유전알고리즘을 사용한 대지의 다층구조 분석

강민제,부창진,김호찬,고영수 제주대학교 공과대학 첨단기술연구소 2005 尖端技術硏究所論文集 Vol.16 No.2

In this paper, a methodology has been proposed according to which, after carrying out a set of soil's resistivity measurements, one can compute the parameters of the multilayer earth structure using a genetic algorithm(GA). The results provided by the GA constitute the indispensable data that can be used in circuital or field simulations of grounding systems. The methodology allows to proceed toward a very efficient simulation of the grounding system and an accurate calculation of potential on the ground's surface.

운동선수의 임장불안에 대한 연구

홍관이,이광재,김두경,부기원,노성규,한상준,박기동,오수일,문병용,이철규,박장평,엄기진,박남환 江原大學校附設 體育科學硏究所 1984 江原大學校附設體育科學硏究所論文集 Vol.- No.9

This study is designed to grasp the elements and situations of stage fright in order to propose a part of ways to cope with it. We make 511 top-class high school players, male and female, in the central districts (Seoul, Inchon, Kyungki, Chungbuk, and Kangweon Province) on object of questionnaire, and get the following results. Through players generally have all-round characters they show weakness in the superiority and emotional stability while showing strength in the sonformity. This fact comes to be related to the elements which cause stage fright. Physiological changes also have many effects on the symptom of stage fright. Especially, stage fright increases when players show sensitive reaction to the self-consciousness of final consequence which comes from the tension or uneasiness of sympathetic nerve, Thus, it turns out that players make use of reducing psychological burden by physical exercise or adjusting the level of demanded result in order to release the stage fright.

말기 신부전 환자에서 적극적 투석 요법이 염증 반응을 통해 좌심실 수축기능에 미치는 영향

부창수 ( Chang Su Boo ),우영석 ( Young Seok Woo ),이재원 ( Jae Won Lee ),고강지 ( Gang Jee Ko ),조상경 ( Sang Kyung Jo ),조원용 ( Won Yong Cho ),김형규 ( Hyoung Kyu Kim ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.3

목적: 울혈성 심부전은 말기신질환자에 있어 생명을 위협하는 급성 합병증이다. 적극적 투석 요법은 효과적으로 체액량을 감소시키고 요독물질을 제거하여 심장의 수축기 기능을 향상시킨다. 비록 심혈관계 질환의 병인에 염증반응이 중요한 역할을 하나, 적극적 투석 요법이 염증인자들과 좌심실의 수축기 기능장애에 어떠한 영향을 미치는지에 대해서는 명확하지 않다. 이번 연구는 적극적 투석요법이 좌심실의 수축기 기능과 혈청 싸이토카인에 어떠한 변화를 일으키는지 조사하였다. 방법: 투석을 받는 말기신질환자 중에서 좌심실 기능부전으로 인한 급성 폐부종이 발생한 환자를 대상으로 하였다. 적극적 투석요법은 매일 4시간씩 7일간 연속적으로 시행하였다. 모든 결과는 전향적으로 모았으며 적극적 투석요법 전후로 심장초음파 검사를 시행하였다. 혈청 TNF-α 와 IL-10을 적극적 투석요법 전후로 비교하였고 내독소 자극 후 이들 싸이토카인들 역시 비교하였다. 결과: 적극적 투석요법 이후에 환자들의 체중과 평균동맥혈압은 의미 있게 감소하였고 그리고 심박출계수는 적극적 투석 이후 의미 있게 증가하였다. 혈청 IL-10과 TNF-α는 적극적 투석요법 후에 의미 있게 감소하였다. 반면 내독소로 자극 후 분비되는 IL-10과 TNF-α는 의미있게 증가하였다. 또한 CRP 변화 정도와 심박출계수 변화 정도는 의미 있는 상관관계를 보여주었다. 결론: 급성 좌심실 기능부전을 동반한 말기신질환자에서 적극적 투석요법은 심박출계수를 의미 있게 증가시켰으며 적절한 면역반응을 회복시키며 염증반응을 조절하는 것으로 나타났다. 따라서 급성 좌심실 기능부전을 동반한 말기신질환자에 있어 적극적 투석요법을 시행하는 것이 심기능 개선 및 염증반응 조절 및 면역반응의 회복증진에 도움이 될 것으로 생각된다. Purpose: CHF is a life threatening acute complication in ESRD populations. An intensive hemodialysis (HD) has been effective in reducing intravascular volume and in removing uremic toxin with improved systolic function. Although recent progress has identified an inflammation as an important contributor to the pathogenesis of CVD, the effect of intensive HD on inflammatory parameters and left ventricle (LV) systolic dysfunction is not clear. The purpose of this study is to examine the effect of intensive HD on LV systolic function and serum cytokines levels. Methods: Among ESRD patients who underwent dialysis and developed acute pulmonary edema due to LV systolic dysfunction were enrolled. Intensive HD consisted of daily 4 hours HD for 7 consecutive days. Data were prospectively collected and 2-D echocardiography was done before and after intensive HD. Serum levels of TNF-α and IL-10 were compared and lipopolysaccharide (LSP)-stimulated of these cytokines were measured. Results: After intensive HD, weight and mean arterial blood pressure decreased significantly and ejection fraction (EF) increased significantly. Serum IL-10 and TNF-α levels decreased significantly after intensive HD. In contrast, LPS stimulated production of these cytokines increased significantly after intensive HD. The difference of CRP between after HD and before HD was negatively correlated with the difference of EF. Conclusion: In ESRD patients with acute LV dysfunction, intensive HD significantly improved EF and restored the immune responsiveness. These results suggest that intensive HD has the advantage of improving EF through modulating inflammation and correcting immune dysfunction in ESRD patients with acute LV dysfunction.

Sprague-Dawley Rat의 자연발생 비종양성 병변

하창수(Chang Su Ha),김형진(Hyoung Chin Kim),송시환(Si Whan Song),강부현(Boo Hyon Kang),한상섭(Sang Seop Han),노정구(Jung Koo Roh) 한국실험동물학회 1993 Laboratory Animal Research Vol.9 No.1

발진열에 동반된 급성 세뇨관 간질성 신염에 의한 급성신부전 1례

부창수 ( Chang Su Boo ),고강지 ( Gang Jee Ko ),성수아 ( So Ah Sung ),조상경 ( Sang Kyung Jo ),조원용 ( Won Yong Cho ),김형규 ( Hyoung Kyu Kim ),원남희 ( Nam Hee Won ) 대한신장학회 2005 Kidney Research and Clinical Practice Vol.24 No.6

저장조건에 따른 콜라비의 이화학적 특성 및 생리활성 변화

허수형(Su Hyeong Heo),부경환(Kyung-Hwan Boo),한상헌(Sang-Heon Han),박성수(Sung-Soo Park),김창숙(Chang Sook Kim) 한국식품영양과학회 2021 한국식품영양과학회지 Vol.50 No.7

본 연구에서는 저온저장 중인 콜라비를 상온 유통 시의 품질, 유효성분 및 생리활성 변화를 조사하여 최적 유통기간 설정과 기능성 활용에 필요한 정보를 제공하고자 하였다. 저온(0°C)에 1주일간 저장하였던 콜라비를 무포장, PP 필름 및 랩으로 각각 밀봉 포장한 후 상온(20°C)에 저장하면서 기간에 따른 이화학적 특성 변화를 조사하였다. 중량 감소율은 저장 20일째에 무포장이 20.9%, PP 필름 및 랩 포장에서는 각각 7.1%와 3.6%로 나타나서 랩 포장이 상대적으로 중량 감소를 최소화하였다. 당도(Brix)는 포장 상태와 무관하게 저장기간에 따라 증가하였으며, pH는 초기에는 변화가 없었으나 20일째에는 약 15~29% 감소하였다. 총 폴리페놀 함량은 저장기간에 따라 초기값 대비 약 5~41% 감소하였다. 특히, rutin 등 5종의 플라보노이드는 저장 2일째에 약 18% 감소하였고 5일째 이후에는 약 60%로 급격히 감소하였다. 비타민 C 함량은 10일째부터 초기값에 비하여 약 39~49%로 크게 감소하였다. 항암 성분으로 알려진 총 glucosinolates는 저장기간에 따라 증가하는 경향을 보여 20일째에는 무포장인 경우 약 28%, 포장 상태에서는 약 67~80% 증가하였다. 저장기간에 따른 콜라비의 DPPH 라디칼 소거능은 2일째부터 감소하기 시작하여 20일째는 약 47~49% 감소하였는데, 이는 플라보노이드 함량 변화와 연관되어 나타났다. 반면에 ABTS 소거능은 5일째까지 초기값을 유지하였으나 10일째 이후부터는 19~26% 범위로 감소하였다. LPS로 자극된 RAW 264.7 세포에서 저장조건에 따른 콜라비 추출물의 항염증 효과를 측정한 결과, 저장조건에 따른 유의적인 차이는 없는 것으로 나타났다. 이상의 결과는 콜라비를 저온저장 후 상온 유통할 경우 외관의 품질 변화가 발생하는 저장 10일째부터 이화학적 변화가 크게 일어나며, 항산화 관련 물질의 감소로 항산화 활성이 감소하고 있음을 보여주고 있다. 향후 포장 유형에 따른 콜라비의 생리활성 변화에 대한 연구는 계속 진행되어야 할 것으로 여겨진다. This study was conducted to investigate the changes in the physicochemical properties and biological activities of kohlrabi according to the storage conditions. The kohlrabi was packed with or without polypropylene (PP) film or wrap, and stored at room temperature for 20 days prior to analysis. The reduction in the kohlrabi weight on the 20th day of storage was 20.9% when in an unpacked state, and 7.1% and 3.6% in PP film and wrap packages, respectively. However, the polyphenol, flavonoid, vitamin C, and glucosinolates content were not significantly affected by packaging conditions, although it varied with storage period. Sugar content (Brix) increased with the storage period. Total polyphenol content decreased by 5∼41% compared to the initial value according to the storage period. The content of the five flavonoids decreased by approximately 18% on the second day of storage and decreased rapidly to about 60% after the 5th day. The vitamin C content decreased significantly to 39∼49% compared to the control group from the 10th day. Total glucosinolates content tended to increase with the storage period. In addition, the DPPH radical scavenging activity decreased from the second day and decreased by 47∼49% on the 20th day, while the anti-inflammatory effect of the kohlrabi extract on lipopolysaccharide-stimulated RAW 264.7 cells was not significantly changed depending on the storage period. These results showed that the physicochemical properties of kohlrabi stored at room temperature significantly changed from the 10th day when the external quality changes occur. Specifically, the results indicated that antioxidant activity decreases due to the decrease in the content of antioxidant-related substances depending on the storage period.

급성신손상 : 급성신손상에서 단기예후인자로서의 요중 Neutrophil Gelatinase-associated Lipocalin

부창수 ( Chang Su Boo ),김혜원 ( Hye Won Kim ),최혜민 ( Hye Min Choi ),우영석 ( Young Seok Woo ),조상경 ( Sang Kyung Jo ),조원용 ( Won Yong Cho ),김형규 ( Hyoung Kyu Kim ) 대한신장학회 2008 춘계학술대회 초록집 Vol.28 No.1

Effects of Transportation on Hematological and Serum Biochemical Values in Cynomolgus Monkeys

Choong-Yong Kim,Su-Cheol Han,Jeong-Doo Heo,Hyun-Sook Lee,Chang-Su Ha,Boo-Hyon Kang,Myung-Sang Kwon,Sang-Seop Han 한국실험동물학회 2004 Laboratory Animal Research Vol.20 No.4

Effects of transportation on hematological and serum biochemical values were investigated in five male cynomolgus monkeys imported from Japan. They were underwent air and ground travel-related stress in transport cages for a 15 hour-transit time. On arrival, body weight was found to have reduced. RBC count, hemoglobin concentration, and hematocrit values were significantly elevated immediately on arrival, and serum biochemical parameters such as creatinine, glucose, triglyceride, total bilirubin, inorganic phosphate, and sodium values were significantly higher immediately on arrival than during subsequent weeks. However, all hematological and serum biochemical values, except for blood urea nitrogen (BUN), total cholesterol, and chloride values, were within the Jimits of reference range data. Blood urea nitrogen (BUN), total cholesterol, and chloride values exceeded the normal reference range, and thus these changes were associated with the process of transportation. These changes should be considered when examining the health status of newly acquired animals during quarantine.

Incidental Case of Sarcocystis in Cynomolgus Monkey

Chang-Su Ha,Yong-Bum Kim,Jae-Woo Cho,Wan-Jung Im,Boo-Hyon Kang,Sang-Seop Han,Choong-Yong Kim 한국실험동물학회 2005 Laboratory Animal Research Vol.21 No.4

Intramuscular cysts were found spontaneously in a 3-year-old Cynomolgus monkey used for 6-week toxicity study. The animal belonged to the control group. It didn’t exhibit any morphological and behavioral defects, and have abnormal lesion at necropsy observation. In the histopathology, there were no specific lesions except that the two cysts, wrapped by thin wall, were located in the muscle fiber of femoral muscle and full of dense substances. There was no inflammatory reaction around cysts. They are considered to be sarcocystis in view of its typical morphology and location.

Ktc:Sprague-Dawley 랫드의 장기중량치의 자료분석

강부현,김일환,김용범,김영희,이현숙,하창수 한국수의병리학회 2001 한국수의병리학회지 Vol.5 No.2

A reference range data base containing organ weight values on animals used in 4 week and 13 week toxicity tests is described. Data listed include the values of minimum, maximum, mean and standard deviation for each of the following organ weights. Organs: Briain, heart, liver, spleen, kidney, adrerial gland, testis, ovary. This study was undertaken to determine organ weight reference values of Ktc: SD rats.