Nucleotide Excision Repair Gene ERCC2 and ERCC5 Variants Increase Risk of Uterine Cervical Cancer

주정남,윤경아,Tomonori Hayashi,공선영,신혜진,박보람,김영민,황상현,김정선,신애선,김주영 대한암학회 2016 Cancer Research and Treatment Vol.48 No.2

Purpose Defects in the DNA damage repair process can cause genomic instability and play an important role in cervical carcinogenesis. The purpose of this study was to analyze the association of 29 candidate single nucleotide polymorphisms (SNPs) in genes in the DNA repair pathway, TP53, and TP53BP1 with the risk of cervical cancer. Materials and Methods Twenty-nine SNPs in four genes in the DNA repair pathway (ERCC2, ERCC5, NBS1, and XRCC1), TP53, and TP53BP1 were genotyped for 478 cervical cancer patients and 922 healthy control subjects, and their effects on cervical carcinogenesis were analyzed. Results The most significant association was found for rs17655 in ERCC5, with an age-adjusted p-value < 0.0001, for which a strong additive effect of the risk allele C was observed (odds ratio, 2.01 for CC to GG). On the other hand, another significant polymorphism rs454421 in ERCC2 showed a dominant effect (odds ratio, 1.68 for GA+AA to GG) with an age-adjusted p-value of 0.0009. The association of these polymorphisms remained significant regardless of the age of onset. The significant result for rs17655 was also consistent for subgroups of patients defined by histology and human papillomavirus (HPV) types. However, for rs454421, the association was observed only in patients with squamous cell carcinoma and non-HPV 18 type. Conclusion The results of this study show a novel association of cervical cancer and the genes involved in the nucleotide excision pathway in the Korean population.

쌀가루 혼합분으로 제조한 스폰지 케이크의 품질 특성

주정은 ( Jung Eun Ju ),남연화 ( Youn Hwa Nam ),이경애 ( Kyong Ae Lee ) 한국조리과학회 2006 한국식품조리과학회지 Vol.22 No.6

Nomogram Estimating the Probability of Intraabdominal Abscesses after Gastrectomy in Patients with Gastric Cancer

엄방울,주정남,박보람,윤홍만,류근원,김수진,김영우 대한위암학회 2015 Journal of gastric cancer Vol.15 No.4

Purpose: Intraabdominal abscess is one of the most common reasons for re-hospitalization after gastrectomy. This study aimed to develop a model for estimating the probability of intraabdominal abscesses that can be used during the postoperative period. Materials and Methods: We retrospectively reviewed the clinicopathological data of 1,564 patients who underwent gastrectomy for gastric cancer between 2010 and 2012. Twenty-six related markers were analyzed, and multivariate logistic regression analysis was used to develop the probability estimation model for intraabdominal abscess. Internal validation using a bootstrap approach was employed to correct for bias, and the model was then validated using an independent dataset comprising of patients who underwent gastrectomy between January 2008 and March 2010. Discrimination and calibration abilities were checked in both datasets. Results: The incidence of intraabdominal abscess in the development set was 7.80% (122/1,564). The surgical approach, operating time, pathologic N classification, body temperature, white blood cell count, C-reactive protein level, glucose level, and change in the hemoglobin level were significant predictors of intraabdominal abscess in the multivariate analysis. The probability estimation model that was developed on the basis of these results showed good discrimination and calibration abilities (concordance index=0.828, Hosmer- Lemeshow chi-statistic P=0.274). Finally, we combined both datasets to produce a nomogram that estimates the probability of intraabdominal abscess. Conclusions: This nomogram can be useful for identifying patients at a high risk of intraabdominal abscess. Patients at a high risk may benefit from further evaluation or treatment before discharge.

Risk of Pancreatic Cancer in Relation to ABO Blood Group and Hepatitis C Virus Infection in Korea: A Case-Control Study

우상명,주정남,이우진,박상재,한성식,김태현,고영환,김현범,홍은경 대한의학회 2013 Journal of Korean medical science Vol.28 No.2

Several studies have reported that ABO blood group, hepatitis B virus (HBV) and hepatitis C virus (HCV) infection contribute to the development of pancreatic cancer. The aim of this study was to evaluate the association between these factors and pancreatic cancer in the Korean population. We retrospectively recruited 753 patients with pancreatic cancer and 3,012 healthy controls, matched 4 to 1 with cancer patients for age and sex, between 2001 and 2011, at the National Cancer Center, Korea. A multivariate logistic regression analysis was employed to estimate adjusted odds ratios (AORs). The AOR for pancreatic cancer in subjects with non-O blood types (A, AB, and B), compared to blood type O, was 1.29 (95% CI, 1.05-1.58; P = 0.01). Seropositivity for hepatitis B virus surface antigen was not significantly related to pancreatic cancer, either in univariate (odds ratio 1.03;95% CI, 0.69-1.53; P = 0.91) or multivariate analysis (AOR, 1.02; 95% CI, 0.67-1.56;P = 0.93). The AOR for pancreatic cancer in subjects displaying seropositivity for anti-HCV was 2.30 (95% CI, 1.30-4.08; P < 0.01). Our results suggest that the non-O blood types and anti-HCV seropositivity, but not HBV infection, may increase the risk of developing pancreatic cancer in Korea, where HBV is endemic.

Validity of Korean Versions of the Multiple Sclerosis Impact Scale and the Multiple Sclerosis International Quality of Life Questionnaire

허소영,주정남,김수현,정애란,박기병,김우준,박민수,김호진 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.2

Background and Purpose Assessment of the health-related quality of life (HRQoL) is important in clinical evaluations of multiple sclerosis (MS) patients for quantifying the impact ofillness and treatment on their daily lives. Although MS-specific HRQoL instruments have beenused internationally, there are no data regarding HRQoL instruments specifically designed forpatients with MS in Korea. The objective of this study was to determine the reliability and validity of the Korean Multiple Sclerosis Impact Scale (MSIS-29) and the Multiple Sclerosis International Quality of Life (MusiQoL) questionnaire. Methods Fifty-six patients with MS were recruited from June 2009 to February 2010 at theNational Cancer Center in Korea. The original English versions of the MSIS-29 scale and theMusiQoL questionnaire were translated into Korean and evaluated for their acceptability, reliability, and validity. Results The patients wereaged 36.5±8.6 years (mean±SD; range, 20–56 years). Their scoreon the Expanded Disability Status Scale was 2.0±1.9 (mean; range, 0–7.5), and their diseaseduration was 5.2±4.7 years (mean±SD; range, 1–24 years). The Korean versions of the MSIS29 and MusiQoL questionnaires showed satisfactory psychometric properties, including construct validity (item-internal consistencies of 0.59–0.95 and 0.59–0.92, respectively; item-discriminant validities of 95–100% and 93.8–100%), internal consistency (Cronbach’s alphacoefficients of 0.96–0.97 and 0.77–0.96), reliability (intraclass correlation coefficients of 0.78–0.90 and 0.50–0.93), unidimensionality (Loevinger scalability coefficients of 0.70–0.78 and0.63–0.90), and acceptability. External validity testing indicated the presence of significant correlations between similar aspects of the two questionnaires. Conclusions The Korean translated versions of the MSIS-29 and MusiQoL questionnairesdemonstrated reliability and validity for measuring HRQoL in Korean patients with MS.

Development and Validation of the Korean Version of the Female Sexual Function Index-6 (FSFI-6K)

이유미,임명철,주정남,박기병,이수지,서시정,이동옥,박상윤 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.5

Purpose: To evaluate the validity and reliability of the Korean version of the FemaleSexual Function Index-6 (FSFI-6K). Materials and Methods: Participants were recruited from February 2013 to July 2013. The primary survey was conductedfor 220 participants, and a follow-up was conducted 3 weeks (±1 week) afterthe primary survey. The FSFI-6K data were analyzed and compared to the referencevalues in the original FSFI. Results: Of the 220 participants, 199 (90.5%) returned to follow-up, 18 (8.2%) had no further contact, and 3 (1.4%) declined to respond. The internal consistency of the FSFI-6K as measured by Cronbach’s alphawas 0.888 and the reliability based on test-retest intraclass correlation was 0.606; these values were acceptable. The cutoff used for diagnosis of female sexualdysfunction by an receiver operating characteristics (ROC) curve was a score of 21; the sensitivity and specificity for this curve are 0.89 and 0.86, respectively. The area under the receiver operating curve was 0.948. Conclusion: The FSFI-6K has high internal consistency and acceptable reliability. This validated questionnaire can be used for the Korean population.

Quality of life and sexuality comparison between sexually active ovarian cancer survivors and healthy women

김세익,이유미,임명철,주정남,KiByung Park,이동옥,박상윤 대한부인종양학회 2015 Journal of Gynecologic Oncology Vol.26 No.2

Objective: To compare quality of life (QoL) and sexual functioning between sexually active ovarian cancer survivors and healthywomen. Methods: A cross-sectional study was performed in 103 successfully treated ovarian cancer survivors and 220 healthy women. All women had engaged in sexual activity within the previous 3 months, and ovarian cancer survivors were under surveillanceafter primary treatment without evidence of disease. QoL and sexual functioning were assessed using three questionnaires; theEuropean Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30), OvarianCancer Module (EORTC QLQ-OV28), and the Female Sexual Function Index (FSFI). Propensity score matching was used to adjustcovariates between the ovarian cancer survivor and healthy women groups. In total, 73 ovarian cancer survivors and 73 healthywomen were compared. Results: Poorer social functioning (mean, 82.4 vs. 90.9; p=0.010) and more financial difficulties (mean, 16.4 vs. 7.8; p=0.019) wereobserved among ovarian cancer survivors than among healthy women. Sexuality, both in terms of desire, arousal, lubrication,orgasm, satisfaction, and pain and in terms of interest in sex, sexual activity, and enjoyment of sex (EORTC QLQ-OV28) weresimilar between the groups. However, vaginal dryness was more problematic in ovarian cancer survivors, with borderlinestatistical significance (p=0.081). Conclusion: Sexuality was not impaired in ovarian cancer survivors who were without evidence of disease after primarytreatment and having sexual activities, compared with healthy women, whereas social functioning and financial status diddeteriorate. Prospective cohort studies are needed.

Application of the International Metastatic Renal Cell Carcinoma Database Consortium and Memorial Sloan Kettering Cancer Center Risk Models in Patients with Metastatic Non-clear Cell Renal Cell Carcinoma: A Multi-institutional Retrospective Study Using t

김정권,김성한,송미경,주정남,서성일,곽철,정창욱,송채린,황의창,서일영,이학민,홍성후,박재영,정진수 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2

Purpose The International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) and the Memorial Sloan Kettering Cancer Center (MSKCC) risk models were developed predominantly with clear cell renal cell carcinoma (RCC). Accordingly, whether these two models could be applied to metastatic non-clear cell RCC (mNCCRCC) as well has not been wellknown and was investigated herein. Materials and Methods From the Korean metastatic RCC registry, a total of 156 patients (8.1%) with mNCCRCC among the entire cohort of 1,922 patients were analyzed. Both models were applied to predict first-line progression-free survival (PFS), total PFS, and cancer-specific survival (CSS). Results The median first-line PFS, total PFS, and CSS were 5, 6, and 24 months, respectively. The IMDC risk model reliably discriminated three risk groups to predict survival: the median firstline PFS, total PFS, and CSS for the favorable, intermediate, and poor risk groups were 9, 5, and, 2 months (p=0.001); 14, 7, and 2 months (p < 0.001); and 41, 21, and 8 months (p < 0.001), all respectively. The MSKCC risk model also reliably differentiated three risk groups: 9, 5, and, 2 months (p=0.005); 10, 7, and 3 months (p=0.002); and 50, 21, and 8 months (p < 0.001), also all respectively. The concordance indices were 0.632 with the IMDC model and 0.643 with the MSKCC model for first-line PFS: 0.748 and 0.655 for CSS. Conclusion The current IMDC and MSKCC risk models reliably predict first-line PFS, total PFS, and CSS in mNCCRCC.

The Role of One-Year Endoscopic Follow-Up for the Esophageal Remnant and Gastric Conduit after Esophagectomy with Gastric Reconstruction for Esophageal Squamous Cell Carcinoma

박승용,이현성,장희진,이종율,주정남,조재일 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.2

Purpose: After esophagectomy and gastric reconstruction for esophageal cancer, patients suffer from various symptoms that can detract from quality of life. Endoscopy is a useful diagnostic tool for evaluating patients after esophagectomy. This observational study was performed to investigate the correlation between symptoms and endoscopic findings one year after esophageal surgery and to assess the clinical usefulness of one-year endoscopic follow-up. Materials and Methods: From 2001 to 2008, 162 patients who underwent esophagectomy with gastric reconstruction were endoscopically examined one year after operation. Results: Patients suffered from the following symptoms: nocturnal cough (n=10), regurgitation (n=7), cervical heartburn (n=3), lump sensation (n=2), dysphagia (n=20) and odynophagia (n=22). Eighty-five (52.5%) patients had abnormal findings on endoscopic examination. Twelve (7.4%) patients had reflux esophagitis, and 37 (22.8%) patients had an anastomotic stricture. Only stricture-related symptoms were correlated with the finding of anastomotic strictures (p<0.001). Two patients had recurrences at the anastomotic sites, and four patients had regional lymph node recurrences with gastric conduit invasion visualized by endoscopy. Newly-developed malignancies in the esophageal remnant or hypopharynx that were not detected by clinical symptoms and imaging studies were reported in two patients. Conclusion: One year after esophagectomy, endoscopic findings were not correlated with clinical symptoms, except those related to stricture. Routine endoscopic follow-up is a useful tool for identifying latent functional and oncological lesions.

Development of the short version of the Gynecologic Cancer Lymphedema Questionnaire: GCLQ-7

김세익,김남주,이수정,주정남,서상수,정승현,박상윤,임명철,이선주 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.2

Objective: The Gynecologic Cancer Lymphedema Questionnaire (GCLQ) was designed to identify gynecologic cancer patients with lower limb lymphedema (LLL). The questionnaire consists of 20 items distributed over 7 symptom clusters. The present study aimed to develop an abridged form of the GCLQ for simpler screening and more effective follow-up of LLL. Methods: Data that had been collected for the development and validation of the Korean version of the GCLQ (GCLQ-K) were used in this study. Receiver-operating characteristic (ROC) curves were drawn according to the individual items of the GCLQ-K. Based on discrimination ability, the candidate items were selected in each symptom cluster. After combining the items, the best model was identified and named GCLQ-7. The area under the ROC curve (AUC) was compared between the GCLQ-7 and the original GCLQ-K. Results: In total, 11 candidate items were selected from the original GCLQ-K. Among the models made with the candidate items, GCLQ-7, the best model, was constructed with 7 items as follows: 1) limited knee movement, 2) general swelling, 3) redness, 4) firmness/tightness, 5) groin swelling, 6) heaviness, and 7) aching. This model exhibited an AUC of 0.945 (95% confidence interval [CI], 0.900–0.991), which is comparable with that of the original GCLQ-K (AUC, 0.867; 95% CI, 0.779–0.956). The best cutoff value was 2 points, at which the sensitivity and specificity were 97.0% and 76.5%, respectively. Conclusion: The newly developed short version model, GCLQ-7, showed acceptable discrimination ability as compared with the original GCLQ-K.