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Evolution Behavior of M23C6 Carbides Under Different Hot Deformation Conditions in Alloy 602 CA
Xiaoyu Qin,Xiaojun Yan,Dawei Huang,Xiaoyong Zhang,Mingjing Qi,Stephen Yue 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.6
Alloy 602 CA is a M23C6carbides strengthened Nickel-based superalloy. In this alloy, M23C6is different from that found inother superalloys because of its high volume fraction, wide size distribution and distinct precipitation locations. To investigateM23C6evolution behaviors during hot deformation in Alloy 602 CA, a series of tests are carried out in this study. Thetest temperature ranges from 900 to 1100 °C and strain rate ranges from 0.001 to 0.1 s−1, with a true strain of 0.7. It is foundthat hot deformation of the material decreases the distance between carbides which leads merging happening to changethe morphology of primary M23C6. Secondary carbides mainly come from the dissolution of large primary carbides andprecipitate along grain boundaries and twin boundaries which impede dynamic recrystallization (DRX) from happening. Volume fractions of M23C6decrease from 900 to 1100 °C. At 900 °C and 1100 °C, the precipitation equilibrium is reachedin the preheating period before hot deformation and deformation only change the size distribution of carbides. 1000 °C isa transition temperature where the volume fraction decreases as strain rate increases. The temperature rise initiated by adiabaticheating has a great influence on this precipitation behavior.
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Qin Lu,Yue Junqing,Guo Mingzhou,Zhang Cong,Fang Xiaoyu,Zhang Shengding,Bai Wenxue,Liu Xiansheng,Xie Min 대한천식알레르기학회 2023 Allergy, Asthma & Immunology Research Vol.15 No.5
Purpose: Although estrogen receptors (ERs) signal pathways are involved in the pathogenesis and development of asthma, their expressions and effects remain controversial. This study aimed to investigate the expressions of ERα and ERβ as well as their mechanisms in airway remodeling and mucus production in asthma. Methods: The expressions of ERα and ERβ in the airway epithelial cells of bronchial biopsies and induced sputum cells were examined by immunohistochemistry. The associations of ERs expressions with airway inflammation and remodeling were evaluated in asthmatic patients. In vitro, the regulations of ERs expressions in human bronchial epithelial cell lines were examined using western blot analysis. The epidermal growth factor (EGF)-mediated ligand-independent activation of ERα and its effect on epithelial-mesenchymal transitions (EMTs) were investigated in asthmatic epithelial cells by western blot, immunofluorescent staining, and quantitative real-time polymerase chain reaction. Results: ERα and ERβ were expressed on both bronchial epithelial cells and induced sputum cells, and the expressions showed no sex difference. Compared to controls, male asthmatic patients had higher levels of ERα on the bronchial epithelium, and there were cell-specific expressions of ERα and ERβ in induced sputum. The expression of ERα in the airway epithelium was inversely correlated to forced expiratory volume in 1 second (FEV1) % and FEV1/forced vital capacity. Severe asthmatic patients had significantly greater levels of ERα in the airway epithelium than mild-moderate patients. ERα level was positively correlated with the thickness of the subepithelial basement membrane and airway epithelium. In vitro, co-stimulation of interleukin (IL)-4 and EGF increased the expression of ERα and promoted its nuclear translocation. EGF activated the phosphorylation of ERα via extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways. ERα knockdown alleviated EGF-mediated EMTs and mucus production in airway epithelial cells of asthma. Conclusions: ERα contributes to asthmatic airway remodeling and mucus production through the EGF-mediated ligand-independent pathway.
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Zhiwei Liu,Mingjing Qi,Xiaoyu Qin,Dawei Huang,Xiaoyong Zhang,Xiaojun Yan 대한금속·재료학회 2020 METALS AND MATERIALS International Vol.26 No.7
Structural collapse caused by uneven stress distribution is one of the main failure modes of Electron Beam Melted (EBM)Ti–6Al–4V porous meshes for medical bone implantation. In this paper, two types of porous meshes with different strutsdistributions are fabricated by EBM methods and experimentally studied through uniaxial compression tests. The first type(mesh 1) with simplified struts distribution consists of horizontal, vertical and diagonal struts, which are connected by onenode. The second type (mesh 2) has relatively complicated struts distribution with four structural nodes connected by vertical,horizontal and diagonal struts, and the inclined struts with an angle of 15° to the vertical or horizontal direction. Themechanical properties of solid Ti–6Al–4V alloy are also tested as reference for model-fitting analysis and the test resultsshow that the EBM specimen can achieve comparable tensile strength (1186.5 MPa) and elastic modulus (106.4 GPa) asthat of forging specimen. For the porous meshes, the deformation behavior of the struts along the load orientation is dominatedby buckling mechanism and the deformation behavior of the struts inclined to the load orientation is governed byboth buckling and bending mechanisms. The test results indicate that mesh 1 with relatively less inclined struts can achievebetter compressive resistance than mesh 2 when taking the factor of mesh density into consideration. Such results indicate asimple yet meaningful view that struts distributions of the porous meshes should be designed and optimized based on theirstress distribution conditions.
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Chemical Constituents from Mussaenda Pubescens
Weimin Zhao,Rensheng Xu,Guowei Qin,Xican Tang,Xiaoyu Li 한국생약학회 1995 Natural Product Sciences Vol.1 No.1
A new triterpenoid saponin named Mussaendoside F(1), along with five known compounds (2-6) were isolated from aerial part of Mussaenda pubescens.
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