도시 및 농촌 노인의 한국판 MMSE 점수에 사회인구학적 변인이 미치는 영향에 관한 연구

여형용(Hyung Yong Yeo),이강욱(Kang Yk Lee),이군희(Gun Hee Lee),주진형(Jin Hyung Jhoo),김기웅(Ki Woong Kim),이정희(Jung Hie Lee),하규섭(Kyoo Seob Ha),정도언(Do Un Jeong),김용식(Yong Sik Kim),우종인(Jong Inn Woo) 한국정신병리진단분류학회 1998 精神病理學 Vol.7 No.1

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Pharmacological interactions between intrathecal pregabalin plus tianeptine or clopidogrel in a rat model of neuropathic pain

Hyung Gon Lee,Yeo Ok Kim,Jeong Il Choi,Xue Hao Han,Yang Un Shin,Myung Ha Yoon 대한통증학회 2022 The Korean Journal of Pain Vol.35 No.1

Background: There is still unmet need in treating neuropathic pain and increasing awareness regarding the use of drug combinations to increase the effectiveness of treatment and reduce adverse effects in patients with neuropathic pain. Methods: This study was performed to determine the individual and combined effects of pregabalin, tianeptine, and clopidogrel in a rat model of neuropathic pain. The model was created by ligation of the L5-L6 spinal nerve in male Sprague–Dawley rats; mechanical allodynia was confirmed using von Frey filaments. Drugs were administered to the intrathecal space and mechanical allodynia was assessed; drug interactions were estimated by isobolographic or fixed-dose analyses. Results: Intrathecal pregabalin and tianeptine increased the mechanical withdrawal threshold in a dose-dependent manner, but intrathecal clopidogrel had little effect on the mechanical withdrawal threshold. An additive effect was noted between pregabalin and tianeptine, but not between pregabalin and clopidogrel. Conclusions: These findings suggest that intrathecal coadministration of pregabalin and tianeptine effectively attenuated mechanical allodynia in the rat model of neuropathic pain. Thus, pregabalin plus tianeptine may be a valid option to enhance the efficacy of neuropathic pain treatment.

Evaluation of hydrogen embrittlement behaviors of steel welds for pipelines in practical hydrogen environments using in-situ SP tests

Hyung-Seop Shin(신형섭),Juho Yeo(여주호),Jaewon Cho(조재원),Eunsu Min(민은수),Un-Bong Baek(백운봉) 대한용접·접합학회 2021 대한용접학회 특별강연 및 학술발표대회 개요집 Vol.2021 No.5

Recently, ANU group has established a simple screening technique for hydrogen embrittlement compatibility of steels, which is adopting an in-situ small-punch (SP) test method and corresponding to the ‘external hydrogen’ condition, and proposed a characterizing factor which is suitable for the SP test. The technique is based on the quantitative evaluation of the hydrogen embrittlement (HE) behaviors of various structural steels for hydrogen energy facilities. To investigate the HE compatibility of metallic materials, the in-situ SP tests were carried out under a high-pressure hydrogen gas environment and at the temperature ranges sensitive to HE. Through the measurement of the reduction of thickness (ROT) at the fractured part of the specimen after SP tests under both H2 and inert gas environments, the relative reduction of thickness (RRT) due to HE can be obtained. The RRT has a similar physical meaning to the relative reduction of area (RRA) obtained by the conventional slow strain-rate tensile test (SSRT), since both factors are based on the ductility induced under hydrogen environments. In this study, it is tried to investigate the hydrogen embrittlement (HE) behaviors of pipeline steels and welds by the in-situ SP test. The ductility-based RRT obtained by in-situ SP tests was used to quantify the HE sensitivity of the base metal and welds under various test conditions corresponding to practical use environments of hydrogen devices. This study will contribute to confirm the validity of in-situ SP tests as a simple test method for the quantitative evaluation of the HE susceptibility of pipeline steel welds.

인시츄 SP 시험을 사용한 오스테나이트계 스테인리스 강의 수소취화 거동에 미치는 수소압력의 영향 평가

여주호(Juho YEO),민은수(Eunsu MIN),조재원(Jaewon CHO),신형섭(Hyung-Seop SHIN),배경오(Kyung-Oh Bae),백운봉(Un-Bong Back) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.06

침윤성 자궁경부암조직에서 Ureaplasma urealyticum의 검출

김도형,김동휘,김준홍,강태경,박은동,여태홍,서남원,안은모,안선의 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.4

Objective : Mycoplasmas have been implicated in many diseases including cervicitis, urethritis, salpingitis, endometritis... and functioning as cofactors catalyzing the HIV disease state. The oncogenic potentiality of mycoplasma was only recently realized when they were shown causing chromosomal changes and in vitro cell transformations through gradual progressive chromsomal loss and translocation. Few study has been reported the prevalence of mycoplasma infection in human cancers and suggested that there was a connection between these organisms and human cancers. The objective of this study was to determine the relationship between Ureaplasma urealyticum infection and cervical cancer. Methods : The detection frequency of Ureaplasma urealyticum in 52 invasive cervical cancer tissues and 17 normal cervical tissues was studied using PCR. Results : U. urealyticum DNA was detected in 8 out of 52(15.4%) invasive cervical cancer tissues and 1 out of 17(5.9%) normal cervical tissues. No statistic significance was observed between the detection frequency of Ureaplasma urealyticum and clinicopathologic parameters. The prevalence of Ureaplasma urealyticum in invasive cervical tissues was 15.4% and this rate was higher than 5.9% in normal cervical tissues but there was no statistic significance. Conclusions : With respect to clinicopathologic parameters of cervical cancer, there was no significant relation between U. urealyticum infection and cervical cancer. There is, however, few study and case on cervical cancer internally and externally. It is considered that more studies on the subject with much cases should be made.

고압수소환경에서 인시츄 SP시험시 수소용 강의 수소취성에 미치는 표면거칠기의 영향 평가

여주호(Ju-Ho Yeo),신형섭(Hyung-Seop Shin),배경오(Kyung-Oh Bae),백운봉(Un-Bong Back) 대한기계학회 2021 대한기계학회 춘추학술대회 Vol.2021 No.11

In order to use steels for hydrogen applications, it is important to secure safety through the evaluation of the hydrogen embrittlement (HE) behaviors. Therefore, it is important to develop a simple test method to examine the HE behaviors under high-pressure hydrogen environment. From this reasons, it is necessary to understand the effect of the surface finish condition of specimens depending on fabrication processes on the HE behaviors. In this study, in addition to austenitic steels, carbon (API-X70 steel) and alloy steels (4Cr-Mo steel) are used for in-situ SP tests in high-pressure environments. The obtained load-displacement curves and absorbed SP energy until gas leakage were obtained. In addition, the relative reduction of thickness (RRT) was evaluated by measuring the thickness of the fractured part of the specimen, and the HE sensitivity depending on the surface roughness was evaluated quantitatively. As a result, it can be found that the effect of the surface roughness of specimens on the HE sensitivity was not clearly observed in both kinds of steels with austenitic and ferritic phases.

위장관 ; 건강검진 환자에서 Polyethylene Glycol with Ascorbic Acid를 이용한 대장내시경 전처치에서 Simethicone 병합, 물 1 L 추가복용의 효과 비교: 전향적 무작위 대조군 연구

여세환 ( Se Hwan Yeo ),곽재훈 ( Jae Hoon Kwak ),김여운 ( Yeo Un Kim ),권태호 ( Tae Ho Kwon ),박정배 ( Jeong Bae Park ),박준형 ( Jun Hyung Park ),이용국 ( Yong Kook Lee ),임윤정 ( Yun Jeong Lim ),양창헌 ( Chang Heon Yang ) 대한소화기학회 2016 대한소화기학회지 Vol.67 No.4

목적: 기존에 널리 사용된 PEG의 단점을 보완하고자 새롭게 도입된 PEGA에 있어 점막 내 기포 제거에 주안점을 둔 연구가 없었다. 이에 이번 연구에서 기포 제거제인 simethicone추가군과 대장 점막의 flushing 효과를 기대한 물 1리터 추가군을 두어 대장 정결도, 점막 기포도, 부작용, 환자 만족도 등을 알아보고자 하였다. 대상 및 방법: 전향적 무작위 대조 연구이며, 건강 검진을 위해 내원한 외래 수검자 90명의 환자 중 각각 30명씩 PEGA군, simethicone 추가군, 물 1리터 추가군에 무작위로 배정하여 대장 정결도, 점막 기포도, 환자가 호소하는 부작용 및 만족도를 평가하였다. 결과: PEGA군에서 대장 정결도가 가장 높았으나, 통계적 유의성은 없었다. 점막 기포도는 세 군에서 2.57±2.05 vs.1.10±1.83 vs. 2.60±2.84로 나타났으며, simethicone 추가군이 통계적으로 유의하게 점막 기포도가 낮은 것으로 나타났다(p=0.017). 환자가 호소하는 부작용은 세 군에서 20.0%vs. 16.7% vs. 53.3%로 나타났으며, 물 1리터 추가군이 다른두 군에 비해 통계적으로 유의하게 많은 것으로 나타났다(p=0.003). 환자의 만족도는 세 군에서 3.37±0.85점, 3.73±0.74점, 3.20±0.66점으로 나타났으며, 이들 중 simethicone추가군이 물 1리터 추가군보다 통계적으로 유의하게 높은 것으로 나타났다(p=0.020). 결론: PEGA가 복용량의 감소에도 불구하고 수긍할 만한 대장 정결도를 보였으며, 점막 기포 제거에 있어서 simethicone병합요법이 필요할 것으로 판단된다. Background/Aims: There are no studies that looked into the bubble eliminating efficacy of polyethylene glycol with ascorbic acid (PEGA), which has been one of the shortcomings of polyethylene glycol (PEG). In this study, we compared newly introduced PEGA regimen by adding either simethicone or 1 L of water. Methods: A prospective randomized controlled study was carried out at Dongguk Universtiy Gyeongju Hospital from July 2014 to September 2014. A total of 90 patients were randomly assigned to 3 groups; PEGA group (n=30) which served as control, simethicone addition group (n=30) to which simethicone 400 mg was additionally prescribed, and water addition group (n=30) to whom additional 1 L of water was given. Cleansing effectiveness, gas elimination efficacy, side effects, and patient satisfaction were compared between the groups. Results: PEGA group demonstrated the highest cleansing effectiveness, but there was no statistically significant difference among the groups. Simethicone addition group showed significantly lesser amount of bubbles than the other groups (2.57±2.05 vs. 1.10±1.83 vs. 2.60±2.84, p=0.017). The rates of side effects in each group were 20.00% vs. 16.77% vs. 53.33%. Water addition group had significantly more side effects than the PEGA group and the simethicone addition group (p=0.003). The patient satisfaction score of each group was 3.37±0.85 vs. 3.73±0.74 vs. 3.20±0.66 with simethicone addition group showing significantly higher satisfaction than water addition group (p=0.020). Conclusions: PEGA bowel preparation agent showed satisfactory bowel cleansing despite the decrease in dosage, and addition of simethicone resulted in better bubble elimination. (Korean J Gastroenterol 2016;67:189-197)

영지(靈芝)버섯 균사(菌絲)의 원형질체(原形質體) 나출(裸出) 및 재생(再生)

신관철,여운형,유영복,박용환,Shin, Gwan Chull,Yeo, Un Hyung,Yoo, Young Bok,Park, Yong Hwan 충남대학교 농업과학연구소 1986 Korean Journal of Agricultural Science Vol.13 No.2

영지(靈芝)버섯의 유전(遺傳) 및 신품종(新品種) 육성(育成)을 위한 기초연구(基礎硏究)로서 원형질체(原形質體) 나출(裸出)에 미치는 몇가지 요인(要因) 구명(究明)하고 원형질체(原形質體)의 재생(再生)에 관한 실험(實驗)을 실시(實施)한 결과(結果)는 다음과 같다. 1. 영지(靈芝)버섯균(菌)의 원형질체(原形質體) 나출(裸出)에 적합(適合)한 배지(培地)는 균사생장(菌絲生長)이 빠르고 기생균사(氣生菌絲)의 발달(發達)이 양호(良好)한 SCM이었다. 2. 영지(靈芝)버섯균사(菌絲)의 세포벽(細胞壁) 분해효소(分解酵素)는 Novozym 234였고 최적농도(最適濃渡)는 $10mg{\cdot}ml^{-1}$이었으며 이때 원형질체(原形質體)의 나출수(裸出數)는 $10.47{\times}10^6ml^{-1}$이었다. 3. 원형질체(原形質體) 나출(裸出)을 위한 최적(最適) 삼투압조절제는 0.6 M Suaose였고 Kcl에서 나출(裸出)된 원형질체(原形質體)는 크기가 매우컸다. 4. 영지(靈芝)버섯균(菌)은 3일간(日間) 배양(培養)한 균사체(菌絲體)에서 원형질체(原形質體)의 형성(形成)이 최대(最大)였고 분해효소액과의 반응시간(反應時間)은 3시간(時間)이 가장 좋았다. 5. 나출(裸出)된 원형질체(原形質體)는 MCM, MMM 및 SCM 배지(培地)에서 0.2~0.27%의 재생율(再生率)을 보였다. 6. 원형질체(原形質體)에서 재생(再生)된 균주(菌株)의 13~29%는 Monokaryon 균주이었다. Some factors affecting the protoplast release from mycelia of Ganoderma lucidum and regeneration of the protoplast were investigated and the results obtained are summarized as follows; Novozym 234 as a lytic enzyme was the most effective for the protoplast release from mycelia of Ganoderma lucidu m and its optimal concentration was 10mg per ml of osmotic stabilizer. The highest number of protoplasts were released after 3 hours incubation in the reciprocal shaking bath at 120 oscillations a minute. Among six osmotic stabilizers tested, 0.6M sucrose showed the best result. SCM medium showed good mycelial growth and high yields of protoplasts. The protoplasts released from the mycelium of G. lucidum were regenerated at 0.20 to 0.27 percent on MCM, MMM and SCM. Of the cultures obtained from protoplasts regenerated, 13 to 29 percent were monokaryon.

온라인 리뷰 분석을 통한 상품 평가 기준 추출: LDA 및 k-최근접 이웃 접근법을 활용하여

이지현(Ji Hyeon Lee),정상형(Sang Hyung Jung),김준호(Jun Ho Kim),민은주(Eun Joo Min),여운영(Un Yeong Yeo),김종우(Jong Woo Kim) 한국지능정보시스템학회 2020 지능정보연구 Vol.26 No.1

Product evaluation criteria is an indicator describing attributes or values of products, which enable users or manufacturers measure and understand the products. When companies analyze their products or compare them with competitors, appropriate criteria must be selected for objective evaluation. The criteria should show the features of products that consumers considered when they purchased, used and evaluated the products. However, current evaluation criteria do not reflect different consumers’ opinion from product to product. Previous studies tried to used online reviews from e-commerce sites that reflect consumer opinions to extract the features and topics of products and use them as evaluation criteria. However, there is still a limit that they produce irrelevant criteria to products due to extracted or improper words are not refined. To overcome this limitation, this research suggests LDA-k-NN model which extracts possible criteria words from online reviews by using LDA and refines them with k-nearest neighbor. Proposed approach starts with preparation phase, which is constructed with 6 steps. At first, it collects review data from e-commerce websites. Most e-commerce websites classify their selling items by high-level, middle-level, and low-level categories. Review data for preparation phase are gathered from each middle-level category and collapsed later, which is to present single high-level category. Next, nouns, adjectives, adverbs, and verbs are extracted from reviews by getting part of speech information using morpheme analysis module. After preprocessing, words per each topic from review are shown with LDA and only nouns in topic words are chosen as potential words for criteria. Then, words are tagged based on possibility of criteria for each middle-level category. Next, every tagged word is vectorized by pre-trained word embedding model. Finally, k-nearest neighbor case-based approach is used to classify each word with tags. After setting up preparation phase, criteria extraction phase is conducted with low-level categories. This phase starts with crawling reviews in the corresponding low-level category. Same preprocessing as preparation phase is conducted using morpheme analysis module and LDA. Possible criteria words are extracted by getting nouns from the data and vectorized by pre-trained word embedding model. Finally, evaluation criteria are extracted by refining possible criteria words using k-nearest neighbor approach and reference proportion of each word in the words set. To evaluate the performance of the proposed model, an experiment was conducted with review on ‘11st’, one of the biggest e-commerce companies in Korea. Review data were from ‘Electronics/Digital’ section, one of high-level categories in 11st. For performance evaluation of suggested model, three other models were used for comparing with the suggested model; actual criteria of 11st, a model that extracts nouns by morpheme analysis module and refines them according to word frequency, and a model that extracts nouns from LDA topics and refines them by word frequency. The performance evaluation was set to predict evaluation criteria of 10 low-level categories with the suggested model and 3 models above. Criteria words extracted from each model were combined into a single words set and it was used for survey questionnaires. In the survey, respondents chose every item they consider as appropriate criteria for each category. Each model got its score when chosen words were extracted from that model. The suggested model had higher scores than other models in 8 out of 10 low-level categories. By conducting paired t-tests on scores of each model, we confirmed that the suggested model shows better performance in 26 tests out of 30. In addition, the suggested model was the best model in terms of accuracy. This research proposes evaluation criteria extracting method that combines topic extraction using LDA and refinement with k-near

[세션초청논문] Evaluation of Hydrogen Embrittlement Behaviors in Different Grade Pipeline Steels using in-situ Small Punch Test

Nick Anthony Custodio(닉 안토니),Ju-Ho Yeo(여주호),Hyung-Seop Shin(신형섭),Un-Bong Baek(백운봉) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.11