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Lupane-Triterpenes from the Leaves of Brassaiopsis glomerulata
Kiem, Phan-Van,Dat, Nguyen-Tien,Minh, Chau-Van,Lee, Jung-Joon,Kim, Young-Ho The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.8
Three known lupane-triterpenes, 3a-hydroxy-lup-20(29)-en-23,28-dioic acid (1), 3$\alpha$-hydroxylup-20(29)-en-23,28-dioic acid 28-Ο-$\alpha$-L-rhamnopyranosyl-(1$\rightarrow4)-\beta-D-glucopyranosyl-(1\rightarow6)-\beta$-D-glucopyranosyl ester (acankoreoside A, 2) and $3\alpha$, $11\alpha$-dihydroxy-23-oxo-lup-20(29)-en-28-oic acid (3) were isolated from the leaves of Brassaiopsis glomerulata (Blume) Regel, a species of Araliaceae family growing in Vietnam. Their structures were determined on the basis of spectroscopic data.
A New 24-Nor-Lupane-Glycoside of Acanthopanax trifoliatus
Kiem, Phan-Van,Minh, Chau-Van,Cai, Xing-Fu,Lee, Jung-Joon,Kim, Young-Ho The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.9
A new 24-nor-lupaneglycoside was isolated from the leaves of Acanthopanax trifoliatus. Based on spectroscopic data its chemical structure was determined as 24-nor-11$\alpha$-hydroxy-3-oxo-lup-20(29)-en-28-oic acid 28-Ο-$\alpha$-L-rhamnopyranosyl-(1$\rightarrow4)-\beta-D-glucopyranosyl-(1\rightarrow6)-\beta$-D-glucopyranosyl ester.
Phenolic Constituents with Inhibitory Activity against NFAT Transcription from Desmos chinensis
Kiem Phan Van,Minh Chau Van,Huang Hoang Thanh,Lee Jung Joon,Lee Im Seon,Kim Young Ho The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.12
Six phenolic constituents, 2-methoxybenzyl benzoate (1), negletein (2), 2',3'-dihydroxy-4',6'dimethoxydihydrochalcone (3), 5,6-dihydroxy-7-methoxy-dihydroflavone (4), astilbin (5), and quercitrin (6) were isolated from the methanol extract of the dried leaves of Desmos chinensis. Their structures were elucidated from spectral and chemical data. Of these constituents, compounds 2 ($IC_{50}$: 3.89 $\pm$ 0.39 $\mu$M) and 3 ($IC_{50}$: 9.77 $\pm$ 0.26 $\mu$M) exhibited potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor, and compound 1 ($IC_{50}$: 28.4 $\pm$ 2.62 $\mu$M) exhibited moderate inhibitory activity.
Chemical Constituents of Acanthus ilicifolius L. and Effect on Osteoblastic MC3T3E1 Cells
Kiem, Phan Van,Quang, Tran Hong,Huong, Tran Thu,Nhung, Le Thi Hong,Cuong, Nguyen Xuan,Minh, Chau Van,Choi, Eun-Mi,Kim, Young-Ho 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.7
A new coumaric acid derivative called acancifoliuside (1) and six known compounds as acteoside (2), isoacteoside (3), acanthaminoside (4), (+)-lyoniresinol 3a-O-$\beta$-glucopyranoside (5), (-)-lyoniresinol (6), and $\alpha$-amyrin (7), were isolated from the methanolic extract of the leaves of Acanthus ilicifolius L. (Acanthaceae). Their structures were determined by spectroscopic methods and a comparison with the spectral data reported in the literature. The effects of the compounds on the function of osteoblastic MC3T3-E1 cells were tested. Compounds 2, 3, and 5 ($30\;{\mu}M$) increased the growth and differentiation of osteoblasts significantly (P<0.05), indicating that A. ilicifolius leaves may help prevent osteoporosis.
Chemical constituents and antioxidant activity of Ficus callosa.
Van Kiem, Phan,Cuong, Nguyen Xuan,Nhiem, Nguyen Xuan,Hang, Dan Thi Thuy,Nam, Nguyen Hoai,Ban, Ninh Khac,Minh, Chau Van,Bing, Zhou,Jang, Hae Dong,Kim, Young Ho Natural Product Communications 2011 Natural product communications Vol.6 No.2
<P>One new megastigmane glycoside, ficalloside (1), and eleven known compounds, were isolated from methanol extract of Ficus callosa leaves by repeated column chromatography. Their structures were established on the basis of spectral and chemical evidence. The antioxidant activities of these compounds were measured using the oxygen radical absorbance capacity (ORAC) assay. Compound 8 exhibited potent antioxidant activity of 10.6 microM trolox equivalents at the concentration of 2 microM. At this concentration, compounds 4-7 and 9-12 showed significant antioxidant activity with ranging of 2.1-6.1 microM trolox equivalents.</P>
Chemical Constituents of the Ficus elastica Leaves and Their Antioxidant Activities
Kiem, Phan Van,Minh, Chau Van,Nhiem, Nguyen Xuan,Tai, Bui Huu,Quang, Tran Hong,Anh, Hoang Le Tuan,Cuong, Nguyen Xuan,Hai, Truong Nam,Kim, Seung-Hyun,Kim, Jin-Kyoung,Jang, Hae-Dong,Kim, Young-Ho Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.10
New Phenylpropanoid Esters of Sucrose from Polygonum hydropiper and Their Antioxidant Activity
Kiem, Phan Van,Nhiem, Nguyen Xuan,Cuong, Nguyen Xuan,Hoa, Tran Quynh,Huong, Hoang Thanh,Huong, Le Mai,Minh, Chau Van,Kim, Young-Ho 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.11
By various chromatographic methods, two new phenylpropanoid esters of sucrose named hidropiperosides A (1) and B (2), and three known compounds as vanicosides A (3), B (4), and E (5) were isolated from the methanolic extract of the whole plant of Polygonum hydropiper L. (Polygonaceae). Their structures were elucidated by extensive spectroscopic methods including 1D- and 2D-NMR experiments, as well as ESI-MS analysis. All the isolated compounds were tested for their antioxidant activity in the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging assay system. Among them, compounds 2 and 3 showed significant antioxidant activity with their $SC_{50}$ values of 23.4 and $26.7{\mu}g/mL$, respectively.
Pentacyclic Triterpenoids from Mallotus apelta
Kiem, Phan-Van,Minh, Chau-Van,Huong, Hoang-Thanh,Nam, Nguyen-Hoai,Lee, Jung-Joon,Kim, Young-Ho The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.11
A new triterpene (1) and six known pentacyclic terpenoids (2-7) were isolated from the methanol extract of the dried leaves from Mallotus apelta. Based on the spectral and chemical evidence, their structures were determined to be 3$\alpha$-hydroxyhop-22(29)-ene (1), hennadiol (2), friedelin (3), friedelanol (4), epifriedelanol (5), taraxerone (6), and epitaraxerol (7).
New Alkaloids and Anti-inflammatory Constituents from the Leaves of Antidesma ghaesembilla
Van Kiem, Phan,Cuong, Le Canh Viet,Trang, Do Thi,Nhiem, Nguyen Xuan,Le Tuan Anh, Hoang,Tai, Bui Huu,Huong, Le Mai,Van Minh, Chau,Lee, Taek Hwan,Kim, Sun Yeou NATURAL PRODUCT COMMUNICATIONS 2017 Natural product communications Vol.12 No.1
Kiem, Phan Van,Anh, Hoang Le Tuan,Nhiem, Nguyen Xuan,Minh, Chau Van,Thuy, Nguyen Thi Kim,Yen, Pham Hai,Hang, Dan Thuy,Tai, Bui Huu,Mathema, Vivek Bhakta,Koh, Young-Sang,Kim, Young Ho The Pharmaceutical Society of Japan 2012 Chemical & pharmaceutical bulletin Vol.60 No.2
<P>The rhizomes of <I>Hedychium coronarium</I> have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, two new labdanes, 15-methoxylabda-8(17),11<I>E</I>,13-trien-16,15-olide (<B>1</B>) and 16-methoxylabda-8(17),11<I>E</I>,13-trien-15,16-olide (<B>3</B>), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (<B>2</B>), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (<B>4</B>), coronarin A (<B>5</B>), and corronarin E (<B>6</B>) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds <B>1</B>—<B>3</B> were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC<SUB>50</SUB> ranging from 4.1±0.2 to 9.1±0.3 μ<SMALL>M</SMALL>. Compounds <B>1</B> and <B>3</B> showed moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC<SUB>50</SUB> values of 46.0±1.3 and 12.7±0.3 μ<SMALL>M</SMALL>. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from <I>H. coronarium</I>.</P>