Baseline Total Metabolic Tumor Volume and Total Lesion Glycolysis Measured on 18F-FDG PET-CT Predict Outcomes in T-Cell Lymphoblastic Lymphoma

Xiaoyan Feng,Xin Wen,Ling Li,Zhenchang Sun,Xin Li,Lei Zhang,Jingjing Wu,Xiaorui Fu,Xinhua Wang,Hui Yu,Xinran Ma,Xudong Zhang,Xinli Xie,Xingmin Han,Mingzhi Zhang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.3

Purpose There is no optimal prognostic model for T-cell lymphoblastic lymphoma (T-LBL). Here, we discussed the predictive value of total metabolic tumor volume (TMTV) and total lesion glycolysis (TLG) measured on 18F-fluorodeoxyglucose positron emission tomography–computed tomography (PET-CT) in T-LBL.Materials and Methods Thirty-seven treatment naïve T-LBL patients with PET-CT scans were enrolled. TMTV was obtained using the 41% maximum standardized uptake value (SUVmax) threshold method, and TLG was measured as metabolic tumor volume multiplied by the mean SUV. Progression-free survival (PFS) and overall survival (OS) were analyzed by Kaplan-Meier curves and compared by the log-rank test.Results The optimal cutoff values for SUVmax, TMTV, and TLG were 12.7, 302 cm3, and 890, respectively. A high SUVmax, TMTV, and TLG indicated a shorten PFS and OS. On multivariable analysis, TMTV ≥ 302 cm3, and central nervous system (CNS) involvement predicted inferior PFS, while high SUVmax, TLG and CNS involvement were associated with worse OS. Subsequently, we generated a risk model comprising high SUVmax, TMTV or TLG and CNS involvement, which stratified the population into three risk groups, which had significantly different median PFS of not reached, 14 months, and 7 months for low-risk group, mediate-risk group, and high-risk group, respectively (p < 0.001). Median OS were not reached, 27 months, and 13 months, respectively (p < 0.001).Conclusion Baseline SUVmax, TMTV, and TLG measured on PET-CT are strong predictors of worse outcome in T-LBL. A risk model integrating these three parameters with CNS involvement identifies patients at high risk of disease progression.

Cohomology of torsion and completion of $N$-complexes

Pengju Ma,Xiaoyan Yang 대한수학회 2022 대한수학회지 Vol.59 No.2

We introduce the notions of Koszul $N$-complex, $\check{\mathrm{C}}$ech $N$-complex and telescope $N$-complex, explicit derived torsion and derived completion functors in the derived category $\mathbf{D}_N(R)$ of $N$-complexes using the $\check{\mathrm{C}}$ech $N$-complex and the telescope $N$-complex. Moreover, we give an equivalence between the categories of cohomologically $\mathfrak{a}$-torsion $N$-complexes and cohomologically $\mathfrak{a}$-adic complete $N$-complexes, and prove that over a commutative Noetherian ring, via Koszul cohomology, via RHom cohomology (resp. $\otimes$ cohomology) and via local cohomology (resp. derived completion), all yield the same invariant.

Microbial short-chain fatty acids: a bridge between dietary fibers and poultry gut health — A review

Ali Qasim,Ma Sen,La Shaokai,Guo Zhiguo,Liu Boshuai,Gao Zimin,Farooq Umar,Wang Zhichang,Zhu Xiaoyan,Cui Yalei,Li Defeng,Shi Yinghua 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.10

The maintenance of poultry gut health is complex depending on the intricate balance among diet, the commensal microbiota, and the mucosa, including the gut epithelium and the superimposing mucus layer. Changes in microflora composition and abundance can confer beneficial or detrimental effects on fowl. Antibiotics have devastating impacts on altering the landscape of gut microbiota, which further leads to antibiotic resistance or spread the pathogenic populations. By eliciting the landscape of gut microbiota, strategies should be made to break down the regulatory signals of pathogenic bacteria. The optional strategy of conferring dietary fibers (DFs) can be used to counterbalance the gut microbiota. DFs are the non-starch carbohydrates indigestible by host endogenous enzymes but can be fermented by symbiotic microbiota to produce shortchain fatty acids (SCFAs). This is one of the primary modes through which the gut microbiota interacts and communicate with the host. The majority of SCFAs are produced in the large intestine (particularly in the caecum), where they are taken up by the enterocytes or transported through portal vein circulation into the bloodstream. Recent shreds of evidence have elucidated that SCFAs affect the gut and modulate the tissues and organs either by activating G-protein-coupled receptors or affecting epigenetic modifications in the genome through inducing histone acetylase activities and inhibiting histone deacetylases. Thus, in this way, SCFAs vastly influence poultry health by promoting energy regulation, mucosal integrity, immune homeostasis, and immune maturation. In this review article, we will focus on DFs, which directly interact with gut microbes and lead to the production of SCFAs. Further, we will discuss the current molecular mechanisms of how SCFAs are generated, transported, and modulated the pro-and anti-inflammatory immune responses against pathogens and host physiology and gut health. The maintenance of poultry gut health is complex depending on the intricate balance among diet, the commensal microbiota, and the mucosa, including the gut epithelium and the superimposing mucus layer. Changes in microflora composition and abundance can confer beneficial or detrimental effects on fowl. Antibiotics have devastating impacts on altering the landscape of gut microbiota, which further leads to antibiotic resistance or spread the pathogenic populations. By eliciting the landscape of gut microbiota, strategies should be made to break down the regulatory signals of pathogenic bacteria. The optional strategy of conferring dietary fibers (DFs) can be used to counterbalance the gut microbiota. DFs are the non-starch carbohydrates indigestible by host endogenous enzymes but can be fermented by symbiotic microbiota to produce shortchain fatty acids (SCFAs). This is one of the primary modes through which the gut microbiota interacts and communicate with the host. The majority of SCFAs are produced in the large intestine (particularly in the caecum), where they are taken up by the enterocytes or transported through portal vein circulation into the bloodstream. Recent shreds of evidence have elucidated that SCFAs affect the gut and modulate the tissues and organs either by activating G-protein-coupled receptors or affecting epigenetic modifications in the genome through inducing histone acetylase activities and inhibiting histone deacetylases. Thus, in this way, SCFAs vastly influence poultry health by promoting energy regulation, mucosal integrity, immune homeostasis, and immune maturation. In this review article, we will focus on DFs, which directly interact with gut microbes and lead to the production of SCFAs. Further, we will discuss the current molecular mechanisms of how SCFAs are generated, transported, and modulated the pro-and anti-inflammatory immune responses against pathogens and host physiology and gut health.

Magnetic Resonance Image Texture Analysis of the Periaqueductal Gray Matter in Episodic Migraine Patients without T2-Visible Lesions

Zhiye Chen,Xiaoyan Chen,Mengqi Liu,Shuangfeng Liu,Shengyuan Yu,Lin Ma 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.1

Objective: The periaqueductal gray matter (PAG), a small midbrain structure, presents dysfunction in migraine. However, the precise neurological mechanism is still not well understood. Herein, the aim of this study was to investigate the texture characteristics of altered PAG in episodic migraine (EM) patients based on high resolution brain structural magnetic resonance (MR) images. Materials and Methods: The brain structural MR images were obtained from 18 normal controls (NC), 18 EM patients and 16 chronic migraine (CM) patients using a 3T MR system. A PAG template was created using the International Consortium Brain Mapping 152 gray matter model, and the individual PAG segment was developed by applying the deformation field from the structural image segment to the PAG template. A grey level co-occurrence matrix was used to calculate the texture parameters including the angular second moment (ASM), contrast, correlation, inverse difference moment (IDM) and entropy. Results: There was a significant difference for ASM, IDM and entropy in the EM group (998.629 ± 0.162 x 10-3, 999.311 ± 0.073 x 10-3, 916.354 ± 0.947 x 10-5) compared to that found in the NC group (998.760 ± 0.110 x 10-3, 999.358 ± 0.037 x 10-3 and 841.198 ± 0.575 x 10-5) (p < 0.05). The entropy was significantly lower among the patients with CM (864.116 ± 0.571 x 10-5) than that found among patients with EM (p < 0.05). The area under the receiver operating characteristic curve was 0.776 and 0.750 for ASM and entropy in the distinction of the EM from NC groups, respectively. ASM was negatively related to disease duration (DD) and the Migraine Disability Assessment Scale (MIDAS) scores in the EM group, and entropy was positively related to DD and MIDAS in the EM group (p < 0.05). Conclusion: The present study identified altered MR image texture characteristics of the PAG in EM. The identified texture characteristics could be considered as imaging biomarkers for EM.

High SMAS face lift: clinical experience

Zhijun Wang,Xiaoyan Ma,Lixiang Yang,Yan Wang,Lili Chen,Hang Lv 대한미용의학회 2018 대한미용의학회지 Vol.2 No.1

Background: The ultimate goal of facelift is to lift the sagging soft tissue as much as possible, so as to restore them to the original anatomical position for facial rejuvenation. Objective: In our High-SMAS facelift, the SMAS-platysma flap were tighten strongly, so as to obtain full and youthful facial morphologic characteristics. In addition, the effectiveness of high-SMAS was evaluated in this paper. Methods: A total of 86 cases of SMAS face lift were performed in 22 months from January 2015 to November 2016. High SMAS technique was applied in 39 cases of them. All the 39 patients were female averaged 44 (29-65) years old. Postoperative follow-up wascarried out in 18 cases for an average of 13 months (4-22 months). After the SMAS-platysma flap was dissected in the lower face and neck,the key point of operating is focus on:The middle temporal fascia and superficial temporal fascia flap was dissected carefully. Break off the ligaments medial to the zygomatic arch and on the malar process exactly, and pay attention to protect the facial nerve. So that the high-SMAS and even higher-SMAS flap can be dissected. Results: In all the 18 cases followed up, most (11/18) obtained a clear mandibular margin after operation and scored even full mark. Perfect nasolabial fold improvement was achieved in few (7/18). In terms of Ogee curve evaluation, most (15/18) made it to the level of “acceptable”, which was shared by the evaluation of lower eyelid shortening effects (13/18). Very satisfied indicators as follow: the obtuse jowl line becomes clear, midface “ogee curve” is vary from linear to curves, and the nasolabial sulcus have been improved. Conclusion: High-SMAS Facelift is one of the most effective rhytidectomy, the most prominent parts of its effect including the improvement of midface and jowl line contour. Level of Evidence: IV

Fire-Induced Failure of Long-Term Service and Fresh Concrete Beams Subjected to Fire

Meng Wang,Zhen Guo,Xiaoyan Jia,Yue Yin,Chuang Ma 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.10

In engineering, reinforced concrete beams are subjected to natural erosion and the working stress state. However, previous studies regarding structural fire have focused on new concrete beams, and most results are obtained from no-stress-state tests. Hence, research that considers the natural erosion and working stress states of beam members in fire is lacking. In this study, fire experiments were performed to investigate the differences between long-term service concrete beams and new elements under loads. A technique using ARAMIS three-dimensional (3D) optical strain measurement was adopted; it provides increased sample throughput and 3D measurements that indicate the change in strain more intuitively. Results show that the moisture content of concrete determines the spalling degree of concrete under the influence of working stress. With the increase of concrete moisture content, the range of temperature of heated and backfire surface increases and the spalling phenomenon is more obvious, especially when the moisture content exceeds 2.5%. In addition, the long-term service specimens are affected by fire more easily, thereby accelerating the destruction process owing to the degree of carbonation.

ON RELATIVE COHEN-MACAULAY MODULES

Zhongkui Liu,Pengju Ma,Xiaoyan Yang Korean Mathematical Society 2023 대한수학회지 Vol.60 No.3

Let a be an ideal of 𝔞 commutative noetherian ring R. We give some descriptions of the 𝔞-depth of 𝔞-relative Cohen-Macaulay modules by cohomological dimensions, and study how relative Cohen-Macaulayness behaves under flat extensions. As applications, the perseverance of relative Cohen-Macaulayness in a polynomial ring, formal power series ring and completion are given.

IL-10 Polymorphisms and Tuberculosis Susceptibility: An Updated Meta-Analysis

Zunqiong Ke,Hui Xiong,Leyong Yuan,Jun Ma,Xiaoyan Zhang,Yi Guo 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.5

Purpose: The association of interleukin-10 (IL-10) polymorphisms (-1082G/A, -819C/T, -592A/C) and interleukin-6 (IL-6) polymorphisms(-174G/C) with tuberculosis (TB) risk has been widely reported. However, the results are controversial. To clarify the role of these polymorphisms in TB, we performed a meta-analysis of all available and relevant published studies. Materials and Methods: Based on comprehensive searches of the PubMed, Medline, Embase, Web of Science, Elsevier Science Direct and Cochrane Library database, we identified outcome data from all articles estimating the association between IL-10 and IL-6 polymorphisms and TB risk. Results: The results indicated significant association of the allele model, heterozygous model and dominant model of IL-6 -174G/C polymorphism with decreased risk of TB. In the stratified analysis by ethnicity, significantly increased risk was observed for IL-10 -1082G/A polymorphism in Europeans under recessive model, for IL-10 -819C/T polymorphism in Asians under heterozygous model and dominant model and IL-10 -592A/C polymorphism in Asians under Allele model, homozygous model and recessive model. Moreover, significantly decreased risk of TB was associated with Asians for IL-6 -174C/G polymorphism in allele model, heterozygous model and dominant model. We also performed the analyses by sample types in IL-10 -1082G/A polymorphism, and observed significantly increased TB risk in mixed group under homozygous model. Conclusion: The results suggested that the IL-10 -1082G/A polymorphism is associated with increased TB risk in Europeans, while IL-10 -819C/T and IL-10 -592A/C polymorphisms in Asians. However, IL-6 -174G/C polymorphism might be a genetic risk factor that decreases TB susceptibility in Asians.

Characterization and Expression Profile of CMTM3/CKLFSF3

Zhong, Ji,Wang, Yu,Qiu, Xiaoyan,Mo, Xiaoning,Liu, Yanan,Li, Ting,Song, Quansheng,Ma, Dalong,Han, Wenling Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.5

CMTM/CKLFSF is a novel family of proteins linking chemokines and TM4SF. In humans, these proteins are encoded by nine genes, CKLF and CMTM1-8/CKLFSF1-8. Here we report the characteristics and expression profile of CMTM3/CKLFSF3. Human CMTM3/CKLFSF3 has a high sequence identity among various species and similar characteristics as its mouse and rat homologues. Established by results both of RT-PCR and Quantitative Real-time PCR, the gene is highly transcribed in testis, leukocytes and spleen. For further verification, we generated a polyclonal antibody against human CMTM3/CKLFSF3 and found that the protein is highly expressed in the testis and some cells of PBMCs. Therefore, CMTM3/CKLFSF3 is an evolutionarily conserved gene that may have important roles in the male reproductive system and immune system. Further studies are necessary to validate its functions in the two systems.

Ferrocene-based hydrazone energetic transition-metal complexes as multifunctional combustion catalysts for the thermal decomposition of ammonium perchlorate

Xiaoju Liu,Haitao Feng,Yang Li,Xiaoyan Ma,Fang Chen,Qilong Yan 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-

Three novel ferrocene-based hydrazone energetic transition-metal complexes denoted as M/E-FcDz-TMCs (M = Co (II), Fe (III), and Co(II)Fe(III)), were successfully prepared to improve the thermal decompositionof ammonium perchlorate (AP) and anti-migration performance of Fc-based catalysts. 1-hydrazinoethylene-ferrocene (E-FcDz) with unique electronic structure and energy bonds (C@N, NAN)as ligand reacted with transition metal Co, or Fe mono-metal nodes, and Co-Fe bimetal nodes, respectively. The chemical structure, crystalline texture, and morphology were confirmed, and the catalytic performancewas investigated. The thermal decomposition kinetics were estimated by applying Kissinger,FWO, and KAS methods. The results revealed that M/E-FcDz-TMCs had superior catalytic performancesfor AP decomposition compared to the traditional catalyst catocene due to their high electron transportcapacity. Especially, CoFe/E-FcDz-TMCs showed the best catalytic efficiency due to the hybridizationbetween Co (II) 3d and Fe (III) 3d orbitals in the structure led to electron redistribution, driving the optimalsynergistic catalytic effect of the bimetal Co-Fe nodes and E-FcDz, and further enhancing catalysis forAP. Moreover, AP/CoFe/E-FcDzTMCs showed the best combustion performance. In addition, the thermaldecomposition products of AP were explored by TG/FTIR, and the AP thermal decomposition processcould be explained by a possible mechanism following the principle of electron transfer theory.