A phase II trial of cytoreductive surgery combined with niraparib maintenance in platinum-sensitive, secondary recurrent ovarian cancer: SGOG SOC-3 study

Ting-Yan Shi,Sheng Yin,Jianqing Zhu,Ping Zhang,Jihong Liu,Libing Xiang,Yaping Zhu,Sufang Wu,Xiaojun Chen,Xipeng Wang,Yin-Cheng Teng,Tao Zhu,Aijun Yu,Yingli Zhang,Yanling Feng,He Huang,Wei Bao,Yanli Li 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.3

Background: In China, secondary cytoreductive surgery (SCR) has been widely used in ovarian cancer (OC) over the past two decades. Although Gynecologic Oncology Group-0213 trial did not show its overall survival benefit in first relapsed patients, the questions on patient selection and effect of subsequent targeting therapy are still open. The preliminary data from our pre-SOC1 phase II study showed that selected patients with second relapse who never received SCR at recurrence may still benefit from surgery. Moreover, poly(ADP-ribose) polymerase inhibitors (PARPi) maintenance now has been a standard care for platinum sensitive relapsed OC. To our knowledge, no published or ongoing trial is trying to answer the question if patient can benefit from a potentially complete resection combined with PARPi maintenance in OC patients with secondary recurrence. Methods: SOC-3 is a multi-center, open, randomized, controlled, phase II trial of SCR followed by chemotherapy and niraparib maintenance vs chemotherapy and niraparib maintenance in patients with platinum-sensitive second relapsed OC who never received SCR at recurrence. To guarantee surgical quality, if the sites had no experience of participating in any OC-related surgical trials, the number of recurrent lesions evaluated by central-reviewed positron emission tomography–computed tomography image shouldn't be more than 3. Eligible patients are randomly assigned in a 1:1 ratio to receive either SCR followed by 6 cycles of platinum-based chemotherapy and niraparib maintenance or 6 cycles of platinum-based chemotherapy and niraparib maintenance alone. Patients who undergo at least 4 cycles of chemotherapy and must be, in the opinion of the investigator, without disease progression, will be assigned niraparib maintenance. Major inclusion criteria are secondary relapsed OC with a platinum-free interval of no less than 6 months and a possibly complete resection. Major exclusion criteria are borderline tumors and non-epithelial ovarian malignancies, received debulking surgery at recurrence and impossible to complete resection. The sample size is 96 patients. Primary endpoint is 12-month non-progression rate. Trial Registration: ClinicalTrials.gov Identifier: NCT03983226

Sensitivity analysis and parameter interval optimization for residual stress in polishing process of GH4169 blisk blade

Xiaojun Lin,Xiaopeng Xin,Rui Yang,Zhaozhao Lei,Luzhou Sun,Bao Yang,Changyou Bai,Yangwei Yan 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.2

Surface integrity has a significant impact on the performance and life cycle of the blisk blade. Residual stress, as one of the important characterization parameters of surface integrity, is closely related to the performance of the aeroengine blisk blade. A certain interval of residual compressive stress can significantly inhibit the generation of microcracks. This paper proposes an optimization method of polishing process parameter interval based on sensitivity analysis. This research studied the effect of polishing parameters of the alumina ACW (abrasive cloth wheel) on the surface residual stress of the GH4169 superalloy blisk blade. Firstly, the experiment was designed by four factors and three levels response surface method, the multiple regression of the experimental data based on Minitab software was used to get a prediction model of polished surface residual stress. And an analysis of variance was performed on the model. Subsequently, the model of relative sensitivity was got based on this model. The sensitivity order of polishing surface residual stress to each polishing parameter was obtained. And the judging method of stable interval and instable interval was put forward. Then, a parameter interval optimization method was proposed, and the optimal interval of process parameters was obtained. Finally, a polishing verification experiment was performed. The results show that: for the polishing of GH4169 superalloy blades, the surface residual stress is most sensitive to the feed rate vf of the ACW, followed by the granularity p and the rotation rate ω, and the compression depth ap is the least sensitive. The optimal interval of polishing process parameters is: the rotation rate ω is [11000 r/min, 11500 r/min], the feed rate vf is [100 mm/min, 200 mm/min], the compression depth ap is [0.6 mm, 1.0 mm], and the granularity p is [400 #, 600 #]. The optimized polishing process parameters can obtain a large and stable surface residual compressive stress, which is helpful to increase fatigue strength of the blisk blade.

Evolution Behavior of M23C6 Carbides Under Different Hot Deformation Conditions in Alloy 602 CA

Xiaoyu Qin,Xiaojun Yan,Dawei Huang,Xiaoyong Zhang,Mingjing Qi,Stephen Yue 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.6

Alloy 602 CA is a M23C6carbides strengthened Nickel-based superalloy. In this alloy, M23C6is different from that found inother superalloys because of its high volume fraction, wide size distribution and distinct precipitation locations. To investigateM23C6evolution behaviors during hot deformation in Alloy 602 CA, a series of tests are carried out in this study. Thetest temperature ranges from 900 to 1100 °C and strain rate ranges from 0.001 to 0.1 s−1, with a true strain of 0.7. It is foundthat hot deformation of the material decreases the distance between carbides which leads merging happening to changethe morphology of primary M23C6. Secondary carbides mainly come from the dissolution of large primary carbides andprecipitate along grain boundaries and twin boundaries which impede dynamic recrystallization (DRX) from happening. Volume fractions of M23C6decrease from 900 to 1100 °C. At 900 °C and 1100 °C, the precipitation equilibrium is reachedin the preheating period before hot deformation and deformation only change the size distribution of carbides. 1000 °C isa transition temperature where the volume fraction decreases as strain rate increases. The temperature rise initiated by adiabaticheating has a great influence on this precipitation behavior.

Refining Characteristics of Hardwood Pulp Using Straight- and Curved-bar Plates: A Time Series Study

Huan Liu,Jixian Dong,Xiaojun Jiang,Chong Luo,Xiaohui Tian,Ruifang Yang,Litao Zhang,Bo Wang,Yan Yan 한국펄프·종이공학회 2019 펄프.종이기술 Vol.51 No.5

There are obvious differences in the refining characteristics of plates with straight bars compared to curved bar plates having the same bar parameters during refining. The objective of this research is to explore the difference in the refining characteristics of the straight bar and curved bar plates on experimental and theoretical studies. The bar angle of the curved bar plate is defined, and the two plates are used in the refining of bleached sulphate eucalyptus pulp (BSEP). Samples at different refining times were collected, and the properties of the fibers, pulp, and paper were detected and analyzed. It was found that the curved bar and straight bar plates have a similar influence on the pulp SR freeness. However, the curved bar plate effectively retained the fiber length, which means that its fiber cutting effect is weaker than that of the straight bar plate. Meanwhile, the fiber external fibrillation of the samples refined by the curved bar plate was better than that of the samples refined by the straight bar, which showed a higher tensile and tear index of the formed paper. Through the theoretical analysis of refining intensity via characterization of the parameter bar edge length (BEL), the specific edge load (SEL) of the curved bar plate was lower, and the refining characteristics predicted by the refining intensity were similar to the results from the experiments conducted in this paper.

Study on the role of gga-miRNA-200a in regulating cell differentiation and proliferation of chicken breast muscle by targeting Grb2

Keren Jiang,Fengbin Yan,Meng Zhang,Fang Li,Donghua Li,Guirong Sun,Xiaojun Liu,Hong Li,Ruili Han,Ruirui Jiang,Zhuanjian Li,Xiangtao Kang 한국통합생물학회 2017 Animal cells and systems Vol.21 No.6

Growth factor receptor-bound protein 2 (Grb2) have been proved by a lot of studies playing a major role in cell proliferation and cell differentiation. However, the regulation of Grb2 expression by microRNAs (miRNAs) in chicken breast muscle still remains unknown. The expression profile of Grb2 was checked based on our previous RNA sequencing data and the Grb2 relative expression level in breast muscle of aged hens (55-week-old) was validated significantly higher than juvenile hens (20-week-old) using qRT-PCR. miRNAs that interact with Grb2 have been predicted in chicken and the relationship between the potential miRNA and Grb2 was verified using dual luciferase reporter assay in chicken DF1 cells. Dual-luciferase reporter assays results demonstrated that the expression of luciferase reporter gene linked with part sequence of the 3′UTR of chicken Grb2 gene was down-regulated by the overexpression of gga (Gallus Gallus)- miR-200a-3p in the DF1 cells, and the down-regulation behavior was abolished when the ggamiR- 200a-3p binding site in 3′UTR of Grb2 was mutated, indicating that gga-miR-200a can suppress the expression level of its target gene Grb2. Therefore, we concluded that the significantly increased expression level of Grb2 in the breast muscle of aged chicken can (at least partly can) be explained by the decreased expression of miR-200a, which reduced the inhibitory effect on Grb2. Taken together, these findings suggest that gga-miR-200a can suppress the expression level of its target gene Grb2 and might be involved in the cell differentiation and proliferation of chicken breast muscle through binding with the 3’UTR of Grb2.

Instantaneous frequency extraction in time-varying structures using a maximum gradient method

Jing-liang Liu,Xiaojun Wei,Ren-Hui Qiu,Jin-Yang Zheng,Yan-Jie Zhu,Irwanda Laory 국제구조공학회 2018 Smart Structures and Systems, An International Jou Vol.22 No.3

A method is proposed for the identification of instantaneous frequencies (IFs) in time-varying structures. The proposed method combines a maximum gradient algorithm and a smoothing operation. The maximum gradient algorithm is designed to extract the wavelet ridges of response signals. The smoothing operation, based on a polynomial curve fitting algorithm and a threshold method, is employed to reduce the effects of random noises. To verify the effectiveness and accuracy of the proposed method, a numerical example of a signal with two frequency modulated components is investigated and an experimental test on a steel cable with time-varying tensions is also conducted. The results demonstrate that the proposed method can extract IFs from the noisy multi-component signals and practical response signals successfully. In addition, the proposed method can provide a better IF identification results than the standard synchrosqueezing wavelet transform.

Instantaneous frequency extraction in time-varying structures using a maximum gradient method

Liu, Jing-liang,Wei, Xiaojun,Qiu, Ren-Hui,Zheng, Jin-Yang,Zhu, Yan-Jie,Laory, Irwanda Techno-Press 2018 Smart Structures and Systems, An International Jou Vol.22 No.3

A method is proposed for the identification of instantaneous frequencies (IFs) in time-varying structures. The proposed method combines a maximum gradient algorithm and a smoothing operation. The maximum gradient algorithm is designed to extract the wavelet ridges of response signals. The smoothing operation, based on a polynomial curve fitting algorithm and a threshold method, is employed to reduce the effects of random noises. To verify the effectiveness and accuracy of the proposed method, a numerical example of a signal with two frequency modulated components is investigated and an experimental test on a steel cable with time-varying tensions is also conducted. The results demonstrate that the proposed method can extract IFs from the noisy multi-component signals and practical response signals successfully. In addition, the proposed method can provide a better IF identification results than the standard synchrosqueezing wavelet transform.

Matrix Channel Width Evolution of Single Crystal Superalloy Under Creep and Thermal Mechanical Fatigue: Experimental and Modeling Investigations

Zixu Guo,Ziyuan Song,Dawei Huang,Xiaojun Yan 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.12

In this study, in the respect of rafting behavior of Ni-based single crystal (SC) superalloy under creep and thermal mechanicalfatigue (TMF), an image processing program is developed to investigate the probability characteristic of γ channel width, anda channel width evolution model considering non-quasi-static modification is proposed. Firstly, the fractured and interruptedtests are conducted on SC superalloy. The channel width evolution behavior under different load conditions is observed viascanning electron microscope. Then, an image processing program based on image binarization is developed to conductstatistics on channel width. The statistical results show that the stress and temperature have significant effects on raftingrate, while the phase difference has a small effect. Meanwhile, the channel width obeys lognormal distribution, and the meanvalues follow linear relationship with standard deviations. In the modeling part, a static model is established to predict themean value evolution of channel width under creep condition. To be generalized to TMF condition, the model is modifiedby considering the non-quasi-static effect. After that, the channel width evolution model is further derived to describe theprobability density distribution of channel width. The predicted channel width evolutions are in good agreement with theexperimental results. The statistical results and models can provide the basis for multiscale modeling of SC superalloy.

Topology and start-up strategy for DC-DC transformers based on voltage balancing unit

Zhang, Jialin,Zha, Kunpeng,Tang, Xiaojun,Yang, Yuefeng,Yan, Hui,Wen, Fuyue,Shi, Mingming The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.7

As a core piece of equipment in DC distribution networks, DC solid-state transformers (DCSSTs) are attracting more and more attention in academia and industry. Due to the limitations in terms of the electrical stress of the switches, the input series output parallel (ISOP) structure is adopted in DCSSTs. This paper proposed an improved DCSST topology based on a voltage balancing unit (VBU). This topology has the advantages of higher power density, reduced weight, and cascaded number without compromising efficiency, cost, or reliability. The working modes, mathematical models, and control strategy are analyzed. In addition, a start-up strategy and a parameter design method are proposed in this paper. Simulation and experimental results verify the correctness and effectiveness of the proposed solution. The proposed DCSST is a practical scheme for the application of DC distribution networks.

Distance Estimation Methods in Vehicular Application: An Experimental Study

Yiwen Cao,Xinglong Lu,Zhonghua Zhao,Xiaojun Ji,Yilin Yan 제어로봇시스템학회 2018 제어로봇시스템학회 국제학술대회 논문집 Vol.2018 No.10

Passive Entry and Passive Start (PEPS) system allows drivers to enter the vehicle and start the engine without activating key fob. With growing demand for location-based service and rapid development of Bluetooth Low Energy (BLE), BLE PEPS with localization service becomes a promising choice for next generation of PEPS. This paper studies the critical problem of localizing the vehicle for user based on BLE received signal strength (RSS) provided by preinstalled BLE Access Points (APs) inside vehicle. Multiple APs are employed to reduce the error caused by RSS fluctuation on distance estimation. Fusion algorithms including Extended Kalman Filter, Monte Carlo Localization and Iterative Trilateration are compared based on experiments in vehicle. Experimental results show that distance estimation based on Extended Kalman Filter gets high accuracy in both long distance and short distance scenario.