Secretory Meningioma with Elevated Serum Carcinoembryonic Antigen

장종희,장진우,박용구,김태승 대한신경외과학회 2003 Journal of Korean neurosurgical society Vol.34 No.2

뇌동정맥기형에 대한 감마나이프 방사선수술시 치료성적에 영향을 주는 인자들

장종희,박용구,최재영,장진우,정상섭,Chang, Jong Hee,Park, Yong Gou,Choi, Jae Young,Chang, Jin Woo,Chung, Sang Sup 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.12

Objective : The goal of this study was to evaluate the effect of Gamma Knife radiosurgery(GKS) on cerebral arteriovenous malformation(AVM) and the factors associated with complete occlusion. Patients and Methods : A total of 369 radiosurgical procedures for 336 patients with cerebral AVMs were performed between December 1988 and June 2001. Three hundreds and twenty-four cases of 293 patients who were treated with GKS procedures from May 1992 to December 2000 were analyzed. Various clinical and radiologic parameters were evaluated. Results : The total obliteration rate for the cases with satisfactory radiological follow-up(more than 2 years) after GKS was 79.3%. In multivariate analysis, maximal diameter, angiographic form of AVM nidus, and number of draining veins significantly influenced the result of radiosurgery. In addition, marginal radiation dose, Spetzler-Martin grade, and flow pattern of AVM nidi also partly influenced the radiosurgical outcome. Conclusion : GKS on cerebral AVM is considered as an effective treatment modality. The risk of hemorrhage seems to decrease within the latency interval between GKS and complete occlusion of nidus. Along with the size, topography, or radiosurgical parameters of AVMs, it is necessary to consider the angioarchitectural and hemodynamic aspects to select proper candidates for radiosurgery.

시상밑핵 병소가 파킨슨병 모델 흰쥐에서 자발적 행동과 뇌심부핵 신경세포 전기활동에 미치는 영향

장종희,박용숙,전미파,장진우,박용구,정상섭 대한신경외과학회 2004 Journal of Korean neurosurgical society Vol.35 No.6

Objective : The purpose of this study is to investigate the effect of ipsilateral subthalamic nucleus(STN) lesioning on the spontaneous behavioral changes and the alteration of neuronal activities of deep cerebral nuclei in the rat parkinsonian model with 6-hydroxydopamine(6-OHDA). Methods : To identify the spontaneous behavioral changes, apomorphine-induced rotational test and forepaw adjusting step were performed. We subsequently investigated the alteration of neuronal activities in the substantia nigra pars reticulata(SNpr) and globus pallidus(GP), in order to compare them with the behavioral changes in rat parkinsonian models. Results : The STN lesioning in the rat parkinsonian model clearly improved behavioral changes. Compared to the normal control rats, rat PD models exhibited a significant increase in mean firing rates and the percentage of bursting neurons in the STN and SNpr. In the STN-lesioned rat PD models, mean firing rates and the percentage of bursting neurons in the SNpr were reduced and those in the GP increased. Conclusion : STN lesioning induced behavior improvement in rat parkinsonian models seems to be consistent with the surgical outcomes of the STN stimulation therapy in advanced Parkinsonn’s disease(PD). The alteration of the neuronal activities in the SNpr and GP suggests that these sites are responsible for the improvement of parkinsonian motor symptoms observed following STN lesioning in rat parkinsonian models. The significance of bursting activity in the SNpr and GP remains obscure. Further study is necessary to elucidate the pathophysiological mechanism of PD

터어키안 주변종양에 대한 감마나이프 방사선 수술

장종희,장진우,박용구,정상섭,Chang, Jong Hee,Chang, Jin Woo,Park, Yong Gou,Chung, Sang Sup 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.10

Objective : Around the sellar area, there are many important structures. But, the optimal radiation dosage for minimal toxicity to surrounding neural tissue has not been firmly established. The purpose of this study is to evaluate the radiosurgical outcome of juxtasellar tumors and to investigate the relationship between radiation dosage and toxicity to neural tissue. Method : Between May 1992 and June 2000, we treated 65 juxtasellar tumors by using the Leksell Gamma Knife. Among them, 52 patients who could be followed more than 1 year were included in this study. The radiosurgical dosage to the optic pathway, cavernous sinus, Meckel's cave, hypothalamus, pituitary gland and stalk, and brain stem was analyzed and correlated with clinical outcome. The mean follow-up period was 33.5 months(range 12.2- 99.0 months). Result : The clinical response rate was 69.2%. The volume response rate was 61.0% and the radiologic control rate was 92.7%. There were 4 complications(7.7%) of 2 trigeminal neuropathy, 1 abducens nerve palsy, and 1 trigeminal and transient abducens nerve palsy. The optic apparatus appeared to tolerate doses greater than 10Gy. The risk of cranial nerve complications in cavernous sinus seemed to be related to doses of more than 16Gy. In 3 of 4 patients who received more than 16Gy to cavernous sinus, the abducens or trigeminal neuropathy occurred. Also, one patient who received more than 15Gy to the Meckel's cave, trigeminal neuropathy developed. The hypothalamus, pituitary gland and stalk, and brain stem were relatively tolerable to radiation. Conclusion : Gamma Knife radiosurgery seems to be an effective method to control the growth of juxtasellar tumors. To avoid injury to surrounding important neural tissue, careful dose planning and further study for radiation toxicity to neural tissue were needed.

국제거래 소비자 상담 매뉴얼 및 사례집 제작

장종희 한국소비자원 2018 조사보고서 Vol.- No.-

경추부에 발생한 결핵성 척추염 : 증례보고 Report of 2 Cases

장종희,진병호,전병윤,노성우,조용은,윤도흠,김영수 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.4

Tuberculous spondylitis occurs in about 1% of all newly diagnosed cases of tuberculosis and it is the most common and most dangerous form of skeletal tuberculosis. It usually involve the lower thoracic and lumbar spine and the cervical involvement is rare. Therapy should consist of administration of antituberculotic agents and if indicated surgical curettage and stabilization The early diagnosis and management was important Due to the MR imaging for the evaluation of spinal disorders and the recent increase of patients with AIDS suggest that the prevalence of skeletal tuberculosis including tuberculous spondylitis is increasing Authors report two cases of cervical tuberculous spondyiitis with review of literatures.

두개인두종에 대한 감마나이프 방사선수술

장종희,장진우,박용구,정상섭,Chang, Jong Hee,Chang, Jin Woo,Park, Yong Gou,Chung, Sang Sup 대한신경외과학회 2001 Journal of Korean neurosurgical society Vol.30 No.5

Objective : The purpose of this study are to evaluate the effectiveness of Gamma Knife radiosurgery(GKS) as a treatment of craniopharyngioma and to investigate the proper dose planning technique in GKS for craniopharyngioma. Method : Between May 1992 and March 1999, seven Gamma Knife radiosurgical procedures were done for residual tumor mass of 6 patients with craniopharyngioma after microsurgical resection. Conventional radiation therapy was not performed. In this study, their clinical, radiological and radiosurgical data were analyzed and the radiation dosage to the optic pathway, hypothalamus, pituitary stalk, and cavernous sinus were calculated and correlation with clinical outcome was evaluated. The mean follow-up period was 33.5 months(12.3-55.2 months). Result : The mean tumor volume was 4.4cc(0.4-18.0cc) and the maximum radiation dose ranged from 14 to 32 Gy(mean 20.9Gy). The radiation was given with isodose curve, 50-90% and the marginal dose varied within 8-22.4Gy(mean 12.7Gy). The mean number of isocenter was 4.3(1-12). The tumor was well controlled in all cases. In 5 of 7 cases, the size of tumor decreased to 10-50% of pre-GKS volume and remaining two showed no volume change. The mean dose to optic pathway was 5.7Gy(5.1-11.2Gy) and there were no complications. Conclusion : GKS seems to be effective for control of craniopharyngioma as an adjuvant treatment after microsurgical resection and even suboptimal dose for tumor margin is considered to be enough for tumor control. It is safe with careful dose planning to protect surrounding important structures, especially optic pathway. We believe conventional radiation therapy should be avoided because it has limitation for dose planning of additional treatments such as radiosurgery or intracystic instillation of radioisotope in case of recurrence.

핍지 교종의 예후 인자

장종희,김동석,최중언,정상섭,이규창 대한신경외과학회 1996 Journal of Korean neurosurgical society Vol.25 No.4

Oligodendrogliomas are uncommon tumors that develop from oligodendrocytes. They may be pure of associated with astrocyte proliferation. These tumors affect middle-aged adults and are characterized by their slow growth and their fairly suggestive neuroradiological features which are those of a large. calcified. poorly enhanced. peripheral frontal lesion. They are usually benign. but their clinical behavior is variable in a retrospective study of 55 cases with pure oligodendroglioma. the 5- and 10-year survival rates were 61% and 42%. respectively. The influences of the age and sex of the patient. size. location and other radiological findings. the extent of surgical resection. effect of additional radiation therapy and pathological findings of the tumor were investigated Among the14 prognostic factors. the location and pathological findings of the tumor significantly affected the survival rates of the patients But. the extent of resection and additional radiation therapy were not related to survival.

해면효과익의 실험적 연구와 PARWIG선의 설계 및 제작

장종희,전호환,정광효,이 준 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-

지면효과(Wing In Ground Effect, WIG)의 개념은 날개가 지면 가까이 비행할 때 유기저항(Induced drag)의 감소와 양력의 증가로 양항비가 증가하는 것이다. 이러한 효과를 이용하여 지면 또는 해면 가까이 항주함으로서 해면효과익선이 같은 속도의 비행기보다 경제성이 좋은 것으로 평가되어지고 있다. 또한 PAR(Power Augmented Ram)현상은 1970년대경 발견된 것으로서 날개 앞에 부착된 프로펠러의 후류를 날개 밑으로 불어넣어 해면효과익선이 저속에서도 이수할 수 있도록 하여 WIG선의 성능을 향상시키는 계기가 되었다. 본 논문은 풍동을 이용하여 지면에서 날개후연까지 높이의 변화, 앙각의 변화 및 날개끝단판(End- plate)의 변화에 따른 날개의 양력, 항력 및 종방향모멘트를 계측하여 분석하고 2.5m급 무선 조종 PARWIG선의 설계개념과 제작과정에 대해서 설명한다. In the early of the 20th century, it was noted that a wing operating in close proximity to the ground exhibits a reduction in induced drag, which increases its lift/drag ratio. For several decades this phenomenon, called the wing-in-ground-effect(WIG), was studied because it complicated the takeoff and landing of aircraft. In the 1970s, the Power Augmented Ram(PAR) phenomenon was discovered, which significantly enhanced the performance of the WIG concept. The main purpose of this study is to design a 2.5m size, remote control PARWIG model aiming to develop an one manned leisure PARWIG craft. The lift and drag force are measured in a wind tunnel for wings with different flying heights, angles of attack and endplates. Based on the experimental results, 2.5m size model craft is designed and constructed.

운동장해질환 환자에서 미세전극기록하에 시행한 심부뇌자극

김상현,장종희,장진우,박용구,정상섭 대한신경외과학회 2002 Journal of Korean neurosurgical society Vol.31 No.1

Objective:The authors analyzed the findings of microelectrode recording data and reported the surgical outcomes of movement disorder patients. Methods:Since February 2000, the authors have used DBS for the movement disorders. We evaluated 4 patients who were followed more than 12 months after operation. One patient with essential tremor was treated with thalamic stimulation and three patients with idiopathic advanced Parkinson's disease with bilateral subthalamic nucleus stimulation. The electrodes were inserted under microelectrode recording. Clinical assessments were performed preoperatively and postoperatively by neurologist. Results:All features of parkinsonian symptoms improved and the greatest benefit occurred in off-time and ADL. Interestingly our three patients with advanced Parkinson's disease did not have off-time after bilateral stimulation of subthalamic nucleus. There were no adverse side effects related to microelectrode recording or DBS procedure in all 4 patients. In our results of microelectrode recording of subthalamic nucleus, subthalamus showed higher firing rate than that of substantia nigra pars reticularis. Mean burst frequency of subthalamic nucleus was much higher than that of substantia nigra pars reticularis. Conclusion:The first trials of DBS in Korea also demonstrated favorable outcomes for movement disorders. Key words:Deep brain stimulation(DBS);Microelectrode recording;Parkinson's disease;Essential tremor;Subthalamic nucleus;Thalamus.