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Shin, Ji-Yon,Lee, Jung-Min,Shin, Heon-Sub,Park, Sang-Yong,Yang, Jung-Eun,KimCho, So-Mi,Yi, Tae-Hoo The Korean Society of Ginseng 2012 Journal of Ginseng Research Vol.36 No.1
The glioblastoma multiforme (GBM) is the most common malignant brain tumor in adults. Despite combination treatments of radiation and chemotherapy, the survival periods are very short. Therefore, this study was conducted to assess the potential of ginsenoside $F_2$ (F2) to treat GBM. In in vitro experiments with glioblastoma cells U373MG, F2 showed the cytotoxic effect with $IC_{50}$ of 50 ${\mu}g/mL$ through apoptosis, confirmed by DNA condensation and fragmentation. The cell population of cell cycle sub-G1 as indicative of apoptosis was also increased. In xenograft model in SD rats, F2 at dosage of 35 mg/kg weight was intravenously injected every two days. This reduced the tumor growth in magnetic resonance imaging images. The immunohistochemistry revealed that the anticancer activity might be mediated through inhibition of proliferation judged by Ki67 and apoptosis induced by activation of caspase-3 and -8. And the lowered expression of CD31 showed the reduction in blood vessel densities. The expression of matrix metalloproteinase-9 for invasion of cancer was also inhibited. The cell populations with cancer stem cell markers of CD133 and nestin were reduced. The results of this study suggested that F2 could be a new potential chemotherapeutic drug for GBM treatment by inhibiting the growth and invasion of cancer.
박용섭 韓國海洋大學校 人文社會科學大學 1996 韓國海洋大學校 人文社會科學論叢 Vol.- No.4
As the former STCW Convention, 1978 has been amended entirely to replace with New STCW Convention on 1995 by IMO, on the ground of the wider international requirements to promote the safe navigation and the quality of seafarers. It is characteristic of New STCW Convention is to form special capability with good seamanship for each seafarer which the flag state shall be quaratered thoroughly. According to the legislative policy of the New STCW Convention, we, as a member of IMO, are at the moment stage to make amendment of the Merchant Marine Officers' Act and Seaman Act respectively. From the view point of the above, this Articles would like to give some issues how to reform the mentioned Acts on the basis of the New STCW Convention.
담낭질환의 Neuron Specific Enolase 반응세포 출현에 관한 면역조직화학적 연구
박용욱,박언섭,유재형 중앙대학교 의과대학 의과학연구소 1992 中央醫大誌 Vol.17 No.1
A total 50 patients who had undergone cholecystectomy for cholecystopathy were included in the study to observe the staining pattern of the cells and distribution of antihuman Neuron Spectific Enolase (NSE) antibody by avidin-biotin immunoperoxidase method. The studies consisted of 31 cased of chronic cholecystitis with lithiasis, 9 cases of adenoma and 10 cases of carcinoma including 6 cases of moderately differentiated adenocarcinoma, 3 cased of poorly differentiated adenocarcinoma, and 1 case of small cell carcinoma of combined type. The results were as follows : 1. In the chronic cholecystitis with lithiasis, nine of 31 cases (29%) with the NSE immunoreactive cells, arranged in single of grouped fashion, are focally observed in the covering surface epithelium. 2. The NSE immunoreactivities of carcinoma is more stronger than that of chronic cholecystitis and adenoma. 3. The coarse granular intracytoplasmic strong positive reaction of small cell carcinoma is diffusely observed in noeplastic small cell and glandular epithelium. Therfore, authors suggested that two elements arise from a common primitive cells of endodermal derivation capapble of differentiation along two cell-endocrine ans epithelial.
성백섭,차용훈,박창언,김일수,김덕중,이연신,손준식 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-
Currently knowledge of strain in welds has mainly been obtained from strain gaging method; that is directly attaching most of the material to the gage. The very few non-contact method are still in the early stage. One of the non-contact methods is by the use of the laser that has high-level of the accuracy for the measurement, and this laser also has excellent characteristics on which many studies for its applications are focused throughout the many fields. The dissertation is on the measurement of the strain caused by the characteristics and the temperature changes of the TIG welded zone which is used with 3D ESPI system that is functionally modified through the laser ESPI system. This system employed the aluminum sheet-metal which are mainly used for the steel plate such as for the electronics, chemistry, food instrument and electronic appliances.
차용훈,김덕중,이연신,채경수,성백섭,박회식 조선대학교 동력자원연구소 1997 動力資源硏究所誌 Vol.19 No.1
The objective of this thesis is to investigate the influence of the initial residual stress on the fatigue crack growth after the distribution of the initial residual stress is measured when the crack is growing from the compressive residual stress to the tensile residual stress field. In the case of as welded material, respective of load ratio, the span of the fatigue is the shortest in base metal, while in weld metal and HAZ, the crack growth was retarded due to the effect of the compressive residual stress at the crack tip as well as the span of the crack is longer than base metal. In region II that is in stable growth state of the fatigue crack, da/dN=C(ΔK)^m of power law was satisfied. Also, it was considered that the value of m is not affected by residual stress. Superimposing welding residual stress intensity factor K_res on ΔK, the value of ΔK_eff calculated was lower than ΔK in the same value of da/dN, while the ΔK_eff is almost the same at the high ΔK.