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일개 권역응급의료센터에서의 중증 외상환자의 전원 현황과 문제점
이원철 ( Won Chul Lee ),조충현 ( Choong Hyun Jo ),정경원 ( Kyoung Won Jung ),민영기 ( Young Gi Min ),최상천 ( Sang Cheon Choi ),김기운 ( Gi Woon Kim ),안정환 ( Jung Hwan Ahn ),정용식 ( Yong Sik Jung ),황선애 ( Sun Ae Hwang ),김지 대한외상학회 2010 大韓外傷學會誌 Vol.23 No.1
Purpose: Trauma is one of the leading causes of death, especially among young people. Life-threatening conditions are very common in multiple-traumatized patients due to concurrent multi-organ injuries. Treating such severely injured patients is time critical. However, in Korea, the transfer of severely injured patients is not uncommon due to the lack of a mature trauma care system. In developed countries, the preventable trauma death rate is very low, but the rate is still very high in Korea. This study`s objective was to demonstrate the current serious state in which severely injured patients have to be transferred from a Regional Emergency Medical Center even though it actually serves as a trauma center. Methods: Ajou University Medical Center is a tertiary hospital that serves as a trauma center in Gyeonggido. The medical records at Ajou University Medical Center for a 1-year period from January 1, 2008, to December 31, 2008, were retrospectively reviewed. A severely injured patient was defined as a patient who showed more than 15 point on the ISS (injury severity score) scale. We investigated the clinical characteristics of such patients and the causes of transfer. Results: Out of 81,718 patients who visited the Regional Emergency Medical Center, 19,731 (24.1%) were injured patients. Among them, 108 severely-injured patients were transferred from one Regional Emergency Medical Center to other hospitals. The male-to-female ratio was about 3.5:1, and the mean ISS was 23.08. The most common mechanism of injury was traffic accidents (41.7%). A major cause of transfer was the shortage of intensive care units (44.4%); another was for emergent operation (27.8%). Most of the hospitals that received the severely-injured patients were secondary hospitals (86.1%). Conclusion: Although the Regional Emergency Medical Center played a role as a trauma center, actually, severely-injured patients had to be transferred to other hospitals for several reasons. Most reasons were related with the deficiencies in the trauma care system. If a mature trauma care system is well-organized, the numbers of transfer of severely injured patients will be reduced significantly. (J Korean Soc Traumatol 2010;23:6-15)
간암 환자에서 발생한 위장관 운동장애 및 소장내 세균과증식
이은희 ( Lee Eun Hui ),이광재 ( Lee Gwang Jae ),김도현 ( Kim Do Hyeon ),송현주 ( Song Hyeon Ju ),최준혁 ( Choe Jun Hyeog ),송영준 ( Song Yeong Jun ),김진홍 ( Kim Jin Hong ),조성원 ( Jo Seong Won ),윤준기 ( Yun Jun Gi ) 대한소화기기능성질환·운동학회 2003 Journal of Neurogastroenterology and Motility (JNM Vol.9 No.2
Gastrointestinal (GI) symptoms such as nausea, vomiting, abdominal pain, and diarrhea are common in patients with advanced liver disease. Changes of the GI function can be caused by malabsorption, GI motility disturbances, small intestinal bacterial overg
UHF 윈드프로파일러 원시 자료의 이중 스펙트럼 첨두 분리
조원기(Won-Gi Jo),권병혁(Byung-Hyuk Kwon),윤홍주(Hong-Joo Yoon) 한국전자통신학회 2019 한국전자통신학회 논문지 Vol.14 No.1
비기상 에코뿐만 아니라 강수와 같은 산란 효과가 큰 기상 에코는 윈드프로파일러 바람 자료의 오류를 유발한다. 강우 상황에서 윈드프로파일러의 도플러 스펙트럼에는 강우 신호와 대기 신호가 모두 첨두로 나타난다. 낙하하는 강우 입자에 의해서 강우 신호의 시선 속도가 매우 크게 나타난다. 강우에 의해 오염된 시선 속도는 수평 바람 벡터의 정확도를 낮추고 부정확한 기상 분석을 초래한다. 본 연구에서는 윈드프로파일러의 원시 데이터를 처리하는 알고리즘을 개발하였고, 강우 환경에서 도플러 스펙트럼에 대한 이중 첨두를 분리하여 강우 신호와 대기 신호를 구분하였다. In addition to non-meteorological echoes, meteorological echoes with large scattering effects, such as precipitation, cause errors in wind data measured by wind profiler. In the rainfall situation, the Doppler spectrum of wind profiler shows both the rainfall signal and the atmospheric signal as two peaks. The vertical radial velocity is very large due to the falling rain drop. The radial velocity contaminated by rainfall decreases the accuracy of the horizontal wind vector and leads to inaccurate weather analysis. In this study, we developed an algorithm to process raw data of wind profiler and distinguished rainfall signal and wind signal by partitioning bimodal peak for Doppler spectrum in rainfall environment.
Effect of Ovarian Extract on Oocyte Maturation and Early Embryonic Development in Pigs
Seul-Gi Yang(Seul-Gi Yang),Jae-Hun Choi(Jae-Hun Choi),Young-Seo Jo(Young-Seo Jo),Ye-Won Kim(Ye-Won Kim),Dong-Mok Lee(Dong-Mok Lee),Hyo-Jin Park(Hyo-Jin Park),Deog-Bon Koo(Deog-Bon Koo) 한국동물보건학회 2022 한국동물보건학회지 Vol.1 No.2
Various factors in the ovary are known to regulate oocyte maturation and hormone secretory functions; however, the effect of ovarian extract (OE) on oocyte maturation and embryonic development in pigs remains unknown. In this study, we first evaluated whether OE supplementation in the in vitro maturation (IVM) medium alters the oocyte maturation capacity by affecting glucose/amino acid metabolites, meiotic maturation, cumulus cell (CC) expansion, and antioxidants. Various OE concentrations (50, 100, 200, 500, and 5000 μg/mL) were included in the IVM medium. Only the oocytes treated with 100 μg/mL OE exhibited an improved meiotic maturation rate when compared with that of the other groups (non-treated group, 78.6 ± 3.0% vs. 100 μg/mL OE-treated group, 81.6 ± 4.3%); however, the difference was not significant. To observe the changes in glucose and amino acid metabolism in the OE-treated oocytes, we measured the amounts of diverse constituents (glucose, lactate, glutamine, and ammonia) in the IVM medium containing OE. Lactate and ammonia levels in the OE-treated group after 44 h of IVM were higher (p < 0.01) than those in the non-treated group. In addition, the expression of the CC expansion factors (Has2 and Tnfaip6) significantly increased (p < 0.05), whereas the mRNA expression levels of antioxidative enzymes (Sod1, Cat, and Gpx1) significantly diminished (p < 0.05) in the OE-treated group. Moreover, mature oocytes treated with 100 μg/mL OE demonstrated increased subsequent embryonic development rates after 144 h of IVM. Thus, the addition of OE in IVM mediums may improve oocyte maturation capacity which could enhance antioxidative enzyme activation, energy metabolism, and expression of the CC expansion factors in porcine oocytes.
조원기(Won Gi Jo),권병혁(Byung Hyuk Kwon),김박사(Park Sa Kim),김민성(Min Seong Kim),윤홍주(Hong Joo Yoon) 한국전자통신학회 2018 한국전자통신학회 논문지 Vol.13 No.2
고정점에서 고도별 바람을 산출할 수 있는 장비인 윈드프로파일러에 의해 관측된 바람 자료는 바람 산출 프로그램인 PCL1300을 활용하여 바람벡터로 제공된다. 현재 프로그램에 설정된 매개변수에 따른 운용의 결과는 3 km 이상 상층 대기 영역의 바람 산출이 어렵다는 것이다. 이는 매개변수에 대한 매우 엄격한 기준으로 인해 다량의 자료가 제거되기 때문이다. 본 연구에서는 바람벡터의 자료 수집 영역을 확장시키고 과소측정을 줄이기 위해 매개변수를 재설정하여 운용 방식을 개선하였다. 바람벡터의 수집률은 72.2%에서 92.2%로 증가하였음에도 풍속의 RMSE는 고도별 오차율 15% 미만에 해당하는 1.5 m/s - 3.1 m/s를 유지하였다. Wind data observed by wind profiler provide wind vectors with the altitudes using PCL1300, wind computation program. As a result of application with parameters set in program currently, it is difficult to compute wind vectors in the upper air over 3 km. This id because a very strict criterion for parameters removes large amounts of data. In this study, therefore, we improve the methods of application by resetting parameters to expand data collection area of wind vectors and reduce underestimation. Although the acquisition rate of the wind vector increased from 72.2% to 92.2%, the RMSE of the wind speed maintained 1.5 m/s - 3.1 m/s, which is less than 15% of the error rate at each altitude.
Yong Hun Jo,Bharat Bhusan Patnaik,Se Won Kang,Seunghan Oh,Dong Hyun Kim,Mi Young Noh,Gi Won Seo,Heon Cheon Jeong,Ju Young Noh,Hee Ju Hwang,Ji-Eun Jeong,Yeon Soo Han,Yong Seok Lee 한국응용곤충학회 2013 한국응용곤충학회 학술대회논문집 Vol.2013 No.10
Most traditional genome sequencing projects involving infectious viruses include culturing and purification of the virus. This can present difficulties as an analysis of multiple populations from multiple locations may be required to acquire sufficient amount of high-quality DNA for sequence analysis. The electrophoretic method provides a strategy whereby the genomic DNA sequences of the Korean isolate of Pieris rapae granulovirus (PiraGV-K) were analyzed by purifying it from host DNA by pulsed-field gel electrophoresis, thus simplifying sampling and labor time. The genomic DNA of infected P. rapae was embedded in agarose plugs, digested with a restriction nuclease and methylase, and pulsed-field gel electrophoresis (PFGE) was used to separate PiraGV-K DNA from the DNA of P. rapae, followed by mapping of fosmid clones of the separated viral DNA. The double-stranded circular genome of PiraGV-K encodes 120 open reading frames (ORFs), covering 92% of the sequenced genome. BLAST and ORF arrangement showed the presence of 78 homologs to other genes in the database. The mean overall amino acid identity of PiraGV-K ORFs was highest with the Chinese isolate of PiraGV (~99%), followed up with Choristoneura occidentalis ORFs at 58%. PiraGV-K ORFs were grouped, according to function, into 10 genes involved in transcription, 11 involved in replication, 25 structural protein genes, and 15 auxiliary genes. Genes for Chitinase (ORF 10) and cathepsin (ORF11), involved in the liquefaction of the host, were found in the genome. The recovery of PiraGV-K DNA genome by pulse-field electrophoretic separation from host genomic DNA had several advantages, compared with its isolation from particles harvested as virions or inclusions from the P. rapae host. We have sequenced and analyzed the 108,658 bp PiraGV-K genome purified by the pulsed field electrophoretic method. The method appears to be applicable to the analysis of genomes of large viruses. The chitinase, identified by PiraGV-K genome sequence, was functionally characterized by quantitative PCR, Western blot analysis, immunohistochemistry and transmission electron microscopy.
Preventive effect of Flavonoid Wogonin against Ethanol-induced Gastric Mucosal Damage in Rats
박수진 ( Park Su Jin ),여말희 ( Yeo Mal Hui ),김종수 ( Kim Jong Su ),이은희 ( Lee Eun Hui ),오태영 ( O Tae Yeong ),이기명 ( Lee Gi Myeong ),진주현 ( Jin Ju Hyeon ),조요원 ( Jo Yo Won ),함기백 ( Ham Gi Baeg ),조성원 ( Jo Seong Won 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
Whether the wogonin (5, 7-dihydroxy-8-methoxyflavone), a flavonoid originated from the root of Scutellaria baicalensis Georgi, which has been shown to have anti-inflammatory and antitumor activities in various cell types, possesss gastric cytoprotective e
Genomic and transcriptomic profiling reveal molecular characteristics of parathyroid carcinoma
Jo Se-Young,Hong Namki,Lee Seunghyun,Jeong Jong Ju,Won Jeongsoo,Park Jiho,Kim Gi Jeong,Kim Sang Kyum,Kim Sangwoo,Rhee Yumie 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Genomic and transcriptomic profiling has enhanced the diagnostic and treatment options for many cancers. However, the molecular characteristics of parathyroid cancer remain largely unexplored, thereby limiting the development of new therapeutic interventions. Herein, we conducted genomic and transcriptomic sequencing of 50 parathyroid tissues (12 carcinomas, 28 adenomas, and 10 normal tissues) to investigate the intrinsic and comparative molecular features of parathyroid carcinoma. We confirmed multiple two-hit mutation patterns in cell division cycle 73 (CDC73) that converged to biallelic inactivation, calling into question the presence of a second hit in other genes. In addition, allele-specific repression of CDC73 in copies with germline-truncating variants suggested selective pressure prior to tumorigenesis. Transcriptomic analysis identified upregulation of the expression of E2F targets, KRAS and TNF-alpha signaling, and epithelial-mesenchymal transition pathways in carcinomas compared to adenomas and normal tissues. A molecular classification model based on carcinoma-specific genes clearly separated carcinomas from adenomas and normal tissues, the clinical utility of which was demonstrated in two patients with uncertain malignant potential. A deeper analysis of gene expression and functional prediction suggested that Wilms tumor 1 (WT1) is a potential biomarker for CDC73-mutant parathyroid carcinoma, which was further validated through immunohistochemistry. Overall, our study revealed the genomic and transcriptomic profiles of parathyroid carcinoma and may help direct future precision diagnostic and therapeutic improvements.