Pim-1 : A serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis

Ze Ping Wang,Nandini Bhattacharya,Matt Weaver,Kate Petersen,Maria Meyer,Leslie Gapter,Nancy S. Magnuson 대한수의학회 2001 Journal of Veterinary Science Vol.2 No.3

Oxygen Uptake Rate Controlling Strategy Balanced with Oxygen Supply for Improving Coenzyme Q10 Production by Rhodobacter sphaeroides

Ze-Jian Wang,Xingzi Zhang,Ping Wang,Zhiwei Sui,Meijin Guo,Siliang Zhang,Yingping Zhuang 한국생물공학회 2020 Biotechnology and Bioprocess Engineering Vol.25 No.3

The effects of different oxygen uptake rates (OUR) on the physiological metabolism of Rhodobacter sphaeroides were investigated systematically in 50 L fermenters due to the significant influence on industrial coenzyme Q10 production under oxygen supply limitation. Meanwhile, the seriously decreased oxygen transfer rate caused by the increased broth viscosity was successfully prevented with OUR-directed continuous ammonium sulfate feeding in the late fermentation phase. The statistical analysis results showed that controlling OUR constantly at 45 ± 2.2 mmol/L/h by the oxygen supply level adjustment and the continuous ammonium sulfate feeding could greatly enhance Q10 production. This OUR-Stat controlling strategy successfully achieved the maximal coenzyme Q10 production (2584 ± 82 mg/L), which was 15.4% higher than that of the control. The highest specific CoQ10 content was 25.9 mg/(g DCW)), and the yield of CoQ10 to glucose consumption was up to 19.37 mg/g. These results demonstrated that the optimal OUR-Stat controlling strategy would be effective and economical for improving the industrial CoQ10 production.

State‑of‑health estimation for lithium‑ion batteries using differential thermal voltammetry and Gaussian process regression

Ping Wang,Xiangyuan Peng,Cheng Ze 전력전자학회 2022 JOURNAL OF POWER ELECTRONICS Vol.22 No.7

The state of health (SOH) of lithium-ion batteries is a key factor to ensure the safe and reliable operation of electric vehicles (EVs). Differential thermal voltammetry (DTV) has been shown to be an effective in situ diagnosis method. In this paper, a SOH estimation method for lithium-ion batteries by a fusion of DTV and Gaussian process regression (GPR) is proposed. First, a wavelet transform (WT) is used to smooth DTV curves. Then the health features (HFs) are extracted, and their correlation with capacity loss is quantitatively evaluated through a Pearson correlation coefficient. To compress the data, canonical correlation analysis (CCA) is applied to obtain the canonical health feature (CHF). Subsequently, the GPR algorithm is used to establish the nonlinear mapping relationship between CHF and SOH. Experiments are performed on two datasets at different temperatures. Results show that the proposed method has high estimation accuracy and robustness.

Dietary inflammatory index and risk of gynecological cancers: a systematic review and meta-analysis of observational studies

Ze-ying Liu,Xu-ping Gao,Sui Zhu,Yan-hua Liu,Li-jun Wang,Chun-xia Jing,Fang-fang Zeng 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.3

Objective: There has been growing body of literatures showing that chronic inflammation might play an important role in cancer development. This meta-analysis aimed to assess the association between the dietary inflammation index (DII) score and gynecological cancers. Methods: A systematic search of PubMed, EMBASE and Web of Science up until October 20, 2018 was carried out to retrieve all related cohort and case-control studies. The summary risk assessments were pooled using random-effects models. The dose-response relationship was estimated by linear relationship model. Results: Twelve case-control studies (10,774 cases/15,958 controls) and six prospective cohort studies (330,363 participants/23,133 incident cases) were included in this meta-analysis. The pooled adjusted relative risk (RR) of gynecological cancers for the highest DII category compared to the lowest category was 1.38, (95% confidence intervals [CIs], 1.21–1.56, p<0.001]. A positive dose-response relationship was also noticed. Stratified by study design indicated that, the pooled RRs was significantly higher for case-control studies than cohort studies (p for interaction<0.001), for studies conducted among participants with body mass index (BMI) ≥25 kg/m2 than participants with BMI <25 kg/m2 (p for interaction=0.026), among participants with ovarian cancer and endometrial cancer than participants with breast cancer (p for interaction = 0.038). Meta-regression analysis further confirmed that study design significantly contributed to inter-study heterogeneity (p<0.001). Conclusion: This meta-analysis suggests that elevated DII is independently associated with a higher risk of gynecological cancers, especially patients with ovarian cancer and endometrial cancer and among obese participants.

Chinese herbal medicine for myasthenia gravis: A systematic review and meta-analysis of randomized clinical trials

Zhu Si-jia,Wang Rui-ting,Yu Ze-yu,Zheng Ruo-Xiang,Liang Chang-Hao,Zheng You-you,Fang Min,Han Mei,Liu Jian-ping 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.2

Background: Myasthenia Gravis (MG) is a disorder of neuromuscular transmission bringing mild ocular weakness to severe generalized muscle weakness and disability. The conventional treatments have longterm side effects, and Chinese herbal medicines (CHM) have shown possible effect and safety for MG patients, but the existing evidence was not robust enough and the results were out of date. Methods: Searching for randomized controlled trials (RCTs) was conducted in 7 databases and clinical trial registries until July 2021. The Risk of Bias (ROB) 2 tool was used to assess the study quality and GRADE was used to assess the quality of whole evidence. Meta-analyses were conducted and the results were presented as risk ratio (RR) or mean difference (MD) with 95% confidence interval (CI). Results: Nineteen RCTs (1283 participants) testing 13 kinds of CHM with adequate randomization were included and six RCTs investigating Compound Huangqi were included in the meta-analyses. In addition to conventional treatment, nine CHMs reduced symptom scores of MG. Compound Huangqi plus conventional treatment (pyridostigmine bromide or prednisone or both) reduced the symptom scores compared with conventional treatment (MD=-3.56, 95%CI -4.86 to -2.26). Less adverse events happened in the CHM groups (3/247 in the CHM groups, 52/245 in the control groups, RR=0.13, 95%CI 0.06 to 0.30, 9RCTs, a total of 492 participants). The effect on quality of life was inconsistent. Conclusion: Nine CHMs could probably bring benefit for MG symptom improvement. Moderate to low certainty of evidence supported Compound Huangqi added-on conventional treatment probably bring extra benefit of improving MG symptoms. Adding CHMs could be safer than giving only conventional treatment. Study registration: The protocol was registered in PROSPERO (CRD42016032718).

Effectiveness and Safety of Dabrafenib in the Treatment of 20 Chinese Children with BRAFV600E-Mutated Langerhans Cell Histiocytosis

Ying Yang,Dong Wang,Lei Cui,Hong-Hao Ma,Li Zhang,Hong-Yun Lian,Qing Zhang,Xiao-Xi Zhao,Li-Ping Zhang,Yun-Ze Zhao,Na Li,Tian-You Wang,Zhi-Gang Li,Rui Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.1

Purpose We sought to investigate the effectiveness and safety of dabrafenib in children with BRAFV600E-mutated Langerhans cell histiocytosis (LCH). Materials and Methods A retrospective analysis was performed on 20 children with BRAFV600E-mutated LCH who were treated with dabrafenib. Results The median age at which the patients started taking dabrafenib was 2.3 years old (range, 0.6 to 6.5 years). The ratio of boys to girls was 2.3:1. The median follow-up time was 30.8 months (range, 18.9 to 43.6 months). There were 14 patients (70%) in the risk organ (RO)+ group and six patients (30%) in the RO– group. All patients were initially treated with traditional chemotherapy and then shifted to targeted therapy due to poor control of LCH or intolerance to chemotherapy. The overall objective response rate and the overall disease control rate were 65% and 75%, respectively. During treatment, circulating levels of cell-free BRAFV600E (cfBRAFV600E) became negative in 60% of the patients within a median period of 3.0 months (range, 1.0 to 9.0 months). Grade 2 or 3 adverse effects occurred in five patients. Conclusion Some children with BRAFV600E-mutated LCH may benefit from monotherapy with dabrafenib, especially high-risk patients with concomitant hemophagocytic lymphohistiocytosis and intolerance to chemotherapy. The safety of dabrafenib is notable. A prospective study with a larger sample size is required to determine the optimal dosage and treatment duration.

SOH estimation of lithium-ion batteries based on least squares support vector machine error compensation model

Zhang, Ji'ang,Wang, Ping,Gong, Qingrui,Cheng, Ze The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.11

Accurate estimation of the state of health (SOH) of lithium-ion batteries is an important determinant of their safe and stable operation. In this paper, a method for the SOH estimation of lithium-ion batteries based on the least squares support vector machine error compensation model (LSSVM-ECM) is proposed. This method achieves a combination of an empirical degradation model and a data-driven method. Battery degradation can be divided into overall trends and local differences, where the former can be described by an empirical degradation model (EDM) established by the historical data of the battery capacity, while the latter can be mapped by a least squares support vector machine (LSSVM). An LSSVM-ECM is established, where the input is the time interval of the equal charging voltage rising (DV_DT) and the output is the fitting error of the EDM, which represents the local difference of the capacity degradation to dynamically compensate the prediction results of the EDM that represents the global trend in terms of the capacity degradation. Validations are carried out with battery data provided by Oxford and NASA datasets. Results show that the proposed method has a high prediction accuracy and a strong robustness.

Stress-strain relationship for recycled aggregate concrete after exposure to elevated temperatures

Jiong-Feng Liang,Ze-Ping Yang,Ping-Hua Yi,Jian-Bao Wang 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.6

In this paper, the effects of elevated temperatures on the strength and compressive stress-strain curve (SSC) of recycled coarse aggregate concrete with different replacement percentages are presented. 90 recycled coarse aggregate concrete prisms are heated up to 20, 200, 400, 600, 800°C. The results show that the compressive strength, split tensile strength, elastic modulus of recycled aggregate concrete specimens decline significantly as the temperature rise. While the peak strain increase of recycled aggregate concrete specimens as the temperature rise. Compared to the experimental curves, the proposed stress-strain relations for recycled aggregate concrete after exposure elevated temperatures can be used in practical engineering applications.

Genome-wide identification and evolution of TC1/Mariner in the silkworm (Bombyx mori) genome

Li‑Qin Xie,Ping‑Lan Wang,Shen‑Hua Jiang,Ze Zhang,Hua‑Hao Zhang 한국유전학회 2018 Genes & Genomics Vol.40 No.5

TC1/Mariner transposons belong to class II transposable elements (TEs) that use DNA-mediated “cut and paste” mechanism to transpose, and they have been identified in almost all organisms. Although silkworm (Bombyx mori) has a large amount of TC1/Mariner elements, the genome wide information of this superfamily in the silkworm is unknown. In this study, we have identified 2670 TC1/Mariner (Bmmar) elements in the silkworm genome. All the TEs were classified into 22 families by means of fgclust, a tool of repetitive sequence classification, seven of which was first reported in this study. Phylogenetic and structure analyses based on the catalytic domain (DDxD/E) of transposase sequences indicated that all members of TC1/Mariner were grouped into five subgroups: Mariner, Tc1, maT, DD40D and DD41D/E. Of these five subgroups, maT rather than Mariner possessed most members of TC1/Mariner (51.23%) in the silkworm genome. In particular, phylogenetic analysis and structure analysis revealed that Bmmar15 (DD40D) formed a new basal subgroup of TC1/Mariner element in insects, which was referred to as bmori. Furthermore, we concluded that DD40D appeared to intermediate between mariner and Tc1. Finally, we estimated the insertion time for each copy of TC1/Mariner in the silkworm and found that most of members were dramatically amplified during a period from 0 to 1 mya. Moreover, the detailed functional data analysis showed that Bmmar1, Bmmar6 and Bmmar9 had EST evidence and intact transposases. These implied that TC1/Mariner might have potential transpositional activity. In conclusion, this study provides some new insights into the landscape, origin and evolution of TC1/Mariner in the insect genomes.

Mechanical properties of recycled fine glass aggregate concrete under uniaxial loading

Jiong-Feng Liang,Ze-Ping Yang,Ping-Hua Yi,Jian-Bao Wang 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.16 No.2

This paper reports the results of an experimental study on the compressive strength and the stress-strain curve (SSC) of recycled fine glass aggregate concrete with different replacement percentages of recycled fine glass aggregate. The results show that the recycled fine glass aggregate contents have significant impact on the workability, compressive strength, the elastic modulus, the peak and the ultimate strains of recycled fine glass aggregate concrete. Analytical expressions for the stress–strain relationship of recycled fine glass aggregate concrete are given, which can satisfactorily describe the effect of the recycled fine glass aggregate on the SSC.