폐실질내의 주변형 결절로 나타난 소세포성 폐암의 CT 소견

이태희,최요원,전석철,서흥석,함창곡,박충기 한양대학교 의과대학 1998 한양의대 학술지 Vol.18 No.2

We evaluated CT findings of the small cell carninoma, which presented as a solitary pulmonary nodule at the periphery of the lung parenchyma. Of pathologically-proven 45 patients with small cell carcinoma, 10 patients was included in this study, who had a solitary, peripheral lung nodule at distal portion of the subsegmental bronchus. We retrospectively reviewed clinical data and CT findings including size, location, margin, enhancement pattern, lymph node enlargement, metastasis. Peripheral small cell carcinomas were 22.2%(10/45). All masses had well-defined margin and lobulated margin was seen in 7 patients. Mean diameter was 3.8cm (2.5-7.0cm). Enhancement pattern were homogeneous in 3 cases and inhomogeneous in seven. Calcification or air-bronchogram was not present, and focal cavitation was seen in one case. In five, only lung mass was present, and lung mass with lymph node enlargement was seen in one. distant metastasis without lymph node enlargement was noted on two patients and another two patients showed lymph node enlargement and distant metastasis. Peripheral small cell carcinoma is not rare(22.2%). Most frequent CT finding is a well-defined, lobulated mass with inhomogeneous enhancement, these findings would be helpful in differentiating small cell carcinoma from other neuroendocrine tumors when differentiataion is difficult cytologically.

Carbon dioxide Fischer-Tropsch synthesis: A new path to carbon-neutral fuels

Choi, Yo Han,Jang, Youn Jeong,Park, Hunmin,Kim, Won Young,Lee, Young Hye,Choi, Sun Hee,Lee, Jae Sung Elsevier BV 2017 Applied Catalysis B Vol.202 No.-

<P><B>Abstract</B></P> <P>Paradigm of climate change mitigation technologies is shifting from carbon capture and storage (CCS) to carbon capture and utilization (CCU). Here we propose a new path to CCU – direct CO<SUB>2</SUB> conversion to liquid transportation fuels by reacting with renewable hydrogen produced by solar water splitting. The highly promising and CO<SUB>2</SUB>-neutral CCU system is possible by our discovery of a new catalyst that produces liquid hydrocarbon (C<SUB>5+</SUB>) selectivity of ∼65% and greatly suppressed CH<SUB>4</SUB> formation to 2–3%, which represents an unprecedented selectivity pattern for direct catalytic CO<SUB>2</SUB> hydrogenation and is very similar to that of conventional CO-based Fischer-Tropsch (FT) synthesis. The catalyst was prepared by reduction of delafossite-CuFeO<SUB>2</SUB> and <I>in-situ</I> carburization to Hägg carbide (χ-Fe<SUB>5</SUB>C<SUB>2</SUB>), the active phase for heavy hydrocarbon formation. The reference catalysts derived from bare Fe<SUB>2</SUB>O<SUB>3</SUB>, CuO-Fe<SUB>2</SUB>O<SUB>3</SUB> mixture, and spinel CuFe<SUB>2</SUB>O<SUB>4</SUB> are much less active and produce mainly light hydrocarbons, highlighting the critical role of delafossite-CuFeO<SUB>2</SUB> as the catalyst precursor. The new catalyst breaks through the limitation of CO<SUB>2</SUB>-based FT synthesis and will open the avenue for new opportunity for carbon recycling into valuable liquid fuels at the similar conditions to industrially practiced CO-FT synthesis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CO<SUB>2</SUB> conversion to liquid fuels by reacting with renewable hydrogen. </LI> <LI> Reduced CuFeO<SUB>2</SUB> catalyst produces C<SUB>5+</SUB> hydrocarbons of ∼65% and CH<SUB>4</SUB> of only 2–3%. </LI> <LI> The catalyst allows facile <I>in-situ</I> carburization to Hägg carbide active for C<SUB>5+</SUB> formation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Mutations of <i>ADAMTS9</i> Cause Nephronophthisis-Related Ciliopathy

Choi, Yo Jun,Halbritter, Jan,Braun, Daniela A.,Schueler, Markus,Schapiro, David,Rim, John Hoon,Nandadasa, Sumeda,Choi, Won-il,Widmeier, Eugen,Shril, Shirlee,Kö,rber, Friederike,Sethi, Sidharth K. Elsevier 2019 American journal of human genetics Vol.104 No.1

<P>Nephronophthisis-related ciliopathies (NPHP-RCs) are a group of inherited diseases that are associated with defects in primary cilium structure and function. To identify genes mutated in NPHP-RC, we performed homozygosity mapping and whole-exome sequencing for >100 individuals, some of whom were single affected individuals born to consanguineous parents and some of whom were siblings of indexes who were also affected by NPHP-RC. We then performed high-throughput exon sequencing in a worldwide cohort of 800 additional families affected by NPHP-RC. We identified two <I>ADAMTS9</I> mutations (c.4575_4576del [p.Gln1525Hisfs<SUP>∗</SUP>60] and c.194C>G [p.Thr65Arg]) that appear to cause NPHP-RC. Although ADAMTS9 is known to be a secreted extracellular metalloproteinase, we found that ADAMTS9 localized near the basal bodies of primary cilia in the cytoplasm. Heterologously expressed wild-type ADAMTS9, in contrast to mutant proteins detected in individuals with NPHP-RC, localized to the vicinity of the basal body. Loss of ADAMTS9 resulted in shortened cilia and defective sonic hedgehog signaling. Knockout of <I>Adamts9</I> in IMCD3 cells, followed by spheroid induction, resulted in defective lumen formation, which was rescued by an overexpression of wild-type, but not of mutant, ADAMTS9. Knockdown of <I>adamts9</I> in zebrafish recapitulated NPHP-RC phenotypes, including renal cysts and hydrocephalus. These findings suggest that the identified mutations in <I>ADAMTS9</I> cause NPHP-RC and that ADAMTS9 is required for the formation and function of primary cilia.</P>

유연 추진기의 유체-구조 연성 해석 연구

장원석(Won-Seok Jang),홍석윤(Suk-Yoon Hong),송지훈(Jee-Hun Song),권현웅(Hyun-Wung Kwon),김민재(Min-Jae Kim),최원석(Woen-Sug Choi),최요셉(Yo-Seb Choi),조범진(Beom-Jin Joe),최현규(Hyun-Gyu Choi) 한국소음진동공학회 2019 한국소음진동공학회 학술대회논문집 Vol.2019 No.10

선천성 기관지 폐쇄증

최요원 ( Yo Won Choi ),윤호주 ( Ho Joo Yoon ),신동호 ( Dong Ho Shin ),박성수 ( Sung Soo Park ) 대한결핵 및 호흡기학회 2004 Tuberculosis and Respiratory Diseases Vol.56 No.4

흉막 및 종격동 질환의 방사선학적 소견

최요원 ( Yo Won Choi ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.6

자발성 흉곽 내 만성 팽창성 혈종

주용원 ( Yong Won Joo ),손창남 ( Chang Nam Son ),정경희 ( Kyong Hee Jung ),박혜정 ( Hae Jeong Park ),김상헌 ( Sang Heon Kim ),김태형 ( Tae Hyung Kim ),손장원 ( Jang Won Sohn ),윤호주 ( Ho Joo Yoon ),최요원 ( Yo Won Choi ),정원상 ( 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.65 No.3

A chronic expanding hematoma (CEH) in the thorax is a rare and specific condition of chronic empyema. CEHs in the thorax are often associated with tuberculosis and/or previous surgical procedures. While the incidental detection of a pleural mass and dyspnea are common clinical manifestations, a few cases present with hemoptysis. We encountered a case of CEH in the thorax. This case is unique in that it developed without a prior history of tuberculosis or surgery and presented with massive hemoptysis accompanied by bronchopleural fistula. We report the third case of CEH in the thorax in Korea with a summary of the clinical characteristics of previous cases. (Tuberc Respir Dis 2008;65:216-221)

Analysis of Decorin Expression in the Uterine Endometrium during the Estrous Cycle and Pregnancy in Pigs

Choi, Yo-Han,Seo, Hee-Won,Kim, Min-Goo,Ka, Hak-Hyun The Korean Society of Animal Reproduction 2010 Reproductive & developmental biology Vol.34 No.2

Decorin (DCN) is a member of small leucine-rich proteoglycans which are ubiquitous components of the extracellular matrix. It regulates many physiological processes, such as matrix formation, collagen fibrillogenesis, angiogenesis, cancer growth, and cardiovascular diseases. It has been shown that DCN is expressed in the uterus during pregnancy and modulates implantation and decidualization for the establishment and maintenance of pregnancy in mice and humans. Expression of DCN in the uterine endometrium during pregnancy has not been investigated in pigs. Thus, this study investigated expression of DCN in the uterine endometrium during the estrous cycle and pregnancy in pigs. Uterine endometrial tissues were from day (D) 12 and 15 of the estrous cycle and D12, D15, D30, D60, D90, and D114 of pregnancy. Northern blot and real-time RT-PCR analyses showed that expression of DCN mRNA was detected throughout the estrous cycle and pregnancy with the highest levels during mid pregnancy. In situ hybridization analysis showed that DCN mRNA was localized to both luminal and glandular epithelia during the estrous cycle and pregnancy and also to chorionic membrane during mid pregnancy in pigs. To determine whether endometrial expression of DCN was affected by the somatic cell nuclear transfer (SCNT) procedure, DCN mRNA levels in the uterine endometrium from gilts with SCNT embryos on D30 of pregnancy were compared with those from gilts with normal embryos using real-time RT-PCR analysis. The result showed that DCN mRNA levels in the uterine endometrium were not significantly different between gilts with normal embryos and SCNT embryos. These results suggest that DCN may play an important role for endometrial tissue remodeling during mid pregnancy, and DCN expression is not affected by the SCNT procedure at the early stage of pregnancy in pigs.

Regulation of S100G Expression in the Uterine Endometrium during Early Pregnancy in Pigs

Choi, Yo-Han,Seo, Hee-Won,Shim, Jang-Soo,Kim, Min-Goo,Ka, Hak-Hyun Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.1

Calcium ions play an important role in the establishment and maintenance of pregnancy, but molecular and cellular regulatory mechanisms of calcium ion action in the uterine endometrium are not fully understood in pigs. Previously, we have shown that calcium regulatory molecules, transient receptor potential vanilloid type 5 (TRPV6) and calbindin-D9k (S100G), are expressed in the uterine endometrium during the estrous cycle and pregnancy in a pregnancy status- and stage-specific manner, and that estrogen of conceptus origin increases endometrial TRPV6 expression. However, regulation of S100G expression in the uterine endometrium and conceptus expression of S100G has been not determined during early pregnancy. Thus, we investigated regulation of S100G expression by estrogen and interleukin-$1{\beta}$ (IL1B) in the uterine endometrium and conceptus expression of S100G during early pregnancy in pigs. We obtained uterine endometrial tissues from day (D) 12 of the estrous cycle and treated with combinations of steroid hormones, estradiol-$17{\beta}$ ($E_2$) and progesterone ($P_4$), and increasing doses of IL1B. Real-time RT-PCR analysis showed that $E_2$ and IL1B increased S100G mRNA levels in the uterine endometrium, and conceptuses expressed S100G mRNA during early pregnancy, as determined by RT-PCR analysis. To determine if endometrial expression of S100G mRNA during the implantation period was affected by the somatic cell nuclear transfer (SCNT) procedure, we compared S100G mRNA levels in the uterine endometrium from gilts with SCNT-derived conceptuses with those from gilts with conceptuses derived from natural mating on D12 of pregnancy. Real-time RT-PCR analysis showed that levels of S100G mRNA in the uterine endometrium from gilts carrying SCNT-derived conceptuses was significantly lower than those from gilts carrying conceptuses derived from natural mating. These results showed that S100G expression in the uterine endometrium was regulated by estrogen and IL1B of conceptus origin, and affected by the SCNT procedure during early pregnancy. These suggest that conceptus signals regulate S100G, an intracellular calcium transport protein, for the establishment of pregnancy in pigs.

Alcohol, NAFLD, Other : Nonalcoholic Fatty Liver Disease is Negatively Associated to Biochemical Recurrence of Prostate Cancer after Radical Prostatectomy

( Won Mook Choi ),( Jeong Hoon Lee ),( Young Ju Lee ),( Young Youn Cho ),( Minjong Lee ),( Jeong Ju Yoo ),( Yuri Cho ),( Dong Hyeon Lee ),( Yun Bin Lee ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung Hwan Yo 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is closely related to metabolic syndrome and obesity which are associated with an increased cancer risk. In this study, we investigated the association between NAFLD and prostate cancer biochemical recurrence (BCR) after radical prostatectomy using imaging modalities. Methods: In total, consecutive 312 prostate cancer patients who underwent radical prostatectomy between 2005 and 2008 in Seoul National University Hospital (Seoul, Korea) were included in this study. The presence of NAFLD, body mass index (BMI), prediagnostic prostate-specific antigen (PSA), and pathologic findings including Gleason score were analyzed with regard to their associations with BCR. NAFLD was diagnosed based on clinical information and ultrasonography or non-contrast CT images. BCR-free survival rates were calculated using the Kaplan-Meier method. Results: A total of 222 patients were analyzed after 90 patients were excluded. We excluded patients with double primary cancers or evidence of liver disease of other etiologies including viral hepatitis, and patients who were treated with neoadjuvant hormone therapy or who failed to achieve PSA nadir < 0.1 ng/ mL. During a median follow-up period of 54 (range, 51-57) months, 45 (20.3%) patients developed BCR. Patients with NAFLD showed significantly better BCR-free survival (P=0.001 by log rank test), while patients grouped according to BMI failed to show any statistical significance (P=0.861). In the multivariate analysis, the presence of NAFLD (hazard ratio [HR], 0.25; 95% confidence interval [CI], 0.08-0.76; P=0.014) and pathological Gleason score (compared to <7, 7: HR, 2.69; 95% CI, 0.92-7.87, >7: HR, 6.02; 95% CI, 1.42-25.52; P=0.049) were independent predictive factors of BCR. Conclusions: Unexpectedly, the results of our study have shown that NAFLD may play a protective role against BCR after radical prostatectomy for prostate cancer. It is warranted to elucidate the mechanism of protective effect, such as the change in male hormone level, in patients with NAFLD.