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RISS 인기검색어
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- 저자 : Yongbo Zhang (검색결과 12 건)
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Zhang Chen,Su Yongbo,Mei Bo,Yang Feng,Zhang Jialin,Yun Huanqing,Liu Bo,Sun Yi,Zhang Haiming,Jin Zhi,Zhong Yinghui 한국물리학회 2023 Current Applied Physics Vol.48 No.-
InP-based hetero-junction bipolar transistors (HBTs) are attractive for various millimeter-wave and terahertz electronics due to their ultrahigh frequency performance. Therefore, the study of their irradiation reliability is extremely urgent. In this work, 2 MeV proton irradiation experiment has been carried out on self-fabricated N+Np+ InP/InGaAs hetero-junction. The degradation mechanisms have systematically been studied after exposure to protons of 5 × 1013 H+/cm2. The voltage range of recombination current at low forward bias has been largely expanded from 0-0.2 V to 0–0.6 V. Furthermore, the interface states properties have been characterized by utilizing the frequency-dependent conductance technique, the interface states density (Dit) has increased from approximately 9.02 × 1012 cm-2 eV-1–1.99 × 1013 cm-2 eV-1 to 9.51 × 1012 cm-2 eV-1–2.00 × 1013 cm-2 eV-1 after irradiation. The study would be great significance for understanding the evolution of proton irradiation on relative devices.
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Yongbo Guo,Zheyingzi Zhu,Dekun Zhang,Kai Chen,Songquan Wang 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.3
An experiment was conducted using a microslip friction test machine to measure reciprocating sliding friction between a K25 friction lining and a 6 × 19 steel wire rope under dynamic loading. Real-time in situ microscopic observation of the interfacial friction in the contact were performed by using a high-speed micro camera. The results showed that during the loading and unloading stages of friction, adhesion, partial adhesion and slip states were observed. The friction coefficient decreases with increasing dynamic load. In the lightly loaded area (3kN-10kN), the variation of the friction coefficient in the sliding stage was stable. In the heavily loaded area (3kN-14kN), the friction coefficient in the slip stage decreased with increasing load, and the proportion of the slip stage in the loading time increased. The wear debris generated at the interface of the contact increased gradually with increasing dynamic load. Then, a dense third body formed, which reduced the friction coefficient. The wear rate of the lining under these experimental conditions was 3.23 × 10–4 after 18 h.
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Test Study on Axial Compression Behavior of GCFST Columns Under Unidirectional Repeated Load
Cun Hui,Yongbo Zhang,Yangguang Wang,Ran Hai 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.4
Geopolymer concrete is one of the directions of green development in the construction industry, and casting geopolymer concrete inside steel tubes can effectively play the respective advantages of both. In order to study the axial compression performance and failure mechanism of geopolymer concrete-filled steel tubular (GCFST) columns, two hollow steel tubular columns were designed as the control group and eight geopolymer concrete-filled steel tubular columns were tested in axial compression with concrete strength grade, length-to-diameter ratio, and steel tube wall thickness as parameters. The load–displacement curve, skeleton curve, and stiffness degradation curve of each specimen were obtained by observing the force process and failure mode of each specimen, analyzing the characteristic load, and characteristic displacement, stiffness degradation, ductility, and energy dissipation capacity, and deriving the method of calculating the axial compression load-bearing capacity of GCFST columns, and comparing with several codes commonly used in the world. The results show that the length-diameter ratio has a significant effect on the failure mode of GCFST columns. The peak load and initial stiffness of each group of specimens are different, but their load–displacement curves, skeleton curves, and stiffness degradation trend are the same. The increase of geopolymer concrete strength and steel tube wall thickness can improve the ultimate load-bearing capacity, average compression capacity, and energy dissipation capacity of GCFST columns. The axial compression load-bearing capacity calculation formula proposed in this paper is in good agreement with the test results, and the calculated values of the formula are compared with the calculation results of the international codes to verify the accuracy and applicability of the axial compression load calculation formula proposed in this paper, and the results of the study can provide reference for the theoretical research and engineering application of geopolymer concrete-filled steel tube composite structure.
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Targeting treatment of bladder cancer using PTK7 aptamer-gemcitabine conjugate
Xiang Wei,Peng Yongbo,Zeng Hongliang,Yu Chunping,Zhang Qun,Liu Biao,Liu Jiahao,Hu Xing,Wei Wensu,Deng Minhua,Wang Ning,Liu Xuewen,Xie Jianfei,Hou Weibin,Tang Jin,Long Zhi,Wang Long,Liu Jianye 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Gemcitabine (GEM) is one of the first-line chemotherapies for bladder cancer (BC), but the GEMs cannot recognize cancer cells and have a low long-term response rate and high recurrence rate with side effects during the treatment of BC. Targeted transport of GEMs to mediate cytotoxicity to tumor and avoid the systemic side effects remains a challenge in the treatment of BC.Based on a firstly confirmed biomarker in BC-protein tyrosine kinase 7 (PTK7), which is overexpressed on the cell membrane surface in BC cells, a novel targeting system protein tyrosine kinase 7 aptamer-Gemcitabine conjugate (PTK7-GEMs) was designed and synthesized using a specific PTK7 aptamer and GEM through auto-synthesis method to deliver GEM against BC. In addition, the antitumor effects and safety evaluation of PTK7-GEMs was assessed with a series of in vitro and in vivo assays.PTK7-GEMs can specifically bind and enter to BC cells dependent on the expression levels of PTK7 and via the macropinocytosis pathway, which induced cytotoxicity after GEM cleavage from PTK7-GEMs respond to the intracellular phosphatase. Moreover, PTK7-GEMs showed stronger anti-tumor efficacy and excellent biosafety in three types of tumor xenograft mice models.These results demonstrated that PTK7-GEMs is a successful targeted aptamer-drug conjugates strategy (APDCs) to treat BC, which will provide new directions for the precision treatment of BC in the field of biomarker-oriented tumor targeted therapy.
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Xiaoling Zhao,Yue Sun,Yongbo Ding,Jun Zhang,Kezhong Li 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.10
Purpose: Research has shown that sevoflurane-induced toxicity causes neurodegeneration in the developing brain. miR-34a has been found to negatively regulate ketamine-induced hippocampal apoptosis and memory impairment. However, the role of miR-34a in sevoflurane-induced hippocampal neurodegeneration remains largely unclear. Materials and Methods: C57/BL6 mice (7-day-old) inhaled 2.3% sevoflurane for 2 h/day over 3 consecutive days. miR-34a expressionwas reduced through intracerebroventricular injection with miR-34a interference lentivirus vector (LV-anti-miR-34a) into mouse hippocampus after anesthesia on the first day of exposure. Hippocampal apoptosis was detected by TUNEL assay and flow cytometry analysis. Spatial memory ability was evaluated by the Morris water maze test. The interaction between miR-34a and Wnt1 was confirmed by luciferase reporter assay, RNA immunoprecipitation, Western blot, and immunofluorescence staining. The effects of miR-34a on protein levels of B-cell lymphoma 2 (Bcl-2), bcl-2-like protein 4 (Bax), and Wnt/β-catenin pathway-related proteins were evaluated using Western blot analysis. Results: Sevoflurane upregulated hippocampal miR-34a, and miR-34a inhibitor attenuated sevoflurane-induced hippocampal apoptosis and memory impairment. miR-34a negatively regulated Wnt1 expression by targeting miR-34a in hippocampal neurons. Moreover, forced expression of Wnt1 markedly undermined miR-34a-mediated enhancement of sevoflurane-induced apoptosis of hippocampal neurons, while Wnt1 silencing greatly restored anti-miR-34a-mediated repression of sevoflurane-inducedapoptosis of hippocampal neurons. Increased expression of miR-34a inhibited the Wnt/β-catenin pathway in hippocampalneurons exposed to sevoflurane, while anti-miR-34a exerted the opposite effects. Conclusion: miR-34a inhibitor may effectively protect against sevoflurane-induced hippocampal apoptosis via activation of the Wnt/β-catenin pathway by targeting Wnt1.
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( Yuhua Chen ),( Lei Zhang ),( Yongbo Zhang ),( Tao Bai ),( Jun Song ),( Wei Qian ),( Xiaohua Hou ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.3
Background/Aims Lipopolysaccharide (LPS) is the key factor inducing mucosal and systemic inflammation in various intestinal and parenteral diseases, which could initially disrupt the epithelial barrier function. EphrinA1/ephA2 is speculated to increase the epithelial permeability for its “repulsive interaction” between adjacent cells. This study aim to investigate the role of ephrinA1/ephA2 in LPS-induced epithelial hyperpermeability. Methods In vivo model challenged with oral LPS in C57BL/6 mice and in vitro model exposed to LPS in Caco2 monolayer were established. The barrier function was assessed including expression of tight junction proteins (occludin and claudin-1), transepithelial electrical resistance, and permeability to macromolecules (fluorescein isothiocyanate-labeled fluorescent dextran 4 kDa [FD4]). Moreover, the expression and phosphorylation of ephrinA1/ephA2 were quantified, and its roles in the process of epithelial barrier disruption were confirmed via stimulating ephA2 with ephrinA1-Fc chimera (ephrinA1-Fc) and inactivating ephA2 with ephA2-Fc chimera (ephA2-Fc), or ephA2 monoclonal antibody (ephA2-mab), as well as inhibiting extracellular signal-regulated kinase 1/2 (ERK1/2) with PD98059. Results LPS induced significant barrier dysfunction with dismissed occludin and claudin-1 expression, reduced transepithelial electrical resistance and increased FD4 permeability, accompanied by upregulated ephrinA1/ephA2 pathway and phosphorylation of ephA2 receptor. Furthermore, ephA2-Fc, and ephA2-mab ameliorated LPS-induced epithelial hyperpermeability, which was also inhibited by PD98059. Additionally, ephrinA1-Fc led to apparent epithelial leakage in Caco2 monolayer by promoting the phosphorylation of ERK1/2, which could be obviously blocked by ephA2-mab and PD98059. Conclusion EphrinA1/ephA2 promotes epithelial hyperpermeability with an ERK1/2-dependent pathway, which involves in LPS-induced intestinal barrier dysfunction. (J Neurogastroenterol Motil 2020;26:397-409)
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Chen, Ping,Qiu, Bowen,Li, Yuanming,Wu, Yingwei,Hui, Yongbo,Deng, Yangbin,Zhang, Kun Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.4
Although there are still controversial opinions and uncertainty on application of SiC<sub>f</sub>/SiC composite cladding as next-generation cladding material for its great oxidation resistance in high temperature steam environment and other outstanding advantages, it cannot deny that SiC<sub>f</sub>/SiC cladding is a potential accident tolerant fuel (ATF) cladding with high research priority and still in the engineering design stage for now. However, considering its disadvantages, such as low irradiated thermal conductivity, ductility that barely not exist, further evaluations of its in-pile behaviors are still necessary. Based on the self-developed code we recently updated, relevant thermohydraulic and mechanical models in FROBA-ATF were applied to simulate the cladding behaviors under normal and accident conditions in this paper. Even through steady-state performance analysis revealed that this kind of cladding material could greatly reduce the oxidation thickness, the thermal performance of UO<sub>2</sub>-SiC was poor due to its low inpile thermal conductivity and creep rate. Besides, the risk of failure exists when reactor power decreased. With geometry optimization and dopant addition in pellets, the steady-state performance of UO<sub>2</sub>-SiC was enhanced and the failure risk was reduced. The thermal and mechanical performance of the improved UO<sub>2</sub>-SiC was further evaluated under Loss of coolant accident (LOCA) and Reactivity Initiated Accident (RIA) conditions. Transient results showed that the optimized ATF had better thermal performance, lower cladding hoop stress, and could provide more coping time under accident conditions.
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