한양방 동시 치료를 통하여 회복되지 않은 양측성 돌발성 난청 환자 1례

송민경,홍승욱,Song, Min-Kyung,Hong, Seung-Ug 대한한방안이비인후피부과학회 2010 한방안이비인후피부과학회지 Vol.23 No.1

Back ground & Objectives : Bilateral sudden sensorineural hearing loss(SSNHL) is very rare disease. This is the first case report in the oriental medical literature. This study describes a case of bilateral SSNHL with incomplete recovery. Methods : We treated 1 patient who had SSNHL sequentially in both ears. He received oriental and western medical treatments for more than 2 weeks and measured the hearing recovery. For diagnosis on this case, pure tone audiometry was used. The degree of improvement was evaluated by Siegel's Criteria. Results & Conclusions : This patient discharged without hearing improvement. For bilateral SSNHL patients, the result of treatment is important for their qualities of life. But the recovery rate of hearing in bilateral SSNHL is lower than unilateral SSNHL. The oriental medical therapy had some theraputic effects on SSNHL and the theraputic effects on bilateral SSNHL requires further study.

알레르기 비염 동물 모델에서 유산균 발효 신이(辛夷)의 효과

송민경,홍승욱,Song, Min-Kyung,Hong, Seung-Ug 대한한방안이비인후피부과학회 2013 한방안이비인후피부과학회지 Vol.26 No.1

Objectives : We aimed to determine therapeutic effects of probiotics-fermented Magnolia denudata(MD) in the allergic rhinitis model mice. Methods : Polyphenol production, DPPH radical scavenging activity and NO inhibition of fermented MD by different bacterial strains were evaluated to select the one that is most suitable for fermentation. Thirty C57BL/6 mice were divided randomly into 5 groups as follows: normal group, ovalbumin(OVA)-treated plus water fed(CON group), OVA-treated plus unfermented MD fed(UMD group), OVA-treated plus fermented autoclaved MD fed(A-FMD group) and OVA-treated plus fermented unautoclaved MD fed(FMD group). After 9 weeks, we observed changes in the blood cell count, OVA-specific IgE level, nasal rubbing, nasal mucosal tissue and body weight. Results : Extract of MD fermented by Bifidobacterium breve(BB) for 48 hours showed the highest anti-oxidant activity and anti-inflammatory activity out of all the other bacterial strains. The number of eosinophil count in A-FMD, FMD group and platelet count in FMD group showed statistically significant decrease(p<0.05). OVA-specific IgE level decreased in all 3 experimental groups, significantly in UMD and A-FMD group. Nasal symptoms were attenuated in all 3 experimental groups, statistically significant in A-FMD and FMD group (p<0.05). Histologically, infiltration of eosinophils into the nasal mucosa decreased in all 3 experimental groups, especially marked decrease in FMD group. Conclusions : According to the above results, it is considered that probiotics-fermented Magnolia denudata has inhibitory effects on the allergic rhinitis animal models.

강 구조물에 대한 폴리아닐린 함유도료의 방청특성

송민경,공승대,오은하,윤철훈,김윤신,임호섭,Song, Min-Kyung,Kong, Seung-Dae,Oh, Eun-Ha,Yoon, Hun-Cheol,Kim, Yoon-Shin,Im, Ho-Sub 한국환경보건학회 2010 한국환경보건학회지 Vol.36 No.3

In preparative anti-corrosive coating experiments, polyaniline was obtained by reacting an oxidizing agent with the monomer aniline. Further, the primer coating was prepared using a variety of widely-used materials such as urethane resin. For the top coating, epoxy resin and acrylic urethane resin were used. Characteristics of the coatings were assessed according to KS and ASTM specifications, and the structure of the polyaniline was characterized using FT-IR and TGA. For analysis of anti-corrosive properties in salt-spray experiments, measurements of the oxidation state of iron and surface atomic analysis were conducted using XPS and SEM-EDX. Unlike general anti-corrosive coatings which exhibit anti-corrosive effects only as a primer coating, the anti-corrosive coatings using polyaniline as the anti-corrosive pigment showed a marked synergistic effect with the top coatings. In other words, the top coatings not only produce a fine view effect, but also increase, through interaction with the primer coatings, the resistance to diffusion of corrosive factors from the external environment. It was also found that, unlike the heavy metal oxide-forming layer of the passive barrier alone, the polyaniline anti-corrosive pigment oxidized iron at the interface with the iron substrate to form a passive barrier in the oxidic layer, and itself formed a potential barrier layer with anti-corrosive factors from the external environment. Although the passive layer was damaged, the damaged area did not become completely oxidized iron; on the contrary, it showed a tendency to reduction. This can be interpreted such that a passive layer is formed again on the damaged area, and that at the same time there is a tendency to self-healing.

연구논문 : 국내 호텔기업의 경영성과 수준에 따른 경영성과 결정요인에 관한 연구: OLS 회귀분석과 Quantile 회귀분석 비교를 중심으로

송민경 ( Min Kyung Song ),장염려 ( Yanli Zhang ),김상혁 ( Sang Hyuck Kim ) 대한관광경영학회 2015 觀光硏究 Vol.30 No.5

본 연구의 목적은 국내 호텔기업의 경영성과 결정요인을 재무요인과 비용요인으로 구분하여 OLS 회귀분석과 분위수 회귀분석의 분석결과의 차이를 제시함으로써 국내 호텔기업의 경영성과수준에 따라 경영성과 결정요인을 측정하고자 한다. 본 연구의 표본은 53개의 국내특급호텔의 3년간 자료를 pooling하여, 총 유효 샘플 159개를 최종분석에 이용하였다. 본 연구의 분석결과를 살펴보면, 호텔기업의 경영성과 수준에 따른 결정요인의 규명을 위해 실시한 분위수 회귀분석 결과는 OLS 회귀분석 결과와는 차이점을 보였다. 비용요인들은 대부분의 경영성과수준에서 영향을 미치지 않는 것으로 나타났다. 그러나, 재무요인은 호텔기업의 경영성과에 영향을 미치나, 그 수준에 따라 영향관계에 차이가 있음을 보여주었다. 구체적으로 살펴보면, 경영성과수준이 낮은 호텔기업의 경우에는 안정성과 활동성비율이 경영성과에 영향을 미치는 결정요인으로 나타났으며, 경영성과수준이 중간인 호텔기업의 경우에는 활동성을 제외한 모든 재무요인이 영향을 미치지 않는 것으로 나타났다. 마지막으로 경영성과수준이 높은 호텔기업의 경우에는 유동성, 활동성, 성장성이 경영성과에 영향을 미치는 결정요인으로 나타났다. 결론적으로 경영성과의 결정요인으로 비용요인보다는 재무요인이 중요한 영향을 미치며, 경영성과 수준에 따라 그 결정요인이 다름을 밝혔다. The purpose of this study is to identify the determinants of hotel company’s business performance by different level of business performance using quantile regression analysis. In sum, 159 sample companies were gathered from secondary database, then collected data were statistically analyzed. The results of this study are as follows: First, the cost variables were not significantly related with hotel company’s business performance based on the quantile regression results. However, some financial variables were significantly related with hotel company’s business performance. This results implies that the financial variables were more important factors to hotel business performance than cost variables. Secondly, the determinants of hotel company’s business performance were differently related with different level of business performance. Thirdly, the quantile regression analysis provides more insights than the OLS regression into understanding hotel company’s business performance. These results would help each hotel companies could establish different business strategies to increase their business performance depending on the level of business performance.

자궁경부 상피내 병변 및 자궁 경부암 186 예에서 자궁경부 세포진 검사의 위음성률에 괸한 연구

송민경(Min Kyung Song),권용일(Yong Il Kwon),박태철(Tae Chul Park),천민정(Min Jung Chon),신진웅(Jin Woong Shin),이진우(Jin Woo Lee),이준모(Jun Mo Lee),남궁성은(Sung Eun Namkoong) 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4

N/A Objective : To estimate false-negative rate of cervical smears in histologically confirmed squamous intraepithelial lesion and squamous cell carcinoma. Method : From 1993 to 1998, total 186 cases of cervical smear performed within 1 year before histological confirmation squamous intraepithelial lesion and squamous cell carcinoma, were reviewed and the false negative rate of the each group was analyzed. Results : 1. Histologic diagnosis of 186 cases includes 8 cases of low grade SIL, 87 cases of high grade SIL, 91 cases of squamous cell carcinoma. 2. Overall false negative rate was 18.8% (35/186). False negative rate of LSIL was higher (50%; 4/8) compared with the other two groups. (HSIL:23% ;20/87, SCC:12.1% ;11/91) 3. 18 of 35 false negative cases were reviewed. 8 cases(44.4%) were sampling error and 10 cases(55.6%) were interpretation error. 4. Estimated overall sampling error was 8-9% ; interpretation error 10-11%. Conclusion : Reducing the false negative rate of cervical smears, especially in cervical intraepithelial neoplasia lesion is important to save the patients from invasive cervical cancer. Further studies on the causes of false negatives and the efforts to eliminate these barriers are actually needed.

화호미곡창고 재생 프로젝트 -"법고창신(法古創新)"을 통해 옛에서 새로움을 찾다-

송민경(주저자) ( Min Kyung Song ),심민주(주저자) ( Min Joo Shim ),유혜리(주저자) ( Hye Lee Yu ),이진민(공동저자) ( Jin Min Rhie ),장미정(공동저자) ( Mi Jeong Jang ) 숙명여자대학교 산업디자인연구소 2015 숙명디자인학 연구 Vol.21 No.-

본 프로젝트는 버려진 공간의 재생이라는 큰 주제를 가지고 정읍시 화호리에 위치한 미곡창고의 디자인 방향을 제시하였다 옛 것을 버리고 새로움을 추구하는 것이 아니라, 옛 것 속에서 새로움을 찾는것이 이 프로젝트의 목표이다. 화호창의 기존의 천장, 벽체, 창문, 우물, 측구를 중심으로 옛 모습에서 새로운 디자인 방향성을 발견하여 새로운 식음문화공간의 모습을 제시한다. 또한 본 프로젝트는 버려진 공간의 역사성과 시간성에 주목하여 공간의 가치를 더하려고 한다. 본 프로젝트는 옛 공간과 새로운 디자인의 융합이라는 의미와 함께 창고로서의 기능도 잃지 않으면서 곡물창고와 어울리는 식음문화 공간을 연출하는 것에 의의가 있다. Under a broad theme of ‘recycling the deserted space,’ this project suggested the designing direction for refurbishing a rice warehouse located in Hwaho-ri, Jeongeup City, and the goal of this project is to create the new based on the old instead of replacing the old with the new. The project found out a new designing direction from the old shapes of the ceiling, walls, window frames, well and side-entrance frames of the rice warehouse in Hwaho-ri and recreate the old rice warehouse into a new dining space. Also, this project intended to add values to the space by placing the focus on the preservation of the historicity and temporality of the abandoned space. This project is meaningful in that is a product of the fusion of the old space with a new design, and that it created a new culinary space well-matched to its original purpose by preserving its function as a warehouse.

폐암과 동반된 Trousseau 증후군

송민경 ( Min Kyung Song ),김영삼 ( Young Sam Kim ),이기명 ( Kee Myung Lee ),김세규 ( Se Kyu Kim ),장준 ( Joon Chang ),김성규 ( Sung Kyu Kim ),이원영 ( Won Young Lee ) 대한결핵 및 호흡기학회 1995 Tuberculosis and Respiratory Diseases Vol.42 No.6

항암제를 투여한 HeLa와 OVCAR-3 세포주에서 Cytokeratin 18-Asp(396) (M30) 항체를 이용한 항암제 감수성의 측정

송민경 ( Min Kyung Song ),박상호 ( Sang Ho Park ),곽현성 ( Hyun Sung Kwack ),류기성 ( Ki Sung Ryu ),한구택 ( Ku Taek Han ) 대한산부인과학회 2010 Obstetrics & Gynecology Science Vol.53 No.1

목적: 항암화학요법제의 투여로 유발되는 세포고사의 과정에서 cytokeratin 18의 분해 산물인 cytokeratin 18-Asp(396) (M30) 단편의 노출된 신항원 결정기와 특이적으로 결합하는 M30 단클론항체를 이용한 세포고사 측정이 자궁경부암과 난소암에서 신보조화학요법의 감수성을 평가하기 위한 표지자로서의 사용가능성을 알아보기 위해 본 실험을 실시하였다. 연구 방법: 1,000 nM의 paclitaxel, 250 μg/mL의 cisplatin과 30 μM의 camptothecin의 투여와 함께 배양한 HeLa와 OVCAR-3 세포주들에서 M30 단클론항체를 이용한 면역형광염색 실시 후, 유세포분석에 의해 세포주기의 변화와 세포고사의 정도를 측정하였으며, 또한 이들의 배양액에서 M30 단클론항체를 이용한 ELISA법으로 세포고사의 정도를 측정했다. 결과: Paclitaxel 투여군에서 HeLa와 OVCAR-3 세포주 모두에서 대조군에 비해 G0G1이 감소되었고, G2M 분기 분획은 증가하였다. Cisplatin 투여군에서 두 세포주에서 G0G1과 S 분획이 대조군과 차이가 없었으며, HeLa 세포주에서는 G2M 분기 분획이 감소되고 OVCAR-3 세포주에서는 감소되는 경향이 관찰되었다. Camptothecin 투여군에서 S와 G2M 분기 분획이 두 세포주 모두에서 대조군과 차이가 없었으며, HeLa 세포주에서는 G0G1 분기 분획이 유의한 증가를 나타냈고, OVCAR-3 세포주에서는 G2M 분기 분획이 감소된 경향을 보였다. G0G1하 첨봉 (Sub-G0G1 peak)에 의해 측정된 세포고사의 정도는 paclitaxel 투여군에서 HeLa와 OVCAR-3 세포주 모두에서 차이가 없었으나, cisplatin 투 여군에서 OVCAR-3 세포주에서 유의하게 증가되었으며, camptothecin 투여군에서는 두 세포주 모두에서 유의하게 증가되었다. M30-FITC 형광도와 배양액 내에서 ELISA법으로 측정된 M30에 의한 세포고사의 정도는 모든 투여군에서 대조군보다 증가되었다. 결론: HeLa와 OVCAR-3 세포주들에서 paclitaxel, cisplatin과 camptothecin을 투여 후 다변수 유세포분석, 면역형광염색 및 ELISA법에 의해 세포주기 변화와 G0G1하 첨봉 및 M30 항원을 측정한 결과 세포고사의 유의한 증가가 확인됐으며, M30 항원의 측정이 좀 더 유의한 반응을 보였다. Objective: The aim of this study was to detect the levels of M30-antigens as a biomarker of apoptosis in cells and their culture media after treatments with anticancer drugs as a preclinical study. Methods: After HeLa and OVCAR-3 cells were treated respectively with paclitaxel, cisplatin, and camptothecin, the harvested cells were stained sequentially with M30 monoclonal antibodies and propidium iodide (PI). Afterwards, they were analyzed using a FACScan flow cytometer and observed under an immunofluorescence microscope for M30-FITC immunofluorescences. Levels of M30 antigens were also detected in their culture media using M30-Apoptosense ELISA kit. Results: The levels of M30-FITC immunofluorescences were elevated in both cell lines after each drug treatments compared with those of control cells. The levels of M30 antigens detected by ELISA in media culturing each cell line treated with each of drugs were elevated compared with those of control cells. Conclusion: This study suggests that M30-antigens representing chemotherapy induced apoptosis may be a useful biomarker for predicting and monitoring the response of neoadjuvant chemotherapy in patients with gynecologic cancers.

지연 허용 네트워크에서 노드의 접촉 이력을 이용한 향상된 메시지 전달 기법

송민경(Min Kyung Song),강민욱(Min Wook Kang),정윤원(Yun Won Chung) 한국정보기술학회 2018 한국정보기술학회논문지 Vol.16 No.9

In delay tolerant network (DTN), a node operates based on store-carry-forward approach, where a node stores messages in bundle layer, carries them while moving, and forwards them via opportunistic contact with another node. In this paper, we propose an improved message delivery scheme which delivers a message efficiently by using duplicated node and complemented node list of contact node in DTN. Performance analysis result shows that the proposed scheme has best delivery ratio, although it has higher overhead ratio than reachable probability centrality (RPC) and friendship and selfishness forwarding (FSF) schemes for varying buffer size and message generation interval.

군집분석을 이용한 수도권 도시의 유형화에 관한 연구

송민경(Song Min Kyung),장훈(Chang Hoon) 대한공간정보학회 2010 한국공간정보학회 학술대회 Vol.2010 No.1

본 논문은 수도권 내 지역을 도시적 특성에 따라 군집 분석하여 수도권의 지역유형을 구분하고 그 특성을 파악하고자 하였다. 수도권 도시의 유형화를 위해 2005년을 시점으로 도시의 구성요소인 인구, 활동, 토지 및 시설을 나타내는 지표 10가지를 선정하였으며, 주성분분석을 통해 변수들의 공통된 특성이나 유사한 성질에 따라 공통인자를 추출하였다. 추출된 인자에 대한 인자득점을 이용하여 군집분석을 행하였고, 군집분석의 방법은 계층적 군집방법인 최단연결법, 최장연결법, 평균연결법, 와드법을 이용하였다. 그 결과 수도권을 5개의 군집으로 유형화 할 수 있었다. This paper has analyzed Seoul metropolitan area on the basis of cluster characteristics and it is to understand the traits of each clusters. In order to modelize the area, 10 different indicators were selected among components of a city such as population, activities, land and facilities. Also through principal component analysis, similar characteristics or congenialities of the variables were derived as a common factor. The result was organized by factor score from hierarchical clustering method and as a final result, metropolitan area was clustered into five areas.