Effect of proton irradiation on interfacial and electrical performance of N+Np+ InP/InGaAs hetero-junction

Zhang Chen,Su Yongbo,Mei Bo,Yang Feng,Zhang Jialin,Yun Huanqing,Liu Bo,Sun Yi,Zhang Haiming,Jin Zhi,Zhong Yinghui 한국물리학회 2023 Current Applied Physics Vol.48 No.-

InP-based hetero-junction bipolar transistors (HBTs) are attractive for various millimeter-wave and terahertz electronics due to their ultrahigh frequency performance. Therefore, the study of their irradiation reliability is extremely urgent. In this work, 2 MeV proton irradiation experiment has been carried out on self-fabricated N+Np+ InP/InGaAs hetero-junction. The degradation mechanisms have systematically been studied after exposure to protons of 5 × 1013 H+/cm2. The voltage range of recombination current at low forward bias has been largely expanded from 0-0.2 V to 0–0.6 V. Furthermore, the interface states properties have been characterized by utilizing the frequency-dependent conductance technique, the interface states density (Dit) has increased from approximately 9.02 × 1012 cm-2 eV-1–1.99 × 1013 cm-2 eV-1 to 9.51 × 1012 cm-2 eV-1–2.00 × 1013 cm-2 eV-1 after irradiation. The study would be great significance for understanding the evolution of proton irradiation on relative devices.

A Dislocation Density Based Crystal Plasticity Model of 3D Complex Sheet Metal Forming

Haiming Zhang,Xianghuai Dong,Qian Wang,Zhiying Chen 한국소성가공학회 2011 기타자료 Vol.2011 No.8

A dislocation density based crystal plasticity model is used to simulate sheet metal forming processes under different temperature. In the present model, dislocation densities in each slip system are taken as internal state variables. An extended Kocks-Mecking-Estrin evolution law is adopted to describe the athermal storage, and the strain rate and temperature sensitive annihilation, of dislocation densities. The critical resolved stress on a specified slip system is related with dislocation densities in all slip systems, the corresponding mesoscopic coefficients of interaction between different slip systems are determined by recent dislocation dynamics simulations. On the basis of thermally activated dislocation motion, this physically based model is capable of describing the softening resulted from dynamic recovery. This model incorporated with a hyperelastic constitutive law is then implemented into an explicit finite element code, to make it deal with the strong nonlinear problems more efficiently. An iteration-free semi-implicit method, which is more suitable for explicit FEM, is adopted as the integration algorithm of the model. This model is used to investigate the deformation characteristics of warm forming of Al-Mg alloy under different temperatures. The simulation results show that the model is robust and efficient, has the potential to be used in the practical engineering simulation. It also confirms that the micromechaincs models can be used to simulate conventional sheet metal forming.

Melatonin protects endothelial progenitor L255cells against AGE-induced apoptosis via autophagy flux stimulation and promotes wound healing in diabetic mice

Haiming Jin,Zengjie Zhang,Chengui Wang,Qian Tang,Jianle Wang,Xueqin Bai,Qingqing Wang,Majid Nisar,Naifeng Tian,Quan Wang,Cong Mao,Xiaolei Zhang,Xiangyang Wang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Wound healing is delayed in diabetic patients. Increased apoptosis and endothelial progenitor cell (EPC) dysfunction are implicated in delayed diabetic wound healing. Melatonin, a major secretory product of the pineal gland, promotes diabetic wound healing; however, its mechanism of action remains unclear. Here, EPCs were isolated from the bone marrow of mice. Treatment of EPCs with melatonin alleviated advanced glycation end product (AGE)-induced apoptosis and cellular dysfunction. We further examined autophagy flux after melatonin treatment and found increased light chain 3 (LC3) and p62 protein levels in AGE-treated EPCs. However, lysosome-associated membrane protein 2 expression was decreased, indicating that autophagy flux was impaired in EPCs treated with AGEs. We then evaluated autophagy flux after melatonin treatment and found that melatonin increased the LC3 levels, but attenuated the accumulation of p62, suggesting a stimulatory effect of melatonin on autophagy flux. Blockage of autophagy flux by chloroquine partially abolished the protective effects of melatonin, indicating that autophagy flux is involved in the protective effects of melatonin. Furthermore, we found that the AMPK/mTOR signaling pathway is involved in autophagy flux stimulation by melatonin. An in vivo study also illustrated that melatonin treatment ameliorated impaired wound healing in a streptozotocin-induced diabetic wound healing model. Thus, our study shows that melatonin protects EPCs against apoptosis and dysfunction via autophagy flux stimulation and ameliorates impaired wound healing in vivo, providing insight into its mechanism of action in diabetic wound healing.

Frequency Response Analysis on Modified Plant of Extended State Observer

Yuqiong Zhang,Yali Xue,Donghai Li,Zhiqiang Gao,Haiming Niu,Huanpao Huang 제어로봇시스템학회 2017 제어로봇시스템학회 국제학술대회 논문집 Vol.2017 No.10

The active disturbance rejection control (ADRC) framework gives birth to a new concept, the modified plant (MP), describing the dynamics after the total disturbance is estimated and cancelled approximately. Ideally the modified plant is in integral form, to greatly simplify and fix the controller design, even though actual plant contains higher-order dynamics or dead time. This paper investigates that when such processes are modified into the integral, how the parameters of the extended state observer (ESO) impact on the dynamic characteristics and stability of the MP. Frequency-domain analyses show that the MP can gradually approach the integral form through parameters tuning. However, it should be cautious that an aggressive set of parameters may lead to an unstable modified plant in the presence of order mismatch.

An Anti-Overvoltage Strategy for Electrolytic Capacitorless IPMSM Drives Using Power Controller

Dawei Ding,Haiming Hu,Gaolin Wang,Guoqiang Zhang,Dianguo Xu,Frede Blaabjerg 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5

Three-phase input diode rectifier interior permanent magnet synchronous motor (IPMSM) drives with small-volume film capacitors have many merits, such as high reliability, low cost and high power density. However, in regenerative braking, the DC-link voltage becomes harder to be controlled than the traditional topology due to the application of slim film capacitors. In this paper, an anti-overvoltage strategy is proposed by controlling the electrical power of the motor directly. The q-axis current boundary is determined by the proposed power controller. Compared with the conventional method of voltage controller, the proposed method is more suitable for electrolytic capacitorless drives.

Wood Defects Recognition Based on Fuzzy BP Neural Network

Hongbo Mu,Mingming Zhang,Dawei Qi,Shuyue Guan,Haiming Ni 보안공학연구지원센터 2015 International Journal of Smart Home Vol.9 No.5

Firstly, we applied the X-ray non-destructive testing technology to detect wood defects for getting the images. After graying the images, we calculated their GLCMS(Gray Level Co-occurrence Matrixes), then we normalized GLCMS to obtain the joint probabilities of GLCMS. The feature vectors of images, which included 13 eigenvalues of images were calculated and extracted by the joint probability of GLCMS. The fuzzy BP neural network(abbreviated as FBP) was designed by combining fuzzy mathematics and BP neural network . And the FBP neural network was regarded as the membership function of feature vectors, the outputs of the network was regarded as the degree of membership to the feature vectors in each category. We use the maximum degree of membership method for the pattern recognition of feature vectors, so the automatic identification and classification for feature vectors were achieved , and then the automatic identification of wood defects was realized. By simulated study and training many times, the results shown that the average recognition success rate of the network was more than 90%, and some FBP networks had an extremely high recognition success rate to training samples and test samples.

The Application of RBF Neural Network in the Wood Defect Detection

Hongbo Mu,Mingming Zhang,Dawei Qi,Haiming Ni 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.2

Wood defect is due to the physiological process, genetic factor or affected by the external environment in the growth period. These defects will reduce the utilization value of wood. However, it is very difficult to determine whether there are defects exist, and the degree of defects. Therefore, the effective detection of wood defect information is particularly important. A new wood defect detection method by using RBF neural network was proposed in this paper. The new RBF defect detection method can be divided into the following main steps: (1) Detect wood defects by using X-ray nondestructive testing technology. (2) Deal with defect images by using digital image processing technology. (3) Analyze the information of different defects, and extract the characteristic value of wood defects. (4) Then, the RBF neural network model was constructed. (5) Finally, the RBF neural network is trained with the known samples and simulated with the unknown samples. The experimental results shown that the RBF neural network method was effectively detect the two typical wood defects. This method provides an important theoretical basis to realize the wood defect automatic detection.

Rapid fabrication of NiFe(OH)x/Fe0.2Co-Se complexes for oxygen evolution reaction electrocatalysis

Kang Gao,Miao Xu,Chuankun Zhang,Haiming Huang,Dongming Cai,Minglei Cao,Jun Wu,Chengrui Wu,Yongjin Hu,Rui Tong 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.124 No.-

Exploiting the inexpensive and efficient oxygen evolution reaction (OER) electrocatalysts is crucial forimproving the efficiency of electrocatalytic water splitting (EWS), since the slow 4-electron OER processis a rate-limiting step in EWS. Herein, we prepared the NiFe(OH)x/Fe0.2Co-Se complexes on carbon paper(CP) via an easy two-step electrochemical deposition strategy. By varying the doping amount of Fe andthe deposition time of Fe0.2Co-Se, the OER property of NiFe(OH)x/Fe0.2Co-Se/CP was optimized to the best:only requiring low overpotentials of 243 and 277 mV at the current density of 20 and 100 mA/cm2 (j20and j100) and a small Tafel slope of 36.8 mV/dec, along with a terrific long-term durability in 1 M KOH. According to the experimental results, the rich exposed active sites, improved intrinsic site activityand enhanced electrical conductivity lead to the superior OER performance. Our work will provide someinspiration for designing other metal selenide/hydroxide heterostructures for other energy conversion orstorage applications.

Small molecule natural compound agonist of SIRT3 as a therapeutic target for the treatment of intervertebral disc degeneration

Jianle Wang,Majid Nisar,Chongan Huang,Xiangxiang Pan,Dongdong Lin,Gang Zheng,Haiming Jin,Deheng Chen,Naifeng Tian,Qianyu Huang,Yue Duan,Yingzhao Yan,Ke Wang,Congcong Wu,Jianing Hu,Xiaolei Zhang,Xiangy 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Oxidative stress-induced mitochondrial dysfunction is implicated in the pathogenesis of intervertebral disc degeneration (IVDD). Sirtuin 3 (SIRT3), a sirtuin family protein located in mitochondria, is essential for mitochondrial homeostasis; however, the role of SIRT3 in the process of IVDD has remained elusive. Here, we explored the expression of SIRT3 in IVDD in vivo and in vitro; we also explored the role of SIRT3 in senescence, apoptosis, and mitochondrial homeostasis under oxidative stress. We subsequently activated SIRT3 using honokiol to evaluate its therapeutic potential for IVDD. We assessed SIRT3 expression in degenerative nucleus pulposus (NP) tissues and oxidative stressinduced nucleus pulposus cells (NPCs). SIRT3 was knocked down by lentivirus and activated by honokiol to determine its role in oxidative stress-induced NPCs. The mechanism by which honokiol affected SIRT3 regulation was investigated in vitro, and the therapeutic potential of honokiol was assessed in vitro and in vivo. We found that the expression of SIRT3 decreased with IVDD, and SIRT3 knockdown reduced the tolerance of NPCs to oxidative stress. Honokiol (10 μM) improved the viability of NPCs under oxidative stress and promoted their properties of anti-oxidation, mitochondrial dynamics and mitophagy in a SIRT3-dependent manner. Furthermore, honokiol activated SIRT3 through the AMPKPGC- 1α signaling pathway. Moreover, honokiol treatment ameliorated IVDD in rats. Our study indicated that SIRT3 is involved in IVDD and showed the potential of the SIRT3 agonist honokiol for the treatment of IVDD.

The role of botulinum toxin type A related axon transport in neuropathic pain induced by chronic constriction injury

Huilian Bu,Pengfei Jiao,Xiaochong Fan,Yan Gao,Lirong Zhang,Haiming Guo 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.4

Background: The mechanism of peripheral axon transport in neuropathic pain is still unclear. Chemokine ligand 13 (CXCL13) and its receptor (C-X-C chemokine receptor type 5, CXCR5) as well as GABA transporter 1 (GAT-1) play an important role in the development of pain. The aim of this study was to explore the axonal transport of CXCL13/CXCR5 and GAT-1 with the aid of the analgesic effect of botulinum toxin type A (BTX-A) in rats. Methods: Chronic constriction injury (CCI) rat models were established. BTX-A was administered to rats through subcutaneous injection in the hind paw. The pain behaviors in CCI rats were measured by paw withdrawal threshold and paw withdrawal latencies. The levels of CXCL13/CXCR5 and GAT-1 were measured by western blots. Results: The subcutaneous injection of BTX-A relieved the mechanical allodynia and heat hyperalgesia induced by CCI surgery and reversed the overexpression of CXCL13/CXCR5 and GAT-1 in the spinal cord, dorsal root ganglia (DRG), sciatic nerve, and plantar skin in CCI rats. After 10 mmol/L colchicine blocked the axon transport of sciatic nerve, the inhibitory effect of BTX-A disappeared, and the levels of CXCL13/CXCR5 and GAT-1 in the spinal cord and DRG were reduced in CCI rats. Conclusions: BTX-A regulated the levels of CXCL13/CXCR5 and GAT-1 in the spine and DRG through axonal transport. Chemokines (such as CXCL13) may be transported from the injury site to the spine or DRG through axonal transport. Axon molecular transport may be a target to enhance pain management in neuropathic pain.