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Keiichi Nakahara,Satoshi Yamashita,Katsumasa Ideo,Seigo Shindo,Tomohiro Suga,Akihiko Ueda,Shoji Honda,Tomoo Hirahara,Masaki Watanabe,Taro Yamashita,Yasushi Maeda,Yasuhiro Yonemochi,Tomohiro Takita,Yuk 대한신경과학회 2014 Journal of Clinical Neurology Vol.10 No.4
Background Listeria monocytogenes (L. monocytogenes) is a rare causative pathogen ofbrain abscess that is often found in immunocompromised patients. Although patients with supratentorial listerial abscesses showed a longer survival with surgical drainage, the standardtherapy for patients with subtentorial lesions has not been established. Case Report We report herein a patient with supra- and subtentorial brain abscesses causedby L. monocytogenes infection. These abscesses did not respond to antibiotics, and his symptoms gradually worsened. Drainage was not indicated for subtentorial lesions, and the patientwas additionally treated with hyperbaric oxygen therapy, which dramatically reduced the volume of abscesses and improved the symptoms. Conclusions This is the first report of drastic therapy for a patient with listerial brain abscesses involving combined antibiotics and hyperbaric oxygen therapy. The findings suggestthat hyperbaric oxygen therapy is a good option for treating patients with deep-seated listerialabscesses and for who surgical drainage is not indicated.
( Kunihiro Hayakawa ),( Keigo Ikeda ),( Maki Fujishiro ),( Yuko Yoshida ),( Takuya Hirai ),( Hiroshi Tsushima ),( Tomoko Miyashita ),( Shinji Morimoto ),( Yasushi Suga ),( Kenji Takamori ),( Hideoki O 대한피부과학회 2018 Annals of Dermatology Vol.30 No.1
Background: Connective tissue growth factor (CTGF) is a multifunctional cellular protein and playing a role as a central mediator in tissue remodeling and fibrosis. The physiological function of CTGF in psoriasis is unknown. Objective: The purpose of this study was to investigate the function of CTGF in psoriasis using the established imiquimod (IMQ)- induced psoriasis murine model and psoriasis patients. Methods: Anti-CTGF monoclonal antibody was applied to IMQ induced psoriasis mice and those skin were clinically, pathologically and immunologically analyzed. Additionally, CTGF expression was analyzes using skin samples and plasma from psoriasis patients. Results: CTGF expression was observed in the dermis from both IMQ-induced psoriatic mice and psoriasis patients. CTGF inhibition using an anti-CTGF antibody slightly worsened IMQ-induced dermatitis. In addition, the increase of CTGF showed tendency to suppress the psoriatic dermatitis through inhibition of suprabasal cells proliferation and macrophage infiltration in the skin. CTGF was also detected significantly higher in plasma from psoriasis patients comparing with healthy control. Conclusion: Our findings suggest that CTGF could contribute to the healing rather than the worsening of psoriasis skin lesions. (Ann Dermatol 30(1) 47∼53, 2018)