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Yuko Ikeda,Archana Parashar,David C. Bressler 한국생물공학회 2014 Biotechnology and Bioprocess Engineering Vol.19 No.4
Efficient biological degradation of lignocellulosicbiomass is a key step towards developing sustainablebiorefineries. One potential approach to improve processefficiency is the use of enzyme immobilization to facilitatereuse of the enzymes. Two different commercial cellulasecontaining enzyme preparations, termed Cellulases 1 (C1)and Cellulases 2 (C2) for the purposes of this manuscript,were separately immobilized on non-porous silica (S1) andporous silica (S2). The effect of pH, ionic strength andenzyme loading on enzyme stability and activity were allinvestigated. Immobilized cellulases on S1 showed equivalentenzyme activity as free cellulases, and those on S2 retained60% enzyme activity. Dissociation of the cellulases fromthe support after immobilization and during hydrolysis wasfound to be minimal, suggesting strong enzyme-supportinteractions. Further, Scanning Electron Microscopy imagesrevealed that S1 and S2 containing immobilized cellulasesdifferentially interact with cellulose, which likely contributesto the observed differences in hydrolysis.
Nature of Japanese Diet : Variations in Intake of Nutrients and Foods
Tokudome, Yuko,Imaeda, Nahomi,Ikeda, Masato,Hagaya, Teruo,Tokudom, Shinkan The Korean Society of Community Nutrition 2003 Journal of community nutrition Vol.5 No.2
We here outlined our study on the variations in intake of nutrients based on four season 7 consecutive day weighed diet records (WDRs) from 80 Japanese female dietitians in 1996 - 1997. Furthermore, we reviewed Japanese, Korean and international articles investigating variability in consumption of foods as well as nutrients. The relative contributions of variation for all nutrients by person were greater than those by day, week and season. Within individual variances were greater than that between individual variances, being generally observed in Korea and in the world. The ratios of within- vs. between-individual variations ranged from 1.3-26.9 in our study, the ratios being greatest in Korean, followed by Japanese and western people. Based on within individual coefficients of variation, minimal days necessary for estimating nutrient consumption per person within 10% (20%) of the true mean with 95% confidence intervals were estimated. They ranged from 10-35 (3-9) days for energy and major nutrients and 15-640(4-160) days for micro-nutrients. Two Japanese studies reported that the ratios for foods were as a whole greater than those for nutrients, except for cereals, rice and milk. (J community Nutrition 5(2) : 72-82,2003).
Influences of Allocating HIV/AIDS Specialized Nurses on Clinical Outcomes in Japan
Masakazu Nishigaki,Yuko Sugino,Jongmi Seo,Megumi Shimada,Kazuko Ikeda,Keiko Kazuma 한국간호과학회 2011 Asian Nursing Research Vol.5 No.1
Purpose This retrospective cohort study was conducted to demonstrate how allocation of nurses specialized in HIV care influences clinical outcomes of antiretroviral therapy (ART) for people living with HIV (PLWH). Methods The medical records of 116 PLWH who started ART between January 2002 and December 2004 were analyzed. Occurrence of viral suppression and viral relapse after suppression achievement and their time from baseline were observed as clinical outcomes related to ART. Clinical outcomes were obtained from medical records between January 2002 and December 2006. PLWH were classified into two groups according to allocation (n = 95, nurse allocated group) or nonallocation (n = 21, nurse nonallocated group) of nurses specialized in HIV. Results Survival analysis showed that HIV viral load was suppressed more rapidly and continuously in nurse allocated group than nonallocated group (p < .0001). Viral relapse after suppression achievement occurred easily in nurse nonallocated group than allocated group (p = .003). Conclusions The present findings demonstrated that the role of specialized nurses is critically important from the viewpoint of clinical outcome. [Asian Nursing Research 2011;5(1):11–18]
Empirical Evaluation of Cellulase on Enzymatic Hydrolysis of Waste Office Paper
EnochY.Park,Yuko Ikeda,Naoyuki Okuda 한국생물공학회 2002 Biotechnology and Bioprocess Engineering Vol.7 No.5
Enzymatic hydrolysis of waste office paper was evaluated using three commercial cellulases, Acremonium cellulase, Meicelase, and Cellulosin T2. Varying the enzyme loading from 1 to 10% (w/w) conversion of waste office paper to reducing sugar was investigated. The conversion increased with the increase in the enzyme loading: in the case of enzyme loading of 10% (w/w), Acremonium cellulase yielded 79% conversion of waste office paper, which was 17% higher compared to Meicelase, 13% higher than that of Cellulosin T2. Empirical model for the conversion (%) of waste office paper to reducing sugar (x) was derived from experimental results as follow, x = kEm t(aE+b) where k, m, a, and b denote empirical constants. E indicates initial enzyme concentration.
Kurasawa, Yoshihisa,Ishikura, Aiko,Ikeda, Kazue,Hosaka, Tomoyoshi,Matsumoto, Yuko,Takada, Atsushi,Kim, Ho Sik,Okamoto, Yoshihisa 대구효성가톨릭대학교 자연과학연구소 1994 基礎科學硏究論集 Vol.1994 No.1
The reaction of 7-chloro-4-ethoxycarbonylmethylene-4,5-dihydro-1,2,4-triazolo[4,3-a]quinoxaline 6 with 4-ethoxycarbonyl-1-methyl-1H-pyrazole-5-diazonium chloride or 4-cyano-1,3-dimethyl-1H-pyra-zole-5-diazonium chloride gave 7-chloro-4-[α-(4-ethoxycarbonyl-1-methyl-1H-pyrazol-5-ylhydrazono)-ethoxycarbonylmethyl]-1,2,4-triazolo[4,3-α]quinoxaline 8a or 7-chloro-4-[α-(4-cyano-1,3-dimethyl-1H-pyrazol-5-ylhydrazono)ethoxycarbonylmethyl]-1,2,4-triazolo[4,3-α]quinoxaline 8b, respectively, while thereaction of 7-chloro-4-ethoxycarbonylmethylene-4,5-dihydrotetrazolo[1,5-α]quinoxaline 7 with 4-ethoxy-carbonyl-1-methyl-1H-pyrazole-5-diazonium chloride or 4-cyano-1,3-dimethyl-1H-pyrazole-5-diazoniumrhloride provided 7-chloro-4-[α-(4-ethoxycarbonyl-1-methyl-1H-pyrazol-5-ylhydrazono)ethoxy-carbonylmethyl]tetrazolo[1,5-α]quinoxaline 9a or 7-chloro-4-[α-(4-cyano-1,3-dimethyl-lH-pyrazol-5-ylhydrazone)ethoxycarbonylmethyl] tetrazolol[1.5-α]quinoxailne 9b, respectively. Compounds 8a,b and 9a,b showed the tautomeric equilibria between the hydrazone imine C and diazenyl enaminc D forms indimethyl sulfoxide and/or trifluoroacetic acid. and the effects of solvent and temperature on the tautomerratios of C to D were studied by the nmr measurements in a series of mixed trifluoroacetic acid/dimethylsulfoxide media (compounds 8a,b and 9a,b) and at various temperatures (compounds 8a,b).
Kurasawa, Yoshihisa,Hosaka, Tomoyoshi,Ikeda, Kazue,Matsumoto, Yuko,Ishikura, Aiko,Takada, Atsushi,Kim, Ho Sik,Okamoto, Yoshihisa 대구효성가톨릭대학교 자연과학연구소 1994 基礎科學硏究論集 Vol.1994 No.1
The 3-(arylhydrazono)methyl-2-oxo-1,2-dihydroquinoxalines 9-11 were synthesized by the reaction of the quinoxalines 6-8 with various p-substituted benzenediazonium salts. Compounds 9-11 showed the tau-tomeric equilibria between the hydrazone imine A and diazenyl enamine B forms in dimethyl sulfoxide media. The substituent effect on the tautomer ratios of A to B was studied by the nmr spectroscopy to clar-ify that the presence of the ester group R^2 on the hydrazone carbon and electron-donating p-substituent R^1 on the side chain benzene ring exhibited a tendency to increase the ratios of the tautomer A.
( Kunihiro Hayakawa ),( Keigo Ikeda ),( Maki Fujishiro ),( Yuko Yoshida ),( Takuya Hirai ),( Hiroshi Tsushima ),( Tomoko Miyashita ),( Shinji Morimoto ),( Yasushi Suga ),( Kenji Takamori ),( Hideoki O 대한피부과학회 2018 Annals of Dermatology Vol.30 No.1
Background: Connective tissue growth factor (CTGF) is a multifunctional cellular protein and playing a role as a central mediator in tissue remodeling and fibrosis. The physiological function of CTGF in psoriasis is unknown. Objective: The purpose of this study was to investigate the function of CTGF in psoriasis using the established imiquimod (IMQ)- induced psoriasis murine model and psoriasis patients. Methods: Anti-CTGF monoclonal antibody was applied to IMQ induced psoriasis mice and those skin were clinically, pathologically and immunologically analyzed. Additionally, CTGF expression was analyzes using skin samples and plasma from psoriasis patients. Results: CTGF expression was observed in the dermis from both IMQ-induced psoriatic mice and psoriasis patients. CTGF inhibition using an anti-CTGF antibody slightly worsened IMQ-induced dermatitis. In addition, the increase of CTGF showed tendency to suppress the psoriatic dermatitis through inhibition of suprabasal cells proliferation and macrophage infiltration in the skin. CTGF was also detected significantly higher in plasma from psoriasis patients comparing with healthy control. Conclusion: Our findings suggest that CTGF could contribute to the healing rather than the worsening of psoriasis skin lesions. (Ann Dermatol 30(1) 47∼53, 2018)