입원 기간 중 발생한 첫 경련발작

이훈복,김종흥,김제,이애영,김재문 대한신경과학회 1997 대한신경과학회지 Vol.15 No.2

국내 설사환자로부터 분리된 Escherichia coli 균의 혈청군 및 Verocytotoxin 생성능

김호훈,강연호,김성한,박미선,유재연,이복권 대한감염학회 1998 감염 Vol.30 No.5

목적: 국내 설사 환자에게서 분리 동정된 인체 감염 유래 E. coli 균의 혈청군, verocytotoxin 생성능을 구명하여 EHEC 균의 인체 감염 실태를 구명하고, 동물 및 식품 유래 분리균주의 성상과 비교 검토하여 인체 감염 위험성에 대한 기초적 자료를 의학계에 제공하고자 하였다. 방법: EHEC 감염의심 설사 환자 분변 검체로부터 분리된 균주 중 생화확적 성상에 따라 대장균을 분리하였고 이들 균주 중 E. coli O157:H7를 분리하기 위해서는 Dsorbitol 음성균을 선별하였으며, 분리균에 대하여 항혈청으로 응집 시험을 실시하여 혈청군을 구명하였다. 혈청군이 확인된 균주에 대하여 중합효소 연쇄반응 (PCR) 및 역수동라텍스 응집시험 (Reversed Passive Latex Agglutination:RPLA) 으로 verocytotoxin 생성능을 구명하였다. 결과: 장출혈성 대장균 감염 의심설사 환자의 분변검체로부터 25주의 E. coli 균을 분리 동정하였으나 이들 균주는 모두 verocytotoxin을 생성하지 않았다. 분리 동정된 대장균으로부터 확인된 혈청군은 16종으로서 E. coli O1, O6, O8, O15, O20, O25 O26, O28, O29, O44, O86a, O119, O126, O128, O152, 및 O157:H-였으며 E. coli O157:H-혈청형 균주와 E.coli O25 혈청군 균주가 각각 3주씩 분리되어 비교적 높은 분리율을 보였다. 결론: 장출혈성 대장균 감염 의심설사 환자 분변 가검물로부터 총 25주의 E. coli균을 분리 동정하였으나 verocytotoxin을 모두 생산하지 않았다. Background: Since 1982, many countries has reported outbreaks or sporadic cases caused by enterohaemorrhagic Escherichia coli (EHEC) serogroup strains, mainly E. coli O157:H7 type strain. However, systemic investigation about EHEC agents, including E. coli O157:H7, have not been done in Korea. Therefore, we investigated serogroup and verotoxin productivity of E. coli strains isolated from diarrheal patients and estimated risk of human infection in comparison with EHEC strains isolated from cow, pig, and food material in Korea. Methods: Diarrheal patient stool samples were collected and E. coli strains were isolated, according to biochemical characteristics. In order to isolate E. coli O157:H7, D-Sorbitol negative strains were selected. Serogrouping of the E. coli isolates was done by agglutination test. Verocytotoxin productivity was investigated by polymerase chain reaction (PCR) and reversed passive latex agglutination (RPLA). Human infection risk was estimated in comparison with EHEC strains isolated from cow, pig and food materials in Korea. Results: Twenty-five E. coli strains were isolated from the diarrheal patients who were suspected to be infected with EHEC. However, none of these E. coli strains produced verocytotoxin. Out of 25 E. coli isolates, 16 serogroups of E. coli O1, O6, O8, O15, O20, O25, O26, O28, O29, O44, O86a, O119, O126, O128, O152 and 157:H-were found. In each of the E. coli O157:H-and O25 serogroups 3 strains were found. Conclusion: None of 25 E. coli isolated from diarrheal patients who were suspected of EHEC infection produced verocytotoxin producing E. coli have been reported recently in Korea.

충주시 농촌지역 주민들에 대한 보건교육 평가

권복규,양준호,송진범,이건세,이원진,장성훈 건국대학교 의과학연구소 1996 건국의과학학술지 Vol.5 No.-

The aim of this study was to evaluate the effect of health education program in Choongju rural area which had conducted by Public Health Doctor during winter in 1994 and 1995. We used two step sampling method for a household survey. First, six were selected from 12 Myuns, which were stratified by the level of health education activity. Second, we applied convenient sample method. Of the 307 respondents, most of them knew Health-subcenter's existence in their region. However, only 149 persons(45%) visited it during last year. They visited Health-subcenter because it was easy to travel and convenient. Some of them thought that Health-subcenter had very poorly equipped and supplied. About 32∼34% of respondents participated the health education program for hypertension and diabetes mellitus which was done last winter, and 59∼70% of participants of the program answered that it was very, moderately helpful. 82∼83% of participants recognized complications of hypertension and diabetes mellitus, and 18∼20% of them did not know that medications of hypertension and diabetes mellitus should be continued one's whole life. The respondents want to receive health educations for cancer, arthritis, viral hepatitis and AIDS in orders. Many of rural residents utilize Health-subcenters because health clinics in Choongju rural area are very few.

Generic BOM에서의 미입력 파라미터에 관한 연구

김훈태,이영복 대진대학교 생산기술연구소 2000 생산기술연구소 논문집 Vol.3 No.-

The adaptation of the range of products within an enterprises to the today customers demands results in an exploding number of different variant parts and variant bills of material. The mentioned problem can be solved from representing one general BOM for all product variants. That is, Generic BOM includes explaining variants of components. Each variant is represented as a pair of parameter and value. When there are unknown parameter values, this paper explains the methodology for mentioned problem, describes problems, types and specifications owing to existence of unknown parameters. If one more unknown parameter values are exited, determining handling orders of unknown parameters is cause of a different result BOM and constraints to still unknown parameter values, So this paper represents a method for handling order of unknown parameter values. The method is composed of two steps. First step is use of inclusion rule, and second step is exclusion rule. The final specification is the result of the decision of BOM administrator. This paper is expected to reduce laborious work of BOM administrator 주요기술용어 : Generic BOM, unknown parameter value(미입력 파라미터), rule(규칙), specification(명세)

탄산칼슘이 포함된 HDPE 필름의 광산화후 생분해

신부영,이훈복,이일희,신용섭 嶺南大學校 工業技術硏究所 1995 工業技術硏究所論文集 Vol.23 No.1

대량생산 체제에서 기계적 산화 공정을 응용하여 공기 분위기에서 광분해성 마스터 뱃치(M/B)를 제조하였다. 제조된 M/B가 40 중량 % 첨가된 광분해성 HDPE 얇은 필름을 인플레이션 법으로 제조하였다. 필름의 광분해성을 시험하기 위하여 필름을 옥외에 노출시켜 기계적 물성 및 필름의 화학적 변화를 FTIR을 사용하여 관찰했다. 생분해 실험은 인큐베이터 및 토양 매립 실험을 동시에 실시했다. 광분해성 필름을 옥외 태양광 노출을 각각 0, 14, 28, 42일간 수행한 후 미생물 배양 시험을 행했다. 미생물 배양 시험에서 필름의 표면에 미생물의 성장과 포자의 형성을 관찰할 수 있었고 옥외 노출 기간이 증가함에 따라 필름 표면에 미생물의 성장이 증대되는 것을 관찰했다. 토양에 매립된 필름에서도 약간의 화학적인 변화를 관찰할 수 있었다. Photodegradable commercial master batch(M/B) was prepared by using mechanical oxidation during melt mixing with high shear under air environment. High density polyethylene(HDPE) thin film containing 40 wt % photodegradable M/B was prepared by inflation film processing. The film was exposed to the sunlight to observe the photodegradability. The degradability of film was determined by the loss of tensile properties and degradation was characterized by FTIR spectroscopy. Biodegradation of exposed and unexposed film was investigated by microbiological test and soil burial test, respectively. Photodegradable film(P-1) was exposed for periods of 0, 14, 28, 42 days before being mixed with fungi. It was found that microorganisms(fungi) growth on the surface of film was augmented as sunlight exposed time increased. Soil buried film showed the chemical changes of matrix polymer.

지속형 항응고성 살서제 중독에 기인한 뇌실질출형 1예

양충용,이진훈,이서울,정복희,노상균,신용일 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

저자들은 brodifacoum성분의 지속형 효과를 갖은 항응고제인 쿠마린계 살서제를 정확한 용량을 추정할 수는 없지만 다회의 약물 복용 17일 후 뇌실질출혈이 발생한 증례를 문헌 고찰과 함께 보고하는 바이다. 지금껏 쿠마린계의 지속형 항응고성 살서제의 약물 중독이 알려져 있다. 이러한 약물은 vitamin K₁ 2,3-epoxide 환원효소를 억제하여 vitamin K₁과 연속적으로 vitamin K₁ 의존성 응고인자 Ⅱ, Ⅶ, Ⅸ, Ⅹ의 합성을 억제하고 이로써 출혈 경향을 증가시킨다. 이 증례를 토대로 향후 출혈성 환자 특히 선행 질환이 없는 젊은 뇌실질출혈 환자에서 원인을 감별진단 함에 있어 환자의 약물 중독 가능성과 치료에 대한세심한 주의가 필요할 것으로 생각한다. Spontaneous intracerebral hemorrhage is one-tenth of all strokes and represents relatively high frequency and morbidity. Hypertension is the most common cause of spontaneous intracerebral hemorrhage and other causes are vascular malformation, intracerebral amyloid angiopathy, hemorrhagic infarction, blood diseases and drug abuse. Some peoples have the intoxication of drug such as long-acting anticoagulant of rodenticides, family of cumarin, that inhibit vitamin K₁ 2,3-epoxide reductase, the synthesis of vitamin K₁ and subsequently vitamin K₁ dependent clotting factors Ⅱ, Ⅶ, Ⅸ, and Ⅹ. Finally these make prolonged PT, INR and aPTT, which are prone to trigger bleeding tendency. We report a rare case of intracerebral hemorrhage maybe caused by after frequent intended ingestion of long-acting anticoagulant rodenticide(brodifacoum) for suicide.

고용량 및 저용량 ticlopidine의 혈소판 응집억제 효과 비교: 예비연구

김제,이훈복,송희정,이태용,김재문 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

비정상 질확대경검사 소견을 보이는 환자에서 환상투열요법의 직접적 적용에 관한 연구

우헌탁,이철민,박교훈,조용균,최훈,김복린,이홍균 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.2

Objective: Large Loop Excision of the Transformation Zone (LLETZ) has been widely used for evaluating cervical dysplasia/cancer. We performed this study to evaluate if colposcopically suspected cervical high-grade dysplasia or cancer could be directly evaluated and treated with LLETZ. Methods: 93 women who were scheduled for colposcopic evaluation because of an abnormal cervical cytology report were included in the study in Sanggye Paik Hospital from Jan to Dec 2001. Mean age of the study population was 38.6±9.0. colposcopy directed punch biopsy was not performed and histologic diagnosis was made by LLETZ. Sensitivity and specificity of colposcopic evaluation was calculated and compared with those of cervical cytology. Results: On histopathological examination by LLETZ, 11(11.8%) patients had invasive cancers including 3(3.2%) adenocarcinomas. The sensitivity and specificity of colposcopy for the detection of cervical dysplasia or cancer was 71.7% and 72.3% respectively, wile those of cytology was 56.5% and 74.5% respectively. Conclusion: LLETZ may be adequately performed for the diagnosis and treatment of cervical dysplasia/cancer based on the results of pap smear and colposcopy without punch biopsy. Cost benefit might be anticipated while cost-effectiveness analysis is necessary in the future.

Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in management of peritoneal carcinomatosis: Single center experience in Korea

Hee Ju Lee1,HyungJoo Baik1,박요한,서상혁,김광희,Ki Beom Bae,Kwan Hee Hong,김기향,변정미,Dae Hoon Jeong,Kyung Bok Lee,오민경,조광래,안민성 대한종양외과학회 2019 Korean Journal of Clinical Oncology Vol.15 No.2

Purpose: Peritoneal carcinomatosis (PC) has been considered a terminal condition and cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIEPC) is regarded as an alternative therapeutic option. This study aimed to evaluate the 30-day clinical outcomes of CRS/HIPEC and the feasibility of the surgery by investigating the morbidity and mortality in Inje University Hospital. Methods: Data were retrospectively collected from 19 patients with PC who underwent CRS/HIPEC at Inje University Hospital in 2018. We evaluated pre-, intra-operative parameters and postoperative clinical outcomes and early complications. Results: The mean operating time was 506.95 minutes and the mean blood loss was 837.11 mL. Six cases (31.58%) had morbidity of grade III or above. A longer operating time (≥560 minutes, P=0.038) and large blood loss (≥700 mL, P=0.060) were positively correlated with grade III or worse postoperative complications. Conclusion: Our early experience with CRS/HIPEC resulted in a 31.58% morbidity rate of grade III and above, with risk factors being longer operating time and greater intraoperative blood loss. As the surgical team’s skills improve, a shorter operating time with less intraoperative blood loss could result in better short-term outcomes of CRS/HIPEC.

전단력 하에서 유도된 광민감군이 첨가된 HDPE 필름의 광분해

조무환,이훈복,신부영 嶺南大學校 環境問題硏究所 1995 環境硏究 Vol.15 No.1

융용 혼합기를 이용하여 공기 분위기 하에서 강한 전단력을 혼합물에 가하여 광분해성 M/B(Master Batch)를 제조하였다. 제조된 M/B가 45 중량 % 첨가된 광분해성 HEPE 얇은 필름과 분해성 M/B가 첨가되지 않은 일반 HDPE 필름을 인플레이션 법으로 제조하였다. 두 필름의 광분해성을 시험하기 위하여 필름을 자외선 조사기와 옥외에 노출시켜 기계적 물성 및 필름의 표면 변화를 살펴보았다. 자외선 조사 시험에서 분해성 필름은 120시간 이내에 처음 신도의 95%를 잃고 매우 취약한 상태로 되었으나, 비분해성 필름은 150시간 조사에도 처음 신도의 80%를 유지하고 있었다. 옥외 노출 시험에서는 분해성 필름의 경우 옥외 노출 21일 후 처음 신도의 약 98%를 상실하였으나, 비분해 필름은 같은 노출 시간에 원래 신도의 98%를 유지하고 있었다. SEM을 이용하여 필름 표면을 관찰한 결과, 특이한 표면 변화를 보여주었다. Photodegradable master batch was prepared by using mechanical oxidation during melt mixing process with high shear and in the presence of air. High density polyethylene (HDPE) thin film containing 45 wt % photodegradable M/B (Master Batch) and common high density polyethylene (HDPE) thin film were prepared by inflation film processing. The films were exposed under both mercury-vapor lamp light and sunlight. The photodegradable film lost about 95 % of its original elongation for 120 hours irradiation and was very brittle. The common film without photodegadability retained 80 % of its original elongation for 150 hours irradiation. Under sunlight, photodegradable HDPE film lost about 98 % of its original elongation at break after 21 days exposure and was very brittle. The common film still retained 88 % of its original elongation at the same period. Surface morphology of the films was examined by using scanning electron microscopy (SEM). SEM micrographs revealed the interesting change of the surface morphology of photodegradable thin film during outdoor exposure.