Tumor evolution and intratumor heterogeneity of an oropharyngeal squamous cell carcinoma revealed by whole-genome sequencing.

Zhang, Xinyi Cindy,Xu, Chang,Mitchell, Ryan M,Zhang, Bo,Zhao, Derek,Li, Yao,Huang, Xin,Fan, Wenhong,Wang, Hongwei,Lerma, Luisa Angelica,Upton, Melissa P,Hay, Ashley,M?ndez, Eduardo,Zhao, Lue Ping Stockton Press 2013 Neoplasia Vol.15 No.12

<P>Head and neck squamous cell carcinoma (HNSCC) is characterized by significant genomic instability that could lead to clonal diversity. Intratumor clonal heterogeneity has been proposed as a major attribute underlying tumor evolution, progression, and resistance to chemotherapy and radiation. Understanding genetic heterogeneity could lead to treatments specific to resistant and metastatic tumor cells. To characterize the degree of intratumor genetic heterogeneity within a single tumor, we performed whole-genome sequencing on three separate regions of an human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma and two separate regions from one corresponding cervical lymph node metastasis. This approach achieved coverage of approximately 97.9% of the genome across all samples. In total, 5701 somatic point mutations (SPMs) and 4347 small somatic insertions and deletions (indels)were detected in at least one sample. Ninety-two percent of SPMs and 77% of indels were validated in a second set of samples adjacent to the discovery set. All five tumor samples shared 41% of SPMs, 57% of the 1805 genes with SPMs, and 34 of 55 cancer genes. The distribution of SPMs allowed phylogenetic reconstruction of this tumor's evolutionary pathway and showed that the metastatic samples arose as a late event. The degree of intratumor heterogeneity showed that a single biopsy may not represent the entire mutational landscape of HNSCC tumors. This approach may be used to further characterize intratumor heterogeneity in more patients, and their sample-to-sample variations could reveal the evolutionary process of cancer cells, facilitate our understanding of tumorigenesis, and enable the development of novel targeted therapies.</P>

A Test of the Mobile Phone Appropriation Model: A Comparison between Chinese and US Samples

Zhang Xinyi (Ceciley),Piercy Cameron W.,Lee Sun Kyong 한국언론학회 2023 Asian Communication Research Vol.20 No.2

The mobile phone appropriation (MPA; Wirth et al., 2007, 2008) model is an integrative model that seeks to explain attitudes and behaviors related to mobile phone usage from a communication perspective, proposing a dynamic loop of metacommunication, evaluations, and usage patterns. Following a previous study (Lee & Cioena, 2023), the current research tests the MPA model with a Chinese sample collected through an online survey (N = 510) and compares it with the U.S. sample (N = 501) collected by Lee and Cionea (2023) using multigroup confirmatory factor analysis and multigroup structural equation modeling. Although the core structure of MPA model was shown to be tenable cross-culturally, the results of comparative analysis reveal some noticeable cultural differences in mobile phone appropriation and call for further model revisions. Noticeably, relational and social implications of mobile communication penetrate more aspects of mobile phone appropriation with greater strength in the Chinese sample, potentially due to the collectivistic Chinese culture, and the results demonstrate a paradox between perceived affordability and usage. The more Chinese participants evaluated the cost of mobile phone usage as a restrictive factor of MPA, corroborate the more they used it for relationship maintenance and daily schedule management. In addition, the results indicate some tensions between instrumental purposes and entertainment and symbolic usage unique to the Chinese context.

Acoustic matching and phonotactic expectations in the adaptation of English /s/ into Korean

Xinyi Zhang,김윤정,오미라 경희대학교 언어정보연구소 2023 언어연구 Vol.40 No.3

This study aims to demonstrate that the adaptation of loanwords cannot be solely explained by speech perception. Specifically, it focuses on the adaptation of the English /s/ sound into Korean. In English, a singleton /s/ is loaned as tense [s*], while a preconsonantal /s/ is adapted as lenis [s] in Korean. Kim and Curtis (2002) and Kang (2008) provided an acoustic cue-based analysis for the adaptation of English /s/, considering duration and voice quality, respectively. To investigate the perception of English /s/ by Korean listeners, we conducted a perception experiment. We examined the impact of prosodic factors, such as domain-edge position and lexical stress, on the perception of /s/. Our findings revealed diverse perception patterns depending on stress and position within a word. Specifically, /s/ in a stressed syllable and /s/ in a word-edge position were more likely to be perceived as tense [s*]. Contrary to Kim and Curtis (2002), the duration of English /s/ alone was insufficient to explain perception patterns. Based on our varied perception patterns, we argue that categorical adaptation of the singleton /s/ as tense [s*] and the preconsonantal /s/ as lenis [s] does not solely reflect speech perception. Instead, we propose that loanword adaptation is a process driven by top-down/phonotactic expectations and acoustic matching, with the goal of maximizing perceptual similarity between the source word and the loanword. This is consistent with the findings of Daland et al. (2019).

Clinical Reference Strategy for the Selection of Treatment Materials for Maxillofacial Bone Transplantation: A Systematic Review and Network Meta-Analysis

Zhang Shuxin,Zhang Xinyi,Li Yanling,Mao Xuran,Liu Rui,Qi Yanxin,Lee Eui-Seok,Jiang Heng Bo 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3

Bone graft materials have mixed effects of bone repair in the field of oral maxillofacial surgery. The qualitative analyses performed by previous studies imply that autogenous odontogenic materials and autogenous bone have similar effects on bone repair in clinical jaw bone transplantation. This retrospective systematic assessment and network meta-analysis aimed to analyze the best effect of clinical application of autogenous odontogenic materials and autogenous, allogeneic, and xenogeneic bone grafts in bone defect repair. A systematic review was performed by searching the PubMed, Cochrane Library, and other journal databases using selected keywords and Medical Subject Headings search terms. 10 Papers (n = 466) that met the inclusion criteria were selected. The assessment of heterogeneity did not reveal any overall statistical difference or heterogeneity (P = 0.051 > 0.05), whereas the comparison between autogenous and allogeneic bone grafts revealed local heterogeneity (P = 0.071 < 0.1). Risk of bias revealed nine unclear studies and one high-risk study. The overall consistency was good (P = 0.065 > 0.05), and the local inconsistency test did not reveal any inconsistency. The publication bias was good. The confidence regarding the ranking of bone graft materials after GRADE classification was moderate. The effects on bone repair in the descending order were as follows: autogenous odontogenic materials, xenogeneic bone, autogenous bone, and allogeneic bone. This result indicates that the autogenous odontogenic materials displayed stronger effects on bone repair compared to other bone graft materials. Autogenous odontogenic materials have broad development prospects in oral maxillofacial surgery.

관광 경험에 따른 도시이미지의 변화가 관광 만족과 재방문의도에 미치는 영향

장신니(ZHANG, XINYI),양찬열(Yang, Chan Yeol) 한국소셜네트워크협회 2022 지속가능저널 Vol.1 No.1

At present, big cities with population over one million in the world have developed into important tourist destinations and part of middle and small cities are also developing toward the goal of becoming tourist city. City image has great influence on the selection of tourist destination no matter in all the information attained through various methods before travelling or the overall image formed for destination city during travelling. The changes for the image of destination city before and after travelling affect the satisfaction, intention of re-visit as well as city tourism marketing. Positive change can improve the satisfaction of tourists; on the contrary, negative change will decrease the satisfaction of tourists. This study has taken pilot study and literature material as basis, attained measuring item applicable for this study through sorting out the theoretical backgrounds of city tourism, city image, city tourism image, satisfaction, intention of re-visit and made questionnaires to Chinese tourists through travel guide. The simple frequency analysis of total preparation; factor analysis, reliability analysis, means analysis and regression analysis of total preparation, first visit group and multiple visit group have been applied. The conclusions attained by theoretical exploration and practical investigation in this study are: positive difference exists in the city image for Seoul among Chinese tourists before and after travelling to Korea, which presented more obviously in the first visit group. But this positive difference has no influence on tourist satisfaction; while the city image after travelling has greater influence on tourist satisfaction, at the same time, it also has great influence on the intention of re-visit for tourists. Based on these conclusions, this study hopes to provide some marketing enlightenments for the market positioning of the tourism image for Chinese tourists visiting Seoul. 도시 관광이미지는 도시를 방문하기 전에 얻은 여러 가지 형태의 정보나 도시에서 실제 경험을 통 해 형성된 전체적인 인상으로써 도시라는 관광목적지를 선택할 때 상당한 영향력을 미치게 된다. 관광경험에 따라 도시이미지의 변화는 관광객 만족도와 재방문 그리고 도시 관광마케팅에 영향을 미치고 있으며 긍정적 불일치는 관광객만족을 증가시키는 반면, 부정적 불일치는 관광객만족을 감 소시킨다. 본 연구에서는 서울을 방문하는 중국관광객 중심으로 방문 전-후 지각한 관광이미지의 변화를 바탕으로 관광만족에 미치는 영향, 도시 관광이미지의 파악과 활성화시키는데 목적이 있다. 이를 위해 관광객이 방문하는 전과 후에 느끼는 서울의 관광이미지에 대해 살펴보고, 관광객 기대 와 경험의 불일치가 관광만족과 어떠한 관련이 있는지를 검토해보고자 한다. 그리고 도시 관광 상 품으로써 중요성을 확인하고 도시 관광에 대한 만족도와 재방문의도를 알아보고자 한다. 이를 위해 선행연구 및 문헌을 토대로 도시 관광, 도시이미지, 관광이미지, 관광만족도, 재방문 등에 대해서 이론적 체계화를 하고 문헌고찰을 통해서 도시 관광이미지 구성요소와 측정항목을 추출하여 연구 목적 달성을 위해 실증분석을 실시하였다. 서울을 방문한 중국관광객들을 대상으로 여행사 가이드 를 통해 관광하는 과정에서 조사를 실시하였다. 수집된 총 231부의 설문지를 연구에 활용하고 분 석을 위해 SPSS 21.0 통계패키지 프로그램을 이용했으며, 빈도분석과 전체표본과 첫 번째 방문한 그룹, 여러 번 방문한 그룹으로 나눠서 요인분석, 신뢰도 분석, 차이분석, 회귀분석을 실시하였다. 분석결과는 중국관광객들이 서울의 관광이미지에 대한 방문 전-후 간의 긍정적 불일치가 있다는 것을 알 수 있었으며, 이는 처음 방문한 관광객 그룹에서 뚜렷하게 나타났다. 하지만 방문 전-후 간의 긍정적 불일치는 만족도에 영향을 미치지 않는 것으로 나타났으나 방문한 후 느끼는 관광이 미지가 만족도에 긍정적인 영향을 미친는 것을 확인하였으며 이는 재방문의도에 긍정적인 영향을 미친다고 볼 수 있다. 본 연구를 통해 향후 서울의 중국관광객에게 관광이미지를 효과적으로 포지 셔닝 하는데 마케팅 시사점을 제공하고자 한다.

커뮤니티 서비스 센터의 공간구성 유형별 이용자 만족도에 관한 연구 -중국 강소성 서주시 커뮤니티 서비스 센터을 중심으로-

장신이 ( Zhang Xinyi ),한태권 ( Han Taekwon ) 한국기초조형학회 2022 한국기초조형학회 학술발표논문집 Vol.2022 No.2

Minus-C odorant binding protein TcasOBP7G contributes to reproduction and defense against phytochemical in the red flour beetle, Tribolium castaneum

Gao Shanshan,Zhang Xinyi,Zhou Can,Zhang Guangyan,Zhang Yong-lei,Li Rui-min,Zhang Kun-peng 한국응용곤충학회 2023 Journal of Asia-Pacific Entomology Vol.26 No.4

Insect odorant binding proteins (OBPs) paly an important role in the recognition and transmission signals. One odorant binding protein gene, TcasOBP7G, was significantly up-regulated after exposure to eucalyptol. Never theless, the causal role of TcasOBP7G in Tribolium castaneum is still unclear. Here, TcasOBP7G was cloned and characterized from T. castaneum, aligning with the typical characteristic of Minus-C OBPs. The analysis of gene expression profile showed that TcasOBP7G is highly expressed at late larval and adult stage, with particularly high expression levels in ovary and testis of adults, suggesting that TcasOBP7G might be associated with reproduction of T. castaneum. Furthermore, RNAi of TcasOBP7G led to a decrease in spawning, while the development of gonads was normal, suggesting that TcasOBP7G may medicate the reproduction of T. castaneum. Additionally, the mRNA level of TcasOBP7G was significantly increased after exposure to eucalyptol, and knockdown of TcasOBP7G resulted in an increased susceptibility of T. castaneum to eucalyptol, indicating that TcasOBP7G is associated with the tolerance of T. castaneum to eucalyptol. Altogether, these results indicate that TcasOBP7G is required for both reproduction and defense against phytochemical in T. castaneum. This study will provide a theoretical basis for the development of novel control strategies based on the olfaction of insects.

Study on the effect of corrosion defects on VIV behavior of marine pipe using a new defective pipe element

Zhang, He,Xu, Chengkan,Shen, Xinyi,Jiang, Jianqun The Society of Naval Architects of Korea 2020 International Journal of Naval Architecture and Oc Vol.12 No.1

After long-term service in deep ocean, pipelines are usually suffered from corrosions, which may greatly influence the Vortex-Induced Vibration (VIV) behavior of pipes. Thus, we investigate the VIV of defective pipelines. The geometric nonlinearity due to large deformation of pipes and nonlinearity in vortex-induced force are simulated. This nonlinear vibration system is simulated with finite element method and solved by direct integration method with incremental algorithm. Two kinds of defects, corrosion pits and volumetric flaws, and their effects of depth and range on VIV responses are investigated. A new finite element is developed to simulate corrosion pits. Defects are found to aggravate VIV displacement response only if environmental flow rate is less than resonance flow rate. As the defect depth grows, the stress responses increase, however, the increase of the defect range reduces the stress response at corroded part. The volumetric flaws affect VIV response stronger than the corrosion pits.

Hydrothermal Synthesis of PbTiO3 Nanocrystals with a pH-Adjusting Agent of Ammonia Solution

Xinyi Li,Zhi-Xiong Huang,Lian-Meng Zhang,Dongyun Guo 대한금속·재료학회 2018 ELECTRONIC MATERIALS LETTERS Vol.14 No.5

The PbTiO3nanocrystals were synthesized by a hydrothermal method, and ammonia solution was firstly used as a pH-adjustingagent. The effect of ammonia concentration on formation and morphologies of PbTiO3nanocrystals was investigated. At low ammonia concentration (0–2.2 mol/L), no perovskite PbTiO3phase was formed. When the ammonia concentrationwas 4.4 mol/L, the rod-like PbTiO3nanocrystals with highly crystalline were successfully synthesized. As the ammoniaconcentration further increased to 13.2 mol/L, the flake-like PbTiO3nanocrystals were formed.

Consumers’ preference for brand prominence in the context of identity-based consumption for self versus for others: The role of self-construal

Zhang Zhe,Liu Xinyi 한국마케팅과학회 2022 마케팅과학연구 Vol.32 No.4

When consumers undertake identity consumption by consuming products or services, their choice can be influenced not only by the brand but also the brand prominence. In order to investigate the relationship between consumers’ preference and identity-based consumption demand, this study examines consumers’ preference for brand prominence in the context of identity-based consumption for self versus for others based on a comparison and interaction between social groups. The results show that, in the scenario of identity-based consumption for self, when consumers are members of the in-group or the high-level identity salience out-group, selfconstrual has no significant influence on their preference with respect to brand prominence. However, when consumers are in the low-level identity salience out-group, self-construal significantly affects their preference in this regard. In addition, in the scenario of identity-based consumption for others (i.e. gift-giving) when giftgivers and gift-receivers have the same fashion status, the selfconstrual of gift-givers does not affect their preference. However, when gift-givers and gift-receivers have different fashion statuses, the self-construal of gift-givers impacts their preference for brand prominence. Specifically, interdependent self-construal consumers are more inclined to choose products according to gift-receivers’ preference for brand prominence. Theoretical and managerial implications are discussed, along with future research directions.