Valuation of ecosystem services in the organic carbon of the Pinus densiflora forest at Mt. Namsan, Seoul Metropolitan City

Lee, Eung-Pill,Lee, Soo-In,Jeong, Heon-Mo,Han, Young-Sub,Lee, Seung-Yeon,Park, Jae-Hoon,Jang, Rae-Ha,Hong, Youg-Sik,Jung, Young-Ho,Kim, Eui-Joo,Lee, Sang-Hun,You, Young-Han The Ecological Society of Korea 2019 Journal of Ecology and Environment Vol.43 No.4

Background: Standing biomass, litter production, rate of litter decomposition, amount of litter on forest floor, and amount of soil organic carbon distribution were investigated from March 2016 to November 2018 in order to evaluate the ecosystem value through organic carbon distribution in the Pinus densiflora forest at Namsan, Seoul Metropolitan City. Results: The amount of organic carbon in the Pinus densiflora forest was 261.09 ton C ha^-1 during the research period, and fixed organic carbon in plant through net photosynthesis was 3.2 ton C ha^-1 year^-1. The organic carbon in plant was 62.77 ton C ha^-1 (24.04%), in litter on the forest floor was 3.65 ton C ha^-1 (1.40%), and in soil was 194.67 ton C ha^-1 (74.56%). The value of plant, litter on forest floor, and soil organic carbon distribution were each 6,277,000 won ha^-1, 365, 000 won ha^-1, and 19,467,000 won ha^-1. The value per ton of fixed organic carbon in plant through net photosynthesis was 320,000 won ha^-1 year^-1 and the value of ecosystem services stored in carbon in the Namsan forest ecosystem was about 26.1 million won ha^-1 for 3 years. Conclusions: The results of this study suggest that the pine forests of Namsan rapidly decompose leaves due to the high atmospheric temperature and accumulate a large amount of organic carbon in the soil to provide climate control regulatory service function.

비글개에서 l-muscone의 급성독성 및 아급성독성시험 연구

유아선,권오경,성하정,곽형일,방명주,박대규,정규혁,윤효인,조명행 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Single and 4 weeks oral administration of l-muscone, a major active ingredient of musk, to beagle dogs of both sexes were performed to investigate both acute and subacute toxicity. Beagle dogs(3 males and 3 females) in acute experiments were administered orally with single dosage of 2,000 ㎎/㎏ and groups of 9 male and 9 female beagle dogs in subacute experiments were given daily different dosage of l-muscone, 0.2㎎/㎏/day(low dosage group), 2 ㎎/㎏/day(middle dosage group), or 20 ㎎/㎏day(high dosage group) once a day for 4 weeks by oral route according to the Established Regulation of Korean Food and Drug Administration(1996.4.16). LD_50 value for beagle dogs was more than 2,000 ㎎/㎏ on oral route for both male and females. In animals administered with l-muscone, there were neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, eye examination, hematology, serum chemistry, organ weight and other findings. No histolopathological lesions were observed in both control and treatment groups. Above data strongly suggest that l-muscone in beagle dogs is considered to be safe.

Dimecron 중독증 환자 6예

류하근,박봉안,류주성,유재등,김정수,김치훈,송종오 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

The authors experienced 6 cases of Dimecron intoxication, an organophosphate, that required mechanical ventilator treatment. Among 6 cases, 4 cases were intoxication due to suicidal attempt and 2 cases were due to accidental exposure. Among 4 cases of intoxication due to suicidal attempt, only one patient recovered even after aggressive treatments using gastric lavage, mechanical ventilation, atropine and PAM(pralidoxime). Two cases of intoxications due to accidental exposure, 1 case needed mechanical ventilation. Both cases were recovered without any sequele, however. Organophosphate, especially Dimecron, showed high rates of resfiratory muscle paralysis and mechanical ventilator support. The mortality rate of organophosphate agents can be decreased by education, wearing protectors, and aggressive mechanical ventilator treatment when respiratory failure develops.

기능적 방법을 이용한 소아의 하악과두 골절의 처치 : 증례 보고 A case report

이정하,박성규,위유민,정현구,이봉규,이창섭 조선대학교 구강생물학연구소 2002 Oral Biology Research (Oral Biol Res) Vol.26 No.2

The pediatric condylar fracture occurs very frequently in the mandible, but this injury is occasionally ignored due to difficulty of diagnosis and no cooperation of patient. The adequate initial diagnosis and active treatment must be performed because delayed and improper treatment lead to possible severe complication such as TMJ ankylosis and retardation of mandibular development. Most pediatric condylar fracture is mainly performed by the conservative or functional treatment. but it may be required open reduction according to cases. In this study, Activator is applied for functional treatment of pediatric condylar fracture and fair recovery of jaw function is acquired.

횡 요천골부 후피부판 (Transverse Lumbosacral Back Flap)을 이용한 천골부 욕창 치험례

전건수,김유승,하재성,박준용,서정오 大韓成形外科學會 1993 Archives of Plastic Surgery Vol.20 No.3

Pressure sore is an area of ischemic tissue loss resulting from prolonged or often repeated pressure, usually over a bony prominence of body. Recently, the prevalence of pressure sore is major clinical problem, due to the increased number of patients with spinal cord injuries or longterm comatous patient after traffic, industrial accidents. The surgical principles in the treatment of pressure sores are total excision of the ulcer, scartissue, bursae, complete removal of all infected bone with recontouring of bony prominences to alleviate discrete pressure points and resurfacing and padding of the defects with healthy and well vascularized tissues. The sacral sore is the most common site for the development of pressure sore in Korea. We had experienced 14 cases who had received surgical treatments for sacral sores with transverse lumbosacral back flap. We obtained the following conclusions. Advantages 1)It is quick and easy procedure 2)The flap elevation itself is relatively bloodless 3)The donor defect is in a non-weight-bearing area 4)Muscle is not sacrified(possibly of importance in the ambulatory patient) 5)Surgical options are preserved in cases of recurrence(the flap itself may be reelevated and inset in some cases of recurrence) Disadvantages 1)It is lacking the bulky padding afforded by alternative musculocutaneous flaps 2)The vascularity of the flap tip is empirically less dependable than that of a musculocutaneous flap 3)The donor defect is large, cannot usually be closed primarily, and may prove of cosmetic concern

Bovine botulism outbreak associated with incidental consumption of presumably contaminated leftover food

( Jae Won Byun ),( Kyung Hyun Lee ),( Ha Young Kim ),( Soon Seek Yoon ),( Ji Youl Jung1 ),( Woo Seog Jeong1 ),( Jae Ku Oem ),( Jong Soo Lim ),( Myoung Heon Lee ),( You Chan Bae ) 한국예방수의학회(구 한국수의공중보건학회) 2013 예방수의학회지 Vol.37 No.1

Nine cattle among 18 in a native Korean herd died or were euthanized within 3 days. The affected cattle showed cowshed. The pigs and dogs had been fed leftover food originating from nearby restaurants, and the cattle could presumably reach the contaminated food in the pig troughs. Necropsy revealed a few chicken bones and red pepper pieces as well as large amounts of grain and rice straw hay mixed in the rumen. Botulism type D was isolated in the ruminal contents of one of the cattle. We speculated that the outbreak was associated with the cattle incidentally eating presumably contaminated leftover food from the pig trough.

Circulating Semaphorin 4D as a Marker for Predicting Radiographic Progression in Patients with Rheumatoid Arthritis

Ha, You-Jung,Han, Dong Woo,Kim, Ji Hyoun,Chung, Sang Wan,Kang, Eun Ha,Song, Yeong Wook,Lee, Yun Jong Hindawi 2018 Disease markers Vol.2018 No.-

<P>Semaphorin 3A (Sema3A) and semaphorin 4D (Sema4D) are molecules which regulate immune responses as well as bone remodeling process. The aim of this study was to evaluate the serum levels of Sema3A and Sema4D and to investigate their clinical significance in rheumatoid arthritis (RA). The serum levels of Sema3A and Sema4D were measured in 130 patients with RA and 65 sex- and age-matched healthy individuals. Circulating levels of biomarkers of RA-related inflammation and bone turnover such as tumor necrosis factor- (TNF-) <I>α</I>, interleukin- (IL-) 6, IL-22, IL-34, osteopontin, Dkk-1, and sclerostin were also measured. Disease activity was determined by the 28-joint disease activity score (DAS28), and radiographic joint damage was assessed by the modified Sharp van der Heijde score (SHS). The serum levels of Sema3A were significantly higher in patients with RA than those in healthy controls (<I>p</I> < 0.001), whereas serum4D levels did not differ between the two groups. The levels of Sema4D showed a positive correlation with C-reactive protein (<I>p</I> = 0.001) and IL-6 (<I>p</I> < 0.001) levels, whereas the levels of Sema3A showed a negative correlation with Dkk-1 (<I>p</I> = 0.007) and TNF-<I>α</I> (<I>p</I> = 0.001). Even though Sema3A and Sema4D levels were comparable between RA patients with DAS28> 3.2 and with DAS28 ≤ 3.2, RA patients with radiographic progression (ΔSHS change/year ≥ 1) had significantly higher baseline levels of Sema4D than those without progression (<I>p</I> = 0.029). Additionally, when RA patients were divided into 3 groups using tertiles of Sema4D levels, the percentage of progressors was significantly increased (<I>p</I> = 0.045). In multivariate logistic regression analysis, serum Sema4D levels were an independent risk factor for radiographic progression. Our results suggest that the baseline levels of Sema4D might be a useful marker to identify RA patients with subsequent radiographic progression and that Sema4D may be an active mediator involved in RA-induced joint damage.</P>

Utilization of PEST questionnaire to detect early psoriatic arthritis in daily clinical practice

( You-jung Ha ),( So Yeon Cho ),( Sang Woong Youn ),( Kichul Shin ) 대한내과학회 2015 대한내과학회 추계학술대회 Vol.2015 No.1

Background: Psoriatic arthritis (PsA) is a systemic inflammatory condition mostly preceded by long-term psoriasis(PsO). The prevalence of PsA in Koreans is regarded to be lower than Caucasians. PsA is still can be a serious rheumatic disease causing articular and extra-articular problems irrespective of ethnicity or region. Several questionnaires have been developed to help identify PsA among PsO patients, but there is currently no validated screening tool in Korea yet. Methods: The Psoriasis Epidemiology Screening Test, or PEST was translated into Korean and then back-translated to English for comparison; a simple,five questionnaire that could be used without assistance. This PEST form was tested on PsO patients visiting the Dermatology clinic at 5 medical facilities in urban areas. Clinical information including body surface area (BSA), psoriasis area severity index (PASI), nail changes were also obtained. Patients who checked ‘yes’ to 2 or more questions were referred to Rheumatology for further evaluation. Joint exams, followed by laboratory tests and plain imaging were performed. Patients meeting the CASAPR criteria were confirmed to have PsA. Results: Data of 80 PsO patients from 2 centers were analyzed. The mean age was 46.1 years, and gender ratio was near 1: 1. Mean BSA and PASI score was 7.4%, 5.9, respectively. Nail Psoriasis was discovered in 29 (36.3%) patients. Among the 20 (25%) patients checked ‘yes’ to ≥2 questions, 11 (55%) met the CASPAR criteria. For those who checked ‘yes’ to ≥3 questions, 5 (46%) were diagnosed as PsA. When comparing baseline characteristics between PsA and PsO (only) patients, nail psoriasis was highly prevalent in PsA patients (63.6 vs. 31.9%, p=0.047). BSA and PASI were also higher in PsA patients, but did not reach statistical significance. Conclusions: This pilot study supports that PsO patients with musculoskeletal symptoms and nail psoriasis should be carefully evaluated for PsA. A validated, well-adapted PsA screening tool is warranted to help both patients and physicians better detect PsA. This investigator-intitiated study was supported by Abbvie.

Characterization of an Catechol 2,3-dioxygenase from Pseudomonas putida SU10

Ha, You Mee Min, Kyung Hee Jung, Young Hee 숙명여자대학교 자연과학연구소 1998 자연과학논문집 Vol.- No.9

Pseudomonas putida SUl0의 4-methylcatechol 2,3-dioxygenase의 정제를 ammonium sulfate 침전, DEAE 5PW, superdex S-200, Resource-Q의 chromatog chromatography를 통하여 실시하였다. Gel filtration 에 의한 분자량을 약 130 kDa이며 SDS/polyacrylamide gel electrophoresis에 의한 subunit의 분자량은 34 kDa이므로 이 효소는 4개의 동일한 subunit로 되어 있음을 확이하였다. 이 효소의 N-terminal amino acid 서열을 결정한 결과 다음 extradiol dioxygenases와 높은 동질성을 보여주었다. Catechol과 methyl로 치환된 catechol에 대한 활성을 조사한 결과 catechol이나 3-methylcatechol보다 4-methylcatechol에 대하여 높게 나타내었다. 이들 기질에 대한 Km 값은 3.5-5.07μM 이다.

PIM-1 kinase is a novel regulator of proinflammatory cytokine-mediated responses in rheumatoid arthritis fibroblast-like synoviocytes

Ha, You-Jung,Choi, Yong Seok,Han, Dong Woo,Kang, Eun Ha,Yoo, In Seol,Kim, Jin Hyun,Kang, Seong Wook,Lee, Eun Young,Song, Yeong Wook,Lee, Yun Jong Oxford University Press 2019 Rheumatology Vol.58 No.1