진행성 비호지킨 림프종 환자에서 ICE 구제 요법에 의한 조혈모세포 가동화 후 자가 말초혈액 조혈모세포이식

이제중,이병환,김여경,변정래,이일권,박무림,정익주,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1

연구배경: 비호지킨 림프종에서 자가 말초혈액 조혈모세포이식술이 폭넓게 이용됨으로 인해서, 높은 치료효과뿐만 아니라 조혈모세포의 가동화 효율이 높은 구제 요법이 요구되었다. 방법: 본 연구에서는 진행성 비호지킨 림프종에서 ICE 요법을 이용하여 조혈모세포를 가동화시킨 후 자가 말초혈액 조혈모세포이식이 시행하였던 환자를 후향적으로 분석하였다. 결과: 대상 환자의 중앙 연령은 38세(범위, 16~61)였으며, ICE 요법은 환자당 4주기(범위, 1~6주기)가 투여되었고, 투여 간격은 중앙값이 24일(범위, 16~36일)이었다. 고위험도 관해군을 제외한 13예의 환자 중 완전반응은 7예(53.8%), 부분반응은 4예(30.8%), 진행성질환은 2예(15.4%)를 보였다. 치료에 따른 3~4등급의 혈액학적 독성은 중성구감소증이 13예(81.3%), 혈소판감소증이 7예(42.8%)에서 관찰되었다. 조혈모세포 채집은 ICE 요법 후 중앙값이 12일(범위, 6~20일)에 시행되었고, 각 ICE 요법당 채집한 단핵구치는 중앙값이 5.75× 10^(8)/체중, CD34^(+) 세포는 중앙값이 1.25× 10^(6)/체중, CFU-GM치는 중앙값이 1.19× 10^(5)/체중이었다. 조혈모세포이식은 11예에서 시행되었고, 중앙 추적기간 401일에 평가한 2년 전체생존율은 70.1±14.7%, 1년 및 2년 무사건생존율은 각각 60.7±15.4%와 32.3±17.1%를 보였다. 결론: ICE 요법은 재발성/불응성 비호지킨 림프종 환자에서 높은 치료 반응률과 만족할 만한 조혈모세포 가동화를 보여 주었지만, 치료에 대한 순응도가 낮아서 투여 간격이 연장되는 문제점을 안고 있어서, 우리나라 환자의 실정에 적합한 구제요법에 대한 연구가 필요할 것으로 생각된다. Background: Due to the extensive application of high-dose chemotherapy with autologous peripheral blood stem cell transplantation (PBSCT), a salvage chemotherapeutic regimen with high response rate as well as effective capacity of PBSC mobilization is needed in non-Hodgkin's lymphoma (NHL). Methods: We analyzed the applicability of ICE (ifosphamide, carboplatin, and etoposide) regimen in NHL patients who underewent autologous PBSCT. Results: The median age was 38 years (range, 16~61 years), the patients received median 4 cycles (range, 1~6 cycles) of ICE regimen, and the median interval between each chemotherapeutic cycle was 24 days (range, 16~36 days). There were 7 (53.8%) complete responses, 4 (30.8%) partial responses, and 2 (15.4%) progressive diseases after ICE regimen. Toxicity included grade 3/4 neutropenia and throm bocytopenia in 13 (81.3%) and 7 (42.8%) patients, respectively. PBSC collection began on median day 12 (range, 6~20 days) after ICE therapy. The median number of mononuclear cells, CD34+ cells, and CFU-GM was 5.75× 10^(8)/kg, 1.25× 10^(6)/kg, and 1.19× 10^(5)/kg, respectively. With a median follow- up of 401 days, the patients who underwent autologous PBSCT had overall survival with 70.1±14.7% at 2 year and event free survival with 60.7±15.4% and 32.3±17.1% at 1 year and 2 years, respectively. Conclusion: ICE chemotherapy is an effective cytoreduction and mobilization regimen in patients with NHL, but profound myelosuppression with delayed recovery might pose difficulties in applying for Korean patients. Further evaluation for appropriate salvage regimens in Korean patients should be needed.

교양체육으로서의 댄스 스포츠 활성화를 위한 기초연구

權炳善,李起和,韓惠媛 홍익대학교 경영연구소 2002 경영연구 Vol.27 No.-

The purpose of this study is to understand the value and effect of Dance Sport as Sport for all, and to activate Dance Sport for university student. The respondents for this study were sampled among 600 university students in Seoul and the final analysis included responses from 568 respondents. The statistical methods employed in this study are frequency analysis and chi-square test. Results obtained from this research are as followed: 1. It is needed to unify the term, "Dance Sport" for the activation of Dance Sport. 2. University students recognize the value and effects of the Dance Sport as Sport For All positive through the class and most of them want to attend advanced class of Dance Sports. 3. In order to activate Dance Sport as Sport For All, the change of the public recognition of Dance Sport, the proper public information of the government, and the educating qualified leaders are urgently asked.

UGR(Unified Glare Rating)의 보정 및 불쾌글레어 주관평가를 위한 실험적 연구

이진숙,김병수,권혁일 대한건축학회 2003 대한건축학회논문집 Vol.19 No.7

Glare in one of the major factors influencing comfort appraisal for lighting. Although a predictive formula for such glare has been proposed by CIE, it has not been investigated for domestic adjustment. The correlation between glare and the closely related dazzling-sensation has not been investigated enough. In the study, subjective discomfort glare appraisal and dazzling-sensation appraisal for discomfort glare was performed to produce a corrected UGR formula. Analyses between appraisal for dazzling-sensation and results of subjective appraisal for discomfort glare were performed to produce a formula that could represent the correlation between discomfort glare and dazzling-sensation. The results of the comparison and analysis is that results computed by UGR differed from those of subjective perception, so a corrected UGR formula and corrected glare index and dazzling-sensation was produced. Also, a formula that could represent the state of dazzling-sensation verying with change of luminance was produce.

플라즈마 표지소자의 제작

이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-

An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.

소프트웨어 재사용의 전략적 추진 방안에 관한 연구

권성우,이병찬 啓明大學校 産業經營硏究所 1997 經營經濟 Vol.30 No.2

SUMMARY Since the late 1960s when the discussion about software crisis - the problem of building large, reliable software system in a controlled and cost-effective way - was risen, many methodologies have been introduced to solve that problem, and software reuse can be regarded as one of these efforts. Software reuse is using existing software components during the construction of a new software system. The types of components that can be reused are not limited to source code but rather may include design specification, documentation, module-level implementation, a variety of knowledge from all the development phases, and so on. In spite of its promise, software reuse has failed to become standard pratice for software construction. In light of this failure, the computer science community has renewed its interest from the late 1980s. Most of the research has focused only on the technical aspect of software reuse since then, and little attention to managerial considerations. A successful adoption of new technology in an organization, however, cannot be achieved only with technology itself, but rather together with managerial aspects. Therefore, we tried to find a business considerations for strategic implementation of software reuse. To achieve this goal, we first study the concept, history, and the effects of strategic implementation of software reuse from the point of management strategu, motivation, and organization structure. Finally, the case of Motorola company was analyzed. We tried to propose managerial guidelines for strategic implementation of software reuse, and this will be helpful to make plans for that and to decrease the chance of trial and error during the adoption phases of new technology. Since the late 1960s when the discussion about software crisis - the problem of building large, reliable software system in a controlled and cost-effective way - was risen, many methodologies have been introduced to solve that problem, and software reuse can be regarded as one of these efforts Software reuse is using existing software components during the construction of a new software system. The types of components that can be reused are not limited to source code but rather may include design specification, documentation, module-level implementation, a variety of knowledge from all the development phases, and so on. In spite of its promise, software reuse has failed to become standard practice for software construction. In light of this failure, the computer science community has renewed its interest from the late 1980s. Most of the research has focused only on the technical aspect of software reuse since then, and little attention to managerial considerations. A successful adoption of new technology in an organization, however, cannot be achieved only with technology itself, but rather together with managerial aspects. Therefore, we tried to find a business considerations for strategic implementation of software reuse. To achieve this goal, we first study the concept, history, and the effects of software reuse. And then we consider the managerial aspects of strategic implementation of software reuse from the point of management strategy, motivation, and organization structure. Finally, the case of Motorola company was analyzed. We tried to propose managerial guidelines for strategic implementation of software reuse, and this will be helpful to make plans for that and to decrease the chance of trial and error during the adoption phases of new technology.

광대역 고출력 공간 전력 증폭 소자에 관한 연구

이성호,권세웅,이병무,윤영중 연세대학교 산업기술연구소 2002 논문집 Vol.33 No.2

In this paper, spatial amplifier using wideband printed dipole antennas is proposed for spatial power combining. The input and output printed dipole antennas have wide bandwidth of 22 %(5.44 ㎓∼6.75 ㎓) and 26.3 %(5.2 ㎓∼6.78 ㎓), respectively. Gain of the designed amplifier is 9.5 ㏈ at 6 ㎓. As a result, the proposed spatial amplifier using wideband printed dipole antennas and amplifiers shows that the gain is 16.8 ㏈ at 6 ㎓ and 3-㏈ gain bandwidth is 1.04 ㎓.

알코올리즘 선별검사 도구들의 진단 효율 비교

박병강,이동배,이태용,조영채,권윤형 충남대학교 의과대학 지역사회의학연구소 2000 충남의대잡지 Vol.27 No.1

To compare the clinical usefulness of four alcoholism-screening tests frequently used in Korea such as MAST, NAST, AUDIT, CAST, 96 drinking males were given diagnostic interview based on DSM-IV criteria and scores from four tests were obtained and analyzed. Of 96 subjects, 52.1% were normal without drinking problems, 38.5% with alcohol abuse and 9.4% with alcohol dependence. In terms of reliability of items in screening tests, four items in MAST were not found to have statistically significant item-total correlation. The appropriate cut-off value for screening tests to detect alcohol use disorders were above 15 points in AUDIT, above 5 points in MAST, above one item in NAST and above 2 items in CAGE. In terms of sensitivity for detection of alcohol use disorders, NAST was highest with 93.5%, and specificity, CAGE was highest with 90.0%. Considering the lowest sensitivity of 76.0% in CAGE and 76.J% of specificity in MAST, AUDIT and NAST were the most appropriate in screening alcohol abuse. The appropriate standard values for screening alcohol dependence were above 26 pants in AUDIT, above 13 points in MAST, above 5 items in NAST, and above 3 items in CAGE. In screening alcohol dependence AUDIT had the highest sensitivity of 100.0%, and both AUDIT and NAST had the highest specificity of 94.3%, respectively. The sensitivity of three screening tools except AUDIT were the same with the value of 88.9% and therefore AUDIT were the most appropriate in detecting alcohol dependence taking into consideration the relatively low specificity of 85.1% in CAGE.

관상동맥질환 환자에서 스텐트 시술 후 재협착에 관한 연구

강진환,권영주,박상호,한대희,이상철,김명구,변정득,최병조,심규혁,온영근,현민수,김성구 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background and aims : In the coronary artery disease, a rate of restenosis was much decreased by placement of coronary stent than when percutaneous transluminal coronary angioplasty has been applied, but there are still important clinical problems of restenosis. There has been many progressive studies about various factors contributed to this restenosis. So, we studied a relation between restenosis after placement of coronary stent in the coronary artery disease and many clinical factors, characteristics of stenotic lesion and procedural factors, and also assessed the restenosis rate of various coronary stents. Methods : Total 58 lesions(46 cases of patients ; man 30, woman 16) were evaluated, which has been performed a follow-up coronary angiography after 6 months (mean 188 days) since coronary stent had been placed. Various stents were implanted and assessed a relation between restenosis and many factors. Results : Of 58 lesions were target stenotic studies, there were 22 of restenotic lesions(37.9%), and the restenosis rate wes statistically significant difference in the relation with diabetes mellitus(p<0.05), group of acute myocardial infarction(p<0.05) among clinical diagnosis of ischemic heart disease(stable angina, unstable angina and acute myocardial infarction) in clinical factors and with high dilation pressure of stent(p<0.05) in procedural factors. When the rate of restenosis was evaluated among implanted stents, it was lowest in the Multilink^(®) stent and highest in the Nir Royal^(®) stent(60%). Conclusion : In this study of restenosis and various factors after placement of stents in the coronary artety disease, factors such as diabetes mellitus, group of acute myocardial infarction and a dilation pressure of stent were significant related with restenosis and the restenosis rate of Multilink^(®) stent was lowest and the highest restenosis rate was of Nir Royal^(®) stent.

儒敎思想이 傳統建築에 미친 影響에 관한 연구 : 朝鮮時代 宗家, 書院을 중심으로

朴載浩,李康宗,權秉俊 三陟大學校 産業科學技術硏究所 2002 産業科學技術硏究論文集 Vol.7 No.2

Root Confucian ideas to spread that principle that contribute all things in universe with human by perfect virtue the nature note and inside be that it be . Human's root had been shy gentle and good temper extremely but have stroma because keep body and because greed for material brings thereby, because it hides good temper or is forgotten, moral culture and education are required. Confucian Treatise of Human Nature gets into theoretical nature of this paradox in Sung Confucianism and by Toegye, Yulgok etc. philosophical by indurate . In Choson period, Sinbunje and formation of powerful family group's same race community form main family naturally and brought qualitative development of private house. Also, lecture-hall developed to place that development of Sung Confucianism learns learning and compose scholars' group. As this dying injunction bore in construction by direct admonition hundred Choson age that Confucian ideas develops.

필라델피아 염색체 양성 급성골수성백혈병에서 Imatinib Mesylate로 분자학적 관해를 유도한 후 성공적인 자가 말초혈액 조혈모세포이식이 시행되었던 1예

김여경,이제중,이병환,변정래,조덕,이일권,정익주,양동욱,김형준 대한조혈모세포이식학회 2003 대한조혈모세포이식학회지 Vol.8 No.1

저자들은 필라델피아 염색체 양성 급성골수성백혈병 환자에서 복합항암화학요법으로 혈액학적 완전관해를 유도하고, imatinib mesylate를 이용하여 분자학적 관해를 유도한 후, 성공적으로 자가 말초혈액조혈모세포이식을 시행하였던 1예를 경험하였기에 이를 보고하는 바이다. Philadelphia chromosome (Ph¹)-positive acute myeloid leukemia (AML) is very rare disease, comprising 3~4% of the AML, and is a clinically distinct entity with poor clinical outcome with conventional chemotherapy. We report a case of Ph¹-positive AML who underwent successful autologous peripheral blood stem cell transplantation after achieving a molecular remission with imatinib mesylate.