Acute exacerbation of interstitial lung disease; subgroup analysis for causes, risk factors for mortality rate, and steroid responsiveness

( Seung Hyun Yong ),( Ah Young Leem ),( Song Yee Kim ),( Kyung Soo Chung ),( Ji Ye Jung ),( Young Ae Kang ),( Young Sam Kim ),( Joon Chang ),( Moo Suk Park ),( Hye Jin Jang ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-

Background: Interstitial Lung Disease (ILD) has known as a poor prognosis disease, particularly idiopathic pulmonary fibrosis (IPF). Corticosteroid is widely used for treatment of acute exacerbation (AE)-ILD. This study aims to clarify efficacy of corticosteroid use, and compare the mortality rate depending on the subgroups of ILD. Materials and Methods: We collected the data from the patients who have diagnosed ILD and visited emergency room (ER) with the respiratory symptoms from January 1, 2016 to December 31, 2018. We classified AE-ILD patients into 3 groups depending on methylprednisolone dose per kilogram. Also, we compared the mortality of IPF patients to that of non-IPF patients. Results: A total case of AE-ILD visited ER from 2016 to 2018 was 209 cases, including IPF cases (n=122) and non-IPF cases (n=87). We divided total patients (n=209) into three groups depending on steroid use, and these include group 1 of 0-0.49 mg/kg (n=78), group 2 of 0.5-0.99 mg/kg (n=58), and above 1.0 mg/kg (n=41), each. We found poor prognosis from the cases of IPF compared to non-IPF cases (p=0.029, OR 2.463). Furthermore, there was significant differences of mortality rate according to steroid dose (p=0.036, OR 1.712), CRP elevation (p=0.016, OR 1.004), and intubated case (p=0.000, OR 8.152). Also, we categorized IPF (n=122) to non-IPF cases (n=87) and analyzed the mortality rate. Most of the patients were death from ILD itself (n=23, 63.9%), Pneumonia(n=8, 22.2%), and Lung cancer (n=5, 13.9%). Bacterial infection (n=26) was dominant cause of AE, followed by fungal infection (n=15), and viral infection (n=10). Conclusions: This retrospective analysis of corticosteroid treatment shows more fatal outcome when we use high dose steroid in AE-ILD cases, and there was significant difference in mortality rate depending on the subgroup of ILD and medical background, such as intubation status, higher CRP level, and IPF cases.

과학영재교육 교사 교수방법 전문지식의 수준 분석

서혜애,박경희,박지은 이화여자대학교 교과교육연구소 2007 교과교육학연구 Vol.11 No.1

본 연구에서는 우리나라 과학영재교육을 담당하는 교사들의 과학영재교육 교수방법 전문지식의 수준을 조사하는 데 목적을 두었다. 2005년 기준 전국 16개 시·도 교육청 산하 영재학급 및 영재교육원에서 과학영재교육을 담당하는 교사 수는 총1,883명으로 조사되었다. 이 가운데 531명(28.2%)의 과학영재교육 교사는 ‘과학영재교육 교사 교수방법 전문지식 측정도구(서혜애·박경희, 2005)’에 응답하였으며, 응답한 교사의 교수방법 전문지식 수준은 최종학력, 연수이수여부, 학교급에 따라 차이가 있는 것으로 나타났다. ‘과학지식 및 과학교육학 지식’과 ‘영재교육학 지식’은 영재교육 연수 이수 유무와 관련 없이 교사의 성별 및 최종학력에 따라 차이를 보였으며, ‘과학영재교육과정 지식’은 교사가 어떤 영재교육 연수를 이수했는지, 어떤 학교급을 지도하고 있는 지에 따라 차이가 있는 것으로 나타났다. ‘교사 전문성 계발 지식’은 학교급, 성별에 따라 차이를 보였다. 연구결과에 근거하여 다음과 같이 과학영재교육의 질을 제고하는 방향을 제안하였다. 첫째, 효과적 과학영재교육교사 연수를 개발하기 위해서는, 연수기관은 연수 대상 교사의 학교급에 따라 연수프로그램의 교육내용을 달리하여 구성해야 할 것이다. 둘째, 과학영재교육 교사 임용정책에서는 최종학력 조건을 강화하고 교사 전문성 계발의 동기 수준을 고려하는 것이 바람직할 것이다. The research aims to investigate the status of teacher's professional knowledge level of teaching the gifted in science. As of 2005, there were 1,883 teachers who teach at gifted educational institutions affiliated with sixteen provincial offices of educations in Korea. Research subjects include 531 out of 1,883 teachers (28.2%) and they responded to the 'Science Teacher Scale of Professional Knowledge for Teaching the Gifted' (Seo & Park, 2005). It was found that there were significant differences in the levels of science teachers' professional knowledge for teaching the gifted in terms of highest degrees earned, school level, completion of inservice training programs of gifted education, etc. It was also found that ‘subject matter content knowledge in science and pedagogical content knowledge in science’ and ‘general pedagogical knowledge in gifted education’ varied along teachers' gender and highest degrees earned. ‘Science curriculum knowledge in gifted education’ were varied along completion of inservice teacher training programs and school levels. In conclusion, in order to raise the quality of gifted education, first, host institutions of inservice teacher training programs of gifted education are recommended to provide program contents in consideration with different schools levels of participating teachers. Second, policy makers may strengthen requirements of highest degrees earned for employing teachers in gifted education.

정신분열병의 유전적 고위험군에서 인지, 정서 및 사회기능 연구

이경진,위휘,유소영,이애라,송지연,하태현,홍경수,김명선,권준수 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objectives : Vulnerability marker in biological relatives of schizophrenia may be very useful in identifying the propensity for the development of schizophrenia. This study suggests that the relatives at risk for genetically developing schizophrenia have impairments in several domains of cognition, social function and affective function as a vulnerability marker. Methods : A neurocognitive function test, a social function test and an affective function test were administered to fifteen healthy relatives from families with two or more patients with schizophrenia (geneticallly high risk subjects). Fifteen healthy controls matched for age and gender were recruited in this study. Results : Compared to the control subject, the genetic high risk subjects performed significantly more poorly in the selective attention and recall memory of neurocognitive function. The high dsk subjects also had lower scores in independence-performance and independence-competence of the social function test and emotion control of the affective function test. Conclusion : Selective attention, recall memory, independence-performance, independence-competence and emotion control ability may be a valuable marker for genetic study of schizophrenia.

삶의 질 향상과 지속가능한 지역경쟁력 : 호순환 관계의 모색

장지상,이성진,조정재,권우현,김애경 慶北大學校 1997 經商論集 Vol.25 No.1

숙명박물관 브랜드 프로모션을 위한 통합적 브랜드 개발 -2D, 3D, 4D 디자인 프로세스를 중심으로-

길혜경,김보현,오정은,이서연,이지원,이진민,장미정,이성애 숙명여자대학교 산업디자인연구소 2017 숙명디자인학 연구 Vol.24 No.-

본 연구는 여성생활사 중심의 유물 박물관인 숙명박물관의 인지도와 브랜딩의 문제를 해결하기 위해 브랜드·스페이스·마케팅을 활용한 통합 브랜드 개발 프로세스를 제안하는데 목적이 있다. 아울러 본 연구는 박물관의 브랜드를 프로모션하고 그래픽, 제품, 공간의 통합 브랜드를 구축하는 일련의 프로세스를 밝히는데 목적이 있다. 이에 본 연구의 시간적 범위는 2017년 3월부터 6월까지 총 15주간 숙명여대 환경디자인학과 <브랜드·스페이스·마케팅>수업에서 진행된 수업의 결과물로서 4개 팀 중, 1개 팀의 작업물로 한다. 본 연구의 대상적 범위는 ‘숙명여자대학교 숙명박물관'의 2D~4D까지의 전반으로 설정한다. 그 결과, 제품부터 공간까지 숙명박물관의 통합된 브랜딩은 일 관성과 객관성, 스토리성을 얻을 수 있었다. ’숙명박물관'은 학교의 박물관이라는 장점을 극대화시켜 가치와 스토리를 부여하고 하나의 브랜드로 리뉴얼했다는 점에서 의의가 있다. 또한 향후 보편적인 박물관들의 차별화된 브랜드 개발의 참고자료로 활용될 수 있을 것으로 기대하며 브랜드 개발에 있어서 G·I, P·I, S·I의 통합 브랜드 메뉴의 기초 자료로 활용될 것으로 사료된다.

두경부 전산화 단층촬영시의 주요 장기선량, 유효선량 및 위험도

김애지,나경수,조봉혜 大韓口腔顎顔面 放射線學會 1995 Imaging Science in Dentistry Vol.25 No.1

The organ or tissue doses were determined with head and neck phantom measurement for multiple axial scans (36 slices), multiple coronal scans (13 slices), 3 types of single axial scans(orbit, maxillary sinus and mandibular canal) and single coronal scan(maxillary sinus). For each scan sequence 30 TLDs were placed in selected sites(16 internal site and 14 external sites) in a tissue-equivalent phantom. The exposure was made at 120kVp, 500mAs with 5 mm slice width. The results were as follows: 1. In multiple axial scans, the greatest effective dose recorded was that delivered to the thyroid glands(2.77 mSv) and the least was that received by the skin(0.05 mSv). From these data, stochastic effects were ?? and ??, respectively. 2. In multiple coronal scans, the greatest effective dose recorded was that delivered to the salivary glands(0.58 mSv) and the least was that received by the skin(0.01 mSv). From these data, stochastic effects were ?? and ??, repectively. 3. Among single axial scans, the greatest effective dose recorded was that delivered to the salivary gland(0.38 mSv) in maxillary sinus scan. From this data, stochastic effect was ??. 4. In single coronal scan, the greatest effective dose recorded was that delivered to the salivary gland(0.01 mSv). From this data, stochastic effect was ??. 5. The equivalent dose measured that delivered to the lens of the eyes was 69.64 mSv in multiple axial scan, 39.32 mSv in multiple coronal scan and 36.77 mSv in single axial scan(orbit).

데이터 글러브를 이용한 손 제스처 기반 3차원 게임 구현

유다연,권차욱,곽지민,백화현,김이조,차경애 대구대학교 정보통신연구소 2010 情報通信硏究 Vol.7 No.1

데이터 글러브(Data Glove)는 손 제스처를 정의하여 시스템을 제어하는 입력장치로 가상현실기술 및 교육, 의료, 산업분야에서 많이 사용되고 있다. 이는 가상현실 속에 존재하는 사물을 현실에서 제어하게 함으로써 사용자에게 마치 현실 세계의 사물을 제어하는 느낌을 주는 장점을 가지고 있다. 이에 본 논문에서는 이러한 데이터 글러브의 장점을 이용하여 3차원 게임에 적용시키는 방법을 제안한다. 먼저 데이터 글러브로 제스처를 정의하고, 트래커(Tracker)와 연동하여 시스템을 구현한다. 구현된 시스템을 실험하기 위해서 OpenGL로 인형 뽑기 게임을 구현하고 사용자가 데이터 글러브를 착용 후 정의된 제스처를 통해 게임을 제어하도록 한다. 본 논문에서 제안한 방법은 사용자들에게 좀 더 높은 몰입감을 제공하며, 향후 게임 산업 발전에도 많은 영향을 줄 것으로 기대한다.

정신분열병의 임상적 고위험군의 특징 : '서울청년클리닉'의 자연 추적 관찰 예비연구

유소영,이경진,강도형,이승재,하태현,위휘,이애라,송지연,김성년,권준수 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.1

Objectives : The aims of this study were to identify the intake and following process for subjects at high risk of transition to schizophrenia and to examine the neurocognitive, social, and emotional functions of the subjects compared with healthy controls. Methods : Symptomatic individuals judged at high risk for schizophrenia ('clinical high risk') within Youth Clinic were assessed and followed up. They performed a neurocognitive function test, a social function test and an affective function test. Twenty healthy controls were recruited in this study. Results : Among eighty-two subjects contacted through the Youth clinic, sixteen subjects were judged as the clinical high risk group. Fourteen subjects among the clinical high risk group showed deficits in several domains of neurocognitive functions, such as visual recall memory, verbal short term memory and executive function. Social and affective functions are also impaired in the Cli-nical high risk group compared with healthy controls. Two of 15 subjects (13%) developed a psychotic disorder within 6 months. Conclusion : This study illustrates the state of follow-up study for a clinical high risk group. Despite low numbers and short durations, some impairment of several functions in the clinical high risk group suggests possible predictors of psychosis.

베체트병에서 비스테로이드성 소염진통제에 의해 발생한 대량 소장출혈 1예

강인숙,류연주,장지은,정성애,이지수,조영주,이경은,이지희 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Bechet's disease(BD) is a chronic inflammatoroy condition involving several organs inclu-ding gastrointestinal tract. Gastrointestinal tracts involvement in BD has been identified throughout the entire alimentary tract and commonly accompanies ulcerative lesions in the small and large bowel. It is debatable whether BD could be included among seronegative spondyloarthropathy (SPA).SPA usually occurs without overt sign of intestinal inflammation, but significant number of patients have asymptomatic intestinal inflammation, usually affecting ileum. Since most patients with SPA in-cluding BD are treated with NSAIDS. However, NSAID may play a role in aggravation or provo-cation of intestinal inflammation. Special attention to asymptomatic intestinal inflammation is needed, especially when NSAIDs are used for management of arthritic symptom in SpA. We experienced a case of BD which was complicated by a massive small bowel bleeding precipitated by NSAID use. 저자들은 베체트병 환자에서 비스테로이드성 소염진통제 사용 후 발생한 대량 소장 출혈의 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

비안와대뇌형 모균증 치험 3례

문영일,김종남,홍순관,이지애,정옥경,김문정 梨花女子大學校 醫科大學 醫科學硏究所 1997 EMJ (Ewha medical journal) Vol.20 No.3

Rhinocerebral mucormycosis is a well-described fulminant fungal infection that typically presents in a rapidly fulminant manner. This condition is more likely to occur among patient with diabetes mellitus, malignant tumors, who have long-term steroid treatment, or who suffer from some debilitating diseases. We report 3 cases of rhinoorbitocerebral mucormycosis, all suffered from diabetes mellitus. In all 3 cases, endoscopic sinus surgery was done and the antifungal agent(amphotericin B) was administered intravenously, and two patients died. One survivor who had focal extension of paranasal sinus and orbit, required one surgical intervention without orbital exenteration and he is alive without recurrence disease. The severity of the disease is probably dependent upon the gost resistance to the invasion of phycomycetes. Early diagnosis and immediate, effective treatment are the key for cure of the disease.