^99mTc-DMSA 검사에서 상대 신섭취율 산출 시 양면상 촬영의 유용성에 대한 고찰

김주연,이한울,권오준,김정열,박민수,조석원,강천구,김재삼,Kim, Joo-Yeon,Lee, Han-Wool,Kwon, O-Jun,Kim, Jung-Yul,Park, Min-Soo,Cho, Seok-Won,Kang, Chun-Goo,Kim, Jae-Sam 대한핵의학기술학회 2015 핵의학 기술 Vol.19 No.1

$^{99m}Tc-DMSA$ 신장 신티그라피는 피질에 주로 섭취되어 신실질을 영상화하고 좌우 신장 및 배후방사능에 관심영역을 설정함으로써 상대 신섭취율을 평가할 수 있는 검사로, 진단 및 치료 후 경과관찰에 이용되고 있다. 본 논문에서는 후면상과 양면상 촬영 시 그리고 신장의 깊이를 적용한 경우의 상대 신섭취율 변화를 비교하여 상관관계를 알아보고자 한다. 실험은 신장 팬텀 및 조직등가물질을 이용하여 신장의 깊이에 차이를 주며 깊이 당 각 5번씩 총 25번을 진행하였다. 임상연구는 2014년 2월부터 10월까지 본원에 내원하여 $^{99m}Tc-DMSA$ 검사를 시행한 36명의 성인 환자를 대상으로 하였다. 장비는 감마카메라 INFINIA를 사용하였으며 GE사의 Xeleris Ver. 2.1220을 이용하여 신장 및 배후 방사능 모두 자동으로 관심영역을 설정하였다. 또한 환자별 신장 깊이의 차이를 고려하여 측면상을 촬영한 후 실제 신장 깊이를 측정하였다. 후면상에서의 산술평균값과 양면상에서의 기하학적 평균값 그리고 후면상에 신장 깊이를 적용해준 상대 신섭취율을 비교해보고 유의한 차이가 있는지 살펴보았다. 팬텀 실험 결과 좌, 우 신장 깊이의 차이가 1 cm 미만인 경우에는 양면상을 촬영했을 때와 후면상에 실제 깊이를 적용해준 경우 유의한 차이를 보이지 않았으나(P>0.05), 1 cm를 초과한 경우에는 유의한 차이를 보였다(P<0.05). 임상 연구에서는 후면상만을 촬영해준 경우와 후면상에 신장 깊이를 적용해준 경우의 상관관계(r=0.988)에 비해 양면상을 촬영해준 경우와 후면상에 신장의 깊이를 적용하여 보정해준 경우가 더 높은 상관관계(r=0.999)를 나타냈다. 본 연구에서는 양면상과 후면상을 촬영했을 때의 상대 신섭취율 차이를 확인할 수 있었다. 후면상만 촬영한 경우에도 깊이를 보정해줬을 때와 비교하여 상관관계가 있음을 알 수 있었으나 오차를 줄이기 위해서는 양면상을 촬영해주는 방법을 권고한다. Purpose $^{99m}Tc-DMSA$ renal scintigraphy serves as location, size and shape of kidney, so it has been used for diagnosis and passage observation after the operation or treatment. There are 3 methods of calculating the relative renal uptake ratio such as geometric mean of the counts from the anterior and posterior views, arithmetical mean from the only posterior view and posterior view which applied the renal depths. In this study, we seek to correlation between the change of total relative uptake ratio according to different inspection methods of obtaining the renal count rate. Materials and Methods The phantom experiments proceeded 5 times depending on each renal depth with the kidney phantom and tissue equivalent materials. In the clinical research, we investigated 36 adult patients who had visited our hospital from february to october, 2014 and received $^{99m}Tc-DMSA$ renal scan. The equipment was used as a gamma camera named INFINIA (General Electric Healthcare, milwaukee, USA) and we drew the region of interests through semiautomatic method by using Xeleris Ver. 2.1220 of GE. In addition, we obtained the lateral view of kidney to measure the renal depth of each patient. Then the results were compared with 3 methods of calculating relative renal uptake ratio. Results The phantom studies show when the difference between the left ant right kidney depth were less than 1 cm, there were no statistically significant difference among values calculated through anterior and posterior views and only posterior view (P>0.05), while the excess of 1cm, the results showed a statistically significant change in the value (P<0.05). In case of clinical research, the correlation between total relative uptake ratio by obtaining both sides of image and posterior view applied the kidney depth (r=0.999) was higher than by obtaining only posterior view and applying the kidney depth to one side image (r=0.988). Conclusion This study has found that, the difference of calculating total relative uptake ratio compared with obtaining anterior and posterior views and only posterior view. In order to reduce the error, we recommend the method of obtaining anterior and posterior views and is considered to be useful, particularly the patients have similar uptake ratio of left and right kidney and difficulties of measurements of kidney depth.

테라비트급 나노 스케일 SONOS 플래시 메모리 제작 및 소자 특성 평가

김주연,김문경,김병철,김정우,서광열,Kim, Joo-Yeon,Kim, Moon-Kyung,Kim, Byung-Cheul,Kim, Jung-Woo,Seo, Kwang-Yell 한국전기전자재료학회 2007 전기전자재료학회논문지 Vol.20 No.12

To implement tera bit level non-volatile memories of low power and fast operation, proving statistical reproductivity and satisfying reliabilities at the nano-scale are a key challenge. We fabricate the charge trapping nano scaled SONOS unit memories and 64 bit flash arrays and evaluate reliability and performance of them. In case of the dielectric stack thickness of 4.5 /9.3 /6.5 nm with the channel width and length of 34 nm and 31nm respectively, the device has about 3.5 V threshold voltage shift with write voltage of $10\;{\mu}s$, 15 V and erase voltage of 10 ms, -15 V. And retention and endurance characteristics are above 10 years and $10^5$ cycle, respectively. The device with LDD(Lightly Doped Drain) process shows reduction of short channel effect and GIDL(Gate Induced Drain Leakage) current. Moreover we investigate three different types of flash memory arrays.

백내장 수술 후 생긴 낭포황반부종에서의 유리체강내 트리암시놀론 주입술 일차치료 효과

김주연,김정목,유영주,김철구,조성원,이태곤.Joo Yeon Kim. MD. Joung Mok Kim. MD. Young Ju Lew. MD. PhD. Chul Gu Kim. MD. Sung Won Cho. MD. PhD. Tae Gon Lee. MD 대한안과학회 2012 대한안과학회지 Vol.53 No.3

Purpose: To report the clinical manifestations of intravitreal triamcinolone injection as a primary treatment method for patients with cystoid macular edema after cataract surgery. Methods: The present retrospective study was comprised of patients diagnosed with cystoid macular edema after cataract surgery performed between March 2006 and March 2008. To treat the edema, intravitreal triamcinolone injection was administered. Best corrected visual acuity (BCVA) and central macular thickness were measured, and complications as well as efficacy of the treatment were evaluated. Results: Twelve eyes were selected for the present study with a mean patient age of 67.3 years. The average period between cataract surgery and diagnosis of cystoid macular edema was 7.6 weeks. All 12 eyes received an intravitreal triamcinolone injection, and the patients were followed up for an average of 6.7 months. BCVA (log MAR) was changed from 0.29 ± 0.12 to 0.11 ± 0.09, showing statistically significant improvement (p = 0.000). The OCT showed that the average CMT was statistically decreased from 390.58 ± 94.98 μm to 165.17 ± 39.95 μm (p = 0.001). No complications were reported after the procedure, and vision and edema improved after one month in all 12 eyes. Conclusions: After performing intravitreal triamcinolone injection as a primary treatment method for cystoid macular edema which developed after cataract surgery, rapid recovery and improvement of vision and macular thickness were confirmed in all 12 eyes. J Korean Ophthalmol Soc 2012;53(3):428-433

Ectopic cervical thymic squamous cell carcinoma misdiagnosed as thyroid cancer: a case report

김주연,정은정,Kim Jae-Myung,Lee Han Shin,박태진,정상호,Jeong Chi-Young,주영태 대한종양외과학회 2022 Korean Journal of Clinical Oncology Vol.18 No.2

Ectopic thymic neoplasm, particularly ectopic thymic carcinoma, is a rare disease that presents as a neck mass. Here, we present a case of ectopic thymic squamous carcinoma in a 65-year-old man who presented with persistent hoarseness. After fine needle aspiration cytology, the patient underwent total thyroidectomy with lymph node dissection. The final histopathological examination revealed the ectopic thymic squamous carcinoma. The patient was discharged without any postoperative complications. The patient received adjuvant radiation therapy and did not progress during the 1-year follow-up period.

대학생 개인정보보호 인식조사를 통한 교육 개선방안 연구

김주연,Kim, Ju-yeon 한국정보통신학회 2019 한국정보통신학회논문지 Vol.23 No.3

개인정보의 수집과 사용이 지속적으로 증가하고 있는 추세에서, 개인정보를 보호하기 위한 법적 근거가 마련되고 각종 정책과 제도가 시행되고 있지만, 개인정보보호에 관한 교육과 그 효과에 대한 분석이 부족한 상황이다. 이에 본 연구에서는 대학생들의 개인정보보호에 인식정도와 실제 인지수준에 대해 분석하고, 개인정보보호 교육의 만족도를 조사하였다. 분석결과에서 학생들의 개인정보보호에 대한 관심이나 개인정보 노출 염려는 매우 높은 편이었으나, 실제 개인정보보호를 위한 노력이나 개인정보보호를 위한 권리 및 제도에 대한 인지수준은 매우 낮은 것으로 분석되었다. 또한 정보보호 교육을 받은 경험 및 만족도도 매우 낮은 것으로 조사되었다. 학생들은 개인정보보호 교육의 필요성은 크게 공감하였고, 일회성 교육보다는 정기적이고 지속적인 교육을 선호하는 것으로 분석되었다. In the trend of continuously increasing collection and use of personal information, there are legal grounds for protecting personal information and various policies and systems are implemented, but there is insufficient analysis about education and its effect of personal information protection. In this study, we surveyed and analyzed the degree of awareness and actual perception level in the protection of personal information of college students, and investigated the satisfaction of personal information protection education. The results of the analysis showed that students' interest in privacy protection and concern about personal information exposure was very high, but the efforts to protect personal information and the perception level of rights and systems for protecting personal information was very low. In addition, the experience and satisfaction of education for personal information protection were found to be very low. Students felt that the necessity of education for personal information protection was strongly agreed and preferred regular and continuous education rather than one-time education.

ELMo 임베딩 기반 문장 중요도를 고려한 중심 문장 추출방법

김은희(Eun Hee Kim),임명진(Myung Jin Lim),신주현(Ju Hyun Shin) 한국스마트미디어학회 2021 스마트미디어저널 Vol.10 No.1

본 연구는 뉴스 기사에서 기사문을 구성하는 문장별 중요도를 고려하여 요약문을 추출하는 방법에 관한 것으로 문장 중요도에 영향을 주는 특성으로 중심 문장(Topic Sentence)일 확률, 기사 제목 및 다른 문장과의 유사도, 문장 위치에 따른 가중치를 추출하여 문장 중요도를 계산하는 방법을 제안한다. 이때, 중심 문장(Topic Sentence)은 일반 문장과는 구별되는 특징을 가질 것이라는 가설을 세우고, 딥러닝 기반 분류 모델을 학습시켜 입력 문장에 대한 중심 문장 확률값을 구한다. 또한 사전학습된 ELMo 언어 모델을 활용하여 문맥 정보를 반영한 문장 벡터값을 기준으로 문장간 유사도를 계산하여 문장 특성으로 추출한다. LSTM 및 BERT 모델의 중심 문장 분류성능은 정확도 93%, 재현율 96.22%, 정밀도 89.5%로 높은 분석 결과가 나왔으며, 이렇게 추출된 문장 특성을 결합하여 문장별 중요도를 계산한 결과, 기존 TextRank 알고리즘과 비교하여 중심 문장 추출 성능이 10% 정도 개선된 것을 확인할 수 있었다. This study is about a method of extracting a summary from a news article in consideration of the importance of each sentence constituting the article. We propose a method of calculating sentence importance by extracting the probabilities of topic sentence, similarity with article title and other sentences, and sentence position as characteristics that affect sentence importance. At this time, a hypothesis is established that the Topic Sentence will have a characteristic distinct from the general sentence, and a deep learning-based classification model is trained to obtain a topic sentence probability value for the input sentence. Also, using the pre-learned ELMo language model, the similarity between sentences is calculated based on the sentence vector value reflecting the context information and extracted as sentence characteristics. The topic sentence classification performance of the LSTM and BERT models was 93% accurate, 96.22% recall, and 89.5% precision, resulting in high analysis results. As a result of calculating the importance of each sentence by combining the extracted sentence characteristics, it was confirmed that the performance of extracting the topic sentence was improved by about 10% compared to the existing TextRank algorithm.

갑상선 결절에 대한 세침흡인 세포검사에서 비진단적 검체의 특징과 치료 전략

김주연,정은정,정상호,주영태,정치영,이영준,홍순찬,최상경,하우송,박순태,Ju-Yeon Kim,Eun-Jung Jung,Sang-Ho Jeong,Young-Tae Ju,Chi-Young Jeong,Young-Joon Lee,Soon-Chan Hong,Sang-Kyeong Choi,Woo-Song Ha,and Soon-Tae Park 대한갑상선-내분비외과학회 2010 The Koreran journal of Endocrine Surgery Vol.10 No.4

Curcuma longae Radix, Phellinus linteus 및 Scutellariae Radix 혼합추출물의 $A{\beta}$ (25-35) 유도 배양신경세포독성 및 마우스기억손상 억제효과

김주연,정하연,반주연,유재국,배기환,성연희,Kim, Joo-Youn,Jeong, Ha-Yeon,Ban, Ju-Yeon,Yoo, Jae-Kuk,Bae, Ki-Hwan,Seong, Yeon-Hee 한국약용작물학회 2009 한국약용작물학회지 Vol.17 No.6

The present study investigated an ethanol extract (HS0608) of a mixture of three medicinal plants of Curcuma longae radix, Phellinus linteus, and Scutellariae radix for possible neuroprotective effects on neurotoxicity induced by amyloid $\beta$ protein ($A{\beta}$) (25-35) in cultured rat cortical neurons and antidementia activity in mice. Exposure of cultured cortical neurons to $10\;{\mu}M$ $A{\beta}$ (25-35) for 36 h induced neuronal apoptotic death. At $1-50\;{\mu}g/m{\ell}$, HS0608 inhibited neuronal death, elevation of intracellular calcium concentration ($[Ca^{2+}]_i$), and generation of reactive oxygen species (ROS) induced by $A{\beta}$ (25-35) in primary cultures of rat cortical neurons. Memory loss induced by intracerebroventricular injection of ICR mice with 15 nmol $A{\beta}$ (25-35) was inhibited by chronic treatment with HS0608 (25, 50 and 100 mg/kg, p.o. for 7 days) as measured by a passive avoidance test. From these results, we suggest that the antidementia effect of HS0608 is due to its neuroprotective effect against $A{\beta}$ (25-35)-induced neurotoxicity and that HS0608 may have a therapeutic role in preventing the progression of Alzheimer's disease.

포도막염에 의한 이차개방각녹내장에서 마이토마이신 섬유주절제술과 아메드밸브삽입술의 임상성적

김주연,심형섭,김황기,손용호.Joo Yeon Kim. MD. Hyoung Sub Shim. MD. Hwang Ki Kim. MD. Yong Ho Sohn. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.4

Purpose: To assess and compare the clinical outcomes of primary trabeculectomy with mitomycin C and Ahmed valve implantation for secondary open-angle glaucoma following uveitis. Methods: This study was conducted retrospectively on 30 eyes of 25 patients with open-angle glaucoma secondary to uveitis that had undergone trabeculectomy with mitomycin C and 33 eyes of 24 patients that had undergone Ahmed valve implantation. The clinical outcome indicators used in this study were intraocular pressure (IOP), number of anti-glaucoma agents, surgical success rate and occurrence of complications. Results: Mean IOP and surgical success rate in patients who had undergone trabeculectomy with mitomycin C after a 12 month postoperative period were 14.0±8.2 mmHg and 76.7%, respectively, while those of patients with Ahmed valve implantation were 13.2±7.7 mmHg and 81.8%. The data did not show clinical significance. There was greater risk of surgical failure in patients at a younger age and/or with diabetes mellitus in cases of having gone through trabeculectomy with mitomycin C. Conclusions: Both trabeculectomy with mitomycon C and Ahmed valve implantation can be considered as primary surgical treatments for patients with open-angle glaucoma secondary to uveitis. However, trabeculectomy with mitomycin C should only be applied to a limited extent in patients that are young and/or have diabetes mellitus. J Korean Ophthalmol Soc 2010;51(4):575-580

국가기록원의 소장기록물 저작권 요청 사례 분석

김주연,최재황,Kim, Joo Yeon,Choi, Jae Hwang 한국도서관정보학회 2014 한국도서관정보학회지 Vol.45 No.2

국가기록원은 소장기록물의 저작권을 보호하기 위하여 현재 '소장기록물 저작권 운영지침'과 '열람실 운영규정'을 마련하여 운영 중이다. 그러나 국가기록원 '소장기록물 저작권 운영지침'과 '열람실 운영규정'은 저작권법의 준용 또는 국가기록원 내부의 저작권 관리 원칙만을 규정하고 있을 뿐 소장기록물에 대한 기록물 유형별 저작권 문제는 제시하지 못하고 있다. 이미 수집된 소장기록물의 이용 활성화를 위해서는 기록의 각 유형별 저작물의 판단 기준이나 원칙을 제시하여, 이용자들이 쉽게 저작권 문제에 접근할 수 있도록 별도의 상세한 세부지침이 마련되어야 하며, 향후 소장기록물 수집을 위해서도 저작재산권이나 저작인격권에 대한 세부사항을 규정할 필요가 있다. 본 연구는 이를 위한 사전분석이다. 향후 소장기록물과 관련된 저작권 측면의 활발한 논의와 운영 방안이 모색되어야 할 것이다. The National Archives of Korea(NAK) has arranged and operated 'Guidelines on Operating Copyright for Archives' and 'Regulations on Operating Reference Room' to protect the copyright for archives. However, the Guidelines and the Regulations only provide application to the Copyright Act and principles on internal managing copyright without presenting copyright issues for each type of archives. Therefore, additional detailed guidelines have to be arranged for the users to access to copyright issues easily by presenting them the standards of judgement or principles on copyright issues for each type of the archives to facilitate the use of archives collected already. We also need to define the details on Copyright Act and Moral Rights Act to collect archives. This study is an prior analysis for that purpose. Lively discussion and way of operation in an aspect of the copyright in relation to private records should be sought in the future.