skin changes. Owing to its low incidence, there are few reports regarding this syndrome. This multicenter study included 84 patients diagnosed with POEMS syndrome in South Korea. Methods: We retrospectively evaluated 84 patients diagnosed with POEMS syndrome at 8 hospitals in South Korea between January 2000 and October 2022. The clinical characteristics and treatment outcomes were analyzed. Results: The median patient age was 53 years (range, 26–77 years), and 63.1% of the patients were male. All patients had peripheral neuropathy, and 81 (96.4%) had monoclonal plasma cell proliferation. Plasma vascular endothelial growth factor levels were available for 32 patients with a median of 821 pg/mL (range, 26–12,900 pg/mL). Other common features included skin changes (54.2%), volume overload (71.4%), and organomegaly (72.6%). Of the 84 patients, 75 received initial treatment (local radiotherapy, 6 [8.0%]; chemotherapy, 17 [22.7%]; both chemotherapy and local radiotherapy, 9 [12.0%]), upfront autologous stem cell transplantation (ASCT), 43 (57.3%; with induction chemotherapy, n = 12, 16.0%; without induction chemotherapy, n = 31, 41.3%). The median follow-up duration was 40.7 months. The 5-year overall survival (OS) was 78%, and the 5-year progression-free survival (PFS) was 55%. Patients who underwent upfront ASCT and were diagnosed after 2014 had a longer OS and PFS. Conclusion: The demographics of Korean patients with POEMS syndrome were similar to those reported previously. Because of the introduction of new treatment agents and the reduced rate of transplant-related mortality related to ASCT, the treatment outcomes of Korean patients with POEMS syndrome have improved in recent years.

고랭지 농업 용수확보를 위한 소규모 빗물 이용시설 적용방안

전계원(Kye Won Jun)(全桂元),장창덕(Chang Deok Jang)(張昌德),정승권(Seung Kwon Jung)(鄭承權),전병희(Byong Hee Jun)(田炳熙) 위기관리 이론과 실천 2013 Crisisonomy Vol.9 No.8

최근 기후변화로 지난 2009년과 2012년에 강원도 태백시에서는 가뭄으로 인하여 엄청난 피해를 경험한 적이 있다. 또한 가뭄과 장마의 예측은 점점 더 어려워져 가는 실정이다. 특히 태백시의 87일간의 가뭄과 제한급수에 따른 피해액은 일상생활 134억원, 산업부문 338억원, 공공부문 47억원, 정신적ㆍ사회적 피해 1, 430억원 등 총 1, 949억원에 달하는 것으로 분석되었다. 태백시에 또 다른 큰 문제점은 가뭄으로 인한 고랭지 농업 피해로 인한 손실이다. 고랭지 배추를 생산하는 태백시는 우리나라 유일의 고산지역의 도시로서, 고랭지 농업이 특히 발달한 지역이다. 특히 태백 고랭지 배추는 태백시 농산품의 95.9%, 총 경지면적의 86.6%를 차지하고 있으므로, 배추의 생산성이 태백시 농산품 생산성을 대변한다고 할 수 있다. 본 연구에서는 태백시의 공공기관과 고랭지 농업 지역을 직접 방문하여 소규모 빗물 이용 시설에 대한 현황조사 및 시설의 상태를 점검하고 가뭄발생시 고랭지 농업지역의 피해를 최소화 할 수 있도록 소규모 빗물 이용 시설의 적용 방안 및 효과를 분석하였다. Recently, drought and rainy season are getting more serious. It is getting hard to forecast about drought because drought frequency is getting shorter than before. In 2009(winter) and 2012(summer), Taebaek-si was suffered from enormous damage due to the drought. Particularly, in 2009, cost of damage due to drought and restriction on water supply for 87days were estimated daily life sector 134 billion won, industry sector 338 billion won, the public sector 47 billion won, mental and social damage 1, 430 billion won. The other big issue of Taebaek is decrease in products of Highland Agricultural caused by the drought. Highland chinese cabbage which is the most important agricultural product in Taebaek-si account for 95.9% of all agricultural production of Taebaek-si and account for 86.6% of all gross area. For this reason, chinese cabbage of Taebaek-si is tropical agricultural product and is in charge of supply cabbage definitely. It is considered that if small scale rainwater harvesting system would be installed in highland agriculture area, it could reduce damage of drought at low cost and damage of cabbage would be decrease by system. For this study, We have researched regarding current status of Small Scale Rainwater Harvesting System of Highland Agriculture area in Taebaek-si and have compared with the amount of damage and installation cost in case of drought for the beneficial effects of Small Scale Rainwater Harvesting System, flexible supply of water and damage minimization of agricultural products.

The Relationship between Psychological Factors and Weight Gain

Hye Jin Jang,Byung-Sung Kim,Chang Won Won,김선영,Myung Weon Seo 대한가정의학회 2020 Korean Journal of Family Medicine Vol.41 No.6

Background: This study aimed to investigate stress, depression, sleeping time, physical activity, and dietary patterns as factors causing weight gain and investigate which of these factors have a greater effect on weight gain. Methods: Data were obtained from the seventh Korea National Health and Nutrition Examination Survey, 2016. Among the respondents, 3,163 adults aged 19–64 years were included in the survey, after excluding non-responders and those with diseases that may affect weight change. The t-test and chi-square test were used to analyze the relationship between weight gain and general characteristics. Logistic regression analysis was performed to evaluate weight changes according to stress, depression, sleep time, physical activity, and dietary patterns and evaluate the odds ratios (ORs) for measuring these associations. Results: Participants in the weight gain group were younger and more likely to be obese than those in the control group. Factors that could cause weight gain among women were stress awareness (OR, 1.271; 95% confidence interval [CI], 1.012–1.597), physical inactivity (OR, 1.250; 95% CI, 1.018–1.535), and skipping breakfast (OR, 1.277; 95% CI, 1.028–1.587). Depression was significantly associated with weight gain among women, but not after adjusting for other variables. There were no significant associations with sleeping time. None of these factors in men were significantly associated with weight gain. Conclusion: Stress awareness was significantly associated with weight gain among women, while other psychological factors were not significantly associated with weight gain.

R&D 투자 영향평가 기반 구축 및 시범분석

황석원(Seog-Won, Hwang),오승환(Seung-Hwan, Oh),우청원(Ceung-Won, Woo),장필성(Pil-Seoung, Jang),홍사균(Sa-Gyun, Hong),강희종(Hee-Jong, Kang),최창택(Chang-Taek, Choi),김기환(Gi-Hwan, Kim),이재진(Jae-Jin, Lee),김지훈(Ji-Hoon, Kim) 과학기술정책연구원 2016 정책연구 Vol.- No.-

This study is a late study of “An Exploratory Study on STI policy impact assessment”. In the research of 2015, in principle, it is necessary to evaluate not only R&D investment but also general policies such as various promotion systems, standards and regulations by putting the term “policy impact assessment” in front of it We emphasized the points. However, it is practically very difficultto collect and analyze detailed data of all STI policies. In addition, it is also restricted to allow policy researchers to access data within a certain range. Therefore, this study focuses on the impact assessment of R&D investment, which accounts for the largest percentage of STI policies. In this research, the impact assessment system of R&D investment is analyzed by classifying it into evaluation of economic impact and social impact assessment. Also, the evaluation of economic impact was analyzed separating into a micro viewpoint and a macro viewpoint. First, The analysis of the economic impact assessment of the micro viewpoint relates to how the government’s R&D investment affects enterprises. Specifically, the main analysis target was the employment and investment of companies, the impact on sales and profits. Second, The Analysis for macroeconomic impact assessment on the economy is related to the influence of government’s R&D investment such as national economic growth, employment etc. We also analyzed the spillover effect by industry according to R&D investment. Third, The social impact assessment is to analyze how R&D investment has impacted technology-based social change. This study is a very difficult attempt. However, we analyzed from the point of view of the consumer considering all social change areas as much as possible. The results of the study are summarized as follows. First, the study of economic impact evaluation shows the effect of R&D investment and it can be used as a basis to improve the efficiency and goal of R&D investment in future sectors such as employment, economic growth and investment. Second, through research on social impact assessment, government R&D investment has focused on specific areas in terms of improving the quality of life and social development of people, and confirmed that most social sectors are neglected. In addition, we proposed policy priorities for specific social change indicators and social sectors and proposed long-term R&D investment strategies. Finally, this study is expected to contribute to the establishment of future strategy of private enterprise through the measurement of social change index, the social influence of private research and development, and the influence of technology shock from abroad.