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황기환,김태민,박철기,장종희,정태영,김진희,남도현,김세혁,유헌,홍용길,김은영,이동은,주정남,김유정,최기영,최병세,강석구,김정훈,김채용 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2
Purpose We investigated the efficacy of temozolomide during and after radiotherapy in Korean adults with anaplastic gliomas without 1p/19q co-deletion. Materials and Methods This was a randomized, open-label, phase 2 study and notably the first multicenter trial for Korean grade III glioma patients. Eligible patients were aged 18 years or older and had newly diagnosed non-co-deleted anaplastic glioma with an Eastern Cooperative Oncology Group performance status of 0-2. Patients were randomized 1:1 to receive radiotherapy alone (60 Gy in 30 fractions of 2 Gy) (control group, n=44) or to receive radiotherapy with concurrent temozolomide (75 mg/m2/day) followed by adjuvant temozolomide (150-200 mg/m2/day for 5 days during six 28-day cycles) (treatment group, n=40). The primary endpoint was 2-year progression-free survival (PFS). Seventy patients (83.3%) were available for the analysis of the isocitrate dehydrogenase 1 gene (IDH1) mutation status. Results The two-year PFS was 42.2% in the treatment group and 37.2% in the control group. Overall survival (OS) did not reach to significant difference between the groups. In multivariable analysis, age was a significant risk factor for PFS (hazard ratio [HR], 2.08; 95% confidence interval [CI], 1.04 to 4.16). The IDH1mutation was the only significant prognostic factor for PFS (HR, 0.28; 95% CI, 0.13 to 0.59) and OS (HR, 0.19; 95% CI, 0.07 to 0.50). Adverse events over grade 3 were seen in 16 patients (40.0%) in the treatment group and were reversible. Conclusion Concurrent and adjuvant temozolomide in Korean adults with newly diagnosed nonco- deleted anaplastic gliomas showed improved 2-year PFS. The survival benefit of this regimen needs further analysis with long-term follow-up at least more than 10 years.
단일 Database Field를 이용한 PHP 무한 File Upload 구현
황기환,변기환,이지영,Hwang, Ki-Hwan,Byun, Ki-Hwan,Lee, Jie-Young 한국정보기술전략혁신학회 2009 情報學硏究 Vol.12 No.2
Currently the Web, multiple files in the Client to upload to the server of the multi-upload method, files are stored in specific folders on the server, the file name field in DB(Database Field) stored in a way that the process has been widely utilized. Therefore, a minimum number of file upload as many file names in the Database and the Table should be created in the field, but also a variable number of files can be uploaded has no limits. In this paper we proposed the new method that files to be uploaded to the server, you can upload a limited number of files, nor due to upload files to reduce load on the database to improve the processing speed of a single field using a multi-method file uploads using PHP directly implemented
황기환 한국정보기술학회 2003 Proceedings of KIIT Conference Vol.2003 No.-
본 논문에서는 3차원 X-ray 토모그라픽 영상의 분해능에 관하여 연구하였다. X-ray 단층 촬영기법을 첨단 산업분야에 적용시키기 위하여 다층구조물에 대한 다중 프로젝션으로부터 토모그라픽 데이터 획득하고 FBP(Filtered Back Projection) 알고리즘을 이 용하여 토모그라픽 영상을 복원하였다. 모의실험을 통해 복원한 X-ray 토모그라픽 영상은 4 프로젝션 이상에서 다층구조물에 대한 각층이 분리된 영상을 얻었다. 결과적으로 X-ray를 이용하여 복원한 토모그라픽 영상은 다층구조물에 대해서도 좋은 분해능을 갖는 영상정보를 획득하는데 유용함을 확인하였다.
Endovascular Treatment for Acute Ischemic Stroke Patients over 80 Years of Age
황기환,Gyojun Hwang,권오기,Chang Hyeun Kim,Seung Pil Ban,한문구,배희준,Beom Joon Kim,Jae Seung Bang,오창완,Boram Lee,Eun-A Jeong 대한뇌혈관외과학회 2015 Journal of Cerebrovascular and Endovascular Neuros Vol.17 No.3
Objective:We evaluated the effect of endovascular treatment (EVT) for acute ischemic stroke in patients over 80 years of age. Materials and Methods:The records of 156 acute stroke patients aged over 80 years who were considered as candidates for EVT were analyzed. Fifty-six patients (35.9%, EVT group) underwent EVT and 100 patients (64.1%, non-EVT group) did not. Outcomes, in terms of functional outcomes and rates of symptomatic hemorrhage, in-hospital morbidity and mortality, were compared between groups. Each comparison was adjusted for age, time from onset, initial National Institute of Health Stroke Scale, and pre-stroke modified Rankin Scale (mRS). Results:More patients in the EVT group achieved good outcomes (mRS score of 0-2) at 3 months (35.7% vs. 11.0%, adjusted odds ratio [OR] 4.779 [95% confidence interval 1.972-11.579], p = 0.001) and 12 months (35.7% vs. 14.0%, adjusted OR 3.705 [1.574-8.722], p = 0.003) after stroke. During admission, rates of hospital-acquired infection including pneumonia (12.5% vs. 29.0%, adjusted OR 0.262 [0.098-0.703], p = 0.008) and urinary tract infection (16.0% vs. 34.0%, adjusted OR 0.256 [0.099-0.657], p = 0.005) were significantly lower in the EVT group. More symptomatic hemorrhages (10.7% vs. 2.0%, adjusted OR 6.859 [1.139-41.317], p = 0.036) occurred in the EVT group, but no significant difference was observed in in-hospital mortality rate (12.5% vs. 8.0%, adjusted OR 1.380 [0.408-4.664], p = 0.604). Conclusion:EVT improved functional outcome and reduced the risk of hospital-acquired infections in acute stroke patients over 80 years of age without increasing the risk of in-hospital mortality, although symptomatic hemorrhage occurred more frequently after EVT.
CT Fluoroscopy-guided Aspiration of Intracerebral Hematomas: Technique and Outcomes
황기환,Gyojun Hwang,권오기,Jae Seung Bang,오창완 대한뇌혈관외과학회 2015 Journal of Cerebrovascular and Endovascular Neuros Vol.17 No.1
Objective:The authors evaluated the feasibility and targeting accuracy of CT fluoroscopy (CTF)-guided catheter placement and aspiration of intracerebral hematoma (ICH)s. Materials and Methods:Nine patients (mean age, 63.3 ± 15.3 years) were treated by CTF-guided hematoma aspiration under local anesthesia. The targeting errors in the lesion center, volume of the aspirated hematoma, accuracy of the final catheter position, procedure time, and clinical outcomes were evaluated. Results:All catheters were successfully placed in the center of the hematoma. The mean volume of the aspirated hematoma was 20.6 ± 8.8 mL (pre-treatment, 44.7 ± 20.1 mL; post-treatment, 24.1 ± 13.8 mL). The average procedure time was 25.1 minutes (range, 18-32 minutes). In one case with a scanty residual hematoma, the catheter was removed at the end of the procedure. In the remaining eight cases, the catheter was left in the residual hematoma for drainage and all catheter tips were accurately located in the final position. There were no procedure-related complications, including rebleeding and infection. Conclusion:CTF-guided ICH aspiration is a feasible, quick, and accurate procedure which could substitute for stereotactic methods. The accurate catheter position provided by real-time observation enables an effective aspiration and drainage of hematomas.
황기환,전계석,Hwang, Ki-Hwan,Jun, Kye-Suk 한국음향학회 1997 韓國音響學會誌 Vol.16 No.3
본 논문에서는 SLAM(Scanning Laser Acoustic Microscope) 시스템을 이용하여 고체 내부에 발생한 크랙의 깊이를 측정하는 방법을 연구하였다. SLAM 시스템은 초음파의 투과계수에 따른 그림자 영상을 재생시키므로 크랙 깊이에 대한 정확한 측정방법이 요구된다. 이를 위하여 시료에 초음파를 사각으로 입사시켜 얻은 SLAM 영상의 그림자영역과 시료내의 초음파 모드 변환에 대한 기하학적 구조를 이용하여 크랙의 깊이를 측정할 수 있는 방법을 제안하고 실험을 통하여 확인하였다. 실험을 위하여 알루미늄에 서로 다른 깊이로 수직형 라인-크랙의 결함을 갖는 시료를 가공하였고 시료에 초음파를 사각 입사시키기 위하여 20$^{\circ}$ 각도로 웨지를 제작하였다. 실험 결과, 크랙의 깊이가 증가할수록 SLAM 영상의 그림자 영역이 비례적으로 증가함을 보였고, 결함의 깊이에 대한 측정치와 실제치를 비교한 결과 약 6% 이하의 측정오차를 보였다. In this paper, we studied the configuration and depth measurement method of the crack in the interior of solid with scanning laser acoustic microscope. Precision measurement method of crack depth is required in SLAM because that system reconstructs the shadow image to the transmission coefficient. We proposed this method that used geometrical structure to the shadow area of SLAM images obtained from oblique incidence and the mode conversion of ultrasound in specimen and then experimented it. For this experiment, we fabricated various specimens which had the vertical line-crack with different depth and made the wedge as 20$^{\circ}$ for oblique incidence. Experimental results showed that the shadow area of SLAM images were proportional to the depth of crack. Measured depth error to the crack was less than 6% compared with practical crack depth.