Prognosis of Colon Cancer Patients Treated with Adjuvant FOLFOX Based Chemotherapy

안민성,유종한,박하경,신재호,김광희,하태권,배기범,김태현,최창수,오민경,홍관희 대한종양외과학회 2014 대한임상종양학회 학술대회지 Vol.2014 No.3

장중첩증을 동반한 Peutz-Jeghers Syndrome

안민성(Min Sung An),김운원(Woon Won Kim),오상훈(Sang Hoon Oh),이난주(Nan Joo Lee) 대한외과학회 2008 Annals of Surgical Treatment and Research(ASRT) Vol.74 No.5

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease where the clinical manifestations are multiple harmatomatous gastrointestinal polyps and pigmentations of the skin. A harmatomatous polyp can develop at any part of the gastrointestinal tract, and the proximal small bowel is frequently involved. Intestinal obstruction, bleeding and intussusception, caused by GI polyps have been reported, which often require repeated surgery. A female patient presented with suffering of abdominal pain for two days duration. The patient was diagnosed with intussusception, and a resection and anastomosis of the small bowel was performed. The patient was treated for 15 days, and was discharged from the hospital without any particular complications. We report this case with a review of the literature.

유방암 조직의 Cox-2 발현

안민성(Min-Sung An),김상효(Sang-Hyo Kim),윤혜경(Hye-Kyoung Yoon),김운원(Woon-Won Kim) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.6

Purpose: Cox-2 expression in breast carcinoma has been reported to be related to angiogenesis, lymph node metastasis and Her-2 expression. The aim of this study is to evaluate the clinicopathologic significance of Cox-2 expression in the invasive ductal carcinomas (IDC) and intraductal carcinomas (DCIS) of the breast. Methods: The materials were 353 IDC cases and 82 DCIS cases. Immunohistochemical stain for Cox-2 was interpreted as 1+ (weak & focal) and 2+ (diffuse), and the relationships between Cox-2 and ER, PR, Her-2, p53, Ki-67 and bcl-2 expressions were analyzed. Results: There was no significant difference of Cox-2 expression between IDC (148/353, 41.9%) and DCIS (38/82, 46.3%). Cox-2 (2+) expression was more frequent in low grade than intermediate and high grade IDC, but the difference was not significant statistically (P=0.0833), and there were no significant differences of Cox-2 expression according to age, tumor size, nuclear grade, lymph node metastasis in IDC and DCIS cases. In IDC cases, Cox-2 (1+ and 2+) expression showed positive relationships with p53 (+) and more than 10% of Ki-67 labeling index (P=0.0029, P=0.0015), and revealed tendencies of positive relationships with ER (+) and bcl-2 (+) (P=0.0750, P=0.0776). However, no significant relationship between Cox-2 and Her-2 expressions was recognized. In DCIS cases, Cox-2 (2+) expression rate was increased in cases showing negative for Her-2 (P=0.0092) and positive for bcl-2 (P=0.0486). Conclusion: Cox-2 expression seems to be involved in the development of breast carcinomas, but not related to the invasiveness. Cox-2 expression, especially 2+, in the DCIS cases suggest a possibility of less aggressive biological behavior.

존 메이슨의 作品에 관한 硏究

원경환,안민성 弘益大學校 人文科學硏究所 2007 人文科學 Vol.15 No.-

현대 도예에 나타난 Installation에 대한 연구

원경환,안민성 사단법인 한국조형디자인협회 2008 조형디자인연구 Vol.11 No.3

Installation Art is the art form of inducing the audience's participation by including the sense of sight, tactile sense, auditory sense, and sometimes the olfactory sensation in 3-dimensional space without remaining in the limitation of visual expression, escaping from the limitation of traditional art genre, which is divided into painting and sculpture, through expanding space of including choice and environment in diverse materials. The installation art has close relationship with a concept called ‘space.’ The installation, which was used in the whole space of exhibition, needs to allow the work to form one relationship rather than being separated from place. Here, the audience is emerged as an important role. An artist allows the audience to participate in the work, thereby leading to the accidental and unpredictable result. And, this can be seen to be the aim to cause the audience to have interest in the work and to provide the artist oneself with an opportunity that can be given inspiration. One of main characteristics in the work of installation art is what has ‘one-time attribute’ of coming to disappear with leaving just photos other records simultaneously with being withdrawal after a number of works had been installed for the fixed period. This is the plastic form that pursues the momentary behavior of escaping from the traditional art idea with saying that art needs to have perpetuity. Thus, in order to avoid a problem that is left just by these materials, the work is preserved by being permanently installed in a public place, or, the special attention is also paid to materials and techniques aiming to prevent damage, if possible. Meanwhile, since the start of the clay revolution centering on Peter Voulkos at the end of the 1950s, the modern art trend and modern ceramic art can be reminisced on one line. The installation art, which is recently showing the remarkable bullish trend in modern art, had natural influence upon modern ceramic art. And, this is possessing one genre in modern ceramic art in the contextual and methodological aspect. The modern ceramic art accepted a concept of modern sculpture, passed through more abundant experience, and arranged the firm position in the new ceramic-art aesthetics. The installation art arranged modern ceramists with the breakthrough of possibility for expression. As this is the sculpture of having the field base after passing through the form like performance, it is adding the motive power to development in ceramic art. Clay comes to have the semi-permanent property after passing through the process of plasticity. This is the part that can judge the possibility of ceramic art as the excellent art medium while supplementing a weak point in the installation art with saying of failing to have independence and permanence as the artistic work.

ERCC1 as a Predictive Marker for FOLFOX Chemotherapy in an Adjuvant Setting

김치영,서상혁,안민성,김광희,배기범,황진원,김지현,김보미,강미선,오민경,홍관희 대한대장항문학회 2015 Annals of Coloproctolgy Vol.31 No.3

Purpose: The purpose of this study was to identify the excision repair cross-complementation group 1 (ERCC1) as a predictive marker for FOLFOX adjuvant chemotherapy in stages II and III colon cancer patients. Methods: A total of 166 high risk stages II and III colon cancer patients were retrospectively enrolled in this study, and data were collected prospectively. They underwent a curative resection followed by FOLFOX4 adjuvant chemotherapy. We analyzed ERCC1 expression in the primary colon tumor by using immunohistochemical staining. The oncological outcomes included the 5-year disease-free survival (DFS) rate. The DFS was analyzed by using the Kaplan-Meier method with the log-rank test. A Cox proportional hazard model was used for the prognostic analysis. Results: ERCC1-positive expression was statistically significant in the older patients (P = 0.032). In the multivariate analysis, the prognostic factors for DFS were female sex (P = 0.016), N stage (P = 0.009), and postoperative carcinoembryonic antigen level (P = 0.001), but ERCC1 expression was not a statistically significant prognostic factor for DFS in the univariate analysis (P = 0.397). The 5-year DFS rate was not significantly associated with the ERCC1 expression in all patients (P = 0.396) or with stage III disease (P = 0.582). Conclusion: We found that ERCC1 expression was not significantly correlated with the 5-year DFS as reflected by the oncologic outcomes in patients with high-risk stages II and III colon cancer treated with FOLFOX adjuvant chemotherapy.

Comparing short-term outcomes after totally laparoscopic distal gastrectomy and laparoscopy-assisted distal gastrectomy with Billroth I anastomosis: early experience of a single institution

이인혁,김광희,서상혁,안민성,백형주,박요한,강상현,오상훈 대한내시경복강경외과학회 2021 Journal of Minimally Invasive Surgery Vol.24 No.1

Purpose: To determine the safety and feasibility of totally laparoscopic distal gastrectomy (TLDG) with modified delta-shaped anastomosis, we compared the short-term outcomes of TLDG to those of laparoscopy-assisted distal gastrectomy (LADG) with Billroth I anastomosis. Methods: We analyzed the characteristics of 85 patients with gastric cancer who underwent laparoscopic distal gastrectomy with Billroth I anastomosis between January 2013 and December 2018. After propensity score matching, each group had 35 patients. Results: Of these 85 patients, 44 underwent TLDG and 41 underwent LADG. Propensity score matching was performed with three covariates (age, underlying disease, and hypertension), and 35 patients from each group were matched 1:1. After matching, the TLDG group was older than the LADG group (64.5 ± 10.6 years vs. 56.3 ± 11.2 years, p = 0.003) and had more patients with hypertension (57.1% vs. 22.9%, p = 0.003). Tumors were larger in the TLDG group than in the LADG group (23.4 ± 16.2 mm vs. 16.0 ± 7.9 mm, p = 0.018). A greater proportion of patients had fever in the TLDG group than the LADG group (42.9% vs. 20.0%, p = 0.039), and C-reactive protein from postoperative days 3 to 6 was greater in the TLDG group (11.4 ± 5.7 mg/dL vs. 7.0 ± 5.0 mg/dL, p = 0.001). Conclusion: Although our data represent only our early experience performing TLDG with modified deltashaped anastomosis, this procedure is relatively safe and feasible. Nevertheless, compared to LADG, which is the conventional method, the operative time for TLDG was longer. Surgeons must also watch out for anastomotic complications.

현대 도예에 나타난 Installation에 대한 연구 비교 연구

원경환(Won, Kyung-Hwan),안민성(Ahn, Min-Sung) 한국조형디자인학회 2008 조형디자인연구 Vol.11 No.3

Installation Art is the art form of inducing the audience's participation by including the sense of sight, tactile sense, auditory sense, and sometimes the olfactory sensation in 3-dimensional space without remaining in the limitation of visual expression, escaping from the limitation of traditional art genre, which is divided into painting and sculpture, through expanding space of including choice and environment in diverse materials. The installation art has close relationship with a concept called ‘space.’ The installation, which was used in the whole space of exhibition, needs to allow the work to form one relationship rather than being separated from place. Here, the audience is emerged as an important role. An artist allows the audience to participate in the work, thereby leading to the accidental and unpredictable result. And, this can be seen to be the aim to cause the audience to have interest in the work and to provide the artist oneself with an opportunity that can be given inspiration. One of main characteristics in the work of installation art is what has ‘one-time attribute’ of coming to disappear with leaving just photos other records simultaneously with being withdrawal after a number of works had been installed for the fixed period. This is the plastic form that pursues the momentary behavior of escaping from the traditional art idea with saying that art needs to have perpetuity. Thus, in order to avoid a problem that is left just by these materials, the work is preserved by being permanently installed in a public place, or, the special attention is also paid to materials and techniques aiming to prevent damage, if possible. Meanwhile, since the start of the clay revolution centering on Peter Voulkos at the end of the 1950s, the modern art trend and modern ceramic art can be reminisced on one line. The installation art, which is recently showing the remarkable bullish trend in modern art, had natural influence upon modern ceramic art. And, this is possessing one genre in modern ceramic art in the contextual and methodological aspect. The modern ceramic art accepted a concept of modern sculpture, passed through more abundant experience, and arranged the firm position in the new ceramic-art aesthetics. The installation art arranged modern ceramists with the breakthrough of possibility for expression. As this is the sculpture of having the field base after passing through the form like performance, it is adding the motive power to development in ceramic art. Clay comes to have the semi-permanent property after passing through the process of plasticity. This is the part that can judge the possibility of ceramic art as the excellent art medium while supplementing a weak point in the installation art with saying of failing to have independence and permanence as the artistic work.

직장암의 종양특이 직장간막절제술 후 종양학적 결과 및 재발인자 분석

배기범,김삼희,이민제,안민성,홍관희,오민경 대한종양외과학회 2011 대한임상종양학회 학술대회지 Vol.2011 No.3

이사무 노구치의 작품에 관한 연구

원경환(Won, kyung-hwan),안민성(Ahn, min-sung) 한국조형디자인학회 2009 조형디자인연구 Vol.12 No.3

The purpose of this study is to examine the relationship between Isamu Noguchi's (1904 ∼1988) works and Japan's traditional characteristics. This can be done by trying to analyze his ceramic sculpture made in Japan, in which when this modern sculptor was immersed in seeking for his identity. The analysis will include and be compared to the formative characteristics in typically environmental sculptures that brought motif from Japanese traditional garden. Noguchi pursued a way to the sculpture that has an abstract quality, as well as a social relationship while concentrating on nature and a human being. He aimed to create sculptural environment for human activities as the actual place that art and society are connected, by introducing sculpture to the daily life. Isamu Noguchi's perspective of modern art was disciplined in Paris Studio of the sculptor Constantin Brancusi (1876〜1957), and was lively-integrated space by combining with the experience on Japan's traditional garden. The forms (what is geometrical and what is organic, what is traditional and what is modern), which are diversely shown in Noguchi's works, are maintaining the dialectical tension between oppositive propensities (what is spiritual and what is scientific, what is ideal and what is practical). Its reason can be found in Noguchi's personal experience and his individual history. These are composed of opposite elements such as his childhood in Japan and his adolescence in America, and the et tic difference that he felt simultaneously between his American mother and Japanese father. Ceramic work became the medium he explores his identity. Through ceramic work in Japan, Noguchi tried to establish his identity by experiencing combination of nature and abstraction and by pursuing connection with Japan. In order to seek for cultural identity in Japan, Noguchi maintained his characteristic of modernism, while utilizing elements in Japan's traditional aesthetics. Noguchi's continuous effort for exploring identity was shown as the uniquely formative characteristic in his work, and brought about expansion in sphere of modern sculpture as a pioneer of new environmental art.