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강부현,서일복,Kang Boo-Hyon,Seo Il-Bok 한국임상수의학회 1992 한국임상수의학회지 Vol.9 No.2
An 11 years old Irish Setter bitch was euthanlzed and necropsied because of clinical findings such as severe purulent nasal discharge and formation of large tumor mass, 8 ${\times}$8cm in size, in the abdominal cavity. A complete unilateral mastectomy had been carried out twice 14 and 22 months before necropsy. The surgically removed masess of the mammary glands had been diagnosed as malignant mixed tumor in each time. Grossly, tumor masses were observed in nasal cavity, infralumbar lymph node, lung, abdominal cavityn and brain. Microscopic findings of the surgically removed masses consisted of tumor epithelial cells, tumor hyaline cartilage-like structures and abundant connective tissues. The mass of the lymph node had similar microscopic features to those of the original malignant mixed tumor of the mammary glands. The tumor osseous tissue and osteoid were observed in the abdominal cavity, lung, and brain. Myoepithelial cells were frequently found on association with the metastatic tumors. From the results, it was concluded that malignant mixed tumor of the mammary glands metastasized to the infralunbar lymph node, abdominal cavity, lung and brain. In addition, the observation in this study supported two theories at the same time that the bone in malignant mixed tumor arises by endochondral ossification of the cartilage formed by the myoepithelial cells and arises by intramembranous ossification of stromal connective tissue or transformed myeopithelial cells. Solid carcinoma of the nasal epielia and granulosa cell tumor were also diagnosed in a mass of the nasal cavity and of the ovaries respectively.
On the generalized boundary and thickness
강부현 강원경기수학회 2020 한국수학논문집 Vol.28 No.3
We introduced the concepts of the generalized accumulation points and the generalized density of a subset of the Euclidean space in [1] and [2]. Using those concepts, we introduce the concepts of the generalized closure, the generalized interior, the generalized exterior and the generalized boundary of a subset and investigate some properties of these sets. The generalized boundary of a subset is closely related to the classical boundary. Finally, we also introduce and study a concept of the thickness of a subset.
MINIMIZATION OF THE DENSE SUBSET
강부현 충청수학회 2020 충청수학회지 Vol.33 No.1
We introduced the concept of the $\epsilon_{0}-$density and the $\epsilon_{0}-$dense ace in [1]. This concept is related to the structure of employment. In addition to the double capacity theorem which was introduced in [1], we need the minimal dense subset. In this paper, we investigate a concept of the minimal $\epsilon_{0}-$ dense subset in the Euclidean $m$ dimensional space.
On the generalized Banach spaces
강부현 강원경기수학회 2019 한국수학논문집 Vol.27 No.3
For any non-negative real number $\epsilon_{0}$, we shall introduce a concept of the $\epsilon_{0}$-Cauchy sequence in a normed linear space $V$ and also introduce a concept of the $\epsilon_{0}$-completeness in those spaces. Finally we introduce a concept of the generalized Banach spaces with these concepts.
1-(4-methylpiperazinyl)-3-phenylisoquinoline(CWJ-a-5)의 Sprague-Dawley(SD)랫드를 이용한 2주간 반복 경구투여 독성시험
강부현,조원제,김대덕,김용범,차신우,장순재 한국독성학회 2002 Toxicological Research Vol.18 No.1
The subacute oral toxicity of 1-(4-methylpiperazinyl)-3- phenylisoquinoline (CWJ-a-5) was investigated in Sprague-Dawley (SD) rats. Five groups of 5 males and 5 females were orally administered at doses of 0, 37.5, 75, 150 and 200 mg/kg with CWJ-a-5 for 2 weeks. In clinical signs, Salivation was observed in the 75, 150 and 300 mg/kg male and female groups. Loss of fur was observed in the 300 mg/kg male and female group. Body weight were significantly decreased in the 150 and 300 mg/kg male groups and in the 300 mg/kg female group. Food consumption was significantly decreased in the 300 mg/kg male group. In serum biochemistry, total cholesterol and phospholipid were significantly increased in 300 mg/kg male and female group. Aspartate aminotransferase was significantly increased in the 300 mg/kg female group. In histopathological examination, vacuolar degeneration of renal tubules in the kidney, vacuolar degeneration of hepatocytes in the liver, vacuolar degeneration of myocytes in the heart, vacuolar degeneration of histiocytes in the spleen and thymus, atrophy of seminiferous tubule and degeneration of germinal epithelium in the testis, vacuolar degeneration of corpus luteum, granulosa cell and theca cell in the ovary were observed in the 150 and 300 mg/kg male and female groups. Based on these results, the no observed adverse effect lever (NOAEL) with CWJ-a-5 was considered to be 75 mg/kg and the absolute toxic dose was considered to be 150 mg/kg in this study
New Zealand White 토끼의 신아세포종(Nephroblastoma) 자연발생례
강부현,하창수,Kang, Booh-yon,Ha, Cbang-su 대한수의학회 1992 大韓獸醫學會誌 Vol.32 No.1
A round, milkish white mass, approximately $4{\times}4{\times}5cm$ in size was found at the cranial part of the left kidney from a New Zealand White rabbit which was used as an untreated control animal in the safety evaluation test in the Toxicology Research Center, Korea Research Institute of Chemical Technology. The mass was lobulated and encapsulated. The cut surface revealed several round well-circumscribed lobules which were 0.5-3cm in diameter. No metastasis was observed. The microscopic features consisted of blastema and epithelial structures at variable stages of differentiation including primitive tubules, ducts, glomeruloid bodies. Normal mesenchymal cells were distributed among them. A diagnosis of nephroblastoma was made on the basis of the gross and microscopic features.