폐와 골 전이를 동반한 후복막강 내 신외 윌름 종양 1례

정재헌,한원철,최두영,Jeong, Jae Heon,Han, Weon Cheol,Choi, Du Young 대한소아청소년과학회 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.1

저자들은 8세 남아에서 교통사고 후 우연히 발견된 혈흉과 복부 종물의 진단 과정에서 확진된 폐 및 골 전이를 동반한 후복강 내 신외 윌름 종양 1례를 경험하였기에 문헌 고찰과 함께 보고 하고자 한다. Extrarenal Wilms' tumor is a very exceptional tumor which is defined as Wilms' tumor found anywhere other than in the kidneys. Until now less than 60 cases have been reported in the English literature. The tumor can be located in the retroperitoneum, inguinal canal, uterus, cervix, testes, skin and even in the thorax. The diagnosis is almost always made after surgical intervention. Distant metastasis of this tumor has only been reported in the case of a 6-year-old girl who developed Wilms' tumor in the inguinal canal with lung involvement. In this paper we report a case of extrarenal Wilms' tumor in retroperitoneum with distant metastasis to lungs, ribs and pelvic bone in a 6-year old male. The tumor was successfully removed without tumor cell spillage. The patient was diagnosed as favorable histologic group, in which the tumor consists of epithelial, blastemal and mesenchymal components without teratomatous elements. He received combination chemotherapy according to NWTS-IV guidelines and radiation to involved lungs, and has been alive and well for the last 6 months without severe complication or relapse.

악하선의 석회화를 동반한 타액선 관암종의 세침흡인 세포학적 소견 - 1예 보고 -

윤기중,한원철,조향정,이광만,Yun, Ki-Jung,Han, Weon-Cheol,Jo, Hyang-Jeong,Lee, Kwang-Man 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1

Salivary duct carcinoma is an uncommon aggressive malignant epithelial neoplasm with similarity to intraductal carcinoma of the breast. This neoplasm occurs most often in the parotid gland of middle-aged and older males. About 7% of reported tumors occured in the submandibular gland. The report of salivary duct carcinoma with calcification is rare. We report a case of salivary duct carcinoma with calcification in the submandibular gland. The patient was a 73-year-old male with a mass of the right submandibular gland for 1 year. On the fine needle aspiration cytology, the aspirate showed scant cellularity, small clusters of tumor cells, and scattered small calcifications. Nuclei of the tumor cells showed mild pleomorphism and round to oval in shape, and cytoplasm was abundant and finely granular. Nucleoli were indistinct and necrosis was not noted. There were no cribriform or papillary arrangements of tumor cells. Cytologlc findings of salivary duct carcinoma are variable depending on histologic findings, and calcifications could be an additional cytologic findings.

무지 근위지골에 발생한 기괴 방골성 골연골성 증식증: 1예 보고

김경일,김유미,한원철,한별,Kim, Kyungil,Kim, Yu-Mi,Han, Weon-Cheol,Han, Byeol 대한족부족관절학회 2021 대한족부족관절학회지 Vol.25 No.4

Nora et al. first reported a bizarre parostealosteochondromatous proliferation (BPOP) as a small size bone malformation mainly in the foot and hand in April 1983 that was called Nora's lesion or Nora's disease. Nora's disease is known for its low incidence and is characterized as a benign lesion, without a malignancy or metastasis with different histological, radiological, and clinical features from other common lesions. Several cases of Nora's disease on the hand, foot, and long bone have been reported in Korea. This paper reports a case of BPOP of the proximal phalanx of the great toe.

수막종에서 혈관내피성장인자의 발현과 종양주변부 부종

김태영,박종태,한원철,문성근,Kim, Tae Young,Park, Jong Tae,Han, Weon Cheol,Moon, Seong Keun 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.9

Objective : Vascular endothelial growth factor(VEGF), an endothelial cell specific cytokine, is a potent angiogenic growth factor implicated in the tumor angiogenesis and increases vascular permeability dramatically. Peritumoral brain edema(PTBE) occurs in 40-60% of meningiomas. Many causative factors have been investigated, but the mechanism of PTBE associate with meningioma is unclear. VEGF has been implicated as one of the causative factors of PTBE. This study was designed to determine whether the extent of VEGF expression is correlated with degree of PTBE in meningiomas. Methods : Meningioma tissue samples from 40 patients(7 men and 33 women, mean age $53{\pm}13years$) who underwent surgery were examined retrospectively for the expression of VEGF immunohistochemically. The extent of PTBE was estimated by using preoperative CT or MRI as an edema index(EI). In addition to VEGF, several causative factors including tumor size, location, histologic type, microvasculature(CD31) were compared with EI. Results : Twenty-six meningiomas demonstrated PTBE, and the other 14 did not. Of the 40 patients of meningiomas, 28 were positive(17 were 1+ and 11 were 2+) for VEGF. The EI increased significantly just as VEGF was strongly expressed(p=0.006). Microvascular proliferation was also closely correlated with the extent of peritumoral brain edema(p<0.05). Conclusion : These data suggest that VEGF expression and microvascular proliferation are closely correlated with PTBE in meningioma.

Human IL-27p28 Gene Polymorphisms are Associated with the Serum Total IgE Levels of Allergic Rhinitis Patients

Ji-In Yu(유지인),Weon-Cheol Han(한원철),Jae-Hoon Lee(이재훈),Hun-Soo Kim(김헌수),Ki-Jung Yun(윤기중),Jae-Hoon Lee(이재훈),Hyung-Bae Moon(문형배),Soo-Cheon Chae(채수천) 한국생명과학회 2009 생명과학회지 Vol.19 No.3

인터루킨 27(IL-27)은 인터루킨 12계열의 이성이량체 사이토카인으로 EBI3와 p28의 두 서브유니트로 구성 되어있다. 인터루킨 27은 Th1 개시의 초기 조절에 관여하는 사이토카인으로 Th2 인자인 GATA-3의 작용을 억제하는 역할을 한다. 이 사이토카인은 CD4? T 림프구와 자연살해세포에서 아주 높게 발현하는 수용체(WSX-1)에 의하여 매개된다. 우리들은 사람의 IL-27p28유전자에서 네 개의 유전자다형성 부위를 찾아서 이들 유전자다형성이 기관지천식의 감수성에 영향을 미치는 것을 보고한 바 있다. 이 연구에서는 IL-27p28 유전자의 유전자다형성이 알레르기성 비염의 감수성에 영향을 미치는 지를 알아보기 위하여 이들 다형성에 있어서 알레르기성 비염환자 군과 정상인군 사이의 유전자형 및 대립형질의 빈도를 비교분석 하였다. 비록 알레르기성 비염환자 군에서 IL-27p28 유전자의 유전자다형성의 유전자형 및 대립형질의 빈도의 차는 정상인 군의 그것과 큰 차이가 없었으나, g.2905T>G SNP에서 두 그룹간에 주목할만한 차이(P=0.037)를 발견하였다. 이 결과는 IL-27p28 유전자의 g.2905T>G 유전자 형성이 알레르기성 비염환자에서 IgE의 생산에 영향을 준다는 것을 암시한다. Interleukin 27 (IL-27) was discovered as a heterodimeric cytokine of the IL-12 family, and is composed of two subunits - Epstein-Barr virus induced gene 3 (EBI3) and p28. It acts as a versatile cytokine in the early regulation of Th1 initiation and in the negative regulation of the Th2 factor GATA binding protein 3 (GATA-3). This cytokine is mediated by the IL-27 receptor (WSX-1), which is highly expressed on CD4? T lymphocytes and NK cells. We previously identified four polymorphisms in the human IL-27p28 gene and suggested that the polymorphism of IL-27p28 is associated with susceptibility to asthma. To determine whether these IL-27p28 SNPs are associated with susceptibility to allergic rhinitis, the genotype and allele frequencies of IL-27p28 SNPs were analyzed between allergic rhinitis patients and healthy controls. Although the genotype and allele frequencies of IL-27p28 SNPs in allergic rhinitis patients were not significantly different from those of the control group, there was a suggestive difference (P=0.037) between these groups in total serum IgE levels in the g.2905T>G SNP of the IL-27p28 gene. Our result implies that the g.2905T>G SNP of the IL-27p28 gene might have an affect on IgE production in allergic rhinitis patients.

성상세포종양에서 혈관내피증식인자의 발현 - 종양주변부 부종 및 미세혈관과의 상관관계 -

김태영,박종태,문성근,한원철,Kim, Tae Young,Park, Jong Tae,Moon, Seong Keun,Han, Weon Cheol 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.10

Objectives : It has been known that vascular endothelial growth factor(VEGF), as an endothelial cell-specific mitogen, induces angiogenesis, and possesses vascular permeability and procoagulant properties. Peritumoral brain edema(PTBE) is a common accompaniment of malignant gliomas. It results from microvascular extravasation of plasma and proteins through the interendothelial spaces. The correlation between pathological grading, PTBE, neovascularization, and the expression of VEGF were analyzed in 31 patients with astrocytic tumors. Methods : Astrocytic tumor samples(8 astrocytomas, 14 anaplastic astrocytomas, and 9 glioblastomas) from 31 patients( 21 males and 10 females : average age $37{\pm}24$ years) who underwent surgery were examined retrospectively for the expression of VEGF and CD31(microvasculature) immunohistochemically. The extent of PTBE was examined by using preoperative CT or MRI as an edema index(EI). In addition to VEGF and CD31, several causative factors including tumor size, histologic type were compared with EI. Results : Only one of 8 astrocytomas, and majority of high grade(21 of 23 anaplastic astrocytomas and glioblastomas) tumors demonstrated PTBE(p<0.05). The majority of high grade tumors showed higher expression of VEGF (p<0.01). High grade tumors showed even higher CD31 expression(p<0.05), however, there was no close correlation between expression of VEGF and CD31. The EI was increased significantly, just as VEGF(p<0.01), but CD31 expression was not correlated with high EI. Conclusion : These data suggest that VEGF expression is closely correlated with PTBE and histological grading in astrocytic tumors. Microvasculature(CD31) in tumors is highly correlated with histological grading, however, shows no correlation with the expression of VEGF and PTBE.

코의 첨부에 발생한 근상피종 : A case report

한원철 圓光大學校 醫科學硏究所 1997 圓光醫科學 Vol.13 No.1-2

Myoepithelioma is a rare tumor of salivary gland, accounting for less than 1 percent of all salivary gland tumors. We experienced a case of myoepithelioma of the nose. Microscopic examination showed characteristic pattern of plasmacytoid type of myoepithelioma.

모기질세포종의 세침흡입 세포학적 소견 1례

한원철,곽효일,이경근,윤기중 圓光大學校 醫科學硏究所 1998 圓光醫科學 Vol.14 No.1

Pilomatrixoma is a benign skin appendage tumor with differentiation toward hair cells, particularly hair cortex cells. Histologically, two types of basophilic and shadow cells compose the islands. The basophilic cells are round or elongated with deeply basophilic nuclei and scanty cytoplasm. Cytologically, this case showed clusters of tightly arranged basaloid cells with a uniform appearance, scanty cytoplasm and round hyperchromatic nuclei. And it may cause when attempting to establish a differential diagnosis with other neoplasms. We report the aspiration cytology findings of a case of pilomatrixoma.

결절성 근막염양 간질을 가진 갑상선의 유두상 암종 : 1예 보고 A Case Report

한원철,윤기중,문형배 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1

Papillary carcinoma of thyroid has variable morphologic variants preserving the characteristic nuclear features; encapsulated, follicular, encapsulated-follicular, diffuse sclerosing, oxyphilic, tall and columnar cell, cribriform and nodular fasciitis-like types. We report a case of papillary thyroid carcinoma with nodular fasciitis-like stroma in a 40-year old woman who had a thyroid mass. The cut surface of the lesion is white myxoid, and the microscopical findings show papillary carcinoma admixed with nodular fasciitis-like stromal cells.

위 이형성증과 선암종에서 CEA, AgNORs 및 PCNA의 진단적 의의

한원철,문형배 대한병리학회 1995 Journal of Pathology and Translational Medicine Vol.29 No.1